Moving Rate of Positive Patient Results as a Quality Control Tool for High-Sensitivity Cardiac Troponin T Assays

Li Tingting,Cao Shunwang,Wang Yi,Xiong Yujuan,He Yuting,Ke Peifeng,Huang Xianzhang 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.1

Background: A small shift in high-sensitivity cardiac troponin T (hs-cTnT) assays can lead to different result interpretation and consequent patient management. We explored whether a small bias could be detected using conventional internal quality control (QC) procedures, evaluated the performance of moving average (MA)-based QC procedures, and proposed a new QC procedure based on the moving rate (MR) of positive patient results of hs-cTnT assays. Methods:The ability of conventional QC to detect a 5 ng/L bias was examined using the13s/ 22s/R4s multi-rule procedure as deviation rules.We developed MA and MR procedures for the hs-cTnT assay using eight months of patient data. The performance of different MA or MR procedures was investigated by calculating the median number of patient samples affected until a bias introduced into the dataset was detected (MNPed). After comparing the MNPed across different procedures, we selected an optimal MA or MR procedure for validation. Validation graphs were plotted using the minimum, median, and maximum number of results affected until bias detection. Results: Our conventional QC procedures could not detect a positive bias of 5 ng/L. When a positive bias was introduced, MNPed was much higher using MA than using MR, with cut-off values of 5 ng/L and 14 ng/L, respectively. MR validation charts for optimal procedures provided insight into the MR performance. Conclusions: The MR procedure could detect different errors with few false alarms. In the hs-cTnT assay, the MR procedure with a smaller cut-off value outperformed MA and conventional QC procedures for small bias detection.

뷰티 영상 특성과 중국 20대 여성의 제품 구매 의도:왕홍의 영향력을 중심으로

이자준(YI, Zijun),비팅팅(BI, Tingting),장벽월(ZHANG Biyue),김주희(KIM, Ju hee),한혜경(HAN, Hye kyoung) 동북아시아문화학회 2022 동북아시아문화학회 국제학술대회 발표자료집 Vol.2022 No.11

Kinetics of 5-Hydroxymethylfurfural Formation in Chinese Acacia Honey during Heat Treatment

Yuyu Zhang,Yi Song,Tingting Zhou,Xiaojun Liao,Xiaosong Hu,Quanhong Li 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.6

In this paper, the 5-hydroxymethylfurfural (HMF) contents of the acacia honeys after heat treatment were determined by HPLC; the kinetics of HMF formation was also investigated. The HMF content of acacia honey was 0.38±0.01mg/kg, but rapidly increased to the maximum of 18,320.07±14.29 mg/kg at 190oC and decreased to 1,180.24±6.54 mg/kg at 230oC after heating. The HMF content increased gradually in honey samples heated in 12h at the temperature of 80, 100, and 120oC. The apparent frequency constant was kf =3.91×1025/h, and the apparent activation energy was Ea=173.10 kJ/mol. The HMF content in the acacia honey was related to honey composition,heating temperature, and time, and the HMF formation could also be related to the initial honey pH.

Recent advances in α-Fe2O3-based photocatalysts for CO2 conversion to solar fuels

Hongru Han,Tingting Han,Yi Luo,Muhammad Arslan Mushtaq,Yuefa Jia,Chunli Liu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-

The conversion of CO2 into hydrocarbon-based fuels by utilizing solar energy has been considered as apromising solution for the exacerbated global environmental pollution and energy crisis. Among manycandidate materials, a-Fe2O3 has been extensively investigated to develop highly active photocatalysts. Despite its suitable energy band position, a-Fe2O3 suffers from the relative low reduction capacity andcharge separation ability, which are detrimental to the photocatalytic efficiency. Accordingly, heterojunctioncomposites have been adopted by many researchers to overcome these problems to achieveimproved CO2 photoreduction performance. In this review, the latest progress in highly active a-Fe2O3-based heterojunction photocatalyst composites utilizing type II, Z- and S-scheme charge transfermechanisms are summarized. In addition, the mechanisms of enhanced CO2 photoreduction efficiencyand interfacial charge transfer are also briefly discussed. Finally, the future development direction ofa-Fe2O3-based heterojunction photocatalysts for CO2 photoconversion is proposed.

