백서의 치아이동 시 피질골 천공이 치주조직의 OPG, RANK, RANKL의 발현에 미치는 영향

박우경,김성식,박수병,손우성,김용덕,전은숙,박미화 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.3

치아이동 시 피질골 천공이 치조골 재형성에 미치는 영향을 알아보기 위해서 생후 15주된 자성백서를 사용하여 피질골 천공 후 치아이동을 실시한 실험군(Tooth movement with cortical punching: TMC group, n = 16)과 교정적 치아이동만 실시한 대조군(Tooth movement only group: TM group, n = 16)의 치아주위조직을 면역조직화학염색을 통하여 관찰하였다. 실험군과 대조군의 실험동물에 20 gm의 힘으로 상악 전치부 사이를 이개시키는 치아이동을 시행하였으며 실험군에서는 상악 전치부 구개부위에 피질골 천공을 실시하였다. 치아이동 후 1, 4, 7, 14일째에 실험군과 대조군의 실험동물을 희생시켰다. 면역조직화학염색법으로 OPG, RANK, RANKL의 발현을 비교한 결과, OPG의 발현은 양 군 모두에서 미처치 대조군에 비하여 감소되었으나, 실험군에서의 발현이 대조군보다 컸으며, RANK, RANKL은 피질골 천공을 시행한 경우에 더 강한 발현을 보이는 것이 관찰되었다. 따라서 피질골 천공이 치주조직의 OPG, RANK, RANKL의 발현에 영향을 미치며 치조골의 재형성을 향상시키는 것을 알 수 있었다. Objective: The purpose of this study was to investigate whether cortical punching could stimulate the expression of OPG, RANK, and RANKL during tooth movement by immunohistochemistry. Methods: 34 sprague-dawley rats (15 weeks old) were allocated into 3 groups: TMC group (experimental group; Tooth Movement with Corticotomy, n = 16), TM group (control group; Tooth Movement only group, n = 16), and non-treatment group (n = 2). 20 gm of orthodontic force was applied to rat incisors by inserting elastic bands. The duration of force application was 1, 4, 7 and 14 days. A microscrew (diameter 1.2 mm) was used for cortical punching of the palatal side of the upper incisors in the TMC group. Results: Distributions of OPG, RANK, and RANKL were evaluated by immunohistochemistry. OPG, RANK and RANKL were observed on experimental and control groups. On the compression side, the degree of the expression of OPG decreased in both groups. The expression of RANK was most prominent in the experimental group of day 4. The expression of RANKL was most intensive and extensive in the experimental group of day 7. However, the expression of OPG was decreased in the experimental and control groups compared to the non treatment group. The expression of OPG, RANK and RANKL after force application were decreased at day 14. Conclusions: These findings suggested that cortical punching might stimulate remodeling of alveolar bone during a 2 week period of tooth movement without any pathologic change.

