항정신병약물 클로자핀이 흰쥐 뇌실로 주입한 인슐린의 반응에 미치는 영향

김세현,유현숙,박소영,김민경,박홍근,김용식,Kim, Se Hyun,Yu, Hyun Sook,Park, So Young,Kim, Min Kyung,Park, Hong Geun,Kim, Yong Sik 대한생물정신의학회 2012 생물정신의학 Vol.19 No.4

Objectives Although antipsychotic drug clozapine has superior efficacy, this is hampered by metabolic side effects such as weight gain and diabetes. Recent studies demonstrate that clozapine induces insulin resistance. However, the identity and location of insulin resistance induced by clozapine has not been clarified. In this study, the effect of clozapine on central insulin response was investigated in rats. Methods Male Sprague-Dawley rats received intraperitoneal injection of clozapine or vehicle, which was followed by intracerebroventricular injection of insulin or its vehicle. The effects of clozapine on insulin-induced changes in blood glucose level and Akt phosphorylation in hypothalamus were investigated. Results Intraperitoneal injection of clozapine (20 mg/kg) increased blood glucose in rats. Intracerebroventricular injection of insulin reduced blood glucose in rats, which was blunted by pretreatment of clozapine. Accompanied with the antagonistic effect of clozapine to central insulin action in terms of blood glucose, clozapine inhibited the insulin-induced phosphorylation of Akt at Ser473 in rat hypothalamus. Conclusion Administration of clozapine inhibited the central insulin-induced changes in blood glucose and Akt phosphorylation in rat hypothalamus. These findings suggest that hypothalamus could be the site of action for the clozapine-induced insulin resistance.

우울장애의 신경생물학적 기전으로서 세포 내 신호전달계의 역할

김세현,Kim, Se-Hyun 대한생물정신의학회 2011 생물정신의학 Vol.18 No.4

Major depressive disorder is characterized by cellular and molecular alterations resulting in the depressive behavioral phenotypes. Preclinical and clinical studies have demonstrated the deficits, including cell atrophy and loss, in limbic and cortical regions of patients with depression, which is restored with antidepressants by reestablishing proper molecular changes. These findings have implicated the involvement of relevant intracellular signaling pathways in the pathogenetic and therapeutic mechanisms of depressive disorders. This review summarizes the current knowledge of the signal transduction mechanisms related to depressive disorders, including cyclic-AMP, mitogen-activated protein kinase, Akt, and protein translation initiation signaling cascades. Understanding molecular components of signaling pathways regulating neurobiology of depressive disorders may provide the novel targets for the development of more efficacious treatment modalities.

남산 금-은광산의 유체포유물 및 안정동위원소 연구

김세현,최상훈,Kim, Se-Hyun,Choi, Sang-Hoon 대한자원환경지질학회 1996 자원환경지질 Vol.29 No.2

Electrum-sulfide minerals of the Namsan Au-Ag mine were deposited in two stages of quartz and calcite veins that fill fault planes in Mesozoic granitic rocks (230~155 Ma). The K/Ar radiometric dating of hydrothermal sericite indicates that mineralization is early Cretaceous age ($127{\pm}3.0Ma$). Mineralogic, fluid inclusion and sulfur isotopic data show that ore minerals were deposited at temperatures between $340^{\circ}C$ and $200^{\circ}C$ from fluid with salinities of 3 to 6 equiv. wt % NaCl. Evidence of fluid boiling (and $CO_2$ effervescence) indicates a maximum pressures of 100 bars. The formation temperature and $fs_2$, of Au-mineralization from the Namsan mines are mainly $280{\sim}230^{\circ}C$ and $10^{-11}{\sim}10^{-13}$ atm, respectively. Au deposition was likely a result of boiling caused to chemical change (pH, $f_{O2}$, ${\Sigma}_{H_2S{\cdot}{\cdot}}$) of ore-fluids. Sulfur isotope composition of sulfide minerals (${\delta}^{34}S=5.1$ to 8.2‰) are consistent with ${\delta}^{34}S_{{\Sigma}{H2S}}$ value of +6 to +7‰, suggesting an igneous source of sulfur partially mixed with wall-rock sulfur.

