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Chemical constituents of the Annona glabra fruit and their cytotoxic activity.
Hien, Nguyen Thi Thu,Nhiem, Nguyen Xuan,Yen, Duong Thi Hai,Hang, Dan Thi Thuy,Tai, Bui Huu,Quang, Tran Hong,Tuan Anh, Hoang Le,Kiem, Phan Van,Minh, Chau Van,Kim, Eun-Ji,Kim, Seung Hyun,Kang, Hee Kyoun Swets Zeitlinger 2015 PHARMACEUTICAL BIOLOGY Vol.53 No.11
<P>Traditional Chinese medicines have attracted increasing interest as potential sources of novel drugs with a wide range of biological and pharmacological activities. Annona glabra Linn (Annonaceae) is used in traditional medicine as an anticancer drug. Phytochemical investigation of this plant led to the isolation of acetogenins, ent-kauranes, peptides, and alkaloids. In addition, compounds exhibited anticancer, anti-HIV-reserve, and antimalaria.</P>
( Hien Thi Thu Le ),( Young-chang Cho ),( Sayeon Cho ) 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.6
Protein tyrosine phosphatases (PTPs) play crucial roles in signal transduction and their functional alteration has been detected in many diseases. PTP inhibitors have been developed as therapeutic drugs for diseases that are related to the activity of PTPs. In this study, PTP inhibitor XIX, an inhibitor of CD45 and PTEN, was investigated whether it inhibits other PTPs. Protein tyrosine phosphatase non-receptor type 2 (PTPN2) was selectively inhibited by the inhibitor in a competitive manner. Drug affinity responsive target stability (DARTS) analysis showed that the inhibitor induces con-formational changes in PTPN2. Phosphorylation levels of signal transducer and activator of transcription 3 (STAT3) at Tyr-705, a crucial site for STAT3 activation and target site of PTPN2, decreased upon exposure to the inhibitor. Our results suggest that PTP inhibitor XIX might be considered as an effective regulator of PTPN2 for treating diseases related to PTPN2. [BMB Reports 2017; 50(6): 329-334]
PTP Inhibitor XIX Inhibits DUSP22 by Conformational Change
Hien Thi Thu Le,조영창,이세웅,김양균,김권섭,박성구,박병철,조사연 대한화학회 2019 Bulletin of the Korean Chemical Society Vol.40 No.2
Protein tyrosine phosphatases (PTPs) play critical roles in signal transduction by dephosphorylating regulatory proteins involved in many signaling cascades. PTP inhibitors have been reported as potential drugs to treat diseases induced by PTP activity. In this study, we show that PTP inhibitor XIX (PI-19) inhibits dual-specificity phosphatase 22 (DUSP22). Kinetic analysis of PI-19 and DUSP22 suggests that PI-19 inhibits DUSP22 at the catalytic site. In addition, we performed drug affinity responsive targets stability (DARTS) analysis to reveal that the conformation of DUSP22 changed upon binding to PI-19. Moreover, PI-19 blocked DUSP22-mediated dephosphorylation of the signal transducer and activator of transcription 3 (STAT3) at Tyr-705, a critical site for STAT3 activity. Collectively, our results imply that PI-19 is an effective inhibitor of DUSP22 that regulates STAT3 activity.
The Determinants of Environmental Information Disclosure in Vietnam Listed Companies
NGUYEN, Thi Le Hang,NGUYEN, Thi Thu Hien,NGUYEN, Thi Thanh Huyen,LE, Thi Hong Anh,NGUYEN, Van Cong Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.2
Environmental pollution and climate change in Vietnam are now becoming a major concern. This situation is increasing the pressure on the companies to improve their social responsibility in production and business activities and disclose the environmental information to meet the requirements of stakeholders. This study investigates the internal and external factors of the company that affects the environmental information disclosure of listed companies on the Vietnam stock market as business sector, firm size, corporate manager perceptions, profitability, financial leverage, community pressure, pressures from stakeholders, government pressure influencing environmental information disclosure. Analytical data collected through the survey of 120 listed companies on the Ho Chi Minh City Stock Exchange (HOSE). By testing Cronbach's Alpha, exploratory factor analysis (EFA) and logistic regression analysis, the results of the study show that the level of environmental information disclosure of listed companies on the stock market in Vietnam depends heavily on government regulations, followed by the pressure from stakeholders, community pressure, views of business managers, companies size, business sector, and particularly profitability and financial leverage factors that have a negative relationship with environmental information disclosure.
Loc My Thi Nguyen,Tien-Trung Nguyen,Thanh Thi Nghiem,Hien Thu Thi Le,Thao Phuong Thi Trinh,Thuan Van Pham,Thanh Chi Nguyen,Linh Khanh Hoang,Trung Tran 한국과학학술지편집인협의회 2020 Science Editing Vol.7 No.1
In the context of the need to ensure appropriate signalling of the publication of high-quality, international-calibre publications in Vietnam, as well as new policies to improve the quality and effectiveness of scientific research in Vietnam, it is practical to investigate the possibility of developing a national open access database (NOAD). This study aims to answer the question of whether it is necessary to establish a NOAD in Vietnam. We used document analysis to evaluate issues related to NOADs. The results of this study show the complexity, lack of consistency, and difficulty in obtaining practical statistics and assessing research and scientific records in Vietnam today. Furthermore, the findings of this study imply that it is necessary to establish a NOAD of scientific research in Vietnam. The information in this report can be used to develop a NOAD for Vietnam in particular, and for any country that lacks one in general.
Trung Tran,Loc Thi My Nguyen,Thanh Thi Nghiem,Hien Thi Thu Le,Cuong Huu Nguyen,Thuy Phuong La,Trung Tien Nguyen,Hang Thi-Thu Nguyen 한국과학학술지편집인협의회 2019 Science Editing Vol.6 No.2
This study aimed at elucidating the present situation of scholarly journals published in Vietnam according to the minimum criteria to be indexed in the ASEAN Citation Index (ACI) and Scopus, with the goal of suggesting development strategies for scholarly journals in Vietnam. From the 387 journals accredited by the Vietnamese State Council for Professorship, 13 education journals were arbitrarily selected, and their compliance with the five minimum criteria for the ACI (peer review, timeliness, abstracts in English, references in Roman script, and a website in English) and the six minimum criteria for Scopus (peer review, timeline, abstracts in English, references in Roman characters, Electronic International Standard Serial Number [ISSN], and publication ethics) were assessed. Two of the 13 journals were eligible to be indexed in the ACI, while none fulfilled the minimum criteria to be indexed in Scopus. An urgent task for the editors of those journals is to establish an informative journal homepage in English that provides basic information on the journal. Then, an Electronic ISSN can be obtained from the ISSN International Center. Furthermore, the following steps are suggested for journal promotion: establishment of appropriate editorial policies and publication ethics procedures, improvement of research integrity, enhancement of the journals’ reputation in the international scientific community, and improvement of the online publishing system by adopting a journal manuscript management system. To achieve those goals, financial support from the Vietnamese government will be invaluable.