항경련제 복용중인 간질 환자의 비타민 A, E, C 상태

허소영,김광수 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

Background and Objective: Free radicals can induce seizure activity by direct inactivation of glutamine synthase thereby permitting an abnormal build up of excitatory neurotransmitter glutamic acid. The biological effects of free radicals are controlled by a wide range of antioxidants such as vitamin A, E and C. The purpose of this study is to measure antioxidative vitamin A, E and C status in blood of epileptic patients, and to evaluate the relationship between plasma vitamin A, E, C levels and the severity of epileptic seizure and the use of anticonvulants. Method: Twenty-three epileptic patients and ten normal controls were recruited for this study. Epileptic patients were treated with antiepileptic drugs more over 1 year. Plasma vitamin A, E and C levels in blood were measured by using the high performance liquid chromatography (HPLC) method. Results: There was no significant decrease in the mean vitamin A, E and C levels in epileptic patients. When compared by seizure frequency and period of medication, there were no significant differences in the serum level of vitamin A, E and C. There was no significant relationship between the vitamin levels and the number of antiepileptic drugs. Conclusion: These results suggest that vitamin A, E and C status may be not associated with the severity of epileptic seizure and the use of anticonvulsants.

화농성 중이염에 의한 경막하 고름집 1예

허소영,이지현,박지영 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

Subdural empyema represents infection within the potential space that lies between the dura and arachnoid. Subdural empyema is a life-threatening and uncommon sequelae of suppurative otitis media. Treatment was invariably surgical with antibiotics. We present the case of a patient with a serious intracranial pyogenic infection due to otitis media, who was successfully treated only with antibiotics. The case shows a complication of subdural empyema, which reveals an importance of early diagnosis and suitable management.

외식산업체에서의 식음료 비용 절감을 위한 통제 방안

허경숙,이복희,이소영 중앙대학교 생활과학연구소 2000 생활과학논집 Vol.13 No.-

Recently, foodservice industry has been expanded rapidly and became the one of tile most profitable organizations in modern society due to the income level and people's perceptions on the quality of life have been changed. Control is the one of the basic management functions along with planning, organizing, directing, and coordinating. These basic functions interact to achieve the beverage costs. The food and beverage cost consists of 2/3 of the operating costs in the restaurants. In many cases, cost control is lacking in the food service industry since most food service operations are relatively small and management skill is relatively unsophiscated. Difficulties in cost control has risen that nature of food hurts control: easily spoiled, limited shelf life, leftovers, hampered food quality without proper storing and preparation, easy to thieve etc. The food cost has risen improper handling of employees by management. To control food and beverage cost, it is better to use the pre-operation and post-operation controls. It complements each other. Food cost control covers from the menu planning until the food is served and money is received from the patrons. A manager can control food costs by closely supervising food production, portion control sizes and serving procedures. Beverage control is believed to be easier than the food-cost control, but it has special problems: tempt to thieve since it is expensive and valuable, and easily transportable. Beverage control is potentially pofitable and thus should be controlled through careful practices in conjunction with various beverage accounting systems including the computerized and automatic-dispensing systems. These systems may lower costs because they reduce spillage and virtually eliminate overpouring. Sven though the practical applications to control the food and beverage cost can achieve the cost reduction. Still it is not the only panacea. It is important to remember that strict controls can be self-defeating because their rigidness can alienate the workers. Therefore, managers should concerned with individuals doing the work rather than supervision and quantified measurement. Also they should stress that if workers feel positively toward an organization they will do their best and need little control.

크론병 환자에게서 발생한 뇌정맥굴혈전증

허소영,김종국,박선자 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

Cerebral venous sinus thrombosis is an uncommon condition with dramatic clinical presentation of progressive headache, papilledema, seizures, focal neurological deficits and coma. It has many etiologies including infections, hypercoagulability, inflammatory disorders, head trauma and cancer. Although it is relatively uncommon, vascular complications are well documented extra-intestinal manifestations of inflammatory bowel disease. Among them, Crohn disease is an extremely rare cause of cerebral vascular disease. We present a case of cerebral venous sinus thrombosis in Crohn disease successfully treated by high dose steroid therapy.

