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Seon, C R,Hong, J H,Jang, J,Lee, S H,Choe, W,Lee, H H,Cheon, M S,Pak, S,Lee, H G,Biel, W,Barnsley, R American Institute of Physics 2014 Review of scientific instruments Vol.85 No.11
<P>To optimize the design of ITER vacuum ultraviolet (VUV) spectrometer, a prototype VUV spectrometer was developed. The sensitivity calibration curve of the spectrometer was calculated from the mirror reflectivity, the grating efficiency, and the detector efficiency. The calibration curve was consistent with the calibration points derived in the experiment using the calibrated hollow cathode lamp. For the application of the prototype ITER VUV spectrometer, the prototype spectrometer was installed at KSTAR, and various impurity emission lines could be measured. By analyzing about 100 shots, strong positive correlation between the O VI and the C IV emission intensities could be found.</P>
Lee, Jong Lyul,Roh, Seon Ae,Kim, Chan Wook,Kwon, Yi Hong,Ha, Ye Jin,Kim, Seon-Kyu,Kim, Seon-Young,Cho, Dong-Hyung,Kim, Yong Sung,Kim, Jin Cheon Baishideng Publishing Group Inc 2019 WORLD JOURNAL OF GASTROENTEROLOGY Vol.25 No.11
<P><B>BACKGROUND</B></P><P>Genomic profiling of tumors has contributed to the understanding of colorectal cancer (CRC), facilitating diagnosis, prognosis and selection of treatments, including targeted regimens. A report suggested that a 19-gene-based risk classifier (TCA19) was a prognostic tool for patients with stage III CRC. The survival outcomes in patients with stage IV CRC are still poor and appropriate selection of targeted therapies and immunotherapies is challenging.</P><P><B>AIM</B></P><P>To assess clinical implication of TCA19 in patients with stage IV CRC, and to identify TCA19 with involvement in immune-oncology.</P><P><B>METHODS</B></P><P>A retrospective review of the medical records of 60 patients with stage IV CRC was conducted, assessing clinicopathological variables and progression-free survival (PFS). TCA19 gene expression was determined by quantitative polymerase chain reaction (qPCR) in matched normal and tumor tissues taken from the study cohort. Expression of potential immune-oncology regulatory proteins and targets was examined by immunohistochemistry (IHC), western blot, immunofluorescence staining in tissues from a validation cohort of 10 patients, and in CRC cell lines co-cultured with monocyte <I>in vitro</I>.</P><P><B>RESULTS</B></P><P>In the patients with TCA19 score higher than the median, the PFS rates of eight patients who received the targeted regimens were significantly higher than the PFS rates of four patients who received 5-fluorouracil-based regimen (<I>P</I> = 0.041). In multivariate analysis, expression of signaling lymphocytic activation molecule family, member 7 (SLAMF7) and triggering receptor expressed on myeloid cells 1 (TREM1) was associated with PFS in the 60-patient cohort. After checking another 10 validate set, the expression of the IHC, the level of real-time qPCR, and the level of western blot were lower for SLAMF7 and higher for TREM7 in primary and metastatic tumors than in normal tissues. In CRC cells expressing SLAMF7 that were co-cultured with a monocytic cell line, levels of CD 68 and CD 73 were significantly lower at day 5 of co-culture than at day 0.</P><P><B>CONCLUSION</B></P><P>The TCA19 score might be prognostic for target-regimen-specific PFS in stage IV CRC. Down-regulation of SLAMF7 and up-regulation of TREM1 occur in primary and metastatic tumor tissues.</P>
Seon-Kyu Kim,Seon-Young Kim,Chan Wook Kim,Seon Ae Roh,하예진,Jong Lyul Lee,Haejeong Heo,Dong-Hyung Cho,이주석,Yong Sung Kim,Jin Cheon Kim 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Approximately half of colorectal cancer (CRC) patients experience disease recurrence and metastasis, and theseindividuals frequently fail to respond to treatment due to their clinical and biological diversity. Here, we aimed toidentify a prognostic signature consisting of a small gene group for precisely predicting CRC heterogeneity. Weperformed transcriptomic profiling using RNA-seq data generated from the primary tissue samples of 130 CRCpatients. A prognostic index (PI) based on recurrence-associated genes was developed and validated in two largerindependent CRC patient cohorts (n = 795). The association between the PI and prognosis of CRC patients wasevaluated using Kaplan–Meier plots, log-rank tests, a Cox regression analysis and a RT-PCR analysis. Transcriptomicprofiling in 130 CRC patients identified two distinct subtypes associated with systemic recurrence. Pathwayenrichment and RT-PCR analyses revealed an eleven gene signature incorporated into the PI system, which was asignificant prognostic indicator of CRC. Multivariate and subset analyses showed that PI was an independent risk factor(HR = 1.812, 95% CI = 1.342–2.448, P < 0.001) with predictive value to identify low-risk stage II patients who respondedthe worst to adjuvant chemotherapy. Finally, a comparative analysis with previously reported Consensus MolecularSubgroup (CMS), high-risk patients classified by the PI revealed a distinct molecular property similar to CMS4,associated with a poor prognosis. This novel PI predictor based on an eleven gene signature likely represents asurrogate diagnostic tool for identifying high-risk CRC patients and for predicting the worst responding patients foradjuvant chemotherapy.
