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Hemophagocytic lymphohistiocytosis diagnosed by brain biopsy
Ju, Hee Young,Hong, Che Ry,Kim, Sung Jin,Lee, Ji Won,Kim, Hyery,Kang, Hyoung Jin,Park, Kyung Duk,Shin, Hee Young,Chae, Jong-Hee,Phi, Ji Hoon,Cheon, Jung-Eun,Park, Sung-Hye,Ahn, Hyo Seop The Korean Pediatric Society 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.9
Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, splenomegaly, jaundice, and pathologic findings of hemophagocytosis in bone marrow or other tissues such as the lymph nodes and liver. Pleocytosis, or the presence of elevated protein levels in cerebrospinal fluid, could be helpful in diagnosing HLH. However, the pathologic diagnosis of the brain is not included in the diagnostic criteria for this condition. In the present report, we describe the case of a patient diagnosed with HLH, in whom the brain pathology, but not the bone marrow pathology, showed hemophagocytosis. As the diagnosis of HLH is difficult in many cases, a high level of suspicion is required. Moreover, the pathologic diagnosis of organs other than the bone marrow, liver, and lymph nodes may be a useful alternative.
Ahn, Chang Won,Borse, Pramod H.,Kim, Ju Hun,Kim, Jae Young,Jang, Jum Suk,Cho, Chae-Ryong,Yoon, Jang-Hee,Lee, Byoung-seob,Bae, Jong-Seong,Kim, Hyun Gyu,Lee, Jae Sung Elsevier 2018 Applied Catalysis B Vol.224 No.-
<P><B>Abstract</B></P> <P>Highly uniform, self-supported PbTiO<SUB>3</SUB> nanotube arrays are fabricated on a transparent conducting glass by an all solution-based, hard-templating procedure. A new concept of site-isolation has been realized by Pt-sol infiltration only in the internal core of deposited nanotube arrays and thus physically separating electron and hole reaction sites on inside and external surface of the nanotubes, respectively. The effective charge separation by the site-isolated Pt-nanodot deposited PbTiO<SUB>3</SUB> nanotube photoanode leads to greatly enhanced photocurrent generation and H<SUB>2</SUB> evolution efficiencies relative to those of the particulate-type photoanode or PbTiO<SUB>3</SUB> nanotube without Pt infiltration in photoelectrochemical water splitting under visible light. The physical site isolation through nano-engineering of the material fabrication is expected to offer an effective strategy for preparation of high-efficiency photoelectrochemical devices.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Site-isolated Pt-dot@PbTiO<SUB>3</SUB> nanotube array is fabricated on FTO glass by an AAO templating method. </LI> <LI> It separates e<SUP>−</SUP> and h<SUP>+</SUP> reaction sites on inside and external surface of the nanotubes, respectively. </LI> <LI> The effective charge separation leads to greatly enhanced PEC water splitting activity. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Sang Hun Lee,Myung Ho Jeong,Joon Ho Ahn,Dae Young Hyun,Kyung Hoon Cho,Min Chul Kim,Doo Sun Sim,Young Joon Hong,Ju Han Kim,Youngkeun Ahn,Jin Yong Hwang,Weon Kim,Jong Seon Park,Chang-Hwan Yoon,Seung Ho 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.4
Background/Aims: Recurrent acute myocardial infarction (AMI) is an adverse cardiac event in patients with a first AMI. The predictors of recurrent AMI after the first AMI in patients who underwent successful percutaneous coronary intervention (PCI) have not been elucidated. Methods: We analyzed the data collected from 9,869 patients (63.2 ± 12.4 years, men:women = 7,446:2,423) who were enrolled in the Korea Acute Myocardial Infarction Registry-National Institute of Health between November 2011 and October 2015, had suffered their first AMI and had received successful PCI during the index hospitalization. Multivariable logistic regression analysis was performed to identify the independent predictors of recurrent AMI following the first AMI. Results: The cumulative incidence of recurrent AMI after successful PCI was 3.6% (359/9,869). According to the multivariable logistic regression analysis, the significant predictive factors for recurrent AMI were diabetes mellitus, renal dysfunction, atypical chest pain, and multivessel disease. Conclusions: In this Korean prospective cohort study, the independent predictors of recurrent AMI after successful PCI for the first AMI were diabetes mellitus, renal dysfunction, atypical chest pain, and multivessel disease.
