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Dietary Capsaicin Attenuates Metabolic Dysregulation in Genetically Obese Diabetic Mice
Ji-Hye Kang,Goto Tsuyoshi,Hoan Le Ngoc,Hong-Min Kim,Thai Hien Tu,Hye-Ji Noh,김추숙,Suck-Young Choe,Teruo Kawada,유훈,Rina Yu 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.3
Metabolic dysregulation (e.g., hyperglycemia, hyperinsulinemia, hyperlipidemia, etc.) is a hallmark of obesity-related diseases such as insulin resistance, type 2 diabetes, and fatty liver disease. In this study, we assessed whether dietary capsaicin attenuated the metabolic dysregulation in genetically obese diabetic KKAy mice, which have severe diabetic phenotypes. Male KKAy mice fed a high-fat diet for 2 weeks received a 0.015% capsaicin supplement for a further 3 weeks and were compared with nonsupplemented controls. Dietary capsaicin markedly decreased fasting glucose/insulin and triglyceride levels in the plasma and/or liver, as well as expression of inflammatory adipocytokine genes (e.g., monocyte chemoattractant protein-1 and interleukin-6) and macrophage infiltration. At the same time expression of the adiponectin gene/protein and its receptor, AdipoR2, increased in adipose tissue and/or plasma, accompanied by increased activation of hepatic AMP-activated protein kinase, a marker of fatty acid oxidation. These findings suggest that dietary capsaicin reduces metabolic dysregulation in obese/diabetic KKAy mice by enhancing expression of adiponectin and its receptor. Capsaicin may be useful as a dietary factor for reducing obesity-related metabolic dysregulation.
Design and Measurement of the RF Properties of a 13 MHz Cavity for the RF Implanter
Tu Anh Trinh,조용섭,권혁중,Ji-Ho Jang,김한성,박범식,설경태,김대일 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.22
A 13 MHz Radio Frequency (RF) cavity for an RF implanter has been designed and fabricated at the Proton Engineering Frontier Project (PEFP). It consists of a coil having a circular cross-section, accelerating electrodes that are directly coupled to the beginning and the end of the coil, and a ground electrode for the inductor. The purpose of this paper is to explain the design concept and the measurement results for the RF properties of this cavity. A resonant frequency of 12.69 MHz with critical coupling and an unloaded quality factor of 1066 were achieved, agreeing well with the simulation results. The field distribution in the cavity was measured by using the bead-pull method. The field flatness is 6.5%, which satisfies the control requirements for the field in the cavity.
Tu, Thu-Hien Thi,Sharma, Naveen,Shin, Eun-Joo,Tran, Hai-Quyen,Lee, Yu Jeung,Nah, Seung-Yeol,Tran, Hoang-Yen Phi,Jeong, Ji Hoon,Jeong, Jung Hwan,Ko, Sung Kwon,Byun, Jae Kyung,Kim, Hyoung-Chun Georg Thieme Verlag KG 2017 Planta medica Vol.83 No.17
<B>Abstract</B><P> Panax ginseng is the most widely used herbal medicine for improving cognitive functions. The pharmacological activity and underlying mechanisms of mountain-cultivated ginseng, however, have yet to be clearly elucidated, in particular, against trimethyltin-induced cognitive dysfunction. We previously reported that interleukin-6 plays a protective role against trimethyltin-induced cognitive dysfunction. Because of this, we have implemented a study system that uses interleukin-6 null (−/−) and wild-type mice. Interestingly, mountain-cultivated ginseng significantly upregulated interleukin-6 expression. With this study, we sought to determine whether the interleukin-6-dependent modulation of the Janus kinase 2/signal transducer activator of transcription 3 and extracellular signal-regulated kinase signaling network is also associated with the pharmacological activity of mountain-cultivated ginseng against trimethyltin-induced cognitive dysfunction. Trimethyltin treatment (2.4 mg/kg, intraperitoneal) causes the downregulation of Janus kinase 2/signal transducer activator of transcription 3, extracellular signal-regulated kinase signaling, and impairment of the cholinergic system. We found that mountain-cultivated ginseng treatment (50 mg/kg, intraperitoneal) significantly attenuated cognitive impairment normally induced by trimethyltin by upregulating p-Janus kinase 2/signal transducer activator of transcription 3, p-extracellular