A Phase 3 Evaluation of Daclatasvir plus Asunaprevir in Treatment-Naive Patients with Chronic HCV Genotype 1b Infection

( L. Wei ),( F. Wang ),( M. Zhang ),( J. Jia ),( A.A. Yakovlev ),( W. Xie ),( E.Z. Burnevich ),( J. Niu ),( Y.J. Jung ),( X. Jiang ),( M. Xu ),( X. Chen ),( Q. Xie ),( J. Li ),( J. Hou ),( H. Tang ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Background/Aims: Treatment-naive GT 1b-infected patients from mainland China, South Korea and Russia were assessed for SVR at follow-up week 12 (SVR12) after receiving daclatasvir (60 mg, QD) and asunaprevir (100 mg, BID) (DCV+ASV). Methods: Patients were randomized 3:1 to receive DCV+ASV (24 weeks; immediate treatment [IM]) or 12 weeks of placebo followed by DCV+ASV (24 weeks; placebo-deferred treatment [PD]). The primary endpoint was to evaluate SVR12 in the IM arm to the historical rate for peginterferon/ribavirin (70%). Secondary endpoints included overall safety and safety comparisons between the treatment arms during the first 12 weeks. Results: 207 patients were randomized to IM (n=155) or PD (n=52); Asian (86%), female (59%), IL28B CC genotype (68%) and median age 49 (range 18-73) years; cirrhosis (13%), HCV RNA ≥6x106 IU/mL (53%). SVR12 in the IM arm was 92% and broadly unaffected by most baseline factors assessed (Figure); SVR12 was higher in patients without (96%) baseline NS5A-L31M/V or Y93H polymorphisms. There were 6 virologic breakthroughs, 6 relapses and 1 detectable HCV RNA at end-of-treatment in the IM arm. Safety was mostly comparable between the two arms during the first 12 weeks. The most frequent adverse events (AEs; ≥5%) during DCV+ASV (24 weeks) treatment in both arms were aminotransferase, bilirubin and INR elevations, hypertension, fatigue and respiratory tract infections; the most frequent treatment-emergent grade 3/4 laboratory abnormalities were aminotransferase (≤4.5%) and hematologic, lipase and total bilirubin abnormalities (≤2%); one patient (IM) discontinued DCV+ASV for aminotransferase elevations, nausea and jaundice (all reversible); one patient PD) discontinued DCV+ASV for a fatal AE unrelated to treatment. Conclusions: These data demonstrate that DCV+ASV is a highly efficacious and well tolerated treatment for treatment-naive HCV GT 1b-infected patients. Those treated immediately with DCV+ASV achieved a 92% SVR12 rate which was unaffected by factors known to attenuate response to interferon.

여대생의 인유두종 바이러스 및 인유두종 바이러스 백신 관련 지식과 예방접종 실태와의 상관관계

Xu, Meiling,김현지,이희수,이윤지,한동연,박소영,엄효윤,최정민,홍서진,홍예림,이경은,이혜림 이화여자대학교 간호과학대학 2017 이화간호학회지 Vol.- No.51

Purpose: Human Papillomavirus (HPV) vaccination is readily available, but immunization rate is minimal. Lack of knowledge concerning the HPV infection and vaccine is expected as the primary reason. The correlation between knowledge levels and vaccination will provide applicable guidelines for successful interventions. Method: 309 female university students have completed surveys September 2016, reporting of HPV infection knowledge, HPV vaccine knowledge, source of knowledge, and attitudes concerning vaccination. Result: HPV infection and vaccine knowledge levels were both suboptimal(9.57±1.84, 7.59±1.58), and the Internet(16.2%) was recognized as the most generally used means of obtaining information on the HPV vaccine. However, vaccination rates were reported to be low(28.2%), with lack of information(46.6%) hindering immunization. Correlations were found between HPV infection knowledge and cervical cancer insight, but the correlations between knowledge levels and vaccination rates were insignificant. Conclusion: Prior information on cervical cancer had an effect on the knowledge levels of HPV infection, but other factors were insignificant. Lack of information on the HPV vaccine was speculated, thus programs should focus on accessibility and effectiveness.

