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Yingran Liang,Yuanyuan Zhang,Miaomiao Liu,Xue Han,Jianping Zhang,Xuan Zhang,Li Chu 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.8
Many studies describe the stimulating eff ect ofquercetin on Ca 2+ channels and the treatment of cardiovasculardiseases such as myocardial ischemia and hypertension. However, these studies are scattered and contradictory. The aim of this study is to elucidate the protective eff ects ofquercetin against isoproterenol (ISO)-induced myocardialischemia and verify the cellular mechanisms based on theL-type Ca 2+ channel (LTCC), Ca 2+ transients, and myocardialcontractility. An animal model of myocardial ischemiawas established by subcutaneous injection of ISO for 2 days. Quercetin significantly reduced J-point elevation, heartrate, reactive oxygen species, serum levels of myocardialenzymes, superoxide dismutase, catalase, glutathione, glutathioneperoxidase, glutathione S-transferase and improvedheart pathologic morphology. L-type Ca 2+ current (I Ca-L )was tested in an experiment with isolated rat myocardialcells by using the whole-cell patch-clamp recording techniqueand IonOptix Myocam detection system. Quercetin reduced I Ca-L in a concentration-dependent fashion with ahalf-maximal inhibitory concentration of 4.67 × 10 –4 M. Quercetin also shifted the current–voltage curve upwards,moved the activation and inactivation curves to the left andinhibited the amplitude of the cell shortening and Ca 2+ transients. The results showed that quercetin acts as a LTCCinhibitor and exerts a cardioprotective eff ect by inhibitingCa 2+ infl ux and contractility in rats.
Jun Li,Liang Zhang,Xiao-Wen Zhang,Hao Zhang,Xue-Yin Jiang,Dong-bin Yu,Wen-Qing Zhu,Zhi-Lin Zhang 한국물리학회 2010 Current Applied Physics Vol.10 No.5
Bottom-contact (BC) copper phthalocyanine (CuPc) thin film transistor with UV/ozone treated Au as a source/drain electrode was fabricated and the contact resistance was estimated from the transmission line method (TLM). Comparing the properties of OTFT with untreated Au electrode, the performance of the BC CuPc-TFT with the UV/ozone treated Au electrodes was significantly improved: saturation mobility increased from 4.69 × 10−3 to 2.37 × 10−2 ㎠/V s, threshold voltage reduced from −29.1 to −6.4 V, and threshold swing varied from 5.08 to 2.25 V/decade. The contact resistance of the device with UV/ozone treated Au electrodes was nearly 20 times smaller than that of the device with untreated Au electrodes at the gate voltage of −20 V. This result indicated that using the UV/ozone treated Au electrode is an effective method to reduce the contact resistance. The present BC configuration with UV/ozone treated Au electrodes could be a significant step towards the commercialization of OTFT technology.
Synthesis and characterization of TiC powders by sol-gel method
Liang Gao,Yun Zhang,Xue Yang,YanBin He,LiHua Song 한양대학교 세라믹연구소 2020 Journal of Ceramic Processing Research Vol.21 No.6
TiC powders were successfully synthesized by carbothermal reduction of Ti-O-C precursor in argon at 1,400 °C for 2 h. Andthe Ti-O-C precursor was formed by sol-gel method using titanium butyrate (Ti(OC4H9)4), fructose (C6H12O6), and acetylacetone (acac). Here, acac was used as chemical modifier to control Ti(OC4H9)4 hydrolysis to obtain stable sol. Furthermore,TG-DSC, XRD, FTIR, Raman, SEM, and EDS were employed to characterize the precursor and TiC powders. Moreover, acacas stabilizer was studied using FTIR when reacted with Ti(OC4H9)4 formed stable six-member ring as a result of the existenceof tautomer, prevent the nucleophilic attack of water, which reduced the hydrolysis rate of Ti(OC4H9)4. Besides, the compositionof TiC phase was further understood by the Raman spectra, and the results showed that the peaks at 403 cm−1, 513 cm−1, and 629 cm−1 were ascribed to the characteristic peaks of TiC. Finally, the photomicrograph revealed an equiaxed shape and theaverage grain size of TiC particles was ca. 1 um. The EDS indicated that the particles contain elements of Ti and carbonaccording to dot and line scan.
Liang Wang,Wei Lu,Li Zhang,Liwei Xue,Seung-Kon Ryu,Ri-guang Jin 한국탄소학회 2011 Carbon Letters Vol.12 No.2
Polyacrylonitrile (PAN) fibers were pre-oxidized in a temperature range of 180-275℃. The effects of positive and negative stretching on the structure and morphology of PAN fiber in the pre-oxidation process were studied by FTIR spectroscopy, XRD, and SEM. Mechanical property changes were also investigated. No changes in the movement and intensity of functional groups of PAN fibers were caused by positive stretching of up to 10% and negative stretching down to -8%. The crystal structure can be affected by the positive stretching and negative stretching. The maximum strength is 479.81 MPa when the stretching is positive, and the maximum strength is 420.55 MPa when the stretching is negative.
