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Lu Xu,Chun-Qing Zhao,De-Jin Xu,Guang-Chun Xu,Xiao-Long Xu,Zhao-Jun Han,Ya-Nan Zhang,Zhong-Yan Gu 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.2
Nuclear receptors (NRs), which belong to a superfamily of ligand-dependent transcription factors, play essential roles in gene regulation to affect numerous physiological pathways. Twenty NR genes were identified in Nilaparvata lugens by using genomic, transcriptomic and GenBank databases, and categorized into NR0-NR6 subfamilies according to standard nomenclature. Among them, three NR geneswere classed into NR0, four into NR1, eight into NR2, one into NR3, one into NR4, two into NR5, and one into NR6, respectively. A phylogenetic tree of NRs from N. lugens and other representative species was constructed, which provided evolutionary insight into genetic distance. In order to investigate the NRs,whichwere induced by sulfoxaflor, time- and tissue-specific expression profiles of NR genes in fourth-instar nymphs were determined following LD50 sulfoxaflor treatment (0.28 ng/insect) and compared with control samples. NlUSP, NlE78, NlTLL, NlHR51, NlHR83, NlPNR and NlFTZ-F1 were highly expressed following 12–48 h of sulfoxaflor treatment. NlHR39 and NlDSF transcripts were detected in the head and the thorax, respectively. High-level and constitutive expression of NlHR3, NlTLL, NlHR83, NlFTZF1 and NlHR4 were found in the abdomen. Feeding of dsRNAs reduced the expression of NlHR3, NlUSP, NlTLL, NlHR83, NlPNR, NlFTZ-F1 and NlHR4 (35.48–49.77%) and caused significant nymph mortality (69.21–81.45%). These NRs, considered as insecticide targets, may play important function in sulfoxaflor detoxification.
서아함(Xu ya han),이동훈(Lee dong hun) 한국콘텐츠학회 2009 한국콘텐츠학회 종합학술대회 논문집 Vol.7 No.1
본 논문은 중국의 ‘和’ 문화사상에서 ‘和’ 라는 자형의 변천으로부터, 기하학 도형으로서의 ‘和’, 동음어의 문화속의 ‘和’, 설화속의 ‘和’ 라는 틀을 통해 ‘和’ 문화사상에 내재된 그 역사적 의미와 내포된 뜻을 알아본다. 또한 전통예술 속에서의 ‘和’ 문화의 표현방식과 2008년 북경 올림픽개막식 속에 나타난 ‘和’ 문화가 현대 중국의 사회문화적 이해의 주요 키워드로 사용되고 있음을 개막식 공연의 다양한 ‘和’ 의 시각적 이미지의 분석을 통해 알아본다. The article is based on the research of the he culture and has discussed the prospect and possibility of application of cultural element "He" in modern design through analyzing the Beijing Olympics' cultural element "He" from its Chinese character's changing forms to its connotation; and the application of the element "He" in traditional design as geometrical figures, homophonic usage, and some legends on it.
( Xin-fei Xu ),( Jiong-jie Yu ),( Ju-dong Li ),( Hao Xing ),( Jun Han ),( Zhen-li Li ),( Han Wu ),( Han Zhang ),( Jian-hong Zhong ),( Yi- Sheng Huang ),( Ya-hao Zhou ),( Ting-hao Chen ),( Hong Wang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Late recurrence (> 2 years) after liver resection of hepatocellular carcinoma (HCC) is usually considered as multi-centric tumors or de novo cancer formation. We aimed to investigate risk factors, patterns and outcomes of late recurrence after HCC resection. Methods: From a multicenter database from 2001 to 2015, 734 patients who were alive and recurrence-free at 2 years after curative resection of initial HCC were enrolled into this retrospective study. Univariate and multivariate Cox-regression analysis were used to identify independent risk factors of late recurrence. Patterns, treatments and outcomes of late recurrence were investigated and analyzed. Results: During a median follow-up of 78.0 months after surgery, 303 patients (41.3%) developed late recurrence. Multivariate analysis revealed that cirrhosis, macroscopic vascular invasion, satellites, and tumor size > 5cm were independent risk factors of late recurrence. Among them, 273 (90.1%) were sole intrahepatic recurrence, 30 (9.9%) were concurrent intrahepatic and extrahepatic recurrence, and none of them was sole extrahepatic recurrence; 165 (54.4%) patients received curative treatments for recurrent HCC, including re-resection, transplantation and local ablation. Multivariate analysis showed regular postoperative surveillance and receiving curative treatments were two independent protective factors of prolonging survival for those patients with late recurrence. Conclusions: Late recurrence is correlated with cirrhosis and certain tumor-related characteristics of initial HCC. The patterns of late recurrence suggest that postoperative surveillance after 2 years of surgery could be adjusted and more targeted. Regular postoperative surveillance improves the probability to receive curative treatments again, yielding to better outcomes for patients with late recurrence.
