단기간 체중감량 시 크레아틴 투여가 혈중 피로유발 요인 변화에 미치는 영향

이복환,하웅의 한국스포츠리서치 2005 한국 스포츠 리서치 Vol.16 No.2

The purpose of this study was to examine the effects of creatine supplementation during weight loss on the changes of blood fatigue factors. The subjects of this study were 11 male college Taekwonclo players. The subjects were divided into two groups; creatine supplementation group and controlled group. The following results were obtained from the analysis of fatigue induction factors(lactic acid, ammonia, inorganic phosphate) by periods of weight loss of controlled group. 1. The lactic acid level in the blood of the creatine supplementation group was lower than the controlled group but the result was not significant statistically(p>.05). 2. The level of ammonia in the blood of the creatine supplementation group was lower than the controlled group and the result was significant statistically(p<.05). 3. The level of inorganic phosphate in the blood of the creatine supplementation group was lower than the controlled group and the result was significant statistically(p<.05).

인터넷을 기반으로 하는 의류용 소재 정보 시스템

박창규,이대훈,이웅의 한국의류학회 2003 한국의류학회지 Vol.27 No.3,4

In this research, an internet-based fabric information system has been developed. Recently, the numbers of textile industries which have their own homepages to advertise their product fabrics for apparel through the Internet and textile e-Commerce web sites rapidly increase. Unfortunately, traditional fabric information systems based on direct meeting and trust cannot give sufficient information to numerous visitors of the Internet sites including fabric buyers for apparel. They can just view 2-dimensional fabric images and text-based specifications such as fabric density, composition, colors, weight, etc. To solve these problems, the new fabric information system for apparel has been developed. The web-based fabric information system is composed of the following six modules; ① fabric database management system, ② a 3-D fabric drape image viewer to illustrate fabric appearances, ③ a virtual wearing system to apply a fabric to garment designs, ④ a fabric property viewer to confirm fabric characteristics, ⑤ a QC (quality control) document generator to manufacture high quality garments with a fabric, and ⑥ a virtual display mall to view actual fabrics. The fabric information system is simply performed by visitors clicking the buttons hyper-linked with JAVA applets on web browser. The web-based fabric information system enables the web site visitors to understand fabric shown on the Internet in more details.

HCC : Histologic Differentiation Predicts the Survival of Patients with Hepatic Resection for Hepatocellular Carcinoma

( Woong Cheul Lee ),( Jae Young Jang ),( Jin Nyoung Kim ),( Soung Won Jeong ),( Eui Ju Park ),( Byoung Moo Lee ),( Yun Nah Lee ),( Sae Hwan Lee ),( Sang Gyune Kim ),( Sang Woo Cha ),( Young Seok Kim ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background: In resection for hepatocellular carcinoma (HCC), patient selection depends on morphological features and liver function. In patients with HCC, we performed a clinico- pathological analysis of risk factors that affected survival after liver resection. Methods: Sixty seven patients with liver resection for HCC were enrolled and data were collected retrospectively. Variables were age, gender, etiology, preoperative alpha-fetoprotein (AFP) levels, Child-Pugh and MELD scores, modified UICC stage, portal vein tumor invasion, and histological differentiation. Results: Sixty seven patients were evaluated and 6 patients were excluded (Three patients with combined hepatocellularcholangiocarcinoma, two patients because of early postoperative death without HCC recurrence and one patient accidental death without HCC recurrence). The mean age of the patients was 57.4±10.5 years. The mean follow-up time was 51.2±34.8 months. The cumulative 1-, 3-, 5-, and 7-year survival rates were 91.3%, 64.5%, 45.0%, and 45.0%, respectively. The 1-, 3-, 5-, and 7-year disease-free survival rates were 80.4%, 50.5%, 12.9%, and 12.9%, respectively. Multivariate analysis showed that modified UICC stage (P=0.005), portal vein tumor invasion (P=0.024) and poor histological differentiation (P=0.012) were independent factors for survival and tumor recurrence. Conclusions: Although morphological stage and liver function are important factors of liver resection, for proper patient selection in liver resection for HCC, prognostic criteria related to tumor histology (especially histological differentiation) should be considered. Poor histological differentiation is indicators of poor prognosis after liver resection for HCC.

Bis-Terminal Hydroxy Polyethers as All-Purpose, Multifunctional Organic Promoters: A Mechanistic Investigation and Applications

Lee, Ji Woong,Yan, Hailong,Jang, Hyeong Bin,Kim, Hong Ki,Park, Sung-Woo,Lee, Sungyul,Chi, Dae Yoon,Song, Choong Eui WILEY-VCH Verlag 2009 Angewandte Chemie Vol.48 No.41

<B>Graphic Abstract</B> <P>Achiral polyether derivatives have been shown to dramatically accelerate S<SUB>N</SUB>2 reactions by the simultaneous activation of both the nucleophile (KF) and electrophile (sulfonate; see picture). By using chiral variants as catalysts, the desilylative kinetic resolution of the silyl ethers of racemic secondary alcohols has been achieved. Density functional calculations provide detailed insight into the modes of action of this type of organic promoter. <img src='wiley_img/14337851-2009-48-41-ANIE200903903-content.gif' alt='wiley_img/14337851-2009-48-41-ANIE200903903-content'> </P>

