http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Sun A Lee,Hee Kyung Jo,Byung Ok Im,Sungun Kim,Wan Kyun Whang,Sung Kwon Ko 고려인삼학회 2012 Journal of Ginseng Research Vol.36 No.1
This study compared the contents of ginsenosides depending on steaming conditions of red ginsengs to provide basic information for developing functional foods using red ginsengs. The red ginseng steamed eight times at 98℃ ranked atop the amounts of prosapogenins ever detected in red ginsengs (ginsenoside Rg₂, Rg₃, Rg?, Rg?, Rh₁, Rh₄, Rk₁, Rk₃, F₁, F₄, 1.15%) among red ginsengs steamed more than twice. When steamed eight times at 98℃, 2.7 times as much prosapogenins such as ginsenosides Rg₂, Rg₃, Rg?, Rg?, Rh₁, Rh₄, Rk₁, Rk₃, F₁, and F₄ as those steamed just once at 98℃ was collected. In addition, the red ginsengs steamed eight times at 98℃ contained more amounting ginsenoside Rg₃ (0.28%) than that in the red ginseng steamed several times at random. Accordingly, it is recommendable that red ginsengs steamed 8 times, which proved to be the optimal steaming condition, be used rather than those steamed 9 times (black ginsengs), in order to develop red ginseng products of high prosapogenin concentration and high functions.
Sun Young Cho,Hyun Duk Yang,Su Jin Hwang,Ji Young Yun,Joon Ki Kim,Beum Ho Jo,Ki Wha Chung,Byung Ok Choi 한국유전학회 2007 Genes & Genomics Vol.29 No.3
Moderately elevated plasma homocysteine level is associated with an increased risk of Alzheimer`s disease. Thymidylate synthase (TYMS) and 5,10-methylenetetrahydrofolate reductase (MTHFR) are involved in the homocysteine metabolic pathway. In this study, we tried to find the association between TYMS tandem repeat polymorphism and Alzheimer`s disease. We analyzed the genotype of the TYMS and MTHFR C677T polymorphisms in 68 Alzheimer`s patients and 413 healthy controls. The mean plasma homocysteine level was higher in Alzheimer`s disease patients than in healthy controls (p < 0.05). Those subjects who carried at least one TYMS 2R allele [2R(+)] showed an increased risk of Alzheimer`s disease (AOR, 2.09; 95%CI, 1.21-4.25). However, the MTHFR C677T polymorphism was not associated with an increased risk of Alzheimer`s disease. In the comparison of the combinations of polymorphisms, the risk of Alzheimer`s disease was highest in the subjects with the [2R(+)/T(+)] combined genotypes (AOR, 2.76; 95%CI, 1.30-6.71). In conclusion, particular genotype of TYMS tandem repeat polymorphism and combined genotypes of the TYMS tandem repeat and MTHFR C677T polymorphisms appeared to be predictive genetic biomarkers for the risk of Alzheimer`s disease.
Sun-Jin Jo,임현우,Myeong Hee Bang,Mi Ok Lee,전태연,Jin-Sook Choi,Myung-Soo Lee,이원철,박용문 대한신경정신의학회 2011 PSYCHIATRY INVESTIGATION Vol.8 No.3
Objective The study was conducted to investigate the association between economic status and depressive symptoms by comparing the prevalence rates of depressive symptoms at community level and analyzing the possibility of depressive symptoms at individual level. Methods A survey was conducted from November, 2006 to November, 2007 on 966 and 992 representative subjects recruited by stratified clustered sampling in two regions located in Seoul. We used a standardized questionnaire including the Center for Epidemiologic Studies-Depression and questions on the socioeconomic characteristics. The adjusted prevalence rates of depressive symptoms were compared at community level, and multiple logistic regression analysis was performed to determine the association between depressive symptoms and economic statuses at individual level among each region. Results The adjusted prevalence of depressive symptoms was higher in the region with a high socioeconomic status (23.1%) than in the region with a lower economic status (16.6%)(p<0.001). However, logistic regression analysis of individual level revealed that a higher economic status was significantly associated with a lower possibility of depressive symptoms among the females in the low economic status region. This tendency was not observed among the males in both of the regions. Conclusion The association between economic status and depressive symptoms was found to be different when it was approached at community level or individual level. In addition, the association of two variables was different by gender at individual level. Further studies that consider the third mediators are needed to determine the association between the two variables. Objective The study was conducted to investigate the association between economic status and depressive symptoms by comparing the prevalence rates of depressive symptoms at community level and analyzing the possibility of depressive symptoms at individual level. Methods A survey was conducted from November, 2006 to November, 2007 on 966 and 992 representative subjects recruited by stratified clustered sampling in two regions located in Seoul. We used a standardized questionnaire including the Center for Epidemiologic Studies-Depression and questions on the socioeconomic characteristics. The adjusted prevalence rates of depressive symptoms were compared at community level, and multiple logistic regression analysis was performed to determine the association between depressive symptoms and economic statuses at individual level among each region. Results The adjusted prevalence of depressive symptoms was higher in the region with a high socioeconomic status (23.1%) than in the region with a lower economic status (16.6%)(p<0.001). However, logistic regression analysis of individual level revealed that a higher economic status was significantly associated with a lower possibility of depressive symptoms among the females in the low economic status region. This tendency was not observed among the males in both of the regions. Conclusion The association between economic status and depressive symptoms was found to be different when it was approached at community level or individual level. In addition, the association of two variables was different by gender at individual level. Further studies that consider the third mediators are needed to determine the association between the two variables.