Ya-Lin Kong,Ying Xing,Jie Li,Cheng-Li Liu,Xiao-Jun He,Cheng Wang,Jiang-Min Chen,Ling-Hong Kong,Xu Han,Hong-Yi Zhang 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.10
Purpose: We compared the clinical outcomes of modified procedures for associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) based on a risk-reduced strategy with those of classic ALPPS procedures in treating large liver carcinoma. Materials and Methods: Short-term outcomes, increases in future liver remnant (FLR) and functional FLR (FFLR), and overall survival (OS) were compared between 45 consecutive patients treated with modified ALPPS procedures and 34 patients treated with classic ALPPS procedures. Results: Clinical outcomes after the 1st-stage operation markedly improved with the modified procedures. Although the proportions of liver cirrhosis and hepatocellular carcinoma were higher in the modified group, the mortality and incidence of severe complications did not increase. FLR and FFLR hypertrophy at 1 week after the 1st-stage operation were similar in both groups; however, kinetic growth rates in the modified group were lower. OS rates were similar. Conclusion: Modified ALPPS procedures could be safely applied to provide long-term survival for patients with liver cirrhosis without sufficient FLR.
Xu-hu Wang,Jian-feng Chen,Jing Han,Ya-meng Jiao 대한조선학회 2014 International Journal of Naval Architecture and Oc Vol.6 No.1
The optimization techniques are explored in the direction of arrival (DOA) estimation based on single acoustic pressure gradient vector sensor (APGVS). By analyzing the working principle and measurement errors of the APGVS, acoustic intensity approaches (AI) and the minimum variance distortionless response beamforming approach based on single APGVS (VMVDR) are deduced. The radius to wavelength ratio of the APGVS must be not bigger than 0.1 in the actual application, otherwise its DOA estimation performance will degrade significantly. To improve the ro-bustness and estimation performance of the DOA estimation approaches based on single APGVS, two modified proce-ssing approaches based on single APGVS are presented. Simulation and lake trial results indicate that the performance of the modified approaches based on single APGVS are better than AI and VMVDR approaches based on single APGVS when the radius to wavelength ratio is not bigger than 0.1, and the two modified DOA estimation methods have excel¬lent estimation performance when the radius to wavelength ratio is bigger than 0.1.
Kim, Han-Joon,Kim, Chung-Ho,Hao, Tianyao,Liu, Lihua,Kim, Kwang-Hee,Jun, Hyunggu,Jou, Hyeong-Tae,Moon, Sunghoon,Xu, Ya,Wu, Zhiqiang,Lu, Chuanchuan,Lee, Sang Hoon Elsevier 2019 Journal of Asian earth sciences Vol.180 No.-
<P><B>Abstract</B></P> <P>Two major tectonic units in NE Asia are the Sino-Korean (or North China) and South China Blocks that collided in the Permo-Triassic periods. The South China Block is suggested to extend eastward to the Korean Peninsula across the southern Yellow Sea. The Gunsan Basin is a well-defined, fault-bounded sedimentary basin in the SE Yellow Sea and is regarded as a structural link of the South China Block to the Korean Peninsula. We collected deep seismic sounding data recorded on ocean bottom seismometers to investigate how the crustal structure and nature of the South China Block vary in the Gunsan Basin toward the middle part of the Korean Peninsula. The main part of the Gunsan Basin is underlain by relatively thin (∼10 km thick) upper and much thicker (∼20 km thick) lower crustal layers, indicating a close affinity to the South China Block; whereas it shows distinction from the Korean Peninsula underlain by upper and lower crustal layers with equal (∼15 km) thickness. A change in crustal structure is recognized under the eastern margin of the Gunsan Basin toward the Korean Peninsula, that features a transition to the Korean Peninsula. The thick lower crustal layer in the Gunsan Basin appears to be inherited from the evolution of the South China Block including crustal shortening associated with the assembly of Rodinia in the Neoproterozoic before the collision between the Sino-Korean and South China Blocks.