LC : Renal Function Predicts 14 Days Mortality in Cirrhotic Patient with Spontaneous Bacterial Peritonitis; Multicenter Retrospective Study

( Woong Cheul Lee ),( Jae Young Jang ),( Young Don Kim ),( Yun Nah Lee ),( Young Sin Cho ),( Jin Nyoung Kim ),( Eui Ju Park ),( Byoung Moo Lee ),( Soung Won Jeong ),( Sae Hwan Lee ),( Sang Gyune Kim ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background: Spontaneous bacterial peritonitis (SBP) is one of severe complications in liver cirrhosis. Early detection of high-risk patients is essential for prognostic improvement. We investigate the predictive factors related with 14 days mortality in patient with SBP. Methods: We conducted a retrospective study of two hundred seventy five SBP patients admitted in four tertiary referral hospitals between August 2002 and February 2013. We collect patients` laboratory and radiologic data from medical record. We calculated Child-Turcotte-Pugh score (CTP), Model for End- Stage Liver Disease-Na (MELD-Na) score using the laboratory data at the time of SBP occurrence. Results: The mean age of the patients was 56.9 years (213 male, 62 female). The cause of liver cirrhosis was hepatitis B (44%), alcohol (41.8%) and hepatitis C (6.9%). Mean score of MELD-Na and CTP score were 27.44 and 10.67, respectively. The patients who die from SBP within 14 days were 17.8% (n=49). The statistically significant factor of multivariate analysis were baseline MELD-Na (P=0.002) and GFR (P=0.034). Two hundred thirty three patients who could follow-up were analyzed. Baseline MELD-Na (P=0.027) and maximal creatinine level during the follow-up (P=0.02) were significantly associated with 14 days mortality. The prognostic accuracy of baseline MELD-Na, initial GFR and maximal creatinine during the follow-up were 75.6%, 74.0% and 78.0%, respectively (P<0.001). The cut-off values were 27 (baseline MELD-Na), 35.9 mL/min (initial GFR) and 2 mg/dL (maximal creatinine), respectively (P<0.001). Conclusions: Renal function was important predictive factor of 14 days mortality in cirrhotic patients with SBP. The patients with SBP and renal insufficiency should be treated more intensively.

HCV, Acute, LT : The Clinico-Pathological Features of Drug Induced Liver Injury

( Woong Cheul Lee ),( Jae Young Jang ),( Jin Nyoung Kim ),( Soung Won Jeong ),( Eui Ju Park ),( Byoung Moo Lee ),( Yun Nah Lee ),( Sae Hwan Lee ),( Sang Gyune Kim ),( Sang Woo Cha ),( Young Seok Kim ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background: Drug-induced liver injury (DILI) has recently increased and is one of major cause of acute hepatitis. We investigated the clinico-pathological findings in patients with DILI whom liver biopsy was conducted. Methods: A retrospective analysis was performed using medical records of sixty five cases of DILI that were selected based on a modified RUCAM (Roussel Uclaf Causality Assessment Method) score of 7 or above. Results: The incidence was higher in women (n=41) than men (n=24). The age (mean±SD) of the patients was 48.2±13.1 years. The major causes of the DILI included the use of herbal medications (43.2%), prescription medications (21.6%) and traditional therapeutic preparations and dietary supplements (35%). At the time of admission, various symptoms (anorexia and abdominal discomfort (46.2%), jaundice and itching (40%), myalgia and fatigue (32.3%), fever and chill (16.9%), headache and dizziness (6.2%)) were presented. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, alkaline phosphatase (ALP) and γ-glutamyl transpeptidase peak levels were 650.1±685.2 IU/L, 855.7±780.9 IU/ 10±9.5 mg/dL, 371±454 IU/L and 247.9±227.2 IU/L, respectively. The mean modified RUCAM score of the patients was 8.01±0.75. The types of liver injury according to R ratio ([ALT/ UNL]/[ALP/UNL]) were hepatocellular type (67.7%), mixed type (10.8%) and cholestatic type (21.5%). The main pathologic findings were zone 3 necrosis and swelling (53.8%), increased eosinophilic infiltration (43.1%) and bridging necrosis (21.5%). Herbal medications and traditional therapeutic preparations were associated with hepatocellular type`s liver injury compared to prescription medications (P<0.002). All patients were recovered without complication. Conclusions: The clinico-pathologic findings of DILI were diverse. Zone 3 necrosis and swelling was most common pathologic feature. The type of liver injury with herbal medications and traditional therapeutic preparations revealed hepatocellular type.