유아교사 평가 척도의 사용실태와 요구도 조사

남미경,손원경 부산유아교육학회 2003 유아교육논총 Vol.11 No.-

본 연구는 부산, 경남 및 서울, 경기 지역 공·사립 유치원 및 어린이집 교사 183명을 대상으로 유아교사평가척도의 사용실태 및 요구도를 조사하였다. 조사결과, 조사 대상자의 45.9%가 유아교사평가를 실시하고 있으며 54.1%는 실시하고 있지 않는 것으로 나타났다. 그리고 교사평가에서 평가도구틀 활용하는 경우는 6.6%에 불과하였는데, 유아교사평가척도를 활용하지 않는 주 이유는 '적절한 평가척도가 없어서'이며 평가척도의 필요성에 대해서는 86.3%가 '필요하다'고 응답하였다. 평가척도가 필요한 이유에 대해서는 '교사의 교수능력 개선'(35.5%)를 우선으로 지적하였고, 다음으로 '교사의 자기반성'(35.0%)이 많은 것으로 나타났다. 평가척도에 가장 필요한 내용으로는 '인성 및 교양으로서 전체의 30.6%를 차지하였다. 유아교사평가척도의 결과가 어떻게 활용되는 것이 좋은지에 대해서 '교사의 자기반성 자료'(45.9%)라는 의견이 가장 많았고, '담임교사 결정 자료'(3.8%)나 '유아교육기관의 질 관리'(1.6%)와 같은 행정적인 부분에의 활용에 대해서는 응답이 낮게 나타났다. The purpose of this study is to investigate actual conditions and need of using evaluation scales for early childhood teacher. Research questions are as follows. First, How about the actual condition of using evaluation scales for early childhood tracher? Second, How about the need of using evaluation scales for early childhood tracher? The subjects of this study were 193 teachers. The data were collected by questionnaire ?es, and analysed by frequencies, percentiles and shi-square. The finding of this study are as follows. First, 45.9% of teachers responded that they take out teacher evaluation, and 54.1% of teachers responded that they did not. Second, 23.8% of teachers responded that they have used ‘Analysis of teaching plans and teacher’s journal’. And 23.5% of teachers responded that they have used ‘analysis of teaching case’ and 17% of teachers responded that they have used ‘peer-teacher nonformal assessment’ as teacher evaluation method. Third, Only 6.6% of teachers responded that they have used early childhood evaluation scale because they have not appropriate evaluation scale. But Most of teacher(83.3%) wanted to assessment scale as early childhood teacher evaluation method.

The prevalidation of alternative methods of new reconstructed human corneal equivalents for the assessment of eye irritation(초)

( Kyoung Mi Jung ),( Su Hyon Lee ),( Chae Wook Kim ),( Kyoung Min Lim ),( Young Sook Son ) 한국동물실험대체법학회 2009 한국동물실험대체법학회 학술대회집 Vol.2009 No.3

Corrosion Behavior between Dental Implant Abutment and Cast Gold Alloy

Son, Mi-Kyoung,Choe, Han-Cheol,Chung, Chae-Heon 대한금속재료학회 2004 METALS AND MATERIALS International Vol.10 No.2

TWO types of HL hexed abutments of a Steri-Oss system, gold/plastic coping and gold coping, were compared in terms of corrosion behavior. The anodic polarization behavior and the galvanic corrosion between abutments and Type III gold alloys, before and after casting, were analyzed. In addition, the crevice corrosion of the casting samples was analyzed with cyclic potentiodynamic polarization tests using the IE-E value and scanning electron microscopy. Before casting, gold/plastic coping and gold coping were shown to have similar corrosion patterns in the anodic polarization test. Type III casting gold alloy was shown to have a lower corrosion potential and passivation film. The corrosion potential of the goldlplastic coping after casting was higher than that of gold coping, but the passive region for the goldplastic coping was smaller than that of gold coping. The contact current density between the cast gold alloys and goldplastic before casting was higher than that between gold coping and cast gold alloy. The contact current density of the samples after casting was shown to be similar to that before casting. The crevice corrosion resistance of cast samples using gold coping was lower than that of cast samples using goldlplastic coping, and severe corrosion was observed by SEM at the abutment-casting gold alloy interface.

Incidence and Risk Factors for Atrial Fibrillation in Korea: the National Health Insurance Service Database (2002–2010)

Mi Kyoung Son,Nam-Kyoo Lim,Myeong-Chan Cho,Hyun-Young Park 대한심장학회 2016 Korean Circulation Journal Vol.46 No.4

