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      • KCI등재후보

        Correlations Between Fasciology and Yin Yang Doctrine

        Hui Tao,Mei-chun Yu,Hui-ying Yang,Rong-mei Qu,Chun Yang,Xin Zhou,Yu Bai,Jing-peng Wu,Jun Wang,Ou Sha,Lin Yuan 사단법인약침학회 2011 Journal of Acupuncture & Meridian Studies Vol.4 No.2

        The aim of this study is to explore the correlations between fasciology and yin yang doctrine. Professor Yuan developed fasciology by three-dimensional reconstruction of connective tissue (fascia) in the trunk and limbs of the human body and tracing back to tissue origins in light of biological evolution and developmental biology. Fasciology states that the human body can be divided into two systems: the supporting-storing system and the functional system. This article elaborates on the roles of the two systems and their mutual relationship. The two systems are used to analyze the yin,the yang, and their relationship. The two systems are promoted but also restricted in different contexts. The supporting-storing system is formed by undifferentiated connective tissue and provides undifferentiated cells and nutrients for differentiated cells of the functional system. Thus, the supporting-storing system could be classified as quiet, similar to yin. The functional system continuously maintains the various functional activities of the human body. Thus, the functional system could be classified as active, similar to yang. In interpreting the yin yang doctrine from the point of view of fasciology, yin can be compared with the supporting-storing system and yang can be compared with the functional system.

      • KCI등재

        Long Noncoding RNA NEAT1 Aggravates Aβ-Induced Neuronal Damage by Targeting miR-107 in Alzheimer’s Disease

        Sha Ke,Zhaohui Yang,Fei Yang,Xiaoming Wang,Juan Tan,Bo Liao 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.7

        Purpose: Alzheimer’s disease (AD) is the most common neurodegenerative disease, with a rising prevalence worldwide. Longnoncoding RNAs (lncRNAs) have been found to play important roles in the development and treatment of AD. However, the exactrole of lncRNA nuclear enriched abundant transcript 1 (NEAT1) in neuronal damage in AD is largely unknown. Materials and Methods: The AD model was established in SH-SY5Y and SK-N-SH cells via treatment with amyloid β1-42 (Aβ). Theexpression of NEAT1 and microRNA-107 (miR-107) was measured by quantitative real-time polymerase chain reaction. Cell viabilityand apoptosis were detected by MTT assay, immunocytochemistry, and flow cytometry. The expression of phosphorylated tauprotein (p-Tau) was measured by Western blot. The interaction between NEAT1 and miR-107 was explored by bioinformaticsanalysis, luciferase activity, and RNA immunoprecipitation assays. Results: NEAT1 expression was enhanced in Aβ-treated SH-SY5Y and SK-N-SH cells, and its knockdown attenuated Aβ-inducedinhibition of viability and promotion of apoptosis and p-Tau levels. NEAT1 was indicated as a decoy of miR-107. miR-107 abundancewas reduced in Aβ-treated cells, and its overexpression reversed Aβ-induced injury. Moreover, interference of miR-107 abatedsilencing of NEAT1-mediated inhibition of neuronal damage in Aβ-treated SH-SY5Y and SK-N-SH cells. Conclusion: LncRNA NEAT1 aggravated Aβ-induced neuronal damage by sponging miR-107, indicating a novel avenue for treatmentof AD.

      • KCI등재

        Antioxidant Activity of Novel Casein-Derived Peptides with Microbial Proteases as Characterized via Keap1-Nrf2 Pathway in HepG2 Cells

        ( Xiao Zhao ),( Ya-juan Cui ),( Sha-sha Bai ),( Zhi-jie Yang ),( Miao-cai ),( Sarah Megrous ),( Tariq Aziz ),( Abid Sarwar ),( Dong Li ),( Zhen-nai Yang ) 한국미생물 · 생명공학회 2021 Journal of microbiology and biotechnology Vol.31 No.8