ONE-DIMENSIONAL MODEL ON FUEL PENETRATION IN DIESEL SPRAYS WITH GAS FLOW

M. XU,Y. C. SUN,Y. CUI,K. Y. DENG,L. SHI 한국자동차공학회 2016 International journal of automotive technology Vol.17 No.1

In diesel engine, spray penetration is usually changed by in-cylinder gas flow. Accurate prediction on diesel spray with gas flow is important to the optimal design of diesel fuel injection system. This paper presents a theory investigation focusing on the penetration of diesel spray with gas flow. In order to understand the effect of gas flow on the penetration of diesel spray, a one-dimensional spray model is developed from an idealized diesel spray, which is able to predict the spray behavior under different gas flow conditions. The ambient gas flow is simplified as ideal flow that has only constant flow velocity along x-axial and y-axial directions of spray. The x-axial and y-axial directions are respectively defined as along and vertical spray directions. The main assumption is that the y-axial direction gas flow has no effect on the penetration of spray along x-axial direction. The principles of conservation of mass and momentum are used in the derivation. Momentum of in-cylinder air flow is also taken into consideration. Validation of the model at stable condition is achieved by comparing model predictions with experimental measurements of diesel spray without gas flow from Naber's experiments. Furthermore, CFD simulations on penetration of diesel spray with gas flow were performed with the commercial code AVL-fire. The onedimensional model is validated by the penetration results with gas flow from CFD calculation. Results show that a reasonable estimation of the spray evolution can be obtained for both with and without ambient gas flow conditions.

Anti-inflammatory activity of 21(α, β)-methylmelianodiols, novel compounds from Poncirus trifoliata Rafinesque

Zhou, H.Y.,Shin, E.M.,Guo, L.Y.,Zou, L.B.,Xu, G.H.,Lee, S.H.,Ze, K.R.,Kim, E.K.,Kang, S.S.,Kim, Y.S. North-Holland ; Elsevier Science Ltd 2007 european journal of pharmacology Vol.572 No.2

The fruits of Poncirus trifoliata (L.) are widely used in Oriental medicine as a remedy for allergic inflammation. As a part of our program to screen medicinal plants for potential anti-inflammatory compounds, 21α-methylmelianodiol (21α-MMD) and 21β-methylmelianodiol (21β-MMD), which are two isomers of 21-methylmelianodiol isolated from the fruits of P. trifoliata for the first time, were found to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. 21α-MMD and 21β-MMD attenuated LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 protein expressions as well as the mRNA levels of iNOS, COX-2, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). To investigate the mechanism involved, we examined the effect of 21α-MMD and 21β-MMD on LPS-induced nuclear factor-κB (NF-κB) activation. Both 21α-MMD and 21β-MMD significantly inhibited LPS-induced NF-κB transcriptional activity in RAW 264.7 macrophages. Moreover, the in vivo anti-inflammatory effect of 21α-MMD was examined in two mouse models of acute inflammation. In the carrageenan-induced paw edema model, administration of 21α-MMD (20 and 100 mg/kg, i.p.) dose-dependently reduced paw swelling. In addition, 21α-MMD significantly inhibited the dye leakage in an acetic acid-induced vascular permeability assay. Taken together, our data indicate that 21-methylmelianodiol is an important constituent of the fruit of P. trifoliata, and that the inhibition of iNOS and COX-2 expression by 21α-MMD and 21β-MMD might be one of the mechanisms responsible for their anti-inflammatory effects.

Association mapping of salinity and alkalinity tolerance in improved japonica rice (Oryza sativa L. subsp. japonica Kato) germplasm

Cui, D.,Xu, C. y.,Yang, C. g.,Zhang, Q. x.,Zhang, J. g.,Ma, X. d.,Qiao, Y. l.,Cao, G. l.,Zhang, S. y.,Han, L. z. Springer Science + Business Media 2015 Genetic resources and crop evolution Vol.62 No.4

Spatiotemporally separating electron and phonon thermal transport in L1₀ FePt films for heat assisted magnetic recording

Xu, D. B.,Sun, C. J.,Brewe, D. L.,Han, S.-W.,Ho, P.,Chen, J. S.,Heald, S. M.,Zhang, X. Y.,Chow, G. M. American Institute of Physics 2014 Journal of Applied Physics Vol.115 No.24

Integration of health monitoring and vibration control for smart building structures with time-varying structural parameters and unknown excitations

Y.L. Xu,Q. Huang,Y. Xia,H.J. Liu 국제구조공학회 2015 Smart Structures and Systems, An International Jou Vol.15 No.3

When a building structure requires both health monitoring system and vibration control system,integrating the two systems together will be cost-effective and beneficial for creating a smart buildingstructure with its own sensors (nervous system), processors (brain system), and actuators (muscular system). This paper presents a real-time integrated procedure to demonstrate how health monitoring and vibrationcontrol can be integrated in real time to accurately identify time-varying structural parameters and unknownexcitations on one hand, and to optimally mitigate excessive vibration of the building structure on the otherhand. The basic equations for the identification of time-varying structural parameters and unknownexcitations of a semi-active damper-controlled building structure are first presented. The basic equations forsemi-active vibration control of the building structure with time-varying structural parameters and unknownexcitations are then put forward. The numerical algorithm is finally followed to show how the identificationand the control can be performed simultaneously. The results from the numerical investigation of anexample building demonstrate that the proposed method is feasible and accurate.