마이크로그로브 형태에 따른 평활근 세포 운동 측정

유소영,박찬영,정석,김동익,이병붕,허세호,한동철,장준근 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.2

Purpose: The spreading, orientation, and chemotaxis the gradient of a chemoattractant of smooth muscle cells (SMCs) were studied on the micro-grooved substrata by the light, fluorescence and scanning electron microscopy. Method: Vertical-walled grooves were produced in silicon wafers by the micromachining technique. All grooves were 4~20㎛ deep and 10~80㎛ wide, SMCs were cultured on each microgroove and examined under stereo-microscope. Result: Cell clusters were markedly oriented by all the grooved substrata examined. Tim-lapse images acquired from CCD (Charge Coupled Device) showed that the grooves directed the migration of SMCs. There was no prominent difference in the migration speed of SMCs according to the grooves. All the cytoskeletal fibers were reoragnized in the same direction with grooves. Especially the alignments of microtubule and intermediate filaments were distinguished in the SMCs on the micro grooves. Conclusion: These results could be applied to the analysis of vascular restenosis and the development of artificial blood vessels.

광고를 통한 상표 이미지 인지에 관한 연구 : 여성 내의 상표를 중심으로 In Terms of Female's Underwear Brand

유태순,허소영 대구효성카돌릭대학교사회과학연구소 1998 사회과학연구 Vol.5 No.-

The female consumer whose ages are between 20 and 29 is segmented according to benefit, similarity table is composed of the brand image in consumer perceptual dimension and the advertising image of that brand, and the purpose of this study is to make positive brand image, to require efficient advertising expression approaching brand perception, brand preference, brand loyalty. This study is a purpose like this ; First The female consumer whose ages are between 20 and 29 is segmented according to benefit. Second, Similarity table is composed of underwear brand image and advertising image by the perception of consumers. Third, Segmentation group is composed, analyzed according to composing of brand image and avdertising image, it is to require avdertising expression. The subject of this study wear gathered into 202 female in 20’s As measurement - implement, questionaire written by investigator wear designed for literature and precedence study. The analysis of data used fator analysis, principal component analysis, cluster analysis, ANOVA, T-test, F-test by using SAS. The result are as follows ; 1. Benefit sought by consumer wear found to included three different factor - brand value, fashionability and practicality on underwear. As a result of subdividing the consumers, three distinctive groups wear found on the basis of benefit factor - fashion oriented group, brand value oriented group, practicality oriented group. 2 Similarity table of brand image and advertising image by the perception of consumers was shown the distinction as each segmented group.

호모시스테인에 의한 흰쥐의 발작 및 행동변화

김광수,허소용 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.1

Background: Homocysteine is epileptogenic and can induce seizures in immature and adult animals. Homocysteine and its derivatives are structurally similar to glutamate and express a direct excitatory effect on N-methyl-D-aspartate (NMDA) receptors. The aim of this study is to characterize the convulsant effect of homocysteine after intraperitoneal administration of homocysteine in rats. Methods: Twenty-four Sprague-Dawley male rats weighing 120-145 g were treated with single intraperitoneal injection of D,L-homocysteine (11 mmol kg). The animals were observed for 90 min after injection. The incidence, latencies, pattern of motor seizures, and behavioral phenomena were noted. Seizure severity was determined by a rating scale with grades defined as: 1-head nodding, lower jaw twitching; 2-myoclonic body jerks, bilateral forelimb clonus with full rearing; 3-progression to generalized clonic convulsion followed by tonic extension of fore- and hind limbs and tail; 4-prolonged tonic-clonic convulsion lasting over 10 seconds. Results: All rats sat motionless for some minutes after the injection of homocysteine, and then washing, sniffing, shuffling, and chewing appeared. The seizure episodes of grade 1 were appeared in 91.7%, grade 2 in 87.5%, grade 3 in 37.5%, and grade 4 in 8.3%. The latencies of grade 1, 2, and 3 seizure episodes were 15.3 ± 9.6 min, 30.9 ± 13.3 min, and 58.9 ± 14.8 min respectively. The seizure episodes of grade 4 were appeared 28 min and 64 min after homocysteine injection in 2 rats. Conclusion: These results show that homocysteine administration elicits seizures and behavioral responses, and suggests a possible animal model for studying epilepsy.