Enzyme-Catalyzed Henry Reaction in Choline Chloride-Based Deep Eutectic Solvents
( Xue Mei Tian ),( Suo Qin Zhang ),( Liang Yu Zheng ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.1
The enzyme-catalyzed Henry reaction was realized using deep eutectic solvents (DESs) as a reaction medium. The lipase from Aspergillus niger (lipase AS) showed excellent catalytic activity toward the substrates aromatic aldehydes and nitromethane in choline chloride:glycerol at a molar ratio of 1:2. Addition of 30 vol% water to DES further improved the lipase activity and inhibited DES-catalyzed transformation. A final yield of 92.2% for the lipase AS-catalyzed Henry reaction was achieved under optimized reaction conditions in only 4 h. In addition, the lipase AS activity was improved by approximately 3-fold in a DES.water mixture compared with that in pure water, which produced a final yield of only 33.4%. Structural studies with fluorescence spectroscopy showed that the established strong hydrogen bonds between DES and water may be the main driving force that affects the spatial conformation of the enzyme, leading to a change in lipase activity. The methodology was also extended to the aza-Henry reaction, which easily occurred in contrast to that in pure water. The enantioselectivity of both Henry and aza-Henry reactions was not found. However, the results are still remarkable, as we report the first use of DES as a reaction medium in a lipase-catalyzed Henry reaction.
Zhang, Zhen-Yong,Tian, Xin,Wu, Rong,Liang, Yuan,Jin, Xue-Ying Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Aim: There is increasing evidence that ERCC1 and XPD have roles in response to chemotherapy among patients with NSCLC, but the results are conflicting. Therefore, we conducted the present prospective study in a Chinese population. Methods: A total of 632 primary NSCLC patients were included, followed-up from May 2006 to May 2011. Polymorphisms were detected by real time PCR with TaqMan probse, using genomic DNA extracted from peripheral blood samples. The Cox regression model was used to analyze the hazard ratios (HR) for ERCC1 and XPD. Results: The median time of follow-up was 31.6 months. Our results showed the ERCC1 118 T/T(HR=1.65, 95% CI=1.17-2.43) and XPD 751 Gln/Gln genotypes (HR=1.52, 95%CI=1.04-2.08) were associated with an increased risk of death from NSCLC. Moreover, the ERCC118 T allele and XPD 751 Gln allele genotypes had a more higher risk of death from NSCLC among both ex-smokers and current smokers. Conclusion: In summary, ERCC1 and XPD gene polymorphisms might provide better prognostic predictive information for NSCLC patients in Chinese populations, with smoking possibly interacting with the genotypes.
Xue Zhang,Yamei Ge,Ashfaq-Ahmad-Shah Bukhari,Qian Zhu,Yachen Shen,Min Li,Hui Sun,Dongming Su,Xiubin Liang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
The main functions of the epithelial sodium channel (ENaC) in the kidney distal nephron are mediation of sodium and water balance and stabilization of blood pressure. Estrogen has important effects on sodium and water balance and on premenopausal blood pressure, but its role in the regulation of ENaC function is not fully understood. Female Sprague–Dawley rats were treated with 17β-estradiol for 6 weeks following bilateral ovariectomy. Plasma estrogen, aldosterone, creatinine, and electrolytes were analyzed, and α-ENaC and derlin-1 protein expression in the kidney was determined by immunohistochemistry and western blotting. The expression levels of α-ENaC, derlin-1, AMPK, and related molecules were also examined by western blotting and real-time PCR in cultured mouse renal collecting duct (mpkCCDc14) epithelial cells following estrogen treatment. Immunofluorescence and coimmunoprecipitation were performed to detect α-ENaC binding with derlin-1 and α-ENaC ubiquitination. The results demonstrated that the loss of estrogen elevated systolic blood pressure in ovariectomized (OVX) rats. OVX rat kidneys showed increased α-ENaC expression but decreased derlin-1 expression. In contrast, estrogen treatment decreased α-ENaC expression but increased derlin-1 expression in mpkCCDc14 cells. Moreover, estrogen induced α-ENaC ubiquitination by promoting the interaction of α-ENaC with derlin-1 and evoked phosphorylation of AMPK in mpkCCDc14 cells. Our study indicates that estrogen reduces ENaC expression and blood pressure in OVX rats through derlin-1 upregulation and AMPK activation.
( Xue Liang Niu ),( Xiao Ran Hao ),( Zhang Yong Hong ),( Long Fei Chen ),( Xi Yu ),( Xu Dong Zhu ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.5
Fungi of the genus Pestalotiopsis have drawn attention for their capability to produce an array of bioactive secondary metabolites that have potential for drug development. Here, we report the determination of a polyketide derivative compound, pestalotiollide B, in the culture of the saprophytic fungus Pestalotiopsis microspora NK17. Structural information acquired by analyses with a set of spectroscopic and chromatographic techniques suggests that pestalotiollide B has the same skeleton as the penicillide derivatives, dibenzodioxocinones, which are inhibitors of cholesterol ester transfer protein (CETP), and as purpactins A and C’, inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). Strain NK17 can make a fairly high yield of pestalotiollide B (i.e., up to 7.22 mg/l) in a constitutive manner in liquid culture. Moreover, we found that a putative histone deacetylase gene, designated as hid1, played a role in the biosynthesis of pestalotiollide B. In the hid1 null mutant, the yield of pestalotiollide B increased approximately 2-fold to 15.90 mg/l. In contrast, deletion of gene hid1 led to a dramatic decrease of conidia production of the fungus. These results suggest that hid1 is a modulator, concerting secondary metabolism and development such as conidiation in P. microspora. Our work may help with the investigation into the biosynthesis of pestalotiollide B and the development for new CETP and ACAT inhibitors.