화자적응과 군집화를 이용한 화자식별 시스템의 성능 및 속도 향상

김세현,오영환,Kim Se-Hyun,Oh Yung-Hwan 대한음성학회 2006 말소리 Vol.58 No.-

One key factor that hinders the widespread deployment of speaker identification technologies is the requirement of long enrollment utterances to guarantee low error rate during identification. To gain user acceptance of speaker identification technologies, adaptation algorithms that can enroll speakers with short utterances are highly essential. To this end, this paper applies MLLR speaker adaptation for speaker enrollment and compares its performance against other speaker modeling techniques: GMMs and HMM. Also, to speed up the computational procedure of identification, we apply speaker clustering method which uses principal component analysis (PCA) and weighted Euclidean distance as distance measurement. Experimental results show that MLLR adapted modeling method is most effective for short enrollment utterances and that the GMMs performs better when long utterances are available.

조현병 환자의 언어성 환청과 정신병리의 PANSS 요인들 간의다차원적 관계

신샘이,김세현,이남영,윤탁,김용식,정인원,Shin, Sam Yi,Kim, Se Hyun,Lee, Nam Young,Youn, Tak,Kim, Yong Sik,Chung, In Won 대한생물정신의학회 2015 생물정신의학 Vol.22 No.4

Objectives This study was aimed to examine the multidimensional relationship between auditory verbal hallucinations (AVHs) and Positive and Negative Syndrome Scale (PANSS) factors of psychopathology in the patients with schizophrenia. And we explored the differences between assessments to hallucination by the clinicians and patients. Methods 82 patients with schizophrenia who were assessed by the Hamilton Program for Schizophrenia Voices Questionnaire (HPSVQ), Psychotic Symptom Rating Scale-Auditory Hallucination (PSYRATS-AHS), and the PANSS were recruited. Hwang's five-factor model of PANSS, items and total scores of hallucination scales, Kim's and Haddock's factor models of hallucination were applied to examine the correlations between psychopathology and AVHs. AVH-positive patients was 50 in PANSS-HPSVQ group and 24 in PANSS-PSYRATS-AHS. These two groups were separately analyzed. Results Among the five factors of the PANSS, negative and depression/anxiety factors were correlated with the total scores of HPSVQ and PSYRATS-AHS, and positive and autistic preoccupation factors were correlated only with the total score of PSYRATS-AHS. The activation factor was correlated with none of the total scores of HPSVQ/PSYRATS-AHS. These correlation patterns of a total score of HPSVQ/PSYRATS-AHS were same in the emotional factor of HPSVQ and physical factor of PSYRATS-AHS respectively. In the items which showed significant correlations, correlation coefficients of PANSS-PSYRATS-AHS group ranged between 0.406-0.755 and those of PANSS-HPSVQ ranged between 0.283-0.420. Conclusions This study suggested that the psychopathological domains of schizophrenia were differentially correlated with AVHs and the assessment of AVHs by clinicians and patients showed substantial differences which should be integrated into the therapeutic interventions.

Preparation of Organic-Inorganic Hybrid Nanoparticles Using Alkoxysilane-functionalized Amphiphilic Polymer Precursors and Their Coating Application

Se Hyun Kim(김세현) 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1

Organic-inorganic (O-I) hybrid nanoparticles could be prepared using an alkoxysilane-functionalized amphiphilic polymer (AFAP) precursor consisting of reactive alkoxysilane groups and amphiphilic polymer backbone. O-I hybrid sols having long-term storage stability with 40–50% solid content could be coated onto glass and polyethylene terephthalate (PET) substrates, and they formed transparent O-I hybrid coating films via a thermal curing process. The formation of O-I hybrid nanoparticles of size 10–15 nm dispersed in cured coating films could be confirmed using scanning electron microscopy. The hardness of the cured coating varied with the type of AFAP used in its preparation, which was monitored using pencil hardness and nanoindentation measurements.

TV 뉴스의 주요뉴스에 따른 여성앵커의 비언어적 커뮤니케이션에 관한 연구 - KBS, SBS, MBC를 중심으로 -

김세현 ( Kim Se-hyun ),김미현 ( Kim Mi-hyun ) 커뮤니케이션디자인학회(구 시각디자인학회) 2019 커뮤니케이션 디자인학연구 Vol.66 No.-

