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Characteristic alterations of gut microbiota in uncontrolled gout
ul-Haq Asad,Lee Kyung-Ann,Seo Hoonhee,Kim Sukyung,Jo Sujin,고경민,Moon Su-Jin,Kim Yun Sung,Choi Jung Ran,Song Ho-Yeon,Kim Hyun-Sook 한국미생물학회 2022 The journal of microbiology Vol.60 No.12
Microbiome research has been on the rise recently for a more in-depth understanding of gout. Meanwhile, there is a need to understand the gut microbiome related to uric acid-lowering drug resistance. In this study, 16S rRNA gene-based microbiota analysis was performed for a total of 65 stool samples from 17 healthy controls and 48 febuxostat-treated gout patients (including 28 controlled subjects with decreased uric acid levels and 20 uncontrolled subjects with non-reduced uric acid levels). Alpha diversity of bacterial community decreased in the healthy control, controlled, and uncontrolled groups. In the case of beta diversity, the bacterial community was significantly different among groups (healthy control, controlled, and uncontrolled groups). Taxonomic biomarker analysis revealed the increased population of g-Bifidobacterium in healthy controls and g-Prevotella in uncontrolled patients. PCR further confirmed this result at the species level. Additionally, functional metagenomics predictions led to the exploration of various functional biomarkers, including purine metabolism. The results of this study can serve as a basis for developing potential new strategies for diagnosing and treating gout from microbiome prospects.
Assembly of polymer micelles through the sol-gel transition for effective cancer therapy
Khaliq, Nisar Ul,Oh, Keun Sang,Sandra, Febrina Carolina,Joo, Yeonhee,Lee, Juhyung,Byun, Youngro,Kim, In-San,Kwon, Ick Chan,Seo, Jae Hong,Kim, Sang Yoon,Yuk, Soon Hong Elsevier 2017 Journal of controlled release Vol.255 No.-
<P><B>Abstract</B></P> <P>Photo-induced apoptosis-targeted chemotherapy (PIATC) was designed and characterized to propose a new protocol for improved chemotherapy. Intratumoral injection was selected as the mode of administration of the anticancer drug, doxorubicin (DOX). To extend the retention time of DOX at the tumor parenchyma, <I>in-situ</I> gel formation was induced through the sol-gel transition of the Pluronic NPs containing a prodrug of DOX or a photosensitizer. The prodrug (DEVD-S-DOX) was designed to be inactive with a peptide moiety (Aspartic acid-Glutamic acid-Valine-Aspartic acid: DEVD) linked to DOX and to be cleaved into free DOX by caspase-3 expressed with apoptosis. For reactive oxygen species (ROS)-mediated apoptosis, photo-irradiation with methylene blue (MB, photosensitizer) was utilized. The sol-gel transition of the Pluronic NPs containing reactive species, DEVD-S-DOX or MB, was examined by measuring the cloud point and the gel strength in response to temperature change. ROS-mediated apoptosis was observed by measuring the ROS and membrane integrity with induced apoptosis. The <I>in vivo</I> antitumor efficacy of PIATC was measured with a cardiotoxicity assay in tumor-bearing mice.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
Choi, Min Hee,Lee, In Kyung,Kim, Gyung Whan,Kim, Bang Ul,Han, Ying-Hao,Yu, Dae-Yeul,Park, Hye Sun,Kim, Kyung Yong,Lee, Jong Seo,Choi, Chulhee,Bae, Yun Soo,Lee, Byung In,Rhee, Sue Goo,Kang, Sang Won Nature Publishing Group 2005 Nature Vol.435 No.7040
Platelet-derived growth factor (PDGF) is a potent mitogenic and migratory factor that regulates the tyrosine phosphorylation of a variety of signalling proteins via intracellular production of H<SUB>2</SUB>O<SUB>2</SUB> (refs 1, 2–3). Mammalian 2-Cys peroxiredoxin type II (Prx II; gene symbol Prdx2) is a cellular peroxidase that eliminates endogenous H<SUB>2</SUB>O<SUB>2</SUB> produced in response to growth factors such as PDGF and epidermal growth factor; however, its involvement in growth factor signalling is largely unknown. Here we show that Prx II is a negative regulator of PDGF signalling. Prx II deficiency results in increased production of H<SUB>2</SUB>O<SUB>2</SUB>, enhanced activation of PDGF receptor (PDGFR) and phospholipase Cγ1, and subsequently increased cell proliferation and migration in response to PDGF. These responses are suppressed by expression of wild-type Prx II, but not an inactive mutant. Notably, Prx II is recruited to PDGFR upon PDGF stimulation, and suppresses protein tyrosine phosphatase inactivation. Prx II also leads to the suppression of PDGFR activation in primary culture and a murine restenosis model, including PDGF-dependent neointimal thickening of vascular smooth muscle cells. These results demonstrate a localized role for endogenous H<SUB>2</SUB>O<SUB>2</SUB> in PDGF signalling, and indicate a biological function of Prx II in cardiovascular disease.