이선영 ( Seon-young Lee ),박대천 ( Dae-cheon Park ),강대식 ( Dae Sik Kang ),이충호 ( Choong Ho Lee ) 한국농업기계학회 2020 한국농업기계학회 학술발표논문집 Vol.25 No.2
땅속 작물 수거기가 지면 위의 작물을 수거하기 위해서는 수거가 이루어지는 속도와 기계의 주행속도가 적절한 조화를 이루어야 한다. 수거기의 주행 변속은 전진 2단(0.20m/s, 0.61m/s), 후진 1단으로 설계되었으며 동력전달은 기어체인과 벨트풀리를 사용한다. 그림과 같이 수거기의 동력전달장치는 6개의 유니트로 구성되어 있으며 각 축을 연결하여 수거회전 부분과 컨베이어 부분으로 동력이 전달된다. 본 연구는 구간별 동력에 대해 설계를 진행하였다. 수식을 통해 구간별 평균속도와 최대, 최소속도를 정의하고 속도 변동률을 도출하였다. 전달힘에 따라 동력을 산출하고 수식으로 정리한 전달 동력은 2.3kw로 기계적 손실을 고려하여 2.5kw 이상의 동력을 사용하는 것이 좋을 것으로 판단된다. 도출된 결과값은 땅속 작물 수거기의 제작에 적용하였다. 결과를 토대로 하중에 따른 속도 분석을 수행하여 부하되는 하중에 대한 최적화 설계가 가능할 것으로 사료된다.
이순천(Lee Soon-Cheon),이선장(Lee Seon-Jang),이해건(Lee Hae-Gun) 한국체육과학회 2002 한국체육과학회지 Vol.11 No.1
The purpose of this study who to analyze a play-skill factor of six teams in the basic of the play record of '2000 Women's Professional Basketball Summer League. The need of this study is to offer some skill factors for improving the tactics of Women's Korea Professional Basketball team in korea and show more useful training method for teaching Basketball through comparing and analyzing the records of the wining games and losing games. Twelve skill factors expected to have an effect to the game who analyzed. First, it shows by significant inspection between wining games and losing games that there are significant differences in two point shoot rate, assist, first break and still Second, the most important skill factors that contributed to the total score of the wining games in '2000 Women's Professional Basketball Summer League is three point shoot rate. And two point shoot rate, free throw rate, first break, still, and defense rebound fellow it.
Stimulation of the Extracellular Matrix Production in Dermal Fibroblasts by Velvet Antler Extract
( Seok Seon Roh ),( Min Ho Lee ),( Yul Lye Hwang ),( Hyun Hee Song ),( Mu Hyun Jin ),( Sun Gyoo Park ),( Cheon Koo Lee ),( Chang Deok Kim ),( Tae Jin Yoon ),( Jeung Hoon Lee ) 대한피부과학회 2010 Annals of Dermatology Vol.22 No.2
Background: Fibroblasts produce many components of the extracellular matrix (ECM) and so they contribute to the maintenance of connective tissue integrity. Objective: The aim of this study is to evaluate the effect of velvet antler extract (VAE) on the ECM production of dermal fibroblasts cultured in vitro. Methods: Primary cultured human dermal fibroblasts were treated with VAE, and then the ECM production was determined by RT-PCR, ELISA and Western blot analysis. Furthermore, the change of gene expression according to VAE treatment was evaluated by cDNA microarray. Results: VAE accelerated the growth of fibroblasts in a dose-dependent manner. VAE increased the production of several ECM components, including type 1 collagen, fibronectin and elastin. In line with these results, the phosphorylations of p42/44 ERK and p38 mitogen-activated protein kinase were markedly increased by VAE, suggesting that the enhancement of ECM production may be linked to the activation of intracellular signaling cascades. VAE also significantly increased cell migration on an in vitro scratch wound test. In cDNA microarray, many genes related with connective tissue integrity were identified to be up-regulated by VAE. Conclusion: These results suggest that VAE has a potential to stimulate ECM production, and VAE may be applicable for maintaining the skin`s texture. (Ann Dermatol 22(2) 173~179, 2010)