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To Dao Cuong,Hoang Thi Ngoc Anh,Tran Thu Huong,Pham Ngoc Khanh,Vu Thi Ha,Tran Manh Hung,김영호,Nguyen Manh Cuong 한국생약학회 2019 Natural Product Sciences Vol.25 No.4
Soluble epoxide hydrolases (sEH) are enzymes present in all living organisms, metabolize epoxy fatty acids to 1,2-diols. sEH in the metabolism of polyunsaturated fatty acids plays a key role in inflammation. In addition, the endogenous lipid mediators in cardiovascular disease are also broken down to diols by the action of sEH that enhanced cardiovascular protection. In this study, sEH inhibitory guided fractionation led to the isolation of five phenolic compounds trans-resveratrol (1), trans-piceatannol (2), sulfuretin (3), (+)-balanophonin (4), and cassigarol E (5) from the ethanol extract of the seeds of Passiflora edulis Sims cultivated in Vietnam. The chemical structures of isolated compounds were determined by the interpretation of NMR spectral data, mass spectra, and comparison with data from the literature. The soluble epoxide hydrolase (sEH) inhibitory activity of isolated compounds was evaluated. Among them, trans-piceatannol (2) showed the most potent inhibitory activity on sEH with an IC50 value of 3.4 mM. This study marks the first time that sulfuretin (3) was isolated from Passiflora edulis as well as (+)-balanophonin (4), and cassigarol E (5) were isolated from Passiflora genus.
Experiment on Nearest Level Modulation algorithm for FPGA based Modular Multilevel Converters
Tran Hung Cuong,Pham Viet Phuong,Tran Van Phuong,Tran Trong Minh 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
Modular Multilevel Converters (MMC) have many advantages in comparison with conventional multilevel converters in application to high voltage system. However, the control system of MMC requires a large amount of I/O signal ports which cannot be generated by a single digital signal processor (DSP) with maximum I/O port of 24. This paper fucuses on the experimental results of aMMC that uses a Field Programmable Gate Array (FPGA) in which embedge the Nearest Level Modulation (NLM) method and capacitor voltage balancing algorithm. The MMC consists of 12 Sub-Modules (SM) in each phase to generate a 13-level ac output voltage. Applying the NLM method and capacitor voltage balancing algorithm have significantly reduced the switching frequency and produced an ac output voltage with very low harmonic distortion. The experimental results have verified by a laboratory-scale prototype and compared with the simulation results.
Phenolic Compounds from <i>Caesalpinia sappan</i> Heartwood and Their Anti-inflammatory Activity
Cuong, To Dao,Hung, Tran Manh,Kim, Jin Cheol,Kim, Eun Hee,Woo, Mi Hee,Choi, Jae Sue,Lee, Jeong Hyung,Min, Byung Sun American Chemical Society and American Society of 2012 Journal of natural products Vol.75 No.12
<P>Four new phenolic compounds, caesalpiniaphenols A–D (<B>1</B>–<B>4</B>), together with eight known compounds were isolated from <I>Caesalpinia sappan</I> heartwood. The chemical structures were established mainly by NMR, MS, ECD, and Mosher’s method. Compounds <B>4</B>, <B>5</B>, and <B>7</B> showed weak inhibitory activity against the LPS-induced NO production in macrophage RAW264.7 cells with IC<SUB>50</SUB> values of 12.2, 3.5, and 5.7 μM, respectively.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2012/jnprdf.2012.75.issue-12/np3003673/production/images/medium/np-2012-003673_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np3003673'>ACS Electronic Supporting Info</A></P>
Trung Tran,Loc Thi My Nguyen,Thanh Thi Nghiem,Hien Thi Thu Le,Cuong Huu Nguyen,Thuy Phuong La,Trung Tien Nguyen,Hang Thi-Thu Nguyen 한국과학학술지편집인협의회 2019 Science Editing Vol.6 No.2
This study aimed at elucidating the present situation of scholarly journals published in Vietnam according to the minimum criteria to be indexed in the ASEAN Citation Index (ACI) and Scopus, with the goal of suggesting development strategies for scholarly journals in Vietnam. From the 387 journals accredited by the Vietnamese State Council for Professorship, 13 education journals were arbitrarily selected, and their compliance with the five minimum criteria for the ACI (peer review, timeliness, abstracts in English, references in Roman script, and a website in English) and the six minimum criteria for Scopus (peer review, timeline, abstracts in English, references in Roman characters, Electronic International Standard Serial Number [ISSN], and publication ethics) were assessed. Two of the 13 journals were eligible to be indexed in the ACI, while none fulfilled the minimum criteria to be indexed in Scopus. An urgent task for the editors of those journals is to establish an informative journal homepage in English that provides basic information on the journal. Then, an Electronic ISSN can be obtained from the ISSN International Center. Furthermore, the following steps are suggested for journal promotion: establishment of appropriate editorial policies and publication ethics procedures, improvement of research integrity, enhancement of the journals’ reputation in the international scientific community, and improvement of the online publishing system by adopting a journal manuscript management system. To achieve those goals, financial support from the Vietnamese government will be invaluable.