Synaptotagmin-like protein 2 gene promotes the metastatic potential in ovarian cancer
Sung, H. Y.,Han, J.,Ju, W.,Ahn, J.-H. Spandidos Publications 2016 Oncology reports Vol.36 No.1
<P>Ovarian cancer (OC) metastasis has unique biological behavior and most commonly occurs via the transcoelomic route. Previously, we established a mouse xenograft model of human ovarian carcinoma and analyzed alterations in gene expression during metastasis. Among the genes that were differentially expressed more than 2-fold in the xenografts compared with the SK-OV-3 cells, we selected synaptotagmin-like protein 2 (SYTL2) and investigated the mechanisms regulating its expression and its gene function in OC. The mRNA expression of SYTL2 was significantly upregulated and the methylation of specific CpG sites within the SYTL2 promoter was decreased in the metastatic implants from the ovarian carcinoma xenografts compared to wild-type SK-OV-3 cells. Treatment with the demethylating agent 5-aza-2'-deoxycytidine and/or the histone deacetylase inhibitor Trichostatin A induced upregulation of SYTL2 in SK-OV-3 cells, implying that a DNA methylation-dependent epigenetic mechanism is involved in the regulation of SYTL2 expression. We also found that overexpression of SYTL2 promoted metastatic potential, including increased migration and invasiveness in the ovarian carcinoma cells. Furthermore, we utilized publicly available gene expression data to confirm the correlation between SYTL2 expression and poor prognosis in serous-type OC patients. Our findings provide novel evidence for the direct association of SYTL2 with the metastatic potential of ovarian carcinoma cells and its influence on metastatic recurrence of OC.</P>
Sung Woon Moon,김태효,Hyeon Sik Kim,Ji-Hyeon Ju,Yeon Jeong Ahn,Hyun Jeong Jang,심상군,김현진,정운태,이옥재 대한소화기내시경학회 2012 Clinical Endoscopy Vol.45 No.4
Background/Aims: The rapid urease test (RUT) is an invasive method to diagnose Helicobacter pylori infection, which relies on the acquisition and examination of gastric antrum and body tissues. We determined and compared the efficacy of RUT when the tissues were examined separately or after being combined. Methods: Two hundred and fourteen patients were included and underwent esophagogastroduodenoscopy from July 2008 to June 2010. The separate test was defined as evaluating the status of infectivity of H. pylori from the antrum and body separately; whereas the united test was carried out putting both tissues from the antrum and body in the same RUT kit. All RUTs were read by a single observer 1, 3,6, 12, and up to 24 hours later. We also got two biopsy specimens stained with hematoxylin and eosin and quantified H. pylori density was calculated on a scale of 0 to 3. Results: Overall positivity for H. pylori was 137 (64%) for the separate test and 148 (69.2%) for the united test (p<0.01). The mean time to a positive test was 3.58 hours for the separate test and 1.69 hours for the united test (p<0.01). The correlation between the time to positive RUT and the severity of histology showed r=+0.556 for the antrum (p<0.01) and r=+0.622 for the body (p<0.01). Conclusions: Combining tissues prior to RUT enhances the detection of H. pylori, as compared with the examination of separate tissues,and shortens the time to develop a positive reaction by approximately 50%. These diagnostic advantages are also accompanied by increased cost-savings.
Sang Hyun Nam,Jae Hyun Park,Ju Hye Kang,Seog Youn Kang,Jae Hong Kim,So Young Kim,Joon Ik Ahn,Ki Sook Park,Hye Joo Chung 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.11
Plasmid DNA vaccines encoding the hepatitis B virus (HBV) surface and hepatitis C virus (HCV) envelope antigens, respectively, were constructed, and attempt were made to find the possibility of a divalent vaccine against HBV and HCV. The expression of each plasmid in Cos- 1 cells was confirmed using immunocytochemistry. To measure the induced immune response by these plasmids in vivo, female BALB/c mice were immunized intramuscularly with 100 μg of either both or just one of the plasmids. Anti-HBV and HCV-specific antibodies and related cytokines were evaluated to investigate the generation of both humoral and cellular immune responses. As a result, specific anti-HBV and anti-HCV serum antibodies from mice immunized with these plasmids were observed using immunoblot. The levels of IL-2 and RANTES showing a Th1 immune response were significantly increased, but there was no change in the level of IL-4 (Th2 immune response) in any of the immunized groups. Compared with each plasmid DNA vaccine, the combined vaccine elicited similar immune responses in both humoral and cell-mediated immunities. These results suggest that the combined DNA vaccine can induce not only comparable immunity experimentally without antigenic interference, but also humoral and Th1 dominant cellular immune responses. Therefore, they could serve as candidates for a simultaneous bivalent vaccine against HBV and HCV infections.
Study of New PMSM Design for Leakage Magnetic Flux Reduction
Ahn, Han-Woong,Jun, Hyun-Woo,Lee, Hyung-Woo,Go, Sung-Chul,Lee, Ju The Korean Institute of Electrical Engineers 2016 Journal of Electrical Engineering & Technology Vol.11 No.5
<P>This paper suggests the new PMSM design that can reduce leakage magnetic flux. Through adapting non-magnetic frame structure, it decreases leakage magnetic flux on the rotor's rib and web structure. And with this, it increases power density of the motor. To verify the effectiveness of the new design of rotor compared to the common type, through small sized real model's test was conducted. To obtain final model, structural FEM analysis was also used for structural stability. Additional loss generation problem that can occur in the new frame structure was checked with the 3D FEM analysis.</P>