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Prevalence and Risk Factors of Abusive Behaviors in the Caregivers of People with Dementia in Korea
Taehyun Kim,Hyeon Jeong,Ji Won Han,Kyung Phil Kwak,Bong-Jo Kim,Shin-Kyeom Kim,Jeong Lan Kim,Tae Hui Kim,Seung-Ho Ryu,Seok Woo Moon,Jae Young Park,Joon Hyuk Park,Jae Nam Bae,Jong Chul Youn,Dong Young L 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.7
Objective We investigated the prevalence and risk factors of physically abusive behaviors (PhAB) and psychologically abusive behaviors (PsAB) towards people with dementia (PWD) in family caregivers, and compared their prevalences between East Asian and Western countries. Methods We estimated the prevalence and risk factors of PhAB and PsAB in 467 Korean pairs of community-dwelling PWD and their primary family caregivers. We evaluated abusive behaviors using the Modified Conflict Tactics Scale. In addition, we compared the prevalence of abusive behaviors between Asian and Western countries through a meta-analysis on 12 studies including the current one. Results More than a half of the caregivers reported PsAB and about one out of seven caregivers admitted PhAB within past three months. PsAB and PhAB were slightly more prevalent in East Asian countries than in Western countries. Non-Alzheimer type and moderate to severe behavioral and psychological symptoms of dementia were associated with the risk of PhAB but not with the risk of PsAB. Severe care burden and low income were associated with the risk of PhAB and PsAB. Conclusion PhAB and PsAB were as prevalent in the family caregivers of PWD in Asian countries including Korea as in Western countries. Prevention strategies should be implemented according to the type of abusive behaviors.
Kim Hoyoung,Lim Taehyun,Ha Go Eun,Lee Jee-Young,Kim Jun-Woo,Chang Nienping,Kim Si Hyun,Kim Ki Hun,Lee Jaeick,Cho Yongju,Kim Byeong Wook,Abrahamsson Alva,Kim Sung Hwan,Kim Hyo-Ji,Park Sehan,Lee Sang Ja 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Thus far, attempts to develop drugs that target corticotropin-releasing hormone receptor 1 (CRF1R), a drug target in stress-related therapy, have been unsuccessful. Studies have focused on using high-resolution G protein-coupled receptor (GPCR) structures to develop drugs. X-ray free-electron lasers (XFELs), which prevent radiation damage and provide access to high-resolution compositions, have helped accelerate GPCR structural studies. We elucidated the crystal structure of CRF1R complexed with a BMK-I-152 antagonist at 2.75 Å using fixed-target serial femtosecond crystallography. The results revealed that two unique hydrogen bonds are present in the hydrogen bond network, the stalk region forms an alpha helix and the hydrophobic network contains an antagonist binding site. We then developed two antagonists—BMK-C203 and BMK-C205—and determined the CRF1R/BMK-C203 and CRF1R/BMK-C205 complex structures at 2.6 and 2.2 Å, respectively. BMK-C205 exerted significant antidepressant effects in mice and, thus, may be utilized to effectively identify structure-based drugs against CRF1R.
Anti-Melanogenic Effect of Cannabis sativa Stem Extracts Fermented with Weissella paramesenteroides
Kim Taehyun,Kim Jin-Woo,Min Huitae,Park Jisu,Kim Taejung,Kim Geun-Hyeong,Park Byung-Joon,Kim Jeong Kook,Park Young-Tae,Kim Jin-Chul,Ham Jungyeob 한국미생물·생명공학회 2023 한국미생물·생명공학회지 Vol.51 No.3
Cannabis sativa (CS) has been in the spotlight not only for its medical uses but also as a raw material for cosmetics. As fermented cosmetics are known to have various health benefits, they have been extensively researched. Here, we investigated the characteristics of CS stems fermented using various gut microbes. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay and melanin content analysis revealed that melan-a cells containing CS stems fermented with Weissella paramesenteroides (CSWP) showed considerably reduced melanin content. Additionally, CSWP downregulated the expression of several melanogenesis factors, tyrosinase-related protein-1, and tyrosinase-related protein-2. This study suggests that the anti-melanogenic effect of CSWP could provide a new basis for the development of skinlightening agents.
사용후핵연료 관리시설에 대한 주민 인식 유형 및 특성 연구 -Q방법론을 중심으로-
김태현 ( Taehyun Kim ),박현주 ( Hyun Joo Park ),문지원 ( Jiwon Moon ),김태현 ( Taehyun Kim ) 한국주관성연구학회 2015 주관성연구 Vol.- No.31
최근 들어 지역기피시설의 설치와 관련된 환경 분쟁이 잦아지고 있다. 특히 원자력이나 핵 관련 시설은 방사성물질의 잠재적 위험성, 건강상의 문제, 시설의 안전성에 대한 불안감 등으로 인해 많은 사람들이 기피하는 시설에 해당하며, 우리나라는 사용후핵연료 임시저장소의 포화시점이 2016년 도래할 것으로 예상되어 사용후핵연료 관리시설의 입지 결정이 시급한 상황이다. 이러한 입지 선정 과정에서 시설에 대한 견해 차이로 극심한 갈등이 발생할 것으로 판단되지만 아직까지 주민 개개인의 주관적인 인식을 파악하기 위한 연구는 부족한 상황이다. 따라서 본 연구에서는 Q방법론을 통해 사용후핵연료 관리시설에 대한 주민의 인식 유형 및 특성을 분석하였다. 56명의 P표본을 대상으로 45개의 Q진술문을 분류하여 분석한 결과, 사용후핵연료 관리시설에 대한 인식은 4개의 유형으로 구분되었다. 제1유형(안전우려·정부불신형)은 정부에 대한 신뢰도 및 안전신뢰도가 낮은 유형, 제2유형(안전신뢰·정부신뢰형)은 정부에 대한 신뢰도 및 안전신뢰도가 높은 유형, 제3유형(안전우려·갈등회피형)은 시설이 필요하지만 내 지역에 입지시킬 수 없다는 유형, 제4유형(주민참여 중시형)은 시설유치에 있어 주민 참여의 중요성을 강조하는 유형이다. 이러한 각 인식 유형의 특성 분석을 통해 지역기피시설의 입지 선정 과정에서 체계적으로 주민 의견을 수렴하는 정책적 시사점을 제시하고자 하였다. Recently, environmental conflicts occur frequently in siting locally unwanted land uses(LULU). Spent nuclear fuel repository is considered as LULU due to concerns about risk, health damage, and facility safety. The spent nuclear fuel repository has almost reached its maximum capacity in Korea and location decisions for the facility become an urgent issue. Even though severe conflicts are expected in process of location decision, only few researches are developed to accept opinions of individuals dwelling around the affected areas. Therefore, this study aims to investigate on the residents’ perception types and characteristics of spent nuclear fuel repository using Q methodology. It identifies four types of spent nuclear fuel repository by conducting Q survey with 45 statements to 56 people. The first type(safety concerns-government distrust) is classified as low reliability on the governmentand safety; the second type(safety trust-government trust) is classified as high reliability on the government and safety; the third type(safety concerns-conflict avoidance) is classified as people who prefer not to have the facility in their residential areas; the fourth type(citizen participation) is classified as people who look for citizen participation. This study holds its significance in identifying the differences among perception types of spent nuclear fuel repository and providing an alternative measure for policy-making.