위 정맥류출혈에 대한 내시경적 결찰요법과 Histoacryl 치료 효과의 비교

이상우,김남재,서승원,이병석,이헌영,이엄석,김선문,양현웅,성재규,임의혁 대한소화기내시경학회 2000 Clinical Endoscopy Vol.21 No.5

Background/Aims: The variceal bleeding has high rebleeding rate, and mortality rate was higher in gastrix varix. Managements of variceal bleeding were included such as drugs, endoscopic procedures, surgical management and radiological intervention. Recently histoacryl^(R) injection method has been introduced. We have compared the effects of the endoscopic ligation and Histoacryl^(R) injection therapy (HAI) in patient with gastric variceal bleeding. Methods: We analyzed the effects of hemostasis, complications, rebleeding rates, and survival rates in gastric varix bleeding of 22 patients with Histoacryl^(R) injection therapy and 20 patients with endoscopic ligation therapy, from January 1995 to March 1999. Results: There were no difference in the complication rate between the 2 stretigies (12/14). Most common complication was chest pain in EVL group, but fever was common in HAI group. Also early and post rebleeding rates were not different in both groups. The main cause of death during follow up period was rebleeding in both groups. The survival rates were 65.0% in EVL group and 77.0% in HAI group (p$gt;0.05, duration: 23±2, 28±4 month), and there was no difference in mortlity rate (p=0.77). Conclusions: There were no difference in the hemostatic effect, complications, rebleeding rate and survival rate in EVL group and HAI group. However, evaluation of larger numbers of patients and prospective studies were needed to define the effectiveness and complications of these therapies.

십이지장 궤양에 의한 유문 협착에서 풍선 확장술의 장기 효과

이상우,김남재,서승원,이승민,이병석,정현용,양현웅,성재규,임의혁,이경태 대한소화기내시경학회 2000 Clinical Endoscopy Vol.21 No.5

Background/Aims: Balloon dilatation is a useful alternative to surgery in patients with benign pyloric stenosis. However, little data are available on the long-term outcome of the procedure. This report was attempted to determine the safety and efficacy of endoscopic balloon dilatation for 14 patients with gastric outlet obstruction caused by duodenal ulcer. Methods: Review of medical records or telephone interview was performed retrospectively. Results: Follow-up was conducted for median 18.5 months (3-48 months). Gastric outlet strictures had a median diameter 6 mm (range, 2-9 mm). Five (35.7%) patients had active ulcer. 12 mm to 18 mm balloons were inflated a median of 1 times (range, 1-4 times) for a median of 4 minutes (range, 1 11 minutes). Thirty-two procedure (1.5/patient) were performed; 9 patients (64.3%) had one treatment and 5 patients (35.7%) had multiple treatment. Immediate symptomatic relief was achieved in 13 patients (92.8%) and 7 patients (50%) achieved sustained symptomatic relief. Dilatation failed only in 2 patients (14.3%) ultimately and both recovered by palliative bypass surgery. No complication was noted during treatment. Conclusions: Endoscopic balloon dilatation is safe and effective for most patients with gastric outlet obstruction induced by duodenal ulcer. And due to limitation of retrospective aspect of this report, further prospective, randomized studies must be performed.

Organotextile Catalysis

Lee, Ji-Woong,Mayer-Gall, Thomas,Opwis, Klaus,Song, Choong Eui,Gutmann, Jochen Stefan,List, Benjamin American Association for the Advancement of Scienc 2013 Science Vol.341 No.6151

<P><B>Catalytic Parachute</B></P><P>Small organic molecules have emerged as catalysts as versatile as transition metal complexes. However, industrial application of such organocatalysts has been hampered by technical challenges. Now <B>Lee <I>et al.</I></B> (p. 1225) have succeeded in tethering a diverse set of high-performance organocatalysts to nylon fabric through ultraviolet photochemistry, making them easy to isolate and reuse.</P>

Hydrogen-bond promoted nucleophilic fluorination: concept, mechanism and applications in positron emission tomography

Lee, Ji-Woong,Oliveira, Maria Teresa,Jang, Hyeong Bin,Lee, Sungyul,Chi, Dae Yoon,Kim, Dong Wook,Song, Choong Eui The Royal Society of Chemistry 2016 Chemical Society reviews Vol.45 No.17

<P>Due to the tremendous interest in carbon-fluorine bond-forming reactions, research efforts in this area have been dedicated to the development of facile processes to synthesize small fluorine-containing organic molecules. Among others, PET (Positron Emission Tomography) is one of the most important applications of fluorine chemistry. Recognizing the specific requirements of PET processes, some groups have focused on fluorination reactions using alkali metal fluorides, particularly through S(N)2-type reactions. However, a common 'misconception'' about the role of protic solvents and hydrogen bonding interactions in this class of reactions has hampered the employment of these excellent promoters. Herein, we would like to review recent discoveries in this context, showing straightforward nucleophilic fluorination reactions using alkali metal fluorides promoted by protic solvents. Simultaneous dual activation of reacting partners by intermolecular hydrogen bonding and the enhancement of the 'effective fluoride nucleophilicity'', which is Nature's biocatalytic approach with the fluorinase enzyme, are the key to this unprecedentedly successful nucleophilic fluorination.</P>