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간세포암환자에서 간동맥 화학 색전술 후 발생한 리피오돌에 의한 폐렴 1예
김소이,김유리,허현미,배서은,이명원,최윤정,김고흔,김태헌,유 권,문일환 이화여자대학교 의과대학 2009 EMJ (Ewha medical journal) Vol.32 No.2
Hepatocellular carcinoma(HCC)is one of common causes of cancer-related death in Korea where the majority of HCC patients were Hepaitc B virus(HBV)carriers and have cirrhosis. Transarterial chemoembolization(TACE)is commonly applied to the treatment of multinodular HCC in Korea and careful selection of candidate is important for the risk of various side effects. Besides common side effects as fever, nausea, abdominal pain and elevation of liver enzyme, TACE may predispose to hepatic failure, ischemic cholecystitis, pulmonary embolism, cerebral embolism and pneumonitis. In previous studies, some cases of pulmonary and cerebral embolism cases were reported but lipiodol pneumonitis after TACE was rarely reported. A 65-year-old woman with a multinodular HCC associated with HBV infection, was treated with TACE. Seven days after the procedure, nonspecific respiratory symptoms such as dyspnea and dry cough developed. Chest X-ray and chest computed tomography showed diffuse ground glass opacities in whole lung fields, suggestive of lipiodol pneumonitis. After several days of supportive care with steroid administration, radiologic abnormalities and subjective symptoms were much improved, considered that the disease was compatible with lipiodol pneumonitis.
Expression of Alzheimer's amyloid precursor protein in human lymphocyte
Suh, Yoo-Hun,Choi, Woong,Kim, Seong-Hun,Kim, Jong-Suk,Rhi, Bou-Yong,Chong, Young Hae,Woo, Jong Inn,Kwang-Woo 이화여자대학교 생명과학연구소 1996 생명과학연구논문집 Vol.7 No.-
β-Amyloid precursor protein(βAPP)has been shown to be involved in cell growth regulation. In spleen, the majority of cells showing βAPP like immunoreactivity was found in the T cell-dependent zone. In Northern blot, the expression of βAPP was increased to reach the peak at 72 h after the treatment of phytohemagglutinin(PHA). But in cytofluorometry, almost all CD4^+ T helper/inducer cells and the majority of CD8^+ T suppressor/cytotoxic cells show βAPP immunoreactivity which remained constant during the stimulation with PHA. These results suggest that βAPP is a surface molecule of T lymphocyte and the turnover or release of APP might be increased with the treatment of T cell mitogen.
SUH, YOO-HUN,CHONG, YOUNG HAE,KIM, SEONG-HUN,CHOI, WOONG,MIN, KYEONGSIK,JEONG, SUNG-JIN,FRASER, S. P.,DJAMGOZ, M. B. A. 이화여자대학교 생명과학연구소 1996 생명과학연구논문집 Vol.7 No.-
APP may be associated with defense mechanisms in the central nervous system involving the immune system.^1 The finding of low levels of APP was initially described in proportion to lymphocytes.^2 We examined APP expression in human lymphocytes and spleen and compared APP expression in lymphocytes from Alzheimer's patients to that in lymphocytes from age-matched controls. In spleen, the majority of cells showing A? immunoreactivity was found in the T cell-dependent zone. Fluorescence activated cell sort analysis(FACS) indicated that around 90% of CD4^+ T cells and 60% of CD8^+ T cells were immunoreactive to A? specific monoclonal antibody (mAb) 4G8. Northern blot analysis showed that lymphocyte APP mRNA was gradually increased to reach a maximum at 3 days
Higenamine과 그 유도체들이 흰쥐 미토콘드리아 Monoamine Oxidase 활성에 미치는 영향
서유헌(Yoo Hun Suh),박혜영(Hae Young Park),임정규(Jung Kyoo Lim),박찬웅(Chan Woong ParK) 대한약리학회 1984 대한약리학잡지 Vol.20 No.2
본 연구에서는 higenamine과 그 유도체들이 백서 뇌 미토콘드리아 Monoamine Oxidase(MAO) 의 활성에 미치는 영향에 관하여 관찰하였다. 시험한 화합물들 중에서 심장의 등장성 수축에는 효과를 나타내지 않는 methoxyhigenamine이 가장 5-hydroxytryptamine(5-HT)과 phenylethylamine(PEA)에 대한 MAO의 활성을 가역적으로 억제시켰으며, 그 억제 양상은 각각 pure competitive형과 hyperbolic mixed 형이었다. 이에 5-HT에 대한 IC<sub>50</sub> 는 PEA에 대한 것보다 10배 정도 낮아서 MAO-B 보다는 MAO-A에서 더 강한 억제 작용을 나타내었다. 이로써 methoxyhigenamine은 가역적이며 비교적 MAO-A에 대해 선택적인 MAO 억제제로 사료된다. The effect of higenamine and its derivatives on the activity of rat bran mitochondrial monoamine oxidase(MAO) was studied. Methoxyhigenamine of drugs tested had no effect on isometric contraction of heart and reversibly inhibited MAO towards 5-hydroxytryptamine(5-HT) and phenylethylamine(PEA) in a pure competitive fashion and in a hyperbolic mixed fashion, respectively, but was found to be relatively MAO-A selective inhibitor, with IC<sub>50</sub> value for 5-HT lower ten fold than for PEA. The results suggest that methoxyhigenamine is a reversible, relatively MAO-A specific inhibitor in virto.