BiOCl/SnS2 Core-Shell Photocatalyst for the Degradation of Organic Pollutants

Hui Meng,Tingting Wang,Hongbin Chen,Yizhu Liu,Xiang Yu,Yi Zhu,Yuanming Zhang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.8

BiOCl/SnS2 core-shell heterojunction is prepared by a facile and economic hydrothermal method. The obtained BiOCl/SnS2 heterojunction displays high photocatalytic activity in the degradation of Rhodamine B (RhB). The high performance is explained by the fast separation of the photoinduced electron–hole pairs promoted by the heterojunction. The cycle life of the heterojunction is also improved compared with individual BiOCl or SnS2.

Microstructural and Textural Differences Induced by Water and Furnace Cooling in Commercially Pure Zr Annealed in the α + β Region

Linjiang Chai,Tingting Wang,Yi Ren,Bo Song,Ning Guo,Liangyu Chen 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.4

In this work, a commercially pure Zr sheet with a typical bimodal basal texture was annealed in an α + β region and thensubjected to Different coolings (in water and furnace). Microstructures and textures of both the as-received and the heat-treatedspecimens were investigated by electron channeling contrast imaging and electron backscatter diff raction techniques. Resultsshow that a duplex microstructure consisting of untransformed bulk α grains and twinned martensitic plates is produced inthe water-cooled specimen, which possesses a weakened texture compared to the initial one. For the specimen cooled in furnace,however, a uniform microstructure fully comprised of coarser equiaxed grains with a strengthened texture is obtained. Analyses reveal that the rapid cooling in water could suppress variant selection behaviors during β → α transformation andallow α plates with scattered orientations to be nucleated inside β phases, contributing to the weakened texture. In contrast,during slow cooling in furnace, β boundaries would act as preferred nucleation sites of α embryos, resulting in a strong variantselection that accounts for the intensifi ed texture.

The Design of LDPC Encoder Based on the WIMAX Standard

Xiumin Wang,Fangfei Hong,Tingting Ge,Yi Wang,Binggang Xiao,Nurul I Sarkar 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.4

To meet the higher data rate requirement of encoder, an encoder structure suitable for both two rates(1/2,2/3B) in WIMAX standard is proposed, combined with the method of Design Space Exploration. According to the quasi cyclic characteristics of sparse parity check matrix, the traditional RU algorithm is simplified and optimized to reduce the complexity of the system. Simultaneously we introduce a barrel shifter, and use the method that two rows of the base matrix be restored in one ROM to reduce resource consumption. The simulation results show that the encoder for two rates not only runs successfully, but also reduces the utilization of hardware resources. The encoder architecture has broad application prospects with high flexibility.

Epidemiologic characteristics and a prognostic nomogram for patients with vulvar cancer: results from the Surveillance, Epidemiology, and End Results (SEER) program in the United States, 1975 to 2016

Shiyuan Wei,Lu Li,Tingting Yi,Licong Su,Qi Gao,Liangzhi Wu,Zhenbo OuYang 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.6

Objective: To elucidate clinical characteristics and build a prognostic nomogram for patients with vulvar cancer. Methods: The study population was drawn from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were randomly assigned to training and validation sets. Cox proportional hazards model and competing risk model were used to identify the prognostic parameters of overall survival (OS) and cancer-specific survival (CSS) to construct a nomogram. The nomogram was assessed by concordance index (C-index), area under the curve (AUC), calibration plot, and decision curve analysis (DCA). Results: A total of 20,716 patients were included in epidemiological analysis, of whom 7,025 patients were selected in survival analysis, including 4,215 and 2,810 in training and validation sets, respectively. The multivariate Cox model showed that the predictors for OS were age, marital status, histopathology, differentiation and tumor node metastasis (TNM) stages, whether to undergo surgery and chemotherapy. However, the predictors for CSS were age, race, differentiation and TNM stages, whether to undergo surgery and radiation. The C-index for OS and CSS in the training set were 0.76 and 0.80. The AUC in the training set for 1-, 3- and 5-year OS and CSS were 0.84, 0.81, 0.80 and 0.88, 0.85, 0.83, respectively, which was similar in the validation set. The calibration curves showed good agreement between prediction and actual observations. DCA revealed that the nomogram had a better discrimination than TNM stages. Conclusions: The nomogram showed accurate prognostic prediction in OS and CSS for vulvar cancer, which could provide guidance to clinical practice.

