http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( L. Wei ),( F. Wang ),( M. Zhang ),( J. Jia ),( A.A. Yakovlev ),( W. Xie ),( E.Z. Burnevich ),( J. Niu ),( Y.J. Jung ),( X. Jiang ),( M. Xu ),( X. Chen ),( Q. Xie ),( J. Li ),( J. Hou ),( H. Tang ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Background/Aims: Treatment-naive GT 1b-infected patients from mainland China, South Korea and Russia were assessed for SVR at follow-up week 12 (SVR12) after receiving daclatasvir (60 mg, QD) and asunaprevir (100 mg, BID) (DCV+ASV). Methods: Patients were randomized 3:1 to receive DCV+ASV (24 weeks; immediate treatment [IM]) or 12 weeks of placebo followed by DCV+ASV (24 weeks; placebo-deferred treatment [PD]). The primary endpoint was to evaluate SVR12 in the IM arm to the historical rate for peginterferon/ribavirin (70%). Secondary endpoints included overall safety and safety comparisons between the treatment arms during the first 12 weeks. Results: 207 patients were randomized to IM (n=155) or PD (n=52); Asian (86%), female (59%), IL28B CC genotype (68%) and median age 49 (range 18-73) years; cirrhosis (13%), HCV RNA ≥6x106 IU/mL (53%). SVR12 in the IM arm was 92% and broadly unaffected by most baseline factors assessed (Figure); SVR12 was higher in patients without (96%) baseline NS5A-L31M/V or Y93H polymorphisms. There were 6 virologic breakthroughs, 6 relapses and 1 detectable HCV RNA at end-of-treatment in the IM arm. Safety was mostly comparable between the two arms during the first 12 weeks. The most frequent adverse events (AEs; ≥5%) during DCV+ASV (24 weeks) treatment in both arms were aminotransferase, bilirubin and INR elevations, hypertension, fatigue and respiratory tract infections; the most frequent treatment-emergent grade 3/4 laboratory abnormalities were aminotransferase (≤4.5%) and hematologic, lipase and total bilirubin abnormalities (≤2%); one patient (IM) discontinued DCV+ASV for aminotransferase elevations, nausea and jaundice (all reversible); one patient PD) discontinued DCV+ASV for a fatal AE unrelated to treatment. Conclusions: These data demonstrate that DCV+ASV is a highly efficacious and well tolerated treatment for treatment-naive HCV GT 1b-infected patients. Those treated immediately with DCV+ASV achieved a 92% SVR12 rate which was unaffected by factors known to attenuate response to interferon.
Isomer spectroscopy of neutron-rich <sup>168</sup>Tb<sub>103</sub>
Gurgi, L.A.,Regan, P.H.,Sö,derströ,m, P.-A.,Watanabe, H.,Walker, P.M.,Podolyá,k, Zs.,Nishimura, S.,Berry, T.A.,Doornenbal, P.,Lorusso, G.,Isobe, T.,Baba, H.,Xu, Z.Y.,Sakurai, H.,Sumikama Elsevier 2017 Radiation physics and chemistry Vol.140 No.-
<P>In-flight fission of a 345 MeV per nucleon U-238 primary beam on a 2 mm thick Be-9 target has been used to produce and study the decays of a range of neutron-rich nuclei centred around the doubly mid-shell nucleus Dy-170 at the RIBF Facility, RIKEN, Japan. The produced secondary fragments of interest were identified event by-event using the BigRIPS separator. The fragments were implanted into the WAS3ABI position sensitive silicon active stopper which allowed pixelated correlations between implants and their subsequent beta-decay. Discrete gamma-ray transitions emitted following decays from either metastable states or excited states populated following beta decay were identified using the 84 coaxial high-purity germanium (HPGe) detectors of the EURICA spectrometer, which was complemented by 18 additional cerium-doped lanthanum bromide (LaBr3) fast-timing scintillation detectors from the FATIMA collaboration. This paper presents the internal decay of a metastable isomeric excited state in the odd-odd nucleus Tb-168, which corresponds to a single proton-neutron hole configuration in the valence maximum nucleus Dy-170. These data represent the first information on excited states in this nucleus, which is the most neutron-rich odd-odd isotope of terbium (Z=65) studied to date. Nilsson configurations associated with an axially symmetric, prolate-deformed nucleus are proposed for the Tb-168 ground state the observed isomeric state by comparison with Blocked BCS-Nilsson calculations.</P>
Xu, Y.,Lee, J.,Yang, H.S.,Lu, Z.R.,Mu, H.,Yang, J.M.,Zhang, Q.,Park, Y.D. Elsevier Science B.V., Amsterdam. 2016 PROCESS BIOCHEMISTRY Vol.51 No.6
In order to gain more insight into the relation between the structure of acetaldehyde dehydrogenase 1 (ALDH1) and its catalytic and regional active site properties, the denaturant guanidine hydrochloride (GdnHCl) was employed in this study. The effects of GdnHCl on ALDH1 conformational and functional changes were evaluated by kinetic analysis and by performing computational molecular dynamics (MD) simulations. We found that direct binding of GdnHCl to ALDH1 induced complete inactivation prior to conspicuous changes in its tertiary structure or hydrophobic exposure, indicating that the active site is flexible compared to the overall structure. Kinetic experimental results and computational simulations indicated that there are specific sites on ALDH1 to which guanidine binds, resulting in blocking of catalytic function without a large degree of structural disruption. These sites may lay specifically in a cofactor-binding region, which was suggested by the observation of mixed-type inhibition. Our study provides insight into the flexibility of the ALDH1 active site through the use of GdnHCl denaturant and computational simulations to suggest possible binding mechanisms of inhibitors for the clinical applications.
Study on the Cooling Performance with Various Coolants of a Ball Screw
Z. Z. Xu,김수상(S. S. Kim),윤기백(G. B. Yun),이인범(Y. B. Lee),류성기(S. K. Lyu) 한국정밀공학회 2012 한국정밀공학회 학술발표대회 논문집 Vol.2012 No.5월
The demand for higher productivity and tight part tolerances requires machine tools to have faster and more accurate feed drive system. As tried and tested technology, ball screw drive systems are still used in majority of machine tools due to their low cost and high stiffness. A high speed ball screw system generates more heat naturally and resultant more thermal expansion, which adversely affects the accuracy of positioning. Therefore, a center hole cooling system was set in ball screw shaft in this paper to dominate the thermal error and achieve temperature equilibrium faster. With the aim to achieve temperature equilibrium faster on the ball screw system to improve the positioning error, a simple structure and low-cost air cooling system was set in the ball screw shaft. The main idea of the air cooling method is that through ball screw center hole air injection to obtain more convection heat loss, so the heat gain-loss balance will be achieve faster which produces a position error directly. In this paper, a liquid/air-cooling system was set in a bulk production center hole ball screw drive system to achieve cooling effect. Circulation and forced cooling methods were employed to perform ball screw shaft cooling to guarantee the positioning error.