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Tingting Han,Xinyi Guo,Botao Zhou,Xin Hao 한국기상학회 2021 Asia-Pacific Journal of Atmospheric Sciences Vol.57 No.2
Northern Central China (NC China) is a seriously arid region. Precipitation variations are vital for environmental protection and socio-economical development. This study investigates the recent changes in summer heavy precipitation (HP) events over NC China and associated atmospheric circulation anomalies. Compared with the period of 1986–2002, the HP amount and frequency both significantly increase during 2003–2016, contributing to the shift to increase in total summer precipitation amount. After the early 2000s, the Northwest Pacific subtropical high becomes intensified and shifts westward and northward, leading to significant moisture convergence anomalies over NC China and divergence anomalies over Northwest Pacific. Therefore, the net moisture budget dramatically increases since the early 2000s. Further results show that the strengthened net moisture influx across the southern boundary contributes dominantly to the increased net moisture budget, especially at the lower level. Despite a relatively small magnitude, the intensified westerly current across western boundary makes a dominant contribution at middle and upper layers. Additionally, the strengthened westerly and easterly anomalies occupy northern and southern China, respectively, along with the eastward expansion of westerly jet stream region. Thus, the lower-level convergence and upper-level divergence both intensify, and further trigger enhanced ascending movement. These conditions jointly contribute to the inter-decadal change in HP events over NC China after the early 2000s.
Recent advances in α-Fe2O3-based photocatalysts for CO2 conversion to solar fuels
Hongru Han,Tingting Han,Yi Luo,Muhammad Arslan Mushtaq,Yuefa Jia,Chunli Liu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-
The conversion of CO2 into hydrocarbon-based fuels by utilizing solar energy has been considered as apromising solution for the exacerbated global environmental pollution and energy crisis. Among manycandidate materials, a-Fe2O3 has been extensively investigated to develop highly active photocatalysts. Despite its suitable energy band position, a-Fe2O3 suffers from the relative low reduction capacity andcharge separation ability, which are detrimental to the photocatalytic efficiency. Accordingly, heterojunctioncomposites have been adopted by many researchers to overcome these problems to achieveimproved CO2 photoreduction performance. In this review, the latest progress in highly active a-Fe2O3-based heterojunction photocatalyst composites utilizing type II, Z- and S-scheme charge transfermechanisms are summarized. In addition, the mechanisms of enhanced CO2 photoreduction efficiencyand interfacial charge transfer are also briefly discussed. Finally, the future development direction ofa-Fe2O3-based heterojunction photocatalysts for CO2 photoconversion is proposed.
( Tingting Yu ),( Junmei Ding ),( Qingxia Zheng ),( Nanyu Han ),( Jialin Yu ),( Yunjuan Yang ),( Junjun Li ),( Yuelin Mu ),( Qian Wu ),( Zunxi Huang ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.4
est19 is a gene from Bacillus sp. K91 that encodes a new esterase. A comparison of the amino acid sequence showed that Est19 has typical Ser-Gly-Asn-His (SGNH) family motifs and could be grouped into the SGNH hydrolase family. The Est19 protein was functionally cloned, and expressed and purified from Escherichia coli BL21(DE3). The enzyme activity was optimal at 60°C and pH 9.0, and displayed esterase activity towards esters with short-chain acyl esters (C2-C6). A structural model of Est19 was constructed using phospholipase A1 from Streptomyces albidoflavus NA297 as a template. The structure showed an α/β-hydrolase fold and indicated the presence of the typical catalytic triad Ser49-Asp227-His230, which were further investigated by site-directed mutagenesis. To the best of our knowledge, Est19 is a new member of the SGNH hydrolase family identified from thermophiles, which may be applicable in the industrial production of semisynthetic β-lactam antibiotics after modification.
