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심성웅(Sung-Woong Shim),김철환(Chul-Hwan Kim),이지영(Ji-Young Lee),M.I. Sheikh,박현진(Hyeon-Jin Park),김성호(Sung-Ho Kim),김경철(Keoung-Chul Kim),조후승(Hoo-Seoung Jo),주종훈(Jong-Hun Joo),김중호(Joong-Ho Kim) 한국펄프·종이공학회 2012 한국펄프·종이공학회 학술발표논문집 Vol.2012 No.4
This study investigated softening effect of softwood chips according to different pulping conditions for CTMP. The amount of both sodium sulfite and sodium hydroxide played a vital role in softening wood chips. Pulping temperature was also a key factor to influence penetration of pulping liquor to wood chips.
Shim, Man Kyu,Park, Jooho,Yoon, Hong Yeol,Lee, Sangmin,Um, Wooram,Kim, Jong-Ho,Kang, Sun-Woong,Seo, Joung-Wook,Hyun, Soo-Wang,Park, Jae Hyung,Byun, Youngro,Kwon, Ick Chan,Kim, Kwangmeyung Elsevier 2019 Journal of controlled release Vol.294 No.-
<P><B>Abstract</B></P> <P>Cancer nanomedicine using nanoparticle-based delivery systems has shown outstanding promise in recent decades for improving anticancer treatment. However, limited targeting efficiency, low drug loading efficiency and innate toxicity of nanoparticles have caused severe problems, leaving only a few available in the clinic. Here, we newly developed carrier-free nanoparticles of cathepsin B-cleavable peptide (Phe-Arg-Arg-Gly; FRRG)-conjugated doxorubicin (DOX) prodrug (FRRG-DOX) that formed a stable nanoparticle structure with an average diameter of 213 nm in aqueous condition. The carrier-free nanoparticles of FRRG-DOX induced cytotoxicity against cathepsin B-overexpressed tumor cells whereas the toxicity was minimized in normal cells. In particular, the FRRG-DOX nanoparticles showed the successful tumor-targeting ability and enhanced therapeutic efficiency in human colon adenocarcinoma (HT-29) tumor-bearing mice <I>via</I> enhanced permeation and retention (EPR) effect. Furthermore, FRRG-DOX nanoparticles did not present any severe toxicity, such as non-specific cell death and cardiac toxicity, in normal tissues due to minimal expression of cathepsin B. This carrier-free nanoparticles of FRRG-DOX can solve the unavoidable problems of current nanomedicine, such as lower targeting efficiency, toxicity of nanoparticles themselves, and difficulty in mass production that are fatally caused by natural and synthetic nano-sized carriers.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
( Ho Jeong Kwon ),( Dong Hoon Kim ),( Joong Sub Shim ),( Jong Woong Ahn ) 한국미생물 · 생명공학회 2002 Journal of microbiology and biotechnology Vol.12 No.4
Apicularen A (Api A) was recently isolated from Chondromyces sp. as a potent antitumor agent. Because of its unique chemical structure, a macrolide with a highly unsaturated amide side chain, and potent growth inhibitory effect in various cancer cell lines, Api A is currently in clinical trial for cancer therapy. In the present study, the effect of Api A on in vitro angiogenesis of bovine aortic endothelial cells (BAECs) was investigated. Api A potently inhibited the proliferation of BAECs in a dose-dependent manner. Treatment of the endothelial cells with up to 10 ng/ml of the compound did not show any cytotoxicity. In addition, it inhibited basic fibroblast growth factor (bFGF)-induced invasion and capillary tube formation of BAECs at concentrations of 2-5 ng/ml. These results, therefore, demonstrate that Api A is a novel antiangiogenic agent and may suppress the growth of tumors, at least in part, by the inhibition of neovascularization.
Jae Woong Shim,Seong Ho Jo,Sang Doo Kim,Ha Young Lee,Jeanho Yun,Yoe-Sik Bae 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.8
In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1β production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1β production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation. In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1β production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1β production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.
