3-D Deformation Behavior Simulation of Cable Stitch Based on Particle System in Weft Knitted Fabrics

Sha Sha,Lei Luo,Zhongmin Deng,Dapeng Yuan,Bin Li,Xuewei Jiang,Hui Tao,Qufu Wei 한국섬유공학회 2018 Fibers and polymers Vol.19 No.9

The static simulation of weft knitting can be efficiently realized by graphics simulation techniques, but there still remains a challenge for mechanical models. The lack of practical mechanical models significantly limit the realistic deformation behaviors of complex cable stitches, which lead to a great different between the simulation effect and the actual fabric. In order to obtain the deformation behavior and volumetric performance of cable stitch, loop models were built based on an improved particle system in this work. Compared with plain weft knitted, the offset value of bonding points of cable stitches were measured. By analyzing the relationship between the deformation of loops and the displacement of the particles, the deformation behavior of cable stitch was simulated. Velocity-Verlet integration was introduced to simulate cable stitches and the stable results were obtained. The results show that these models and algorithm displayed the accurate deformation behavior of cable stitches, as demonstrated by qualitative comparisons to measure the deformations of actual samples.

A Construction Method of Gene Expression Data Based on Information Gain and Extreme Learning Machine Classifier on Cloud Platform

Wei Sha-Sha,Lu Hui-Juan,Jin Wei,Li Chao 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.2

In vitro evaluation of 9-(2-phosphonylmethoxyethyl)adenine ester analogues, a series of anti-HBV structures with improved plasma stability and liver release

Sha Liao,Shi-Yong Fan,Qin Liu,Chang-Kun L,Jia Chen,Jing-Lai Li,Zhi-Wei Zhang,Zhen-Qing Zhang,Bo-Hua Zhong,Jian-Wei Xie 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.11

Chronic hepatitis B virus (HBV) infection maylead to liver cirrhosis and hepatocellular carcinoma, butfew drugs are available for its treatment. Acyclic nucleosidephosphonates (ANPs) have remarkable antivirusactivities but are not easily absorbed from the gastrointestinaltract and accumulate in the kidneys, resulting innephrotoxicity. Therefore, there is a need to find effectiveliver site-specific prodrugs. The dipivaloyloxymethyl esterof 9-(2-phosphonylmethoxyethyl)adenine (PMEA)—adefovirdipivoxil (ADV)—is a first-line therapy drug forchronic hepatitis B with a low therapeutic index because ofrenal toxicity and low hepatic uptake. In this study, a seriesof PMEA derivatives were synthesized to enhance plasmastability and liver release. The metabolic stability of ADV(Chemical I) and its two analogues (Chemicals II and III)was evaluated in rat plasma and liver homogenate in vitro. An ion-pair reverse-phase HPLC–UV method and a hybridion trap and high-resolution time-of-flight mass spectrometry(LC-IT-TOF-MS) were used to evaluate the degradationrate of the analogues and to identify their intermediatemetabolites, respectively. Chemicals I and II were hydrolyzedby cleavage of the C–O bond to give monoesters. Sufficient enzymatic activation in the liver homogenatethrough a relatively simple metabolic pathway, in additionto a favorable stability profile in rat plasma, made ChemicalII an optimal candidate. Next, six analogues based onthe structure of Chemical II were synthesized and evaluatedin plasma and liver homogenate. Compared toChemical II, these compounds generated less active PMEAlevels in rat liver homogenate. Therefore, chemical modificationof Chemical II may lead to new promising PMEAderivatives with enhanced plasma stability and liveractivation.