Han Wu,Xiuhong Wang,Tingting Wu,Su Yang 한국유전학회 2020 Genes & Genomics Vol.42 No.3
Background Dysregulation of miR-489 in human tumors has been widely reported. Lactate dehydrogenase isoform A (LDHA)-mediated aerobic glycolysis participates in proliferation of multiple myeloma (MM) cells. Objective To investigate whether miR-489 induced MM growth inhibition via targeting to LDHA-mediated aerobic glycolysis. Methods Expression of miR-489 in representative MM cell lines was determined via qRT-PCR (quantitative real-time polymerase chain reaction). MTT (3-(4, 5-di methyl thiazol-2-yl)-2, 5-di phenyl tetrazolium bromide) and colony formation assays were utilized to detect cell viability and proliferation. Effect of miR-489 on aerobic glycolysis was detected via glucose uptake, lactate and ATP production. Binding ability between miR-489 and LDHA was conducted via luciferase activity assay. Results MiR-489 was down-regulated in representative MM cell lines. Gain-of functional assays indicated that over-expression of miR-489 decreased cell viability and inhibited cell proliferation of MM cells. Moreover, miR-489 inhibited aerobic glycolysis via decrease of glucose uptake, lactate and ATP production. LDHA was identified as target of miR-489, suggesting a negative correlation between miR-489 and LDHA in MM cells. Mechanically, the inhibition ability of miR-489 on proliferation of MM cells was through inhibition of LDHA-mediated aerobic glycolysis. Conclusions miR-489 inhibited MM tumor growth via LDHA-mediated glycolytic metabolism, suggesting potential therapeutic target ability of miR-489/LDHA for MM.
Han Zhang,Qi Zhang,Tingting Gao,Yixi Kong,Zeying Qin,Yueyang Hu,Ruilin Cao,Songli Mei 대한신경정신의학회 2019 PSYCHIATRY INVESTIGATION Vol.16 No.5
Objective: This study aims to examine the parallel multiple mediators of depressive symptoms and sleep quality in the relations between stress and physical health-related quality of life (PHQOL)/mental health-related quality of life (MHQOL) among the women in late pregnancy. Methods: Of 1120 pregnant women participated in the cross-sectional study which consisted of Perceived Stress Scale, Edinburgh Postnatal Depression Scale, Pittsburgh Sleep Quality Index and MOS 12-item Short Form Health Survey. Parallel multiple mediator models were used to analyze the relations between stress, depressive symptoms, sleep quality and PHQOL/MHQOL. Results: The effect of perceived stress on PHQOL was partially through the indirect path of sleep quality (β=-0.061). But in the model for MHQOL, depressive symptoms and sleep quality played parallel mediators, and the indirect path effect of depressive symptoms (β=-0.179) was higher than sleep quality (β=-0.029). Conclusion: The findings contributed to the understanding about the influential mechanism of stress on PHQOL/MHQOL. And it reminded the importance of sleep quality and depressive symptoms for improving QOL in late pregnancy.
Tengzhou Ma,Tingting Hu,Dandan Jiang,Jinli Zhang,Wei Li,You Han,Banu Örmeci 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.4
Supercritical water oxidation (SCWO) of penicillin (PCN) was investigated under different operating conditions. The chemical oxygen demand (COD) removal rate could reach 99.4% at 400 oC, 24MPa, 1min and oxidation coefficient (OC) of 2. Experimental results showed that COD removal had no significant dependence on temperature and pressure variations. By contrast, COD removal could be significantly promoted with OC increasing from 0 to 2.0, but the effect was negligible as the OC further increased; similarly, longer residence time than a definite value seemed to contribute little to COD removal. Initial and deeper degradation pathways of penicillin were proposed based on the reactive force field (ReaxFF) molecular dynamics (MD) simulations. By tracing the evolution of intermediates, the migration routes of S and N during the SCWO process were obtained with H2S and NO2 produced as the corresponding products. Simulation results showed that SCW and oxidant not only accelerated the degradation by producing highly reactive radicals or molecules, but also participated in reactions by serving as H and O sources. Moreover, catalysis of water clusters in C-heteroatom bond cleavage was also observed.