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Watanabe, H.,Lorusso, G.,Nishimura, S.,Otsuka, T.,Ogawa, K.,Xu, Z. Y.,Sumikama, T.,Sö,derströ,m, P.-A.,Doornenbal, P.,Li, Z.,Browne, F.,Gey, G.,Jung, H. S.,Taprogge, J.,Vajta, Zs.,Wu, J.,Yagi, American Physical Society 2014 Physical Review Letters Vol.113 No.4
<P>A new isomer with a half-life of 23.0(8) ms has been identified at 2406 keV in (126)Pd and is proposed to have a spin and parity of 10(+) with a maximally aligned configuration comprising two neutron holes in the 1h(11/2) orbit. In addition to an internal-decay branch through a hindered electric octupole transition, β decay from the long-lived isomer was observed to populate excited states at high spins in (126)Ag. The smaller energy difference between the 10(+) and 7(-) isomers in (126)Pd than in the heavier N=80 isotones can be interpreted as being ascribed to the monopole shift of the 1h(11/2) neutron orbit. The effects of the monopole interaction on the evolution of single-neutron energies below (132)Sn are discussed in terms of the central and tensor forces.</P>
Fertility sparing surgery in early stage epithelial ovarian cancer
Antonino Ditto,Fabio Martinelli,Domenica Lorusso,Edward Haeusler,Marialuisa Carcangiu,Francesco Raspagliesi 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.4
Objective: Fertility sparing surgery (FSS) is a strategy often considered in young patients with early epithelial ovarian cancer. We investigated the role and the outcomes of FSS in eEOC patients who underwent comprehensive surgery. Methods: From January 2003 to January 2011, 24 patients underwent fertility sparing surgery. Eighteen were one-to-one matched and balanced for stage, histologic type and grading with a group of patients who underwent radical comprehensive staging (n=18). Demographics, surgical procedures, morbidities, pathologic findings, recurrence-rate, pregnancy-rate and correlations with disease-free survival were assessed. Results: A total of 36 patients had a complete surgical staging including lymphadenectomy and were therefore analyzed. Seven patients experienced a recurrence: four (22%) in the fertility sparing surgery group and three (16%) in the control group (p=not significant). Sites of recurrence were: residual ovary (two), abdominal wall and peritoneal carcinomatosis in the fertility sparing surgery group; pelvic (two) and abdominal wall in the control group. Recurrences in the fertility sparing surgery group appeared earlier (mean, 10.3 months) than in radical comprehensive staging group (mean, 53.3 months) p<0.001. Disease-free survival were comparable between the two groups (p=0.422). No deaths were reported. All the patients in fertility sparing surgery group recovered a regular period. Thirteen out of 18 (72.2%) attempted to have a pregnancy. Five (38%) achieved a spontaneous pregnancy with a full term delivery. Conclusion: Fertility sparing surgery in early epithelial ovarian cancer submitted to a comprehensive surgical staging could be considered safe with oncological results comparable to radical surgery group.
Watanabe, H.,Wang, H.K.,Lorusso, G.,Nishimura, S.,Xu, Z.Y.,Sumikama, T.,Sö,derströ,m, P.-A.,Doornenbal, P.,Browne, F.,Gey, G.,Jung, H.S.,Taprogge, J.,Vajta, Zs.,Wu, J.,Yagi, A.,Baba, H.,Benzon Elsevier 2019 Physics letters: B Vol.792 No.-
<P><B>Abstract</B></P> <P>The neutron-rich isotopes of palladium have attracted considerable interest in terms of the evolution of the N = 82 neutron shell closure and its influence on the <I>r</I>-process nucleosynthesis. In this Letter, we present the first spectroscopic information on the excited states in <SUP>125</SUP>Pd<SUB>79</SUB> and <SUP>127</SUP>Pd<SUB>81</SUB> studied using the EURICA <I>γ</I>-ray spectrometer, following production via in-flight fission of a high-intensity <SUP>238</SUP>U beam at the RIBF facility. New isomeric states with half-lives of 144(4) ns and 39(6) μs have been assigned spins and parities of ( 23 / <SUP> 2 + </SUP> ) and ( 19 / <SUP> 2 + </SUP> ) in <SUP>125</SUP>Pd and <SUP>127</SUP>Pd, respectively. The observed level properties are compared to a shell-model calculation, suggesting the competition between proton excitations and neutron excitations in the proton-hole and neutron-hole systems in the vicinity of the doubly magic nucleus <SUP>132</SUP>Sn.</P>
A critical assessment on the role of sentinel node mapping in endometrial cancer
Giorgio Bogani,Antonino Ditto,Fabio Martinelli,Mauro Signorelli,Stefania Perotto,Domenica Lorusso,Francesco Raspagliesi 대한부인종양학회 2015 Journal of Gynecologic Oncology Vol.26 No.4
Endometrial cancer is the most common gynecologic malignancy in the developed countries. Although the high incidence of this occurrence no consensus, about the role of retroperitoneal staging, still exists. Growing evidence support the safety and efficacy of sentinel lymph node mapping. This technique is emerging as a new standard for endometrial cancer staging procedures. In the present paper, we discuss the role of sentinel lymph node mapping in endometrial cancer, highlighting the most controversies features.
βdecay ofCd129and excited states inIn129
Taprogge, J.,Jungclaus, A.,Grawe, H.,Nishimura, S.,Doornenbal, P.,Lorusso, G.,Simpson, G. S.,Sö,derströ,m, P.-A.,Sumikama, T.,Xu, Z. Y.,Baba, H.,Browne, F.,Fukuda, N.,Gernhä,user, R.,Gey, American Physical Society 2015 PHYSICAL REVIEW C - Vol.91 No.5
Alice Indini,Lorenza Di Guardo,Carolina Cimminiello,Domenica Lorusso,Francesco Raspagliesi,Michele Del Vecchio 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.6
Objective: immunotherapy with immune checkpoint inhibitors has become one of thestandard therapeutic modalities for patients with advanced melanoma. Melanoma of thefemale lower genital tract is a rare and aggressive disease, with poor long-term clinicaloutcomes. To date, no study evaluated the role of immunotherapy in metastatic melanoma ofthe lower genital tract. Methods: Data of women with metastatic melanoma of the lower genital tract wereprospectively collected. Survival outcomes over time was assessed using Kaplan-Meier model. Results: Seven cases of metastatic melanoma of the lower genital tract (vulva [n=2], vagina[n=4], and uterine cervix [n=1]) treated with immune checkpoint inhibitors are reviewed. Two patients had metastatic disease at diagnosis, while 5 patients developed metastaticdisease at a mean (standard deviation) time of 9.9 (±3.0) months from primary diagnosis. Four patients received an anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA4)(ipilimumab) and 3 received an anti-programmed cell death 1 (PD-1) (pembrolizumab[n=2], nivolumab [n=1]) therapy. The response rate to immunotherapy was 28.5%. Patientsreceiving an anti-PD-1 experienced a better progression-free survival than patients treatedwith anti-CTLA4 (p=0.01, log-rank test). Although not reaching statistical significance,overall survival was better in patients having an anti-PD-1 therapy in comparison to anti-CTLA4 (p=0.15, log-rank test). Conclusion: Results from our series confirm the poor prognosis of women with metastaticmelanoma of the lower genital tract, thus supporting the need of exploring newtreatment modalities. Further studies are warranted to improve knowledge on the role ofimmunotherapy in metastatic melanoma of the lower genital tract.