The K+/H+ antiporter AhNHX1 improved tobacco tolerance to NaCl stress by enhancing K+ retention

Wei-Wei Zhang,Jing-Jing Meng,Jin-Yi Xing,Sha Yang,Feng Guo,Xin-Guo Li,Shu-Bo Wan 한국식물학회 2017 Journal of Plant Biology Vol.60 No.3

High salinity is the one of important factors limiting plant growth and crop production. Many NHX-type antiporters have been reported to catalyze K+/H+ exchange to mediate salt stress. This study shows that an NHX gene from Arachis hypogaea L. has an important role in K+ uptake and transport, which affects K+ accumulation and plant salt tolerance. When overexpressing AhNHX1, the growth of tobacco seedlings is improved with longer roots and a higher fresh weight than the wild type (WT) under NaCl treatment. Meanwhile, when exposed to NaCl stress, the transgenic seedlings had higher K+/H+ antiporter activity and their roots got more K+ uptake. NaCl stress could induce higher K+ accumulation in the roots, stems, and leaves of transgenic tobacco seedlings but not Na+ accumulation, thus, leading to a higher K+/Na+ ratio in the transgenic seedlings. Additionally, the AKT1, HAK1, SKOR, and KEA genes, which are involved in K+ uptake or transport, were induced by NaCl stress and kept higher expression levels in transgenic seedlings than in WT seedlings. The H+-ATPase and H+-PPase activities were also higher in transgenic seedlings than in the WT seedlings under NaCl stress. Simultaneously, overexpression of AhNHX1 increased the relative distribution of K+ in the aerial parts of the seedlings under NaCl stress. These results showed that AhNHX1 catalyzed the K+/H+ antiporter and enhanced tobacco tolerance to salt stress by increasing K+ uptake and transport.

The Correlation between NK Cell and Liver Function in Patients with Primary Hepatocellular Carcinoma

( Wei Hong Sha ),( Xiao Hui Zeng ),( Lu Min ) 대한소화기학회 2014 Gut and Liver Vol.8 No.3

Background/Aims: This study aimed to detect the expression of natural killer (NK) cell receptor natural killer group 2D (NKG2D) in the peripheral blood of patients with primary hepatocellular carcinoma and to discuss the correlation between NK cell cytotoxicity and liver function. Methods: The number of NK cells and the expression of NK cell receptor NKG2D in peripheral blood were determined by flow cytometry in patients with primary hepatocellular carcinoma, hepatitis B cirrhosis, chronic hepatitis B, and healthy controls. Results: When compared with patients in the healthy and the chronic hepatitis B groups, the primary hepatocellular carcinoma group showed significant decreases in all parameters, including the cytotoxicity of NK cells on K562 cells, expression rate of NKG2D in NK cells, number of NKG2D+ NK cells, expression level of NKG2D, and number of NK cells (p<0.05). The activity of NK cells showed a positive correlation, whereas the Child-Pugh scores in the primary hepatocellular carcinoma and the hepatitis B cirrhosis groups showed a negative correlation with all parameters detected above. Conclusions: The decrease of NK cell activity in patients with primary hepatocellular carcinoma is closely related to their lower expression of NKG2D. Liver function affects the expression of NKG2D and the activity of NK cells.

Radiation-induced Cochlea Hair Cell Death: Mechanisms and Protection

Tan, Pei-Xin,Du, Sha-Sha,Ren, Chen,Yao, Qi-Wei,Yuan, Ya-Wei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Cochlea hair cell death is regarded to be responsible for the radiation-induced sensorineural hearing loss (SNHL), which is one of the principal complications of radiotherapy (RT) for head and neck cancers. In this mini-review, we focus on the current progresses trying to unravel mechanisms of radiation-induced hair cell death and find out possible protection. P53, reactive oxygen species (ROS) and c-Jun N-terminal kinase (JNK) pathways have been proposed as pivotal in the processes leading to radiation hair cell death. Potential protectants, such as amifostine, N-acetylcysteine (NAC) and epicatechin (EC), are claimed to be effective at reducing radiation-inducedhair cell death. The RT dosage, selection and application of concurrent chemotherapy should be pre-examined in order to minimize the damage to cochlea hair cells.