signal-regulated kinase signaling, and the cholinergic system. Trimethyltin-induced cognitive impairments were more pronounced in interleukin-6 (−/−) mice than wild-type mice, and they were markedly reduced by treatment with either mountain-cultivated ginseng or recombinant interleukin-6 protein (6 ng, intracerebroventricular). Additionally, treatment with either AG490 (20 mg/kg, intraperitoneal), a Janus kinase 2/signal transducer activator of transcription 3 inhibitor, or U0126 (2 µg/head, intracerebroventricular), an extracellular signal-regulated kinase inhibitor, reversed the effects of mountain-cultivated ginseng treatment. The effects of mountain-cultivated ginseng treatment were comparable to those of recombinant interleukin-6 protein in interleukin-6 (−/−) mice. Our results, therefore, suggest that mountain-cultivated ginseng acts through interleukin-6-dependent activation of Janus kinase 2/signal transducer activator of transcription 3/extracellular signal-regulated kinase signaling in order to reverse cognitive impairment caused by trimethyltin treatment.</P>
Friction-Assisted Dissimilar Solid State Lap Joining of Aluminum and Copper Pipes
Ji-Won Kang,Shengwei Zhang,Tu-Anh Bui Thi,Sung-Tae Hong,Siwhan Lee,Heung Nam Han 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.2
The friction-assisted solid state lap joining process of dissimilar metal pipes is proposed by joining copper (Cu) and aluminum (Al) pipes. The joining process is designed to have two successive stages. In the first stage, the Cu pipe rotating with a mandrel rotates against the inner surface of the Al pipe. In the first stage, the relative rotation between the Cu and Al pipes breaks the oxide layers on the contacting surfaces and increases the temperature at the interface. In the second stage, as the area of the contact surface between the Cu and Al pipes increases due to the linear motion of the mandrel; as the mandrel begins to rotate alone against the Cu pipe, which now becomes stationary to induce diffusion bonding between the Cu and Al pipes. The results of microstructural analysis and mechanical testing show that solid state lap joining between the Cu and Al pipes for a light-weight heat exchanging component is successfully achieved. The microstructure evolution suggests that grain refinement by recrystallization occurs in the joining region for both the Cu and Al sides.
Tu, Yunjie,Shu, Jingting,Ji, Gaige,Zhang, Ming,Zou, Jianmin Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.10
Objective: We report monitoring conservation effect for a Chinese indigenous chicken (Langshan) breed using major histocompatibility complex (MHC) and DNA barcords. Methods: The full length of MHC B-G gene and mitochondrial cytochrome oxidase I (COI) gene in generations 0, 5, 10, 15, 16, and 17 was measured using re-sequencing and sequencing procedures, respectively. Results: There were 292 single nucleotide polymorphisms of MHC B-G gene identified in six generations. Heterozygosity (He) and polymorphic information content (PIC) of MHC B-G gene in generations 10, 15, 16, and 17 remained stable. He and PIC of MHC B-G gene were different in six generations, with G10, G15, G16, G17 >G5>G0 (p<0.05). For the COI gene, there were five haplotypes in generations 0, 5, 10, 15, 16, and 17. Where Hap2 and Hap4 were the shared haplotypes, 164 individuals shared Hap2 haplotypes, while Hap1 and Hap3 were the shared haplotypes in generations 0 and 5 and Hap5 was a shared haplotype in generations 10, 15, 16, and 17. The sequence of COI gene in 6 generations was tested by Tajima's and D value, and the results were not significant, which were consistent with neutral mutation. There were no differences in generations 10, 15, 16, and 17for measured phenotypic traits. In other generations, for annual egg production, with G5, G10, G15, G16, G17>G0 (p<0.05). For age at the first egg and age at sexual maturity, with G10, G15, G16, G17>G5>G0 (p<0.05). Conclusion: Combined with the results of COI gene DNA barcodes, MHC B-G gene, and phenotypic traits we can see that genetic diversity remained stable from generations 10 to 17 and the equimultiple random matching pedigrees conservation population conservation effect of Langshan chicken was effective as measured by these criteria.