        Casein-derived antioxidant peptides by using microbial proteases have gained increasing attention. Combination of two microbial proteases, Protin SD-NY10 and Protease A “Amano” 2SD, was employed to hydrolyze casein to obtain potential antioxidant peptides that were identified by LC-MS/MS, chemically synthesized and characterized in a oxidatively damaged HepG2 cell model. Four peptides, YQLD, FSDIPNPIGSEN, FSDIPNPIGSE, YFYP were found to possess high 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging ability. Evaluation with HepG2 cells showed that the 4 peptides at low concentrations (< 1.0 mg/ml) protected the cells against oxidative damage. The 4 peptides exhibited different levels of antioxidant activity by stimulating mRNA and protein expression of the antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), as well as nuclear factor erythroid-2-related factor 2 (Nrf2), but decreasing the mRNA expression of Kelch-like ECH-associated protein 1 (Keap1). Furthermore, these peptides decreased production of reactive oxygen species (ROS) and malondialdehyde (MDA), but increased glutathione (GSH) production in HepG2 cells. Therefore, the 4 casein-derived peptides obtained by using microbial proteases exhibited different antioxidant activity by activating the Keap1-Nrf2 signaling pathway, and they could serve as potential antioxidant agents in functional foods or pharmaceutic preparation.

      • KCI등재

        Enhanced Hydrogen Evolution Properties Obtained by Ultrasonic-Cyclic Voltammetry Modification of C-Supported PtCu Thin Film Catalyst

        Sha Yi,Bin Yang,Zhan- Sheng Zhang 대한금속·재료학회 2017 METALS AND MATERIALS International Vol.23 No.3

        Carbon-supported Pt-Cu (Pt-Cu/C) bimetallic catalyst was synthesized by Ion Beam Sputtering technologyand subsequently annealed in vacuum and electrochemically etched by Ultrasonic-Cyclic Voltammetry (US-CV). Electrochemical measurements indicate that the sample was modified electrochemically by US-CV shows highercatalytic activity towards hydrogen evolution reaction than pure Pt/C. Scanning and transmission electron microscopyand electronic differential system analysis reveal that the surface of post-processed catalyst producedPtCu@Pt core-shell structure which increasing the efficiency of Pt. Transmission electron microscope analysisdisplays that on the surface of PtCu@Pt core-shell particles detects lattice compressive strain, the lattice compressionvariable is around 1.12%. X-ray photoelectron spectroscopy analysis confirms that the Pt4f7/2 binding energyof the post-processed PtCu/C is 71.10 eV, decreased by 0.2 eV compared to pure Pt/C (71.3 eV). It can be inferredthat the enhancement of catalytic property attribute to the Cu atoms modified the geometric structure and electronicstructure of the Pt atoms.

      • KCI등재

        Integrated Optimization Design of Carbon Fiber Composite Framework for Small Lightweight Space Camera

        Shuai Yang,Wei Sha,Changzheng Chen,Xingxiang Zhang,Jianyue Ren 한국광학회 2016 Current Optics and Photonics Vol.20 No.3

        A Carbon Fiber Composite (CFC) framework was designed for a small lightweight space camera. According to the distribution characteristics of each optical element in the optical system, CFC (M40J)was chosen to accomplish the design of the framework. TC4 embedded parts were used to solve the lowaccuracy of the CFC framework interface problem. An integrated optimization method and the optimizationstrategy which combined a genetic global optimization algorithm with a downhill simplex local optimizationalgorithm were adopted to optimize the structure parameters of the framework. After optimization, thetotal weight of the CFC framework and the TC4 embedded parts is 15.6 kg, accounting for only 18.4%that of the camera. The first order frequency of the camera reaches 104.8 Hz. Finally, a mechanicalenvironment test was performed, and the result demonstrates that the first order frequency of the camerais 102 Hz, which is consistent with the simulation result. It further verifies the rationality and correctnessof the optimization result. The integrated optimization method mentioned in this paper can be applied tothe structure design of other space cameras, which can greatly improve the structure design efficiency.

      • KCI등재

        Identification, fine mapping and characterization of Rht-dp, a recessive wheat dwarfing (reduced height) gene derived from Triticum polonicum

        Hou-Yang Kang,Li-Juan Lin,Zhi-Jian Song,Jing-Ya Yuan,Mei-Yu Zhong,Hai-Qin Zhang,Xing Fan,Li-Na Sha,Yi Wang,Li-Li Xu,Jian Zeng,Yong-Hong Zhou 한국유전학회 2012 Genes & Genomics Vol.34 No.5

