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김천숙,박은정,강규식,김지은,안기량,권진형,유시현,주영철,권순정 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1
Background: The OR(operating room) should provide an optimum environment that is safe for the patient and the working personnel. The air ventilation system of OR has been studied to decrease the contamination of air. We investigated the flow and contamination of the air in OR at our hospital. Method: Cultures in OR were made and the number of bacteria and fungi were calculated. A two-dimensional model for the cross-section of an operation room is developed for the CFD (computational fluid dynamics) analysis. The characteristics of air flow in the empty operation room and in the occupied operation room are calculated by using a CFD program. Results: The current air ventilation system of our hospital does not deliver the clean air to the operating site efficiently in occupied OR. Conclusions: We suggested a new location of air ventilation system which improves air venting with little increase of the cost of equipment.
요하지통 환자에서 두 개의 캐눌라를 이용한 박동성 고주파 신경근 응고술의 임상 연구
김천숙,배재영,배덕구,강규식,안기량,권진형,김지은,유시현 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1
Dorsal root ganglion(DRG) block by the local anesthetics and steroids which has done classically in low back pain(LBP) patients with radiculopathy has high incidence of recurrence rate and side effects of steroids. Recently a new technique of pulsed radiofrequency thermocoagulation(P-RFTC) was introduced and substituted for it because of the benefits such as relatively low recurrence rate, low risk of nerve injury and comfort during the procedure. We experienced 15 patients who had LBP with radiculopathy and no or little response to epidural steroid injection. When we performed DR ganglionotomy by P- RFTC under the C-arm guide in these patients, we tried to approach the exact DR ganglion using tow cannulas - the one for obtaining patient's subjective symptoms and injection of contrast dye, the other for making a RF lesioning after identifying the impedance of sensory and motor stimulation. In conclusion, DR ganglionotomy by P- RFTC using two cannulas in LBP patients is an easy and safe procedure with satisfactory results.
Kim, Hyun-Min,Kim, Hyun-Min,Lee, Min-Jung,Cho, Min-Gi,Kang, Deok,Kim, Yu-Kyung,Kim, Changmin,Kang, Do-Hyun,Jeong, Si-Hwa,Ahn, Ik-Gyun,Hwang, Jun-Hyeok,Kim, Jae-Hyun,Lee, Hyun-Jin,Jang, Jun-Yeong,Park, Cellmed Orthocellular Medicine and Pharmaceutical 2018 셀메드 (CellMed) Vol.8 No.1
Pharmacopuncture, or herbal acupuncture, is a new form of therapy derived from combinations of two traditional therapeutic methods, herbal medicine and acupuncture therapy. To compare the efficacy between loratadine-pharmacopuncture (LP) and loratadine-oral administration (LO), the effect of loratadine was investigated in murine models. Anti-anaphylactic effects of loratadine treatments were investigated in compound 48/80-induced systemic anaphylactic reaction and passive cutaneous anaphylaxis (PCA). LP treatment significantly inhibited the compound 48/80-induced systemic anaphylactic reaction and PCA. The effect between LP and LO were on a similar level. These results indicate that LP can be used as an alternative method for LO in case of emergency.
참모자반 (Sargassum fulvellum) 물 추출물의 염증 억제 활성
정다현(Da-Hyun Jeong),김꽃봉우리(Koth-Bong-Woo-Ri Kim),강보경(Bo-Kyeong Kang),정슬아(Seul-A Jung),김현지(Hyun-Jee Kim),정희예(Hee-Ye Jeong),박시우(Si-Woo Bark),안동현(Dong-Hyun Ahn) 한국생물공학회 2012 KSBB Journal Vol.27 No.6
The anti-inflammatory effects of Sargassum fulvellum water extracts (SFWE) were investigated using lipopolysaccharide (LPS)-induced inflammatory response in this study. To examine the potential anti-inflammatory properties of SFWE, the NO, TNF-α, IL-6, IL-1β, and cell proliferation were measured. It was confirmed that the NO and TNF-α secretion were significantly suppressed when SFWE was added to LPS-stimulated RAW 264.7 cells. Moreover, the expression of IL-6 and IL-1β cytokines was suppressed by SFWE in a dose-dependent manner. Especially, IL-6 inhibition activities were over 50% at 1% of SFWE. The cytotoxicity of SFWE and the proliferation of macrophages was measured by MTT assay. As a result, there was no cytotoxicity in the macrophage proliferation treated with SFWE compared to the control. In conclusion, these results suggested that the SFWE may have significant effects on inflammatory factors and can be a potential anti-inflammatory therapeutic materials.