Topical 0.03% Tacrolimus for Treatment of Pemphigus Erythematosus in a Korea Jindo Dog
BHANG, Dong-Ha,CHOI, Ul-Soo,JUNG, Yun-Chan,KIM, Min-Kyu,CHOI, Eun-Wha,SEO, Kyoung-Won,KANG, Min-Soo,HWANG, Cheol-Yong,KIM, Dae-Yong,YOUN, Hwa-Young,LEE, Chang-Woo Japanese Society of Veterinary Science 2008 The Journal of veterinary medical science Vol.70 No.4
<P>Topical 0.03% tacrolimus was used for treatment of a Korea Jindo dog diagnosed with pemphigus erythematosus. The dog was slowly improved following application of tacrolimus but did not achieve complete remission until end of this study. No adverse effects on clinical or laboratory parameters were noted during the topical tacrolimus therapy period.</P>
A Modified YoloV4 Network with Medium-Scale Challenging Benchmark for Efficient Animal Detection
Habib Khan,Bui Quang Huy,Zain Ul Abidin,Juhee Yoo,Minho Lee,Kyeong Wook Seo,Dong Yun Hwang,Mi Young Lee,Jae Kyu Suhr 한국차세대컴퓨팅학회 2023 한국차세대컴퓨팅학회 학술대회 Vol.2023 No.06
Animal detection and classification are crucial for effective wildlife management (WM) and reducing risks associated with animals related road accidents and attacks. Previous attempts trained the models using imbalanced data with fewer representative features and baseline models without improvement. This paper presents a new dataset of five animal classes captured in various poses, lighting conditions, and intraclass variations. The standard coupled detection head of the YoloV4 algorithm faces limitations when performing simultaneous classification and localization due to shared parameters and inputs. To address this issue, we propose a decoupled detection head (DDH) that handles these tasks separately, improving performance. We conducted extensive experiments using the proposed dataset. We found that the optimal backbone features marginally improve the performance of the modified network compared to state-of-the-art (SOTA) works in the subject domain. Our work contributes by addressing the limitations of the standard YoloV4 algorithm and proposing a new dataset for researchers to use in future studies.
Ju Eun-Jin,Kwak Dong-Hoon,Lee Dae-Hoon,Kim Sung-Min,Kim Ji-Su,Kim Sun-Mi,Choi Han-Gil,Jung Kyu-Yong,Lee Seo-ul,Do Su-Il,Park Young-Il,Choo Young-Kug The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.9
Apoptosis may occur in early embryos where the execution of essential developmental events has failed, and gangliosides, sialic acid-conjugated glycosphingolipids, are proposed to regulate cell differentiation and growth. To evaluate the regulatory roles of ganglioside GM3 in early embryonic development, this study examined its expressional patterns in apoptotic cells during early embryonic development in mice. Pre-implanted embryos were obtained by in vitro fertilization, which were treated at the 4-cell stage with three the apoptosis inducers, actinomycin D, camptothecin and cycloheximide, for 15 h. All three inducers significantly increased the percentage of apoptotic cells, as measured using a TUNEL method, but remarkably reduced the total cell numbers. The numbers of morula and blastocyst stages were significantly decreased by treatment of the embryos with the three apoptosis inducers compared with the control, with a similar result also observed in the number of blastomeres. Staining of early embryos with Hoechst 33342 revealed a significant percentage of apoptotic nuclei. Prominent immunofluorescence microscopy revealed a significant difference in the ganglioside GM3 expression in apoptotic embryos compared with the control, and RT-PCR also demonstrated a dramatic increase in ganglioside GM3 synthase mRNA in the apoptotic embryos. These results suggest that ganglioside GM3 may be pathophysiologically implicated in the regulation of early embryonic development through an apoptotic mechanism.