Viet Hung Pham,정진석,Thanh Truong Dang,Tran Viet Cuong,Seung Hyun Hur,Byung-Seon Kong,김의정 한국화학공학회 2012 Korean Journal of Chemical Engineering Vol.29 No.5
We report the effect of temperature on the extent of graphene oxide reduction by hydrazine and the dispersibility of the resulting chemically converted graphene (CCG) in polar organic solvents. The extent of graphene oxide reduction at high temperatures was only slightly higher than at low temperatures (30-50 oC), while the dispersibility of the resulting CCG in organic solvents decreased markedly with increasing temperature. The low dispersibility of CCGs prepared at high temperatures was greatly affected by reduction and influenced by the formation of an irreversible agglomerate of CCG at high temperatures. The reduction of graphene oxide at low temperatures is necessary to prepare highly dispersible CCG in organic solvents. CCG prepared at 30 oC is dispersible in N-methyl-2-pyrrolidone concentrations as high as 0.71 mg/mL. The free-standing paper made of this CCG possessed an electrical conductivity of more than 22,000 S/m, one of the highest values ever reported.
Isolation of Compounds from Cimicifugae Rhizoma and their Cytotoxic Activity
TODAO CUONG,Chae Jin Lim,Sang Won Kim,Ji Eun Park,Tran Manh Hung,민병선 한국생약학회 2011 Natural Product Sciences Vol.17 No.2
Five known compounds, cimigenol (1), 25-O-acetylcimigenol (2), cimigenol 3-O-b-D-xylopyranoside (3), ferulic acid methyl ester (4), and visnagin (5), were isolated from Cimicifugae Rhizoma (Ranunculaceae). The chemical structures of these compounds were determined on the basis of spectroscopic analyses including 2D NMR. Compounds 1 - 5 were evaluated for their cytotoxic activity against the HL-60, MCF-7, and A549 cancer cell lines in in vitro. Among them, compounds 4 and 5 showed moderate inhibitory activity against HL-60 cancer cell lines with IC50 values of 24.8 and 18.1 ?M, respectively.
Compounds from the Seeds of Myristica fragrans and Their Cytotoxic Activity
TODAO CUONG,Chae Jin Lim,Tran Thi Thu Trang,Yoon Ho Bae,NGUYENVAN THU,Nguyen The Tung,Tran Manh Hung,우미희,최재수,민병선 한국생약학회 2012 Natural Product Sciences Vol.18 No.2
Six lignan compounds, 1-(17,21-dihydroxyphenyl)-9-(12,13-dihydroxyphenyl)-1-nonanone (malabaricone C) (1), 7'-(3',4'-methylenedioxyphenyl)-8,8'-dimethyl-7-(3,4-dihydroxyphenyl)-butane (2), 7'-(3',4'-dimethoxyphenyl)-8,8'-dimethyl-7-(3-methoxy-4-hydroxyphenyl)-butane (3), 7-(4-hydroxy-3-methoxyphenyl)-7′-(3′,4′-methylenedioxyphenyl)-8,8′-lignan-7-methyl ether (4), (+)-erythro-(7S,8R)-Δ8′-7-hydroxy-3,4,3′,5′-tetramethoxy-8-O-4′-neolignan (5), and (+)-erythro-(7S,8R)-Δ8′-7-acetoxy-3,4,3′,5′-tetramethoxy-8-O-4′-neolignan (6), were isolated from the seeds of Myristica fragrans. The chemical structures of these compounds were determined on the basis of spectroscopic analyses including 2D NMR. Compounds 1 - 6 were evaluated for their cytotoxic activity against the HL-60, MCF-7, and A549 cancer cell lines in in vitro.
유대황,Tran Viet Cuong,Viet Hung Pham,정진석,Nguyen Tri Khoa,김의정,한성홍 한국물리학회 2011 Current Applied Physics Vol.11 No.3
Photocatalytic TiO_2 films were prepared using RF magnetron sputtering and three kinds of graphene oxide (GO) solutions with different concentration of 0.05 mg GO, 0.03 mg GO, and 0.01 mg GO in 10 ml ethanol were coated on TiO_2 films, respectively. Structures and morphologies of the samples were examined by AFM, SEM, and Raman and photocatalytic properties under UV and visible irradiation were examined respectively. The efficiency of the photodegradation is enhanced when TiO_2 thin film was coated with GO, it is related to its giant π-conjugation system and two-dimensional planar structure and efficient charge separation by coating GO. The maximum photodegradation rate was observed for TiO_2thin film coated with 0.03 mg GO. It is attributed to the increase of absorbance and scattering of photons through excess carbon in the photosystem.
Cholinesterase Inhibitors from Cleistocalyx operculatus Buds
민병선,TODAO CUONG,이주상,신범수,우미희,Tran Manh Hung 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.10
Five flavonoids, myricetin-3'-methylether 3-O-β-D-galactopyranoside (1), myricetin-3',5'-dimethylether 3-O-β-D-galactopyranoside (2), quercetin (3), kaempferol (4), and tamarixetin (5) were isolated from the buds of Cleistocalyx operculatus (Myrtaceae). The chemical structures of these compounds were determined on the basis of spectroscopic analyses, including 2D NMR. Their anti-Alzheimer effects were evaluated via acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. All five compounds 1-5 showed potential inhibitory activities against AChE with IC50 values of 19.9, 37.8, 25.9, 30.4 and 22.3 μM, respectively, while compounds 1, 3, 4 and 5 also possessed BChE inhibitory activity with IC50 values of 152.5, 177.8, 62.5, and 160.6 μM, respectively.