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      • Modern Innovative Research in the Field of Education

        Ganna Taran,Dmytro Chornomordenko,Nataliia Bondarenko,Danylo Bohatyrov,Mykola Spiridonov,Vasyl Matviiv International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.12

        The main purpose of the study is to identify the key aspects of modern innovative research in the field of education. In the modern informatized world, education is becoming a decisive factor in social development and an important component in the development of the human personality, increasing respect for human rights and freedoms. Today it is quite obvious that without the necessary education a person will not be able to provide himself with proper living conditions and realize himself as a person. The high level of education of the population is an important factor that positively influences the creation of favorable conditions for the full realization of the rights and freedoms of man and citizen. Today, active and interactive teaching methods are widely used. The use of interactive teaching methods ensures complete immersion of students in the learning process and is the main source of learning. The radical difference between traditional and interactive learning is that the student not only replenishes and strengthens his knowledge, but also complements and constructs new ones. The methodology includes a number of theoretical methods. As a result of the study, current trends and prerequisites of modern innovative research in the field of education were investigated.

      • KCI등재

        질산으로 표면처리한 대나무 활성탄을 첨가한 폴리술폰 담체의 세슘제거 효율 규명

        Ni Wayan Sukma Taraning Rahayu,김선희,탁현지,김경태,이민희 대한자원환경지질학회 2020 자원환경지질 Vol.53 No.5

        The cesium (Cs) sorption characteristics of a bead-type polysulfone carrier contained HNO3-treated bamboo charcoal (3 – 5 mm in diameter) in water system were investigated and its Cs removal efficiency as an adsorbent from water was also identified by various laboratory experiments. From the results of batch sorption experiments, the bead-type polysulfone carrier with only 5% HNO3-treated bamboo charcoal (P-5NBC) represented the high Cs removal efficiency of 57.8% for 1 hour sorption time. The Cs removal efficiency of P-5NBC in water after 24 hours reaction maintained > 69% at a wide range of pH and temperature conditions, attesting to its applicability under various water systems. Batch sorption experiments were repeated for P-5NBC coated with two cultivated microorganisms (Pseudomonas fluorescens and Bacillus drentensis), which were typical indigenous species inhabited in soil and groundwater. The Cs removal efficiency for two microorganisms coated polysulfone carrier (BP-5NBC) additionally increased by 19% and 18%, respectively, compared to that of only P-5NBC without microorganisms coated. The average Cs desorption rate of P-5NBC for 24 h was lower than 16%, showing the Cs was stably attached on HNO3-treated bamboo charcoal in so much as its long-term use. The maximum Cs sorption capacity (qm) of P-5NBC calculated from the Langmuir isotherm model study was 60.9 mg/g, which was much higher than those of other adsorbents from previous studies for 1 h sorption time. The results of continuous column experiments showed that the P-5NBC coated with microorganisms packed in the column maintained > 80% of the Cs removal efficiency during 100 pore volumes flushing. It suggested that only 14.7 g of P-5NBC (only 0.75 g of HNO3 treated bamboo charcoal included) can successfully clean-up 7.2 L of Cs contaminated water (the initial Cs concentration: 1 mg/L; the effluent concentration: < 0.2 mg/L). The present results suggested that the Cs contaminated water can be successfully cleaned up by using a small amount of the polysulfone carrier with HNO3-treated bamboo charcoal.

      • The Cesium Sorption Characterictics of Polysulfone Carrier with the HNO3 Treated Bamboo Charcoal

        ( Ni Wayan Sukma Taraning Rahayu ),( Jinkyun Lee ),( Taehyoung Kim ),( Minhee Lee ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2

