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류승렬(Seung Rel Ryu),김혜진(Hye Jin Kim),홍진태(Jin Tae Hong),이종권(Jong Kwon Lee),이선희(Sun Hee Lee),이병무(Byung Mu Lee),김부영(Pu Young Kim) 대한약학회 1999 약학회지 Vol.43 No.5
Abuse liability of ephedrine was investigated by measurement of locomotor activity and self-administration in Sprague-Dawley rats. Locomotor activity was determined in rats treated with 3, 10 and 30mg/kg ephedrine for 14 days. Self-administration by ephedrine (0.23, 1 and 2.3mg/kg) was examined in food-trained rats. We also examined effect of dopamine receptor antagonist (spiperone, 30mcg/kg) on the ephedrine-induced response of self-administration. Body weight was not statistically difference between control and ephedrine treatment group, but locomotor activity was dose-dependently increased. Self-administration for ephedrine was decreased in the early response (day 1 and 2) but the response was increased by higher dose of ephedrine. Self-administration was decreased by dopamine receptor antagonist (spiperone). These data showed that ephedrine increased locomotor activity and induced response of self-administration, and the effects of ephedrine were partially related to the dopaminergic system, which suggest that ephedrine may have abuse liability.
소염진통제 약물에 대한 In vitro 피부자극 시험연구
이종권,김대병,이은희,이선희,류승렬,최기환,김윤정,김부영,Lee, Jong-Kwon,Kim, Dai-Byung,Lee, Eun-Hee,Lee, Sun-Hee,Ryu, Seung-Rel,Choi, Ki-Hwan,Kim, Yoon-Jeong,Kim, Pu-Young 한국독성학회 1998 Toxicological Research Vol.14 No.3
In vitro skin iritation of anti-inflammatory drugs was investigated in terms of the cytotoxicity method to human skin fibroblast cells. Five anti-inflammatory drugs (Diclofenac, Naproxen, Meclofenamic acid, Ibuprofen and Fnoprofen) which are commercially available as oral preparations or injections were tested. The cytotoxicity of 5 chemicals was evaluated by using MTT[tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay. NRU (neutral red uptake) assay and Alamar Blue assay after fibroblast cells had been exposed to the chemicals for 24 hours or 489 hours. The $IC_{50}$ values of the chemicals showed the comparative strength of cytotoxicity as following order of Meclofenamic acid>Diclofenac>Fenoprofen>Ibuprofen>Naproxen. The values of $IC_{50}$ determined by Alamar Blue assay were lower than those of MTT and NRU assay. These data suggest Alamar Blue assay can be useful method for assessing in vitro skin irritation potential of anti-inflammatory drugs.
MK-801 투여에 의한 몰핀의존성랫드 뇌선조체중 도파민신경전달물질의 변화
이선희(Sun Hee Lee),신대섭(Dae Sup Shin),이덕주(Duck Joo Rhie),유영아(Young A Yoo),류승렬(Seung Rel Ryu),김대병(Dai Byung Kim),이종권(Jong Kwon Lee),김부영(Pu Young Kim) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.1
The roles of dopamine(DA) and N-methyl-D-aspartate(NMDA) system in the development and expression of morphine dependence were investigated by monitoring the concentrations of extracellular DA and its metabolites by in vivo microdialysis and simultaneous observation of behavioral changes in morphinedependent rats. Extracellular DA level in caudate putamen of morphine-dependent rat was decreased and the concentrations of its metabolites, dihydroxy phenylacetic acid(DOPAC) and homovanillic acid(HVA), were increased during naloxone-precipitated withdrawal. DA contents were recovered to normal levels by pretreatment of MK-801, a noncompetitive NMDA receptor antagonist, which may explain the mechanism of diminishing effect of MK-801 on withdrawal symptoms in morphine-dependent rats. MK-801(0.3 mg/kg, i.p.) induced the untoward harmful neurological signs such as ataxia and severe rotations, which may be produced by hyperactivation of dopaminergic system. These results suggest that MK-801 may inhibit the expression of morphine dependence by altering the dopamine release.
곤충세포유래 생명공학제품의 바이러스 제거 검증을 위한 모델바이러스로서의 일본뇌염 바이러스 정량
정혜성(Hye-Sung Jeong),박영남(Young-Nam Park),최정윤(Jung-Yun Choi),김영림(Young-Lim Kim),김병국(Byoung-Guk Kim),류승렬(Seung-Rel Ryu),신진호(Jin-Ho Shin),백선영(Sun-Young Baek),이석호(Seok-Ho Lee),박순희(Sue-Nie Park) 대한미생물학회 2002 Journal of Bacteriology and Virology Vol.32 No.2
낮은 복제수 플라스미드를 활용한 일본뇌염바이러스 SA14-14-2주의 Full-Length cDNA 클론의 제작및 안정적 유지
민경일(Kyung-Il Min),김영민(Young-Min Kim),추미성(Mi-Sung Choo),백선영(Sun-Young Baek),김재옥(Jae-Ok Kim),류승렬(Seung-Rel Ryu),민복순(Bok-Soon Min),김연희(Yeonhee Kim),박미경(Mi-Kyung Park),변우현(Woo-Hyeon Byeon),허숙진(Sook-Jin Hu 대한미생물학회 2004 Journal of Bacteriology and Virology Vol.34 No.4
재조합 사람 파필로마바이러스 16형 L1 바이러스 유사입자 제조과정 중의 JEV와 BVDV의 제거 검증
최정윤(Jung-Yun Choi),정혜성(Hye-Sung Jeong),김영림(Young-Lim Kim),손화경(Hwa-Kyung Son),김병국(Byoung-Guk Kim),류승렬(Seung-Rel Ryu),신진호(Jin-Ho Shin),백선영(Sun-Young Baek),민홍기(Hong-Ki Min),박순희(Sue-Nie Park) 대한미생물학회 2004 Journal of Bacteriology and Virology Vol.34 No.3