Jo, Sung Jun,Kim, Jeung Won,Choi, Hye Ok,Kim, Jung Hwan,Kim, Hyung Joong,Woo, Sun Hee,Han, Byung Hoon The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.3
Adipogenesis in murine preadipocyte 3T3L-1 has been used as a model system to study anti-obese bioactive molecules. During adipogenesis in 3T3-L1 preadipocytes, we found that capsanthin inhibited adipogenesis ($IC_{50}$; $2.5{\mu}M$) and also showed lipolytic activity in differentiated adipocytes from the preadipocytes ($ED_{50}$; 872 nM). We identified that the pharmacological activity of capsanthin on adipogenesis in 3T3-L1 was mainly due to its adrenoceptor-${\beta}_2$-agonistic activity. In high-fat diet animal model study, capsanthin significantly enhanced spontaneous locomotive activities together with progressive weight-loss. The capsanthin-induced activation of kinetic behavior in mice was associated with the excessive production of ATP initiated by both the enhanced lipolytic activity together with accelerated oxidation of fatty acids due to the adrenoceptor ${\beta}_2$-agonistic activity of capsanthin. Capsanthin also dose-dependently increased adiponectin and p-AMPK activity in high fat diet animals, suggesting that capsanthin has both anti-obesity and insulin sensitizing activities.
Expression profiles of HERV-K Env protein in normal and cancerous tissues
Jo, Jin-Ok,Kang, Yun-Jeong,Ock, Mee Sun,Song, Kyoung Seob,Jeong, Moon-Jin,Jeong, Soon-Jeong,Choi, Yung Hyun,Ko, Eun-Ji,Leem, Sun-Hee,Kim, Suhkmann,Kim, Heui-Soo,Cha, Hee-Jae Springer-Verlag 2016 Genes & Genomics Vol.38 No.1
<P>Human endogenous retroviruses (HERVs) have been proposed as etiological cofactors in chronic diseases such as cancer, autoimmunity and neurological disease. HERV RNA expression is also increased in several autoimmune diseases and cancers. However, only a few studies have analyzed the expression levels of HERV-derived proteins in normal and diseased tissues. Here, we investigated the expression profiles of HERV-K Env protein, which is the most well-known pathogen, from normal and cancer tissue microarray. Normal and cancer tissue microarray slides containing 59 normal or 60 tumor surgical specimens, respectively were immunostained with mouse monoclonal antibody to HERV-K and staining intensity was scored. The expression of HERV-K Env protein is generally low in normal tissues but high in specific tissues including bronchus submucosal gland, salivary gland acini, pancreas acini, testis seminiferous tubule, uterine cervix epithelium, ovary stroma, skin epidermis, and heart. The expression of HERV-K Env protein in tumors was usually higher than normal tissues and specifically high in breast, liver, stomach, prostate, and ovarian cancer. This study provides protein expression profiles of HERV-K Env protein in human normal and cancer tissues and provides a good reference for further studies on the expression patterns and roles of HERV-K Env protein in normal organs and various cancers. Further studies with specific organs or cancers and a statistically significant numbers of samples are necessary.</P>
Development of autoimmune hepatitis in a psoriasis patient without immunosuppressive therapy
( Wonyong Jo ),( Young-sun Suh ),( Sang-il Lee ),( Yun-hong Cheon ),( Jeongmin Hong ),( Sang Su Lee ),( Ji Eun Kim ),( Gyung Hyuck Ko ),( Hyun-ok Kim ) 대한간학회 2017 Clinical and Molecular Hepatology(대한간학회지) Vol.23 No.2
We present a case of a 65-year-old man with psoriasis who developed autoimmune hepatitis (AIH) without receiving immunosuppressive therapy with either anti-tumor necrosis factor-α or methotrexate. The AIH had completely resolved at 2 months after prednisolone and azathioprine therapy. This case confirms the need to consider AIH in psoriasis patients who experience new elevations in liver enzymes. To our knowledge, this is first description of the development of AIH in an immunosuppressant-naive patient with psoriasis. (Clin Mol Hepatol 2017;23:184-187)