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We image how the crustal stucture nature vary in the SE Yellow Sea. </LI> <LI> The Gunsan Basin is underlain by relatively thin upper and much thick lower crustal layers. </LI> <LI> A transition in crustal structure is recognized from the South China Block to the Korean Peninsula. </LI> <LI> The crustal structure is inherited from the growth of Rodinia. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Wang, Xu-Hu,Chen, Jian-Feng,Han, Jing,Jiao, Ya-Meng The Society of Naval Architects of Korea 2014 International Journal of Naval Architecture and Oc Vol.6 No.1
The optimization techniques are explored in the direction of arrival (DOA) estimation based on single acoustic pressure gradient vector sensor (APGVS). By analyzing the working principle and measurement errors of the APGVS, acoustic intensity approaches (AI) and the minimum variance distortionless response beamforming approach based on single APGVS (VMVDR) are deduced. The radius to wavelength ratio of the APGVS must be not bigger than 0.1 in the actual application, otherwise its DOA estimation performance will degrade significantly. To improve the robustness and estimation performance of the DOA estimation approaches based on single APGVS, two modified processing approaches based on single APGVS are presented. Simulation and lake trial results indicate that the performance of the modified approaches based on single APGVS are better than AI and VMVDR approaches based on single APGVS when the radius to wavelength ratio is not bigger than 0.1, and the two modified DOA estimation methods have excellent estimation performance when the radius to wavelength ratio is bigger than 0.1.
Ying-Ya Cao,Zhong-Han Wang,Qian-Cheng Xu,Qun Chen,Zhen Wang,Wei-Hua Lu 대한생리학회-대한약리학회 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.4
The intestinal barrier function disrupted in sepsis, while little is known about the variation in different phases of sepsis. In this study, mouse models of sepsis were established by caecal ligation and puncture (CLP). The H&E staining of sections and serum diamine oxidase concentration were evaluated at different timepoint af-ter CLP. TUNEL assay and EdU staining were performed to evaluate the apoptosis and proliferation of intestinal epithelium. Relative protein expression was assessed by Western blotting and serum concentrations of pro-inflammatory cytokines was mea-sured by ELISA. The disruption of intestinal barrier worsened in the first 24 h after the onset of sepsis and gradually recovered over the next 24 h. The percentage of apop-totic cell increased in the first 24 h and dropped at 48 h, accompanied with the prolif-erative rate of intestinal epithelium inhibited in the first 6 h and regained in the later period. Furthermore, the activity of nuclear factor kappa B (NF-κB) presented similar trend with the intestinal barrier function, shared positive correction with apoptosis of intestinal epithelium. These findings reveal the conversion process of intestinal barrier function in sepsis and this process is closely correlated with the activity of NF-κB signaling.
Jiao, De-Chao,Zhou, Qi,Han, Xin-Wei,Wang, Ya-Feng,Wu, Gang,Ren, Jian-Zhuang,Wang, Yan-Li,Ding, Peng-Xu,Ma, Ji,Fu, Ming-Ti Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2
To evaluate efficacy of microwave ablation in a primary clinical study, sixty patients (44 men, 16 women; mean age 53 years) with 96, 1-8 cm (mean $3.20{\pm}0.17$ cm) liver cancers were treated with 2,450-MHz internally cooled-shaft antenna. Complete ablation (CA) and local tumor progression (LTP) rates as well as complications were determined. CA rates in small (< 3.0 cm), intermediate (3.1-5.0 cm) and large (5.1-8.0 cm) liver cancers were 96.4% (54/56), 92.3% (24/26) and 78.6% (11/14), respectively. During a mean follow-up period of $17.17{\pm}6.52$ months, LTP occurred in five (5.21%) treated cases. There was no significant difference in the CA and LTP rates between the HCC and liver metastasis patient subgroups (P<0.05). Microwave ablation provides a reliable, efficient, and safe technique to perform hepatic tumor ablation.