Background and Objectives: Atrial fibrillation (AF) is a common arrhythmia that is known as an important independent risk factor for stroke. However, limited information is available on AF in Korea. This study evaluated the incidence of AF, its associated co-morbidities and risk factors for AF in Korea. Subjects and Methods: The National Health Insurance Service database between 2002 and 2010 was used in the study. Individuals<30 years old and those diagnosed with AF between 2002 and 2004 were excluded. Hazard ratios (HRs) according to co-morbidities and risk factors for AF were determined using a Cox proportional hazard model. Population attributable fractions (PAFs) of AF risk factors were determined. Results: During a 6-year follow-up period, 3517 (1.7%) developed AF. The incidence rates in men and women aged 30-39 years were 0.82 and 0.55 per 1000 person-years, respectively; the incidence rates further increased with age to 13.09 and 11.54 per 1000 person-years in men and women aged≥80 years, respectively. The risk factors for incident AF were age, sex, body mass index (BMI), hypertension, ischemic heart disease (IHD) and heart failure. After adjusting for variables related to AF, the risk of AF was significantly associated with hypertension (HR 1.667), IHD (HR 1.639), heart failure (HR 1.521), and the PAFs for age, sex, BMI, hypertension, IHD, heart failure and diabetes mellitus were 30.6%, 10.1%, 3.4%, 16.6%, 8.2%, 5.3% and 0.8%, respectively. Conclusion: Incidence of AF increased with age and was higher in men than in women. A larger proportion of AF events was attributable to hypertension than to other co-morbidities.

Trend of Prevalence of Atrial Fibrillation and use of Oral Anticoagulation Therapy in Patients With Atrial Fibrillation in South Korea (2002–2013)

Son, Mi Kyoung,Lim, Nam-Kyoo,Park, Hyun-Young Japan Epidemiological Association 2018 Journal of epidemiology Vol.28 No.2

<P><B>Background</B></P><P>This study examined the annual prevalence of atrial fibrillation (AF) and its associated comorbidities, as well as the prevalence of warfarin therapy in South Korean patients with AF.</P><P><B>Methods</B></P><P>The National Health Insurance Service-National Sample Cohort database was searched for subjects aged ≥30 years diagnosed with AF from 2002–2013. The prevalence of AF was analyzed by sex and age, as was the current status of warfarin therapy in AF patients according to CHA<SUB>2</SUB>DS<SUB>2</SUB>-VASc score and comorbidities.</P><P><B>Results</B></P><P>The age-standardized prevalence of AF in men and women was 0.15% and 0.14%, respectively, in 2002, increasing to 0.54% and 0.39%, respectively, in 2013. In 2013, the prevalence of AF in men and women aged 30–39 years was 0.08% and 0.03%, respectively, increasing to 2.35% and 1.71%, respectively, in those in aged ≥60 years. During 2002–2013, the prevalence of AF in men significantly increased among subjects aged ≥30 years and increased in women aged ≥60 years. The age-standardized prevalence of hypertension and diabetes mellitus among AF patients were markedly increased during 2002–2013. Of these AF patients, 86.1% had a CHA<SUB>2</SUB>DS<SUB>2</SUB>-VASc score of ≥2; however, only 39.1% of these were receiving warfarin.</P><P><B>Conclusions</B></P><P>The age-standardized prevalence of AF increased 2.89-fold over the 12-year study period. The total number of patients with AF in South Korea has been drastically increasing, due to not only aging society but also increasing age-specific prevalence of AF, especially in middle-aged and elderly individuals. The rate of warfarin therapy increased slightly over the study period but remains low.</P>

상호 호환성 있는 임플랜트 지대주와 고정체간의 적합도에 관한 연구

김미정(Mi Jeong Kim),손미경(Mi Kyoung Son),권혁신(Hyuk Sin Kwon),정재헌(Chae Heon Chung) 조선대학교 구강생물학연구소 1998 Oral Biology Research (Oral Biol Res) Vol.22 No.2

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Midazolam 및 Remifentanil의 사전 투여가 Propofol 마취유도 및 기관내 삽관 시 혈역학적 변화에 미치는 영향

손미경 ( Mi Kyoung Son ),이귀용 ( Guie Yong Lee ),김치효 ( Chi Hyo Kim ),정락경 ( Rack Kyung Chung ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.56 No.6