        Semi-dwarfism is an agronomically important trait in breeding for resistance to damage by wind and rain (lodging resistance)and for stable high yields. Dwarf Polish wheat (Triticum polonicum L., 2n = 4x = 28, AABB AS304) is a potential donor of dwarfing and other traits for common wheat improvement. A genetic analysis using an F2 population derived from a cross of AS304 and tall cultivar AS302 and derived F2:3 lines indicated that AS304 carries a recessive dwarfing gene, temporarily designated Rht-dp. Molecular markers and bulked segregant analysis were used to characterize and map the gene. Eight polymorphic SSR markers (Xwmc511, Xgwm495, Xgwm 113, Xgwm192, Xgpw7026, Xgpw3017, Xgpw1108 and Xgpw7521) on chromosome arm 4BS and two AFLP markers (M8/E5 and M4/E3) were mapped relative to the dwarfing locus. The closest linked markers, Xgpw3017 and M8/E5 at 0.5 and 3.5 cM, respectively, from Rht-dp will enable its marker assisted transfer to wheat breeding populations. Allelic tests indicated that Rht-dp was allelic to Rht-B1b; hence it may be an alternative allele at the Rht-B1 locus.

      • SCIESCOPUSKCI등재

        Novel impedance matching method based on negative resistors for WPT

        Li, Yang,Liu, Jiaming,Jiang, Shan,Ni, Xin,Ma, Jingnan,Wang, Rui,Sha, Lin The Korean Institute of Power Electronics 2020 JOURNAL OF POWER ELECTRONICS Vol.20 No.4

        In a wireless power transfer (WPT) system via coupled magnetic resonance, the transmission power and efficiency dramatically decrease with increased in the transfer distance and load variations. In the conventional impedance matching method, different resistors are matched by adjusting passive devices such as capacitors and inductors. The corresponding matching range changes with different topological network structures. In particular, there exists a matching forbidden zone. In this paper, a novel impedance matching method based on a negative resistor is proposed to match the impedance in the forbidden zone. First, the conventional impedance matching network is analyzed based on circuit theory. Then, the feasibility of the proposed method is verified. In addition, the receiving power obtained using the conventional matching method is compared with that obtained using the proposed method. It is theoretically verified that the novel method can break the upper power limit related to the conventional method, which realizes a higher receiving power. A prototype was built in the laboratory. Experimental results show the feasibility of the novel method. Moreover, derived simulation results were basically consistent with the experimental values, which also demonstrates the validity of the proposed method.

      • SCOPUSKCI등재
      • KCI등재

        Georgenia faecalis sp. nov. isolated from the faeces of Tibetan antelope

        Wang Xiaoxia,Yang Jing,Huang Yuyuan,Wu Xiaomin,Wang Licheng,Han Limei,Li Sha,Li Huan,Fu Xiaoying,Chen Hai,Zhu Xiong 한국미생물학회 2020 The journal of microbiology Vol.58 No.9

        Two aerobic, Gram-stain-positive, non-motile, non-sporulating coccoid strains, designated ZLJ0423T and ZLJ0321, were isolated from the faeces of Tibetan antelope (Pantholops hodgsonii). Their optimal temperature, NaCl concentration and pH for growth were 28°C, 0.5% (w/v) NaCl and pH 7.5, respectively. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strains ZLJ0423T and ZLJ0321 were very similar to each other (99.8%) and had a sequence similarity of 97.0% with Georgenia satyanarayanai NBRC 107612T and Georgenia subflava CGMCC 1.12782T. Phylogenomic analysis based on 688 core genes indicated that these strains formed a clade with G. satyanarayanai NBRC 107612T and Georgenia wutianyii Z294T. The predominant cellular fatty acids were anteiso-C15:0, anteiso-C15:1 A and C16:0. The major menaquinone was MK-8(H4). The cell-wall amino acids consisted of alanine, lysine, glycine and aspartic acid, with lysine as the diagnostic diamino acid. Diphosphatidylglycerol, phosphatidylglycerol, phosphatidylinositol, phosphatidylinositol mannosides and two unidentified lipids formed the polar lipid profile. The DNA G + C content of both isolates was 73.9 mol%. The digital DNA–DNA hybridization value between strains ZLJ0423T and ZLJ0321 was 91.2%, but their values with closely related species and other available type strains of the genus Georgenia were lower than the 70% threshold. On the basis of polyphasic taxonomic data, strains ZLJ0423T and ZLJ0321 represent a novel species within the genus Georgenia, for which the name Georgenia faecalis sp. nov. is proposed. The type strain is ZLJ0423T (= CGMCC 1.13681T = JCM 33470T).

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