초기임신부 및 융모상피종 환자에 있어서의 세포 매개면역

김장흡 ( JH Kim ),조봉춘 ( BC Cho ),김진홍 ( CH Kim ),한구택 ( GT Han ),석준호 ( JH Suk ),강홍일 ( HI Kang ),안웅식 ( WS An ) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.1

결론 저자들은 초기 임신부와 치료전 상태의 융모상피종 0기 및 I~IV기 환자에 대하여 말초혈액내 임파구 절대수, DNCB 감작에 의한 피부반응 및 임파구 배양에 의한 PHA 반응도 그리고 rosette 형성시험을 통한 T-임파구 절대수를 측정하였으며, 이를 비임신 건강대조군과 비교하였고, 융모상피종의 임상경과 등과 연관지 어 다음과 같은 결론을 얻었다. 1. 초기 임산부에 있어서의 임파구 백분율, DNCB 피부반응 및 PHA 자극반응은 대조군에 비하여 유의한 감소가 있었으나 임파구 절대수와 T-임파구수는 차이가 없었다. 2. 융모상피종 0기 (포상기태)환자에서는 DNCB 피부반응과 PHA 자극반응이 임산부에서와 비슷하게 감소되었으며, 역시 임파구 절대수와 T-임파구수는 변화가 없었다. 포상기태 배출후 15~72시간에 일시적인 PHA 자극반응의 저하가 관찰되었으며, 1년간의 임상 추적증에 면역기능이 낮은 7예에서 악성변화가 발견되 었다. 3. 융모상피종 I∼IV기 환자중, 특히 전이가 진행된 III~IV기 환자에서 임파구 절대수, DNCB피부반응과 PHA 자극에 대한 임파구 분화도 그리고 T-임파구수가 유의하게 감소하였으며, 면역기능이 낮을수록 항암 화학요법에 대한 반응이 불량하였다. 4. 말초혈액내 임파구수, DNCB 피부반웅 및 PHA 자극반응 등의 검사방법 사이에는 유의한 비례관계가 있었다. 5. 임산부와 융모상피종 0기 환자에서 임파구배양액에 자가혈청을 가하였을 때 ,H-thymidine uptake치의 감소 현상이 있었으며, 이를 당시의 요중hCG호르몬 농도와 비교하였을때 유의한 역상관관계가 관찰되었다. 이상의 결과로 보아 임신부 및 융모상피종 환자에서 세포매개 면역이 유의하게 감소되었으며, 그 원인은 혈청인자, 특히 hCG흐르몬의 영향일 것으로 생각된다. 또한 융모상피종 환자의 세포매개 면역은 임상경과 및 화학요법의 치료효과와 밀접한 관계가 있음을 알 수 있었다. The role of the immune system in pregnancy and neoplastic diseases has long been a subject of controversy. lmmunoregulatory process tolerating the fetus and the trophobl-astic neoplasia, as natural allografts, is not fully understood but usually explained by the suppressed host immunocompetence. Several authors recommended somne humoral factors (serum proteins, immune complex or hormones etc.) as the key depressants affecting the maternal immunologic system. Patients with advanced cancer have a depressed immunological function and in view of the accumulating evidence for a relationship between immunologic reactivity and prognosis, information of indⅳidual patient on immunocompetence may be of great importance in the clinical evaluation of the cancer patients. In an effort to study the cell-mediated immunity of pregnant women and patients with gestational trophoblastic neoplasia (GTN), authors employed a battery of lymphocytem- onitoring techniques: absolute lymphocyte counts, DNCB skin testings, PHA-induced ly-mphocyte transformation and T_lymphocyte rosettes. The results were as follows: 1. In healthy nonpregant women, the peripheral lymphocyte count and the T-cell subpopulation were 2,146±813/ui and 83.9±6.2% (1,796 810/ul) respectively. The positⅳe rate of DNCB skin response was 90.0%, and H-thymidine uptake of PHA-stimulated lymphocytes was 126,248±38,038 cpm/2x1,000,000 cells. 2. Women with early gestation revealed the significant decrease in DNCB skin react- ion,H-thymidine uptake of PHA-stimulated lymphocytes and proportion of peripheral lymphocytes, but there were no differences of absolute lymphocyte count and T-cell rosettes as compared with the healthy nonpregnant control. 3. In patients with GTN stage 0(hydatidiform mole) : (1) DNCB skin reactⅳity and PHA-induced lymphocyte transformation were, although not statistically in DNCB test (0.083)

개량형 피질충격모델의 개발(제1부:역학)

최석민,석종식,권정택,민병국,김영백,황성남,최덕영,김재현,이성민,엄윤용 대한신경외과학회 2002 Journal of Korean neurosurgical society Vol.32 No.1

개량형 피질 충격 모델의 개발(제2부:기능적 결과)

최석민,석종식,민병국,황성남,김영백,김재현 대한신경외과학회 2002 Journal of Korean neurosurgical society Vol.32 No.5

대망임신 1 례

이원명,이주명,석지혜,이흥관,최윤석,김익수 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.11

Omental pregnancy is an extremely rare form of abdominal pregnancy that may cause life threatening massive hemorrhage in case of rupture. It may occur by primary implantation of the fertilized ovum in the omentum. The diagnosis is very difficult, but prompt surgical intervention is required when it is suspected, because perinatal mortality and maternal mortality in abdominal pregnancy were 85∼95% and 0.5∼6%. We experienced a case of omental pregnancy in the first times and reported it with brief review of literature.

