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Spontaneous Oscillatory Rhythm in Retinal Activities of Two Retinal Degeneration (rd1 and rd10) Mice
구용숙,Kun No Ahn,Yeong Jun Song,Su Heok Ahn,한승기,류상백,김경환 대한약리학회 2011 The Korean Journal of Physiology & Pharmacology Vol.15 No.6
Previously, we reported that besides retinal ganglion cell (RGC) spike, there is ∼10 Hz oscillatory rhythmic activity in local field potential (LFP) in retinal degeneration model, rd1 mice. The more recently identified rd10 mice have a later onset and slower rate of photoreceptor degeneration than the rd1 mice, providing more therapeutic potential. In this study, before adapting rd10 mice as a new animal model for our electrical stimulation study, we investigated electrical characteristics of rd10 mice. From the raw waveform of recording using 8×8 microelectrode array (MEA) from in vitro-whole mount retina, RGC spikes and LFP were isolated by using different filter setting. Fourier transform was performed for detection of frequency of bursting RGC spikes and oscillatory field potential (OFP). In rd1 mice, ∼10 Hz rhythmic burst of spontaneous RGC spikes is always phase-locked with the OFP and this phase-locking property is preserved regardless of postnatal ages. However, in rd10 mice, there is a strong phase-locking tendency between the spectral peak of bursting RGC spikes (∼5 Hz) and the first peak of OFP (∼5 Hz) across different age groups. But this phase-locking property is not robust as in rd1 retina, but maintains for a few seconds. Since rd1 and rd10 retina show phase-locking property at different frequency (∼10 Hz vs. ∼5 Hz), we expect different response patterns to electrical stimulus between rd1 and rd10 retina. Therefore, to extract optimal stimulation parameters in rd10 retina, first we might define selection criteria for responding rd10 ganglion cells to electrical stimulus.
Spontaneous Oscillatory Rhythm in Retinal Activities of Two Retinal Degeneration (rd1 and rd10) Mice
Goo, Yong-Sook,Ahn, Kun-No,Song, Yeong-Jun,Ahn, Su-Heok,Han, Seung-Kee,Ryu, Sang-Baek,Kim, Kyung-Hwan The Korean Society of Pharmacology 2011 The Korean Journal of Physiology & Pharmacology Vol.15 No.6
Previously, we reported that besides retinal ganglion cell (RGC) spike, there is ~10 Hz oscillatory rhythmic activity in local field potential (LFP) in retinal degeneration model, rd1 mice. The more recently identified rd10 mice have a later onset and slower rate of photoreceptor degeneration than the rd1 mice, providing more therapeutic potential. In this study, before adapting rd10 mice as a new animal model for our electrical stimulation study, we investigated electrical characteristics of rd10 mice. From the raw waveform of recording using $8{\times}8$ microelectrode array (MEA) from in vitro-whole mount retina, RGC spikes and LFP were isolated by using different filter setting. Fourier transform was performed for detection of frequency of bursting RGC spikes and oscillatory field potential (OFP). In rd1 mice, ~10 Hz rhythmic burst of spontaneous RGC spikes is always phase-locked with the OFP and this phase-locking property is preserved regardless of postnatal ages. However, in rd10 mice, there is a strong phase-locking tendency between the spectral peak of bursting RGC spikes (~5 Hz) and the first peak of OFP (~5 Hz) across different age groups. But this phase-locking property is not robust as in rd1 retina, but maintains for a few seconds. Since rd1 and rd10 retina show phase-locking property at different frequency (~10 Hz vs. ~5 Hz), we expect different response patterns to electrical stimulus between rd1 and rd10 retina. Therefore, to extract optimal stimulation parameters in rd10 retina, first we might define selection criteria for responding rd10 ganglion cells to electrical stimulus.