        The cesium (Cs) has been known as a dangerous radionuclide for human health and ecosystem due to its high solubility. Adsorption is considered as one of the effective Cs removal treatment processes. In this study, the polysulfone carrier with HNO<sub>3</sub> treated bamboo charcoal was used to remove Cs from solution and its removal efficiency was calculated based on results of batch adsorption experiments with different conditions such as carrier dosages, contact times, pH, and temperature. The Cs concentration before and after the experiment was analyzed on ICP/OES to calculate the Cs removal efficiency. Scanning Electron Micrograph (SEM) analysis was also performed to visualize the structure of the carrier. From results, the Cs removal efficiency generally increased with the increase of both the bamboo charcoal amount in the carrier and the carrier amount in solution. The Cs removal efficiency reached to 72.67% with the carrier dosage 1.2g per 100 mL of solution for 6 for sorption experiment. The high Cs removal efficiency was maintained at the wide range of pH and the highest removal efficiency was shown at pH of 5-7 in solution. The Cs removal efficiency was maintained around 70% at the temperature range of 5-30°C. SEM analyses presented that the bamboo charcoal included polysulfone carrier has complicated porous structures where the Cs was sorbed as a form of a solid phase. This study suggests that polysulfone carrier with HNO<sub>3</sub> treated bamboo charcoal is available to remove Cs from water system under a wide range of pH and temperature conditions.

      • Prognostic Factors and Survival in Acute Myeloid Leukemia Cases: a Report from the Northeast of Iran

        Allahyari, Abolghasem,Tajeri, Tarane,Sadeghi, Masoud Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3

        Background: Acute myeloid leukemia (AML) is a clonal hematopoietic disorder resulting from genetic alterations in normal hematopoietic stem cells. The aim of this study was to evaluate prognostic factors and survival of AML patients in the Northeast of Iran. Materials and Methods: This retrospective study covered 96 patients with AML referred to Emam Reza Hospital, Mashhad city, Iran, from 2009 to 2015. Age, sex, blood group, type of AML, fever, consumption of amphotericin B, cytogenetic forms and survival were analyzed. Also, WBC, hemoglobin and platelet levels were checked. Mean follow-up was 30.5 months (60.4% mortality). Survival was plotted by GraphPad Prism 5 with Log-rank test. Results: The mean age for all AML patients at diagnosis was 40.4 years (range, 17-77 years). Some 42.7% patients were aged <35 years and 40.6% were male. In all patients, 76% had fever and 50% consumed amphotericin. T(15;17)(q22;q21) had the most prevalence (37.7%) compared to other forms. Out of 92 patients, O+(30.4%) was the most common blood group and AML-M5 (28.3%) the most common subtype. There was a significant difference in survival based on WBC and consumption of amphotericin B (P<0.05). Conclusions: WBC level, fever and consumption of amphotericin B proved to be factors for survival of AML patients. The mean age for patients in Iran is lower than other areas in the World and also survival in this study was higher than in other studies.

      • KCI등재

        Ocimum sanctum Linn. Leaf Extracts Inhibit Acetylcholinesterase and Improve Cognition in Rats with Experimentally Induced Dementia

        Vijayasree Vayalanellore Giridharan,Rajarajan Amirthalingam Thandavarayan,Vasudevan Mani,Taranalli Ashok Dundapa,Kenichi Watanabe,Tetsuya Konishi 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.9

        Cognitive disorders such as dementia, attention deficits, and Alzheimer's disease (AD) have been well investigated. However, effective interventions for the promotion and progression of AD are unavailable to date. The present work was undertaken to investigate the effects of the aqueous (300 and 500 mg/kg) and alcoholic (300 and 500 mg/kg) extracts of Ocimum sanctum Linn. leaves as an antidementic and anticholinesterase agent and also as an immunostimulant in rats. Maximal electroshock, atropine, and cyclosporine were used to induce dementia. The passive avoidance task was used for assessing memory. Acetylcholinesterase (AChE) activity was estimated in different parts of the brain, and immune status was studied using dinitrochlorobenzene (DNCB) skin sensitivity tests. In all the three models both aqueous and alcoholic O. sanctum extracts decreased the time taken to reach the shock-free zone and the number of mistakes and significantly decreased the AChE activity in rats. O. sanctum treatment significantly increased the induration in the DNCB skin test. Therefore, O. sanctum was shown to be useful for the management of experimentally induced cognitive dysfunctions in rats.