LPS로 유도된 RAW 264.7 세포와 마우스 귀조직에 대한 참모자반 (Sargassum fulvellum) 에탄올 추출물의 항염증 효과
정다현(Da-Hyun Jeong),김꽃봉우리(Koth-Bong-Woo-Ri Kim),김민지(Min-Ji Kim),강보경(Bo-Kyeong Kang),박시우(Si-Woo Bark),박원민(Won-Min Pak),김보람(Bo-Ram Kim),안나경(Na-Kyung Ahn),최연욱(Yeon-Uk Choi),안동현(Dong-Hyun Ahn) 한국식품영양과학회 2014 한국식품영양과학회지 Vol.43 No.8
본 연구에서는 천연식물자원인 참모자반 에탄올 추출물 (SFEE)의 항염증 활성을 알아보기 위하여 in vitro 및 in vivo 실험을 진행하였다. 먼저 SFEE의 세포독성을 살펴보기 위하여 RAW 264.7 대식세포를 이용하여 세포 생존율을 살펴본 결과, SFEE 100 μg/mL의 농도까지 전혀 독성을 나타내지 않았다. 또한 항염증 효과를 알아보기 위하여 in vitro type으로 LPS로 염증을 유도한 RAW 264.7 세포에 대하여 NO, IL-6, TNF-α 및 IL-1β 분비량과 iNOS, COX-2 및 NF-κB와 같은 염증성 단백질의 발현량을 측정하였다. 대식세포 배양액의 NO₂- 농도를 측정한 결과 SFEE 첨가 농도에 따라 유의적으로 분비량이 감소하는 것을 확인하였으며, 100 μg/mL의 농도에서 90% 이상 억제됨을 확인하였다. 또한 100 μg/mL의 농도로 첨가 시 염증성 사이토카인인 IL-6, TNF-α 및 IL-1β 분비량을 각각 79, 73, 87%억제함을 확인하였으며, NO 생성과 연관이 있는 iNOS 단백질과 COX-2 및 NF-κB 단백질의 발현이 현저히 억제됨을 확인하였다. 이러한 SFEE의 항염증 효과를 동물모델에서 확인하기 위해 in vivo 실험을 진행한 결과 croton oil로 유도한 마우스 귀 부종을 유의적으로 억제함을 확인하였고, 조직검사 결과 염증 반응에 의한 경피 및 진피 두께의 발달을 현저히 억제시키고 염증성 세포인 비만세포의 조직으로의 침윤을 억제하여 항염증 효과를 가짐을 입증하였다. 결론적으로 참모자반 에탄올 추출물은 염증 반응의 전사인자인 NF-κB의 발현을 억제하여 iNOS와 COX-2의 발현을 억제시키고 그에 의해 NO, IL-6, TNF-α 및 IL-1β 분비를 억제하여 항염증 활성을 가지는 것을 확인하였으며, 따라서 참모자반 에탄올 추출물이 염증성 질환의 예방 및 개선에 유용할 것으로 사료된다. This study investigated the anti-inflammatory effects of Sargassum fulvellum ethanol extract (SFEE) on the lipopolysaccharide (LPS)-induced inflammatory response. SFEE remarkably suppressed production of NO and pro-inflammatory cytokines (IL-6, TNF-α, and IL-1β) at 50 and 100 μg/mL. There were no cytotoxic effects on proliferation of macrophages treated with SFEE compared to the control. SFEE reduced expression of iNOS and COX-2 proteins in a dose-dependent manner. The formation of edema in mouse ears was reduced at the highest dose tested compared to the control. Moreover, in the acute toxicity test, no mortality occurred in mice administered 5,000 mg/kg body weight of SFEE over the 2-week observation period. These results suggest that SFEE may have significant effects on inflammatory factors and be a potential anti-inflammatory therapeutic material.