Distribution of arthropod in the field of pepper plant covered with living mulching plants
Jong-Ho Park,Young-Woong Byeon,Yong-Uk Kim,Eun-Jung Han,Chang-Ki Shim,Min-Jeong Kim,Yong-Ki Kim 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10
많은 유기농가에서는 토양의 물리성을 개선하고 양분을 공급하는 등 다양한 목적을 위해 녹비작물을 활용하고 있다. 본 연구에서는 이러한 녹비를 활용하여 해충을 억제하고 생물다양성을 높이는 효과를 구명하고자 하였다. 재배시험은 전북 완주군 내 국립농업과학원 유기재배 포장에서 이루어졌다. 시험 처리구에 헤어리베치를 재배하고 경운을 하지 않고 일부 녹비를 남겨둔 생물피복 상태에서 고추를 정식하였다. 고추 재배기간 헤어리베치 피복포장에 나타난 해충 등 곤충과 거미의 밀도를 비닐로 피복을 한 대조구와 비교하여 조사하였다. 시험포장의 해충을 조사한 결과, 고추의 주요 해충인 진딧물은 6월 초부터 말까지 대조구에 비해 헤어리베치 피복구에서 지속적으로 낮게 나타났다. 진딧물의 주요 천적인 무당벌레의 경우 6월 초에는 헤어리베치 피복구가 높게 나타났으나 6월 말에는 대조구에서 높은 밀도를 보여주었다.
Chan Woong Choi,Wonick Jang,Sun Bo Shim,Ho-Jin Song,JungHwan Cho,Hyungsil Moon,Sang-Mi Park,Kiwon Han,Kyung Hee Sohn 대한약학회 2021 약학회지 Vol.65 No.3
Human immunoglobulin is a plasma-derived medicinal product that is the second-largest product in the number of the national lot release in the National Institute of Food and Drug Safety Evaluation (NIFDS), following human serum albumin. Reference standards are used to confirm the validity of each national lot release test. This study aims to establish a national reference standard (NRS) for the molecular size distribution test applied to immunoglobulin based biologics. 7200 vials, containing 2 mL/vial, were prepared according to the approved manufacturing process for human immunoglobulin intended for intramuscular administration. Four laboratories, including the NIFDS, and manufacturers of human immunoglobulin products, participated in this collaborative study, in which a molecular size distribution test was performed on candidate vials using size-exclusion high-performance liquid chromatography. Retention of dimer relative to monomer was 0.851. Relative to a human immunoglobulin (molecular size) biological reference preparation, relative retention times of monomer and dimer from the candidate vial were 1.001 and 1.000, respectively. This result satisfies the requirements of monographs in the European Pharmacopoeia. Based on a real-time stability evaluation over 24 months following manufacture, and a short-term stability evaluation over 14 days after opening, the dimer to monomer relative retention ratios were found to be distributed within control limits, thereby validating stability. The results of this study support registration of this candidate with the NIFDS as the NRS for molecular size distribution test of human immunoglobulin products.
Jong-Ho Park,Young-Woong Byeon,Hye-Sun Kim,Yong-Uk Kim,Chang-Ki Shim,Min-Jeong Kim,Yong-Ki Kim 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10
유기농경지에서 문제가 되는 해충을 방제하기 위하여 농가에서는 식물추출물 등 다양한 자가제조 유기농업자재를 활용하고 있다. 본 연구에서는 농가 자가제조 유기농업자재를 이용하여 목화진딧물(Aphis gossypii)과 꽃노랑총채벌레(Franklineilla occidentalis)에 대한 살충효과를 시험하였다. 유기농업자재는 유기재배 농가에서 직접 수집하였으며 식물추출물로는 마늘, 돼지감자, 은행잎 등의 식물추출물과 목초액, 식물오일 등 8종의 자재를 이용하였다. 해충에 대한 살충시험은 25℃, 60% 습도 조건의 곤충사육실에서 이루어졌다. 처리시험을 위해 오이절편을 페트리디쉬에 넣고 시험곤충을 접종하여 농가수집자재를 원액, 30배, 100배, 300배로 희석하여 충체 살포법으로 처리하였다. 처리 후 24시간, 36시간, 72시간 후 사충률을 조사하였다. 진딧물의 경우 100배 희석처리에서 약초액비가 75%, 유화오일이 62.5% 은행잎액비가 42.5%의 살충효과를 각각 보여주었다. 꽃노랑총채벌레에는 협죽도와 마늘이 94.7%와 88.0% 살충효과를 보여주었다.