방광 크롬친화세포종과 동반된 배뇨후 벼락두통

하윤석,강성진,허소영,이지현,김민정,김종국,김광수 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

Thunderclap headache is a hyperacute, severe headache that is so named because the pain strikes suddenly and severely, and is sometimes a sign of a medical emergency. We report a case of pheochromocytoma in the urinary bladder in a 48-year-old woman who presented with recurrent thunderclap headache after voiding and exercise. So we think thunderclap headache during or immediately after micturition may be an important diagnostic clue of bladder pheochromocytoma.

실신으로 발현된 기립성빈맥증후군 : 단일 기관 예비 연구

이동준,김종국,허소영 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background and Objectives : Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive tachycardia without prominent hypotension in the upright position. Most of the patients experience symptoms of orthostatic intolerance such as lightheadedness, dizziness, palpitation, nausea, or headache. There were limited POTS cases presenting as syncope thus, we analyzed syncope patients who showed orthostatic tachycardia in tilt table test. Methods : A single center retrospective analysis was done for patients with POTS who developed syncope. We reviewed their clinical records and results of autonomic function tests (sympathetic skin response, heart rate variability test to hyperventilation, heart rate variability test to Valsalva maneuver, 15:30 ratio and blood pressure and heart rate response to tilt table test). Results : There were 13 patients of POTS with syncope. Mean age of onset was 22.3 (14-38) years old. Men were eight and women were five. In autonomic function tests, mean orthostatic heart rate increments were 35.2 beats per minutes (bpm). Mean maximal heart rate within 10 minutes and the time for maximal heart rate were 99.9 (87-128) bpm and 7 minutes, respectively. Mean systolic blood pressure was not changed significantly during tilt table tests but, mean diastolic blood pressure was increased as much as 14.4 (±8.0) mmHg compared with supine position. Conclusions : POTS patients who manifested assyncopal attack showed similar patterns in clinical characteristics and autonomic function tests compared with ordinary POTS reported previously. These suggest that syncope can be one of the leading features of POTS. This preliminary study suggests that structured and controlled studies about POTS and syncope are needed.

The usefulness of brain MRI at onset in the differentiation of multiple sclerosis and seropositive neuromyelitis optica spectrum disorders

Huh, So-Young,Min, Ju-Hong,Kim, Woojun,Kim, Su-Hyun,Kim, Ho Jin,Kim, Byung-Jo,Kim, Byoung Joon,Lee, Kwang Ho SAGE Publications 2014 Multiple sclerosis journal: clinical and laborator Vol.20 No.6

<P><B>Background:</B></P><P>Although neuromyelitis optica (NMO) is a central nervous system (CNS) autoimmune disease distinct from multiple sclerosis (MS). NMO and NMO spectrum disorder (NMOSD) sometimes show asymptomatic lesions on brain magnetic resonance imaging (MRI) at onset, and even present with symptomatic brain involvement.</P><P><B>Objectives:</B></P><P>We investigated whether brain MRI at onset can be helpful for the differentiation of MS and NMOSD.</P><P><B>Methods:</B></P><P>We retrospectively analyzed initial brain MRIs, performed within three months of onset, in patients with MS (<I>n</I> = 51) and anti-aquaporin4-antibody-positive patients with NMOSD (<I>n</I> = 67).</P><P><B>Results:</B></P><P>NMOSD patients met the Paty (37%) and Barkhof (13%) criteria, and the criteria of the European Magnetic Imaging in MS (MAGNIMS) study group (9%), for MS. Ovoid lesions perpendicular to the lateral ventricle, isolated juxtacortical lesions in U-fibers and isolated ovoid/round cortical lesions were found only in MS patients, whereas longitudinal corticospinal tract lesions, extensive hemispheric lesions, periependymal lesions surrounding the lateral ventricle and cervicomedullary lesions were found only in NMOSD patients.</P><P><B>Conclusions:</B></P><P>Our study suggests that it is difficult to differentiate MS from NMOSD by the fulfillment of the MRI criteria for MS on brain MRI at onset; however, the characteristic morphology of brain lesions is highly useful for the early differentiation of the two disorders.</P>