Understanding of the capacity contribution of carbon in phosphorus-carbon composites for high-performance anodes in lithium ion batteries

Xu, J.,Jeon, I. Y.,Ma, J.,Dou, Y.,Kim, S. J.,Seo, J. M.,Liu, H.,Dou, S.,Baek, J. B.,Dai, L. Springer Science + Business Media 2017 Nano research Vol.10 No.4

<P>Phosphorus has recently received extensive attention as a promising anode for lithium ion batteries (LIBs) due to its high theoretical capacity of 2,596 mAh.g(-1). To develop high-performance phosphorus anodes for LIBs, carbon materials have been hybridized with phosphorus (P-C) to improve dispersion and conductivity. However, the specific capacity, rate capability, and cycling stability of P-C anodes are still less than satisfactory for practical applications. Furthermore, the exact effects of the carbon support on the electrochemical performance of the P-C anodes are not fully understood. Herein, a series of xP-yC anode materials for LIBs were prepared by a simple and efficient ball-milling method. 6P-4C and 3P-7C were found to be optimum mass ratios of x/ y, and delivered initial discharge capacities of 1,803.5 and 1,585.3.mAh.g(-1), respectively, at 0.1 C in the voltage range 0.02-2 V, with an initial capacity retention of 68.3% over 200 cycles (more than 4 months cycling life) and 40.8% over 450 cycles. The excellent electrochemical performance of the 6P-4C and 3P-7C samples was attributed to a synergistic effect from both the adsorbed P and carbon.</P>

Effects of Replacement of Fish Meal by Soy Protein Isolate on the Growth, Digestive Enzyme Activity and Serum Biochemical Parameters for Juvenile Amur Sturgeon (Acipenser schrenckii)

Xu, Q.Y.,Wang, C.A.,Zhao, Z.G.,Luo, L. Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.11

An 8-wk experiment was conducted to evaluate the effect of replacing fish meal (FM) with soy protein isolate (SPI) on the growth, digestive enzyme activity and serum biochemical parameters of juvenile Amur sturgeon (Acipenser schrenckii). SPI was used to replace 0, 25, 50, 62.5, 75, 87.5, 100% of dietary FM and 100% replacement supplemented crystalline amino acid. Healthy sturgeon with an average initial weight of $26.38{\pm}0.24$ g were randomly assigned to 24 aquaria (8 treatments with triplicates each) at an initial stocking density of 11 fish per aquarium and cultured for 8 wks. The results showed that 75.00% or more substitution resulted in a poor weight gain rate, feed conversion ratio and survival rate compared to that of fish fed the control diet (p<0.05), whereas no significant differences were observed between diets of 25.00% to 62.50% substitution. Protease, lipase and amylase activity in foregut, mid-gut and hindgut were significantly (p<0.05) decreased by diets where SPI replacement levels were 62.50% or more. Levels of serum total protein (TP) and globulin decreased significantly from 21.03, 10.34 to 14.05, 5.63 g/L with the increasing dietary SPI (p<0.05), but alkaline phosphatase activity significantly increased (p<0.05). In addition, supplemental crystalline amino acid in the FM absence diet did not improve growth performance, intestine digestive enzyme activities and serum biochemical parameters. In conclusion, the results from this study showed adverse effects of inclusion of SPI in diets on growth performance, feed utilization and serum biochemical parameters in juvenile Amur sturgeon. Based on WGR and replacement ratio presented in this report, a 57.64% replacement level was recommended.

NUMERICAL ANALYSIS OF FUEL INJECTION IN INTAKE MANIFOLD AND INTAKE PROCESS OF A MPI NATURAL GAS ENGINE

XU B. Y.,LIANG F. Y.,CAI S. L.,QI Y. L. The Korean Society of Automotive Engineers 2005 International journal of automotive technology Vol.6 No.6

Unsteady state free natural gas jets injected from several types of injectors were numerically simulated. Simulations showed good agreements with the schlieren experimental results. Moreover, injections of natural gas in intake manifolds of a single-valve engine and a double-valve engine were predicted as well. Predictions revealed that large volumetric injections of natural gas in intake manifolds led to strong impingement of natural gas with the intake valves, which as a result, gave rise to pronounced backward reflection of natural gas towards the inlets of intake manifolds, together with significant increase in pressure in intake manifold. Based on our simulations, we speculated that for engines with short intake manifolds, reflections of the mixture of natural gas and air were likely to approach the inlets of intake manifolds and subsequently be inbreathed into other cylinders, resulting in non-uniform mixture distributions between the cylinders. For engines with long intake manifolds, inasmuch as the degrees of intake interferences between the cylinders were not identical in light of the ignition sequences, non-uniform intake charge distributions between the cylinders would occur.