Background: The combined induction using two or more agents has a potential benefit that anesthesia could be induced with smaller anesthetic agents with fewer side effects. We studied the effects of co-administration with midazolam and remifentanil on the dose of propofol, the time to loss of consciousness (LOC) and hemodynamics during tracheal intubation. Methods: Sixty patients were randomly assigned to three groups. Group 1 was induced with target-controlled propofol alone. Group 2 received midazolam (0.05 mg/kg) and target-controlled propofol. Group 3 received midazolam (0.025 mg/kg), remifentanil (2 ng/ml) and target-controlled propofol. The time to LOC, the infused propofol dose and the effect site concentration at LOC were recorded. After LOC, rocuronium (0.6 mg/kg) was given and tracheal intubation was performed. The noninvasive blood pressure, heart rate (HR) and bispectral index were recorded. Results: The time and the dose of propofol to LOC were significantly reduced in group 2, 3 than in group 1 (P<0.05). Compared with pre-induction values, mean blood pressure at immediately after intubation was increased in group 1, 2 with no change in group 3. The HR immediately after intubation was significantly increased in all groups compared to the pre-induction values, but the rate of increase of HR in group 3 were significantly lower than those group 1, 2 (P<0.05). Conclusions: The co-administration with midazolam and remifentanil reduces the time to LOC and the dose of propofol. That also attenuates hemodynamics during tracheal intubation under target-controlled infusion of propofol. (Korean J Anesthesiol 2009: 56: 619~23)

Induction of thioredoxin is required for nodule development to reduce reactive oxygen species levels in soybean roots.

Lee, Mi-Young,Shin, Ki-Hye,Kim, Yun-Kyoung,Suh, Ji-Yeon,Gu, Young-Yun,Kim, Mi-Ran,Hur, Yoon-Sun,Son, Ora,Kim, Jin-Sun,Song, Eunsook,Lee, Myeong-Sok,Nam, Kyoung Hee,Hwang, Keum Hee,Sung, Mi-Kyung,Kim, American Society of Plant Physiologists 2005 PLANT PHYSIOLOGY - Vol.139 No.4

<P>Nodules are formed on legume roots as a result of signaling between symbiotic partners and in response to the activities of numerous genes. We cloned fragments of differentially expressed genes in spot-inoculated soybean (Glycine max) roots. Many of the induced clones were similar to known genes related to oxidative stress, such as thioredoxin and beta-carotene hydroxylase. The deduced amino acid sequences of full-length soybean cDNAs for thioredoxin and beta-carotene hydroxylase were similar to those in other species. In situ RNA hybridization revealed that the thioredoxin gene is expressed on the pericycle of 2-d-old nodules and in the infected cells of mature nodules, suggesting that thioredoxin is involved in nodule development. The thioredoxin promoter was found to contain a sequence resembling an antioxidant responsive element. When a thioredoxin mutant of yeast was transformed with the soybean thioredoxin gene it became hydrogen peroxide tolerant. These observations prompted us to measure reactive oxygen species levels. These were decreased by 3- to 5-fold in 7-d-old and 27-d-old nodules, coincident with increases in the expression of thioredoxin and beta-carotene hydroxylase genes. Hydrogen peroxide-producing regions identified with cerium chloride were found in uninoculated roots and 2-d-old nodules, but not in 7-d-old and 27-d-old nodules. RNA interference-mediated repression of the thioredoxin gene severely impaired nodule development. These data indicate that antioxidants such as thioredoxin are essential to lower reactive oxygen species levels during nodule development.</P>

임플랜트 지대주와 주조 금합금과의 접합 및 부식에 관한 연구

손미경(Mi Kyoung Son),마장선(Jang Seon Ma),정재헌(Chae Heon Chung) 조선대학교 구강생물학연구소 1999 Oral Biology Research (Oral Biol Res) Vol.23 No.1

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