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Anti-Melanogenic Effect of Cannabis sativa Stem Extracts Fermented with Weissella paramesenteroides
Kim Taehyun,Kim Jin-Woo,Min Huitae,Park Jisu,Kim Taejung,Kim Geun-Hyeong,Park Byung-Joon,Kim Jeong Kook,Park Young-Tae,Kim Jin-Chul,Ham Jungyeob 한국미생물·생명공학회 2023 한국미생물·생명공학회지 Vol.51 No.3
Cannabis sativa (CS) has been in the spotlight not only for its medical uses but also as a raw material for cosmetics. As fermented cosmetics are known to have various health benefits, they have been extensively researched. Here, we investigated the characteristics of CS stems fermented using various gut microbes. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay and melanin content analysis revealed that melan-a cells containing CS stems fermented with Weissella paramesenteroides (CSWP) showed considerably reduced melanin content. Additionally, CSWP downregulated the expression of several melanogenesis factors, tyrosinase-related protein-1, and tyrosinase-related protein-2. This study suggests that the anti-melanogenic effect of CSWP could provide a new basis for the development of skinlightening agents.
Kim Hoyoung,Lim Taehyun,Ha Go Eun,Lee Jee-Young,Kim Jun-Woo,Chang Nienping,Kim Si Hyun,Kim Ki Hun,Lee Jaeick,Cho Yongju,Kim Byeong Wook,Abrahamsson Alva,Kim Sung Hwan,Kim Hyo-Ji,Park Sehan,Lee Sang Ja 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Thus far, attempts to develop drugs that target corticotropin-releasing hormone receptor 1 (CRF1R), a drug target in stress-related therapy, have been unsuccessful. Studies have focused on using high-resolution G protein-coupled receptor (GPCR) structures to develop drugs. X-ray free-electron lasers (XFELs), which prevent radiation damage and provide access to high-resolution compositions, have helped accelerate GPCR structural studies. We elucidated the crystal structure of CRF1R complexed with a BMK-I-152 antagonist at 2.75 Å using fixed-target serial femtosecond crystallography. The results revealed that two unique hydrogen bonds are present in the hydrogen bond network, the stalk region forms an alpha helix and the hydrophobic network contains an antagonist binding site. We then developed two antagonists—BMK-C203 and BMK-C205—and determined the CRF1R/BMK-C203 and CRF1R/BMK-C205 complex structures at 2.6 and 2.2 Å, respectively. BMK-C205 exerted significant antidepressant effects in mice and, thus, may be utilized to effectively identify structure-based drugs against CRF1R.
Prevalence and Risk Factors of Abusive Behaviors in the Caregivers of People with Dementia in Korea
Taehyun Kim,Hyeon Jeong,Ji Won Han,Kyung Phil Kwak,Bong-Jo Kim,Shin-Kyeom Kim,Jeong Lan Kim,Tae Hui Kim,Seung-Ho Ryu,Seok Woo Moon,Jae Young Park,Joon Hyuk Park,Jae Nam Bae,Jong Chul Youn,Dong Young L 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.7
Objective We investigated the prevalence and risk factors of physically abusive behaviors (PhAB) and psychologically abusive behaviors (PsAB) towards people with dementia (PWD) in family caregivers, and compared their prevalences between East Asian and Western countries. Methods We estimated the prevalence and risk factors of PhAB and PsAB in 467 Korean pairs of community-dwelling PWD and their primary family caregivers. We evaluated abusive behaviors using the Modified Conflict Tactics Scale. In addition, we compared the prevalence of abusive behaviors between Asian and Western countries through a meta-analysis on 12 studies including the current one. Results More than a half of the caregivers reported PsAB and about one out of seven caregivers admitted PhAB within past three months. PsAB and PhAB were slightly more prevalent in East Asian countries than in Western countries. Non-Alzheimer type and moderate to severe behavioral and psychological symptoms of dementia were associated with the risk of PhAB but not with the risk of PsAB. Severe care burden and low income were associated with the risk of PhAB and PsAB. Conclusion PhAB and PsAB were as prevalent in the family caregivers of PWD in Asian countries including Korea as in Western countries. Prevention strategies should be implemented according to the type of abusive behaviors.
아크스프링의 이산화 모델링을 사용한 DMF 차량 성능 시뮬레이터
김태현(Taehyun Kim),김민성(Minsung Kim),송한림(Hanlim Song),어순기(Sunki Uh),김현수(Hyunsoo Kim) 한국자동차공학회 2004 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
This paper presents a discrete analysis approach to investigate performance of dual mass flywheel(DMF). In the discrete analysis, arcspring installed between the flywheels is modeled as N- discrete elements. Each element consists of mass, spring and nonlinear friction element. LuGre friction model is used to describe nonlinear friction characteristic. Based on the dynamic models of the DMF, clutch, engine, manual transmission and vehicle, a DMF performance simulator is developed using MATLAB Simulink. Simulation results of the engine speed, driveshaft torque and vehicle velocity are compared with test results. It is found that the discrete DMF model describes the vehicle behavior closely, especially during the clutch actuation period.