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김기운,김시영,이종서,김철,정윤석 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4
Background: In most cases of a foreign body in the esophagus, an ENT specialist is consulted, which may be time consuming if not evaluated in a timely fashion. The patients are admitted to the hospital and sent to the operating room, where they are placed under anesthesia and the object is removed by using an esophagoscope. Methods: A prospective randomized trial was conducted during the period from January 1998 to June 2000. All patients presenting to emergency department with blunt objects in the esophagus were included. In one group, with fluoroscopic guidance, a Foley catheter was placed to remove the blunt foreign bodies. And in the other group, we removed them by using the esophagoscpe. We used the t-test for statistical analysis in this study. Results: Total number of patients enrolled in this study was 38.22 patients were enrolled in the Foley Catheter removal group, and the remaining 16 were enrolled in the esophagoscope removal group. The success rate for the Foley catheter was 21/22(95.5%), and that for the esophagoscope was 15/16(93.8%). The average time of removal for the Foley catheter group was 0.70± 0.28 hours while that for the esophagoscope group was 5.96 ± 2.22 hours. One side effect, nonfatal hypoxia, was noted in the Foley catheter removal group. The average cost for the Foley catheter group were 78,800 won(approximately 600 US dollars) while that for the esophagoscope group took 722,800 won(approximately 600 US dollars). Conclusion: In our study, we found that the success rate for removing blunt foreign bodies from the esophagus by using a simple Foley catheter was high, also the Foley catheter was a time saving and cost effective procedure with an excellent safety profile.
김시운,정길수,박병수,유남재 江原大學校 産業技術硏究所 2005 産業技術硏究 Vol.25 No.A
In this research, centrifuge model experiments and numerical approach of finite element method to analyze experimental results were performed to investigate the behavior of improved ground with sand compaction piles. One of typical clay minerals, kaolinite powder, were prepared for soft ground in model tests. Jumunjin standard sand was used to sand compaction pile installed in the soft soil. In order to investigate the characteristics of mechanical behavior of sand compaction piles with low replacement ratios, centrifuge model experiments with the replacement ratio of 40%, changing the width of improved area with respect to testing results the width of surcharge loads, were carried out to obtain of bearing capacity, characteristics of load-settlement, vertical stresses acting on the sand pile and the soft soil failure mechanism in improved ground.
Si-Woon Park,You-lim Yim,Sook-hee Yi,Hyun-young Kim,Seung-min Jung 대한재활의학회 2012 Annals of Rehabilitation Medicine Vol.36 No.2
Locked-in Syndrome is a severe pontine stroke causing quadriplegia, lower cranial nerve paralysis, and mutism with preservation of only vertical gaze and upper eyelid movement in a conscious patient. We present a case of a Locked-in Syndrome patient who received communication training with augmentative and alternative communication equipment by using eye blinks. After 3 weeks of training, the patient was able to make an attempt to interact with other people, and associate a new word by Korean alphabet selection. Augmentative and alternative communication equipment which uses eye blinks might be considered to be benefi cial in improving the communication skills of locked-in syndrome patients.
<i>Leeuwenhoekiella polynyae</i> sp. nov., isolated from a polynya in western Antarctica
Si, Ok-Ja,Kim, So-Jeong,Jung, Man-Young,Choi, Seon-Bin,Kim, Jong-Geol,Kim, Song-Gun,Roh, Seong Woon,Lee, SangHoon,Rhee, Sung-Keun International Union of Microbiological Societies 2015 International journal of systematic and evolutiona Vol.65 No.5
<P>A Gram-stain-negative, motile by gliding, rod-shaped bacterial strain, designated SOJ2014-1<SUP>T</SUP> was isolated from surface water of a polynya in the Antarctic Ocean. A comparative 16S rRNA gene sequence analysis showed that strain SOJ2014-1<SUP>T</SUP> belongs to the genus <I>Leeuwenhoekiella</I> and is most closely related to <I>Leeuwenhoekiella marinoflava</I> DSM 3653<SUP>T</SUP> (97.5 % 16S rRNA gene sequence similarity). The G+C content of the genomic DNA of strain SOJ2014-1<SUP>T</SUP> was 38.8 mol%. Its predominant cellular fatty acids were summed feature 3 (composed of C<SUB>16 : 1</SUB>ω6<I>c</I> and/or C<SUB>16 : 1</SUB>ω7<I>c</I>), iso-C<SUB>17 : 0</SUB> 3-OH, iso-C<SUB>15 : 0</SUB>, iso-C<SUB>15 : 1</SUB> G and summed feature 9 (composed of iso-C<SUB>17 : 1</SUB>ω9<I>c</I> and/or 10-methyl C<SUB>16 : 0</SUB>). DNA–DNA relatedness between strain SOJ2014-1<SUP>T</SUP> and close relatives, <I>L. marinoflava</I> DSM 3653<SUP>T</SUP> and <I>Leeuwenhoekiella aequorea</I> LMG 22550<SUP>T</SUP>, was below 49 %. The respiratory quinone was MK-6. The major polar lipids were phosphatidylethanolamine, an unidentified aminolipid and two unidentified lipids. The strain grew at 0–35 °C (optimum, 25 °C) with 0–14.0 % (w/v) NaCl (optimum, 1.0–5.0 %). It was strictly aerobic and had different carbohydrate utilization traits compared with <I>L. marinoflava</I> DSM 3653<SUP>T</SUP>. Based on the phenotypic, chemotaxonomic and phylogenetic analyses, strain SOJ2014-1<SUP>T</SUP> is proposed as a representative of a novel species, <I>Leeuwenhoekiella polynyae</I>. The type strain is SOJ2014-1<SUP>T</SUP> ( = KCTC 42185<SUP>T</SUP> = JCM 30387<SUP>T</SUP>).</P>