Gradient doping simulation of perovskite solar cells with CH3NH3Sn1−xPbxI3 as the absorber layer

Yang Qingchen,Yang Sui,Xi Tingting,Li Hongxing,Yi Jie,Zhong Jianxin 한국물리학회 2022 Current Applied Physics Vol.44 No.-

In this study, we built a perovskite solar cells(PSCs) model with a Au/CuSCN/CH3NH3Sn1-xPbxI3/TiO2/FTO glass structure using the SCAPS program and use polynomial fitting to obtain the relationship between the conduction/valence bands of CH3NH3Sn1-xPbxI3 and the x value, which is more complex and accurate than that in any previous research. The influences of thickness, electron and hole mobilities, relative permittivity, effective conduction band density, effective valence band density, and the value of x on the solar cell performance are analyzed. Furthermore, we simulate the situation where the doping concentration changes with the absorption layer depth of the device and a special bandgap is formed. The power conversion efficiency of the device improves from 19.96% to 20.52%, with an open-circuit voltage of 0.776 V, a short-circuit current of 33.79 mA/cm2, and a filling factor of 77.39% when double gradient doping is performed. The application value of gradient doping in the device absorption layer is obtained.

Dual-Responsive Cross-Linked Micelles from Amphiphilic Four-Arm Star Copolymers with Different Block Ratios for Triggering DOX Release

Yunwei Huang,Yanzhe Li,Zilun Tang,Qiuping Su,Tingting Liao,Yuxin Gu,Xiaofeng Lin,Xihong Zu,Wenjing Lin,Guobin Yi 한국고분자학회 2020 Macromolecular Research Vol.28 No.8

The four-arm star copolymers poly(methacrylic acid)-poly(2-hydroxyethyl methacrylate-disulfide~)-poly(poly(ethylene glycol) methyl ether methacrylate) (4AS-PMAAx-(PHEMA-SS~)y-PPEGMAz) with four different block ratios were synthesized and could self-assembled into cross-linked polymer micelles for the exploration of the structure-property relationship. The cross-linked polymer micelles in aqueous solution had low critical micelle concentration (CMC) values (1.9-4.6 mg/L), which exhibited better stability than non-cross-linked micelles. The CMC value decreased with the increase of the length of inner PMAA core and hydrophobic PHEMA cross-linked middle layer. The blank and doxorubicin (DOX)- loaded micelles with different block ratios were prepared by dialysis with the particle sizes of 120-240 nm. The longer inner PMAA core and cross-linked middle layer enhanced the drug loading content (DLC) results and led to relatively bigger particle sizes of polymer micelles. The in vitro DOX release data revealed that DOX-loaded micelles had low DOX cumulative release percentages of 18-37% after 110 h at pH 7.4, but up to 83-90% when introducing reductant GSH at pH 5.0. The 4AS-PMAA21.2-(PHEMASS~) 13.1-PPEGMA5.1 micelles with the longest PMAA core had the largest cumulative release of 90.1%. The DOX release process and mechanism of the micelles at different conditions fitted well with the semi-empirical equation. Overall, the results demonstrated that the block ratios and pH/redox-responsiveness of these four-arm star copolymers could be well-controlled and their self-assembled cross-linked micelles as anticancer drug carrier system could be improved by optimizing the different ratios.