Net Phosphorus Requirements of Dorper×Thin-tailed Han Crossbred Ram Lambs
Ji, Shoukun,Xu, Guishan,Jiang, Chenggang,Deng, Kaidong,Tu, Yan,Zhang, Naifeng,Ma, Tao,Lou, Can,Diao, Qiyu Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.9
A comparative slaughter trial was conducted to estimate the phosphorus (P) requirement for maintenance and growth of crossbred lambs of Dorper with a Chinese indigenous sheep breed, thin-tailed Han sheep. Thirty-five Dorper${\times}$thin-tailed Han crossbred, noncastrated ram lambs ($20.3{\pm}0.22kg$ of shrunk body weight (SBW)) were used. Seven lambs were randomly chosen and slaughtered at 20 kg SBW as the baseline group for measuring initial body composition. Another seven lambs were also randomly chosen and offered a pelleted mixed diet for ad libitum intake and slaughtered at 28 kg SBW. The remaining 21 sheep were randomly divided into 3 groups with 7 sheep each and subject to the same diet of either 70 or 40% of ad libitum intake. The 3 groups were slaughtered when the sheep fed ad libitum reached 35 kg of SBW. Body P contents were determined after slaughter. The results showed that the net P requirement for maintenance was 30.0 mg/kg of empty body weight (EBW) or 23.4 mg/kg body weight (BW), and the P requirement for growth decreased from 5.3 to 5.0 g/kg of EBW gain as the lamb grew from 20 to 35 kg. The net P requirement for growth of Dorper${\times}$thin-tailed Han crossbred ram lambs was lower than that of sheep adopted by the American nutritional system.
( Lei Tu ),( Payam Gharibani ),( Yi Yang ),( Bo Zhang ),( Feng Ji ),( Jieyun Yin ),( Jiande D Z Chen ) 대한소화기 기능성질환·운동학회 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.1
Background/Aims Gastroparesis is commonly seen in patients with diabetes and functional dyspepsia with no satisfactory therapies. Dysautonomia is one of the main reasons for the imbalanced motility. We hypothesized that spinal cord stimulation (SCS) is a viable therapy for gastroparesis via the autonomic modulation to improve gastric motility. The aim is to find an optimal method of SCS for treating gastroparesis. Methods Eight healthy-female dogs were implanted with a gastric cannula, a duodenal cannula, 2 multi-electrode spinal leads, and an implantable pulse generator. Gastric motility index (MI) was used to determine the best stimulation location/parameters of SCS. Optimized SCS was used to improve glucagon-induced gastroparesis. Results With fixed parameters, SCS at Thoracic 10 (T10) was found most effective for increasing gastric MI (37.8%, P = 0.013). SCS was optimized with different parameters (pulse width: 0.05-0.6 msec, frequency: 5-500 Hz, motor threshold: 30-90%) on T10. Our findings revealed that 0.5 msec, 20 Hz with 90% motor threshold at T10 were the best parameters in increasing MI. Glucagon significantly delayed gastric emptying, and this inhibitory effect was partially blocked by SCS. Gastric emptying at 120 minutes was 25.6% in the control session and 15.7% in glucagon session (P = 0.007 vs control), while it was 22.9% with SCS session (P = 0.041 vs glucagon). SCS with the optimal parameters was found to maximally enhance vagal activity and inhibit sympathetic activity assessed by the spectral analysis of heart rate variability. Conclusions SCS with optimized stimulation location and parameters improves gastric motility in healthy-dogs and accelerates gastric emptying impaired by glucagon via enhancing vagal activity.
Yanwei Ji,Yang Xu,Yanping Li,Zhui Tu,Zhibing Huang,Xue Liu,Da Lei 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.1
The purpose of this study was to develop a membrane filtration method to isolate uninuclei conidium of Aspergillus oryzae, then the method was adopted to develop a transformation system of A. oryzae. A. oryzae 3.951 contained 1–4 nuclei in each conidium. The percentages of uninucleate and binucleate conidia were approximately 16.15 and 74.22%, respectively. Conidia suspension was filtrated with a 5-μm membrane to overcome the bottleneck caused by multinucleate conidia and to remove excess multinucleate conidia before UV mutagenesis. Uninucleate conidia of 5-fluoroorotic acid (5-FOA)-resistant strains were enriched by filtration with a 3-μm membrane. The pyrG mutant strain AS11 was obtained and GFP-pyrG was successfully transformed into AS11.