      • KCI등재

        Boswellic acid suppresses cyclophosphamide induced chromosomal damage in mice

        Kuntal Ganguly,N. V. Jagadeesh,Rakesh Singh,B. S. Thippeswami,Ashok D. Taranalli,Anandrao R. Kulkarni 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.3

        This study was performed to determine whether Boswellic acid suppresses genotoxicity induced by cyclophosphamide in mice. Genotoxicity was induced by the administration of cyclophosphamide (50 mg/kg) in swiss albino mice and was measured by counting the number of micronuclei and observing chromosomal aberration. In test group Boswellic acid was given in the dose of 200 mg/kg and various chromosomal aberration and formation of micronuclei were observed. Boswellic acid in dose of 200 mg/kg significantly (P<0.001) inhibited the cyclophosphamide induced micronucleus formation and also significantly (P<0.001) inhibited chromosomal aberrations in mice. Whereas Boswellic acid alone did not either induce formation of micronuclei or chromosomal aberration in mice. Boswellic acid itself doesn’t have any genotoxic effect and suppresses genotoxicity induced by cyclophosphamide.

      • KCI등재

        Boswellic acid suppresses cyclophosphamide induced chromosomal damage in mice

        Ganguly, Kuntal,Jagadeesh, N.V.,Singh, Rakesh,Thippeswami, B.S.,Taranalli, Ashok D.,Kulkarni, Anandrao R. 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.3

        This study was performed to determine whether Boswellic acid suppresses genotoxicity induced by cyclophosphamide in mice. Genotoxicity was induced by the administration of cyclophosphamide (50 mg/kg) in swiss albino mice and was measured by counting the number of micronuclei and observing chromosomal aberration. In test group Boswellic acid was given in the dose of 200 mg/kg and various chromosomal aberration and formation of micronuclei were observed. Boswellic acid in dose of 200 mg/kg significantly ($P$ <0.001) inhibited the cyclophosphamide induced micronucleus formation and also significantly ($P$ <0.001) inhibited chromosomal aberrations in mice. Whereas Boswellic acid alone did not either induce formation of micronuclei or chromosomal aberration in mice. Boswellic acid itself doesn't have any genotoxic effect and suppresses genotoxicity induced by cyclophosphamide.

      • KCI등재

        Simultaneous Detection of Disseminated and Circulating Tumor Cells in Primary Breast Cancer Patients

        Andreas D. Hartkopf,Markus Wallwiener,Markus Hahn,Tanja N. Fehm,Sara Y. Brucker,Florin-Andrei Taran 대한암학회 2016 Cancer Research and Treatment Vol.48 No.1

        Purpose Disseminated tumor cells (DTCs) from bone marrow (BM) are a surrogate of minimal residual disease (MRD) in primary breast cancer (PBC) patients and associated with an adverse prognosis. However, BM sampling is an invasive procedure. Although there is growing evidence that circulating tumor cells (CTCs) from the blood are also suitable for monitoring MRD, data on the simultaneous detection of DTCs and CTCs are limited. Materials and Methods We determined the presence of DTCs using immunocytochemistry and the pan-cytokeratin antibody A45-B/B3. CTCs were determined simultaneously using a reverse transcription- polymerase chain reaction–based assay (AdnaTest Breast Cancer) and CellSearch (at least one CTC per 7.5 mL blood). We compared the detection of DTCs and CTCs and evaluated their impact on disease-free and overall survival. Results Of 585 patients, 131 (22%) were positive for DTCs; 19 of 202 (9%) and 18 of 383 (5%) patients were positive for CTCs, as shown by AdnaTest and CellSearch, respectively. No significant association was observed between DTCs and CTCs (p=0.248 and p=0.146 as shown by AdnaTest and CellSearch, respectively). The presence of DTCs (p=0.046) and the presence of CTCs as shown by CellSearch (p=0.007) were predictive of disease-free survival. Conclusion Our data confirm the prognostic relevance of DTCs and CTCs in patients with PBC. As we found no significant relationship between DTCs and CTCs, prospective trials should include their simultaneous detection. Within those trials, the question of whether or not DTCs and CTCs are independent subpopulations of malignant cell clones should be determined by molecular characterization.

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