Comparative evaluation of a 20-day thyroid/pubertal male assay and Hershberger assay for the detection of androgenic/antiandrogenic activity

Moon HJ,Kim HS,Shin JH,Kim TS,Kang IH,Suk JH,Kim lY,Lee KM,Hwang IK,Han SY 大韓藥學會 2000 大韓藥學會 總會 및 學術大會 Vol.49 No.-

디피리다몰 정주로 유발된 심근허혈시 심박 변이도의 변화 : 심근허혈 지표로서 심박 변이도의 임상적 유용성

김민경,신동구,박용호,석준호,박종선,김영조,심봉섭,조인호 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.9

임신성 고혈압 환자에서 혈소판 및 혈청의 화학적 검사에 관한 연구

박일수,최영철,이동진,석지혜,최윤석,박학렬,최은주 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.2

This study was undertaken to evaluate the significance of platelet counts and blood chemical assays in predicting pregnancy induced hypertension and differentiating its severity. And so the differences in platelet counts and blood chemical assays between 4(0∼24.9, 25.0∼49.9, 50.0∼74.9, 75.0∼100) birth weight- for-date percentile groups in cases with normal pregnancy, mild and severe pregnancy induced hypertension(PIH) and also between normal pregnancy cases and PIH cases in the same birth weight-for-date percentile group were evaluated. 50 cases with mild PIH, 67 cases with severe PIH, and 82 cases with normal pregnancy for control were taken part in this study at the department of Obstetrics and Gynecology, Fatima Hospital from July, 1996 to June, 1997. Platelet counts, aspartate aminiotransferase(AST), alanine aminotransferase(ALT), total protein, albumin, blood urea nitrogen(BUN) and creatinine levels were measured and analyzed in cases with normal pregnancy, mild and severe PIH according to birth weight-for-date percentile groups. The results were as follows: 1. There was a significant correlation between the birth weight-for-date percentile groups and the pregnancy cases. 62.5% of 0∼24.9 birth weight-for-date percentile group were distributed in severe PIH cases and 55.3% of 75.0∼100 birth weight-for-date percentile group were distributed in normal pregnancy cases. 2. There was no significant difference on platelet count between each birth weight-for-date percentile groups in cases with normal pregnancy, mild and severe PIH and also between normal pregnancy and mild PIH cases in the same birth weight-for-date percentile group. There were significant differences between normal pregnancy and severe PIH cases in the 25.0∼49.9 and 50.0∼74.9 birth weight-for-date percentile groups. 3. There was no siginificant difference in serum AST and ALT levels between each birth weight-for-date percentile groups in cases with normal pregnancy, mild and severe PIH and also between normal, mild and severe PIH cases in the same birth weight-for-date percentile group. 4. There was no significant difference in serum total protein levels between each birth weight-for-date percentile groups in cases with normal pregnancy, mild and severe PIH and also between normal pregnancy, mild and severe PIH cases in the same birth weight-for-date percentile group except 0∼24.9 birth weight-for-date percentile group. The serum albumin levels in severe PIH cases were significantly different between 0∼24.9 and 75.0∼100 birth weight-for-date percentile groups. The serum albumin level in severe PIH cases was significantly lower than that in normal pregnancy at 0∼24.9 birth weight-for-date percentile group. 5. There was no significant difference in BUN levels between each birth weight-for-date percentile groups in mild and severe PIH cases but a difference was found between normal pregnancy and severe PIH cases in 25.0∼49.9 and 50.0∼74.9 birth weight-for-date percentile groups. There was no significant difference in serum creatinine levels between each birth weight-for-date percentile groups in normal pregnancy , mild and severe PIH cases and also between normal pregnancy, mild and severe PIH cases in the same birth weight-for-date percentile group.

난소임신 1 례 및 광인대임신 1 례

최영철,이동진,장호성,한동근,석지혜 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.11

Ovarian pregnancy is a rare form of ectopic gestation. However, improved diagnosis of acute hemoperitoneum may reveal a higher incidence than reported earlier. But it still an uncommon experience of any obstetrician and gynecologist. Intraligamentary pregnancy is also one of the most unusual accidents in obstetrics. Two cases of different ectopic pregnancy are reported with a brief review of literatures concerned.

난소 임신 2례

차인종(IJ Cha),안영준(YJ Ahn),강병철(BC Kang),석준호(JH Suk),김창이(CY Kim) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.11

저자들은 성 바오로 병원 산부인과에서 Spiegelberg의 진단기준에 충족한 난소임신 2예를 경험하였기에 간단한 문헌적 고찰과 함께 이를 보고하는 바이다. Two cases of primary ovarian pregnancy, which we have experienced, are reported and literature are briefly reviewed.