Kiloniella antarctica sp. nov., isolated from a polynya of Amundsen Sea in Western Antarctic Sea
Si, Ok-Ja,Yang, Hye-Young,Hwang, Chung Yeon,Kim, So-Jeong,Choi, Sun-Bin,Kim, Jong-Geol,Jung, Man-Young,Kim, Song-Gun,Roh, Seong Woon,Rhee, Sung-Keun Microbiology Society 2017 International journal of systematic and evolutiona Vol.67 No.7
Therapeutic Potential of Adipose Tissue-Derived Stem Cells in Acute Lung Injury Rat Model
( Woon Jeong Lee ),( Yeon Hee Jung ),( Si Kyung Jung ),( Melissa K. Middleton ),( Seung Phil Choi ),( Gyu Nam Park ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.1
Acute respiratory distress syndrome (ARDS) is a major cause of morbidity and mortality in critically ill patients. We evaluated the therapeutic potential of adipose tissue-derived stem cells (ATSCs) in a murine model of acute lung injury (ALI). ATSCs, labeled with PKH-26, were injected intravenously into rats 24 hours after intratracheal lipopolysaccharide (LPS) challenge. Two or 14 days later, the rats were sacrificed to assess cell migration to injured lung and the degree of lung injury. ATSCs were identified both in ALI lung and in normal lung at 2 d after cell transplantation. However, after 14 d, more ATSCs were found in the ALI lung than in the normal lung. Furthermore, ATSC-treated rats demonstrated a trend towards decreased lung inflammation as measured by BAL cytokines and cellular response. These data suggest that intravenously injected ATSCs can migrate to acutely injured lung and may potentially play a role in attenuating the inflammatory response.
( Jung Hyun Kwon ),( Si Hyun Bae ),( Jong Young Choi ),( Seung Kew Yoon ),( Kwan Soo Byun ),( Seung Woon Paik ),( Young Suk Lim ),( Han Chu Lee ),( Kwang Hyub Han ),( Kwan Sik Lee ) 대한내과학회 2009 The Korean Journal of Internal Medicine Vol.24 No.3
Background/Aims: The virologic response of Koreans to combination therapy for chronic hepatitis C is similar to westerns; however, dose modification occurs more frequently in Koreans. We evaluated the rates of peginterferon α-2a and ribavirin dose modifications and their effect on the virologic response in Koreans. Methods: Patients with detectable HCV RNA and enrolled from multicenters were treated with peginterferon α-2a (180 μg/week) and ribavirin (800 mg/day) for 24 weeks (genotype non-1, n=37) or peginterferon α-2a (180 μg/week) and ribavirin (1,000-1,200 mg/day) for 48 weeks (genotype 1, n=55). Results: Early virologic response (EVR) and sustained virologic response (SVR) were 77.2% (genotype 1, 75%; non-1, 81%) and 66.3% (genotype 1, 56%; non-1, 81%), respectively. The frequency of dose modification was 32.6% within the first 12 weeks and 52.2% during the entire treatment period. No difference was found in SVR regardless of dose modification. However, the SVR for patients using ≥80% of the peginterferon dose was significantly higher than for those using <80% (81.3 vs. 50.0%, p=0.007), despite varying ribavirin doses. No difference was found in SVR regardless of whether the ribavirin dose was <80% or not. These results did not change based on genotype. Conclusions: We suggest that using at least 80% of the peginterferon α-2a dose in Koreans not only maintains SVR but also reduces drug side effects during the entire treatment period. A lower dose of ribavirin may be as efficacious as a standard dose. (Korean J Intern Med 2009;24:203-211)
A Unique Small Molecule Inhibitor of Enolase Clarifies Its Role in Fundamental Biological Processes
Jung, Da-Woon,Kim, Woong-Hee,Park, Si-Hwan,Lee, Jinho,Kim, Jinmi,Su, Dongdong,Ha, Hyung-Ho,Chang, Young-Tae,Williams, Darren R. American Chemical Society 2013 ACS CHEMICAL BIOLOGY Vol.8 No.6
<P>Enolase is a component of the glycolysis pathway and a “moonlighting” protein, with important roles in diverse cellular processes that are not related to its function in glycolysis. However, small molecule tools to probe enolase function have been restricted to crystallography or enzymology. In this study, we report the discovery of the small molecule “ENOblock”, which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity. ENOblock was isolated by small molecule screening in a cancer cell assay to detect cytotoxic agents that function in hypoxic conditions, which has previously been shown to induce drug resistance. Further analysis revealed that ENOblock can inhibit cancer cell metastasis <I>in vivo</I>. Moreover, an unexpected role for enolase in glucose homeostasis was revealed by <I>in vivo</I> analysis. Thus, ENOblock is the first reported enolase inhibitor that is suitable for biological assays. This new chemical tool may also be suitable for further study as a cancer and diabetes drug candidate.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/acbcct/2013/acbcct.2013.8.issue-6/cb300687k/production/images/medium/cb-2012-00687k_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cb300687k'>ACS Electronic Supporting Info</A></P>