큰 관상동맥 병변에서 약물방출스텐트와 금속스텐트의 임상경과 비교
김우종 ( Woo Jong Kim ),조장현 ( Jang Hyun Cho ),정종혁 ( Jong Heok Jung ),이민근 ( Min Kun Lee ),윤재성 ( Jae Sung Yoon ),안용수 ( Young Soo Ahn ),황영준 ( Young Jun Hwang ),정홍명 ( Hong Myung Jung ),김수현 ( Su Hyun Kim ),김준 대한내과학회 2011 대한내과학회지 Vol.80 No.6
Background/Aims: Drug-eluting stents (DES) are superior to bare metal stents (BMS) in reducing restenosis rates across a wide range of patients and lesion subsets.This study compared the clinical outcomes of DES versus BMS in patients with large coronary Methods: The study compared 134 patients (59.9±10.6 years, 90 men, 44 women) who underwent single vessel angioplasty with DESimplantation in large vessels with 115 patients (60.3±8.9 years, 82 men, 33 women) who received BMS. The clinical outcomes at 12 months were compared between groups. The study end points were major adverse cardiac events (MACE), including cardiac death, nonfatal myocardial infarction, and the need for target vessel and target lesion revascularization. Results: The baseline clinical coronary angiography and procedural characteristics were similar in both groups. The duration of dual antiplatelet therapy was longer in the DES group than in the BMS group (240±2.7 vs. 348±1.7 days, p=0.042). During the 12-month clinical follow-up, MACE were observed in 13 patients (11.3%) with BMS and 12 patients (9.0%) with DES (p=0.486). Conclusions: For coronary stents implanted in large coronary arteries, DES seems to be more favorable, although no significant differences were observed in the clinical outcomes between DES and BMS during a 1-year clinical follow-up. (Korean J Med2011;80:664-671)
Kim, Young-Min,Kim, Jihyun,Han, Youngshin,Lee, Byung-Jae,Choi, Dong-Chull,Cheong, Hae-Kwan,Jeon, Byoung-Hak,Oh, Inbo,Bae, Gwi-Nam,Lee, Jae Young,Kim, Chang-Heok,Seo, SungChul,Noh, Su Ryeon,Ahn, Kangmo Elsevier BV 2017 Science of the Total Environment Vol.579 No.-
<P><B>Abstract</B></P> <P>We estimated the exposure to ambient air pollutants and analyzed the associations with allergic diseases. We enrolled 177 children with atopic dermatitis (AD) and 70 asthmatic adults living in Seoul Metropolitan Area, Korea, and followed for 17months between August 2013 and December 2014. Parents or patients recorded symptom scores on a daily basis. Exposure to particulate matter with a diameter <10μm (PM<SUB>10</SUB>) and nitrogen dioxide (NO<SUB>2</SUB>) was estimated in four different ways in each individual, using the AQ1 (measurements from the nearest air quality monitoring station to residential houses), AQ2 (measurements modified from AQ1 with the indoor level of air pollutants and time activity of each individual), AQ1-DI, and AQ2-DI (measurements modified from AQ1 and AQ2, respectively, with daily inhalation intakes of air pollutants). A generalized linear mixed model (GLMM) was used to analyze the associations between exposure metrics and clinical symptoms after adjusting for ambient temperature and humidity, age, season, gender, and time trend. The exposure metrics for PM<SUB>10</SUB> and NO<SUB>2</SUB> showed different distributions. Symptoms of AD and asthma were positively associated with exposure to PM<SUB>10</SUB>, but not NO<SUB>2</SUB>, in all exposure metrics. The effect size of PM<SUB>10</SUB> exposure on asthma symptoms was slightly greater in metrics with inhalation capacity (AQ-DIs) than in those without (AQs). This pattern was not observed in AD. Exposure to PM<SUB>10</SUB> is associated with symptom aggravation in childhood AD and adult asthma. Different exposure estimates may be used to evaluate the impact of air pollution on different allergic diseases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new method for estimating personal exposure to air pollutants was proposed. </LI> <LI> Personal exposure of air pollution showed different spatial and temporal distribution from ambient concentration. </LI> <LI> The effects of air pollution on allergic symptoms varied by exposure metric and disease. </LI> <LI> The effect sizes of PM<SUB>10</SUB> exposure on asthma symptoms can be greater in metrics that considered inhalation capacity. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>