Robust Unit Commitment with Virtual Synchronous Renewables

Zhang Wei-Chao,Sheng Wanxing,Duan Qing,Sha Guanglin,Zhang Yao,Huang Hanyan,Yan Xiangwu 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.6

With the increasing penetration of renewable energy sources and the consequent displacement of synchronous generators, the frequency stability of power systems deteriorates since RESs cannot participate in active power and frequency control. By emulating the outer characteristics of SGs and deloading a controllable margin, RESs can also keep headroom and provide frequency responses. This paper focuses on incorporating virtual synchronous renewables into the unit commitment to optimize the joint scheduling of energy production and spinning reserves. First, based on the interval representation of renewable uncertainty, the renewable output is decomposed into the stochastic and dispatchable portions. The dispatchable portion, defi ned as VSRs, can keep deterministic regulation headroom and participate in power balance regulation. Second, a robust security-constrained unit commitment model is proposed to achieve optimal scheduling in face of multiple uncertainties. The fl exibility of the pumped-storage hydro station is also considered. Third, the solution strategies which linearize the nonlinear terms in the objective function and constraints are introduced. Finally, the correctness and eff ectiveness of the robust unit commitment model are tested and verifi ed in the modifi ed 39-bus system.

Study on Treatment of Basic Yellow 28 dye Wastewater by Micro-nano Bubble Ozone Catalytic Oxidation

Jie Wei,Hongwei Sha,Ruonan Wang 대한환경공학회 2023 Environmental Engineering Research Vol.28 No.5

Integrated Modeling for the Design of Deformable Mirrors Using a Parametric Module Method

Junqing Zhu,Wei Sha,Changzheng Chen,Xingxiang Zhang,Jianyue Ren 한국광학회 2015 Current Optics and Photonics Vol.19 No.5

Active optics is a key technology for future large-aperture space telescopes. In the design of deformablemirrors for space applications, the design parameter trade-off between the number of regularly configuredactuators and the correction capability is essential but rarely analyzed, due to the lack of design legacy. This paper presents a parametric module method for integrated modeling of deformable mirrors withregularly configured actuators. A full design parameter space is explored to evaluate the correctioncapability and the mass of deformable mirrors, using an autoconstructed finite-element parametric modelingmethod that utilizes manual finite-element meshing for complex structures. These results are used to providedesign guidelines for deformable mirrors. The integrated modeling method presented here can be used forfuture applied optics projects

Prebiotics enhance the biotransformation and bioavailability of ginsenosides in rats by modulating gut microbiota

Xiaoyan Zhang,Sha Chen,Feipeng Duan,An Liu,Shaojing Li,Wen Zhong,Wei Sheng,Jun Chen,Jiang Xu,Shuiming Xiao 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.2

Background: Gut microbiota mainly function in the biotransformation of primary ginsenosides into bioactive metabolites. Herein, we investigated the effects of three prebiotic fibers by targeting gut microbiota on the metabolism of ginsenoside Rb1 in vivo. Methods: Sprague Dawley rats were administered with ginsenoside Rb1 after a two-week prebiotic intervention of fructooligosaccharide, galactooligosaccharide, and fibersol-2, respectively. Pharmacokinetic analysis of ginsenoside Rb1 and its metabolites was performed, whilst the microbial composition and metabolic function of gut microbiota were examined by 16S rRNA gene amplicon and metagenomic shotgun sequencing. Results: The results showed that peak plasma concentration and area under concentration time curve of ginsenoside Rb1 and its intermediate metabolites, ginsenoside Rd, F2, and compound K (CK), in the prebiotic intervention groups were increased at various degrees compared with those in the control group. Gut microbiota dramatically responded to the prebiotic treatment at both taxonomical and functional levels. The abundance of Prevotella, which possesses potential function to hydrolyze ginsenoside Rb1 into CK, was significantly elevated in the three prebiotic groups (P < 0.05). The gut metagenomic analysis also revealed the functional gene enrichment for terpenoid/polyketide metabolism, glycolysis, gluconeogenesis, propanoate metabolism, etc. Conclusion: These findings imply that prebiotics may selectively promote the proliferation of certain bacterial stains with glycoside hydrolysis capacity, thereby, subsequently improving the biotransformation and bioavailability of primary ginsenosides in vivo.