본 연구에서는 TV 뉴스의 전달 효과를 높이기 위하여 여성앵커의 신뢰성, 호감도, 전문성, 공정성 있는 이미지 연출 모색을 비언어적 커뮤니케이션의 관점에서 살펴보았다. 연구 대상인 지상파 3사의 TV 뉴스에서 동일한 주요뉴스를 보도하더라도 앵커의 비언어적 커뮤니케이션적 요소에 따라 전달력이 다르게 나타날 수 있다. 이에 따른 본 연구의 결과는, 첫째, 신체적 기호언어의 관점에서 비보의 뉴스를 전달할 때 앵커의 얼굴표정은 어둡고, 제스처의 행위는 자제하였고 시청자의 시각과 청각을 통해 뉴스 내용에 집중할 수 있도록 비언어적 표현을 동반하고 있었다. 그러나 낭보의 경우는 비보와는 다르게 밝은 표정, 시선, 제스처가 상대적으로 자유롭게 표현되고 있었다. 둘째, 인공적 대상언어의 관점에서 비보의 뉴스를 보도할 때는 모노톤의 의상을 착용하고 액세서리는 배제하여 차분함을 나타내고 있었다. 그러나 낭보가 주요뉴스일 때는 선명한 비비드(vivid) 컬러의 의상을 착용하였고 아나운서의 전문성과 신뢰도를 높이기 위하여 메이크업과 헤어스타일의 강조는 배제되었다. 셋째, 상황적 행위언어의 관점에서는 앉아서 진행하던 과거 뉴스의 진행방식과는 다르게 스튜디오 공간을 활용하는 연출이 많아졌는데 앵커가 서기, 걷기, 걷다가 서기 등의 비언어적 커뮤니케이션의 행위로 뉴스의 내용을 강조하였다. 경직된 TV 뉴스를 시청하는 시청자에게 앵커의 비언어적 커뮤니케이션 표현은 뉴스의 이해를 높이고 뉴스에 대한 신뢰와 믿음을 강조할 수 있는 연출이라 할 수 있다. This study examined characteristics of image making for raising reliability, likeability, professionalism and fairness of anchorwomen from the perspective of nonverbal communication. Results of this study show that nonverbal communication elements of anchors affect viewers differently even when TV news of 3 terrestrial channels that are the objects of this study report the same main news. First, characteristics of anchorwomen from the viewpoint of physical symbolic language, facial expression of anchors was dark and they restrained gestures etc., when delivering sad news, accompanying nonverbal expression for concentrating on the contents of news through sight and hearing of views. As for good news, however, cheerful look, eyes and gestures were expressed freely unlike sad news. Second, as for the characteristics of anchorwomen from the aspect of artificial object language, they maintained simplicity, neatness and calmness by wearing worn monotone clothes and removing accessories when reporting sad news. Contrary to the foregoing, they gave change to brightness and chroma wearing vivid color clothes, excluding splendor in hair style while reporting good news. Third, when looking characteristics of anchorwomen from the viewpoint of situational behavior language, they use studio space as the method of production changed from the previous one that reported news sitting on the chair, anchorwomen showed nonverbal communication such as standing, walking, standing after walking etc. Anchor's nonverbal communication expression for viewers of rigid television news is a way to enhance understanding of the news and emphasize trust and trust.

친환경 해양관광시설 조성을 위한 관련 제도에 대한 검토 -도서지역 골프장입지의 지형, 지질 특수성을 중심으로-

김세현 ( Se Hyun Kim ) 한국환경영향평가학회 2009 환경영향평가 Vol.18 No.5

TV 뉴스 여성 앵커의 슈트 스타일 특성 연구

김세현 ( Kim Se Hyun ),김미현 ( Kim Mi Hyun ) 한국상품문화디자인학회(구 한국패키지디자인학회) 2021 상품문화디자인학연구 Vol.64 No.-

본 연구는 KBS, SBS, MBC TV 방송 채널의 메인 뉴스 프로그램에서 여성 앵커의 방송 의상 스타일링 구성 특성의 이해를 위한 슈트 사례 연구를 통한 디자인 이해와 시사점을 제안하기 위한 것이다. 연구의 목적은 첫째, TV 뉴스 여성 앵커를 대표하는 상징적 이미지를 이해하고, 여성 앵커의 이미지 연출을 위한 여성 슈트의 개념과 구성을 연구의 관점에서 유형화 한다. 둘째, 지상파 방송사 KBS, SBS, MBC의 TV 뉴스 여성 앵커가 착용한 슈트 사례를 조사 및 분석하여 특성을 도출한다. 셋째, TV 뉴스 여성 앵커가 착용한 슈트 스타일 특성을 방송사별로 비교 분석하여 현대 전문직 여성의 슈트 스타일을 이해하고 시사점을 제안한다. 2020년 주중 방송된 262회의 KBS, SBS, MBC 방송사 뉴스 여성 앵커의 방송 의상 이미지 총 786장의 사례를 분석한 연구 결과는 다음과 같다. 첫째, TV 뉴스 여성 앵커의 전문적 이미지를 강조하는 방송 의상으로 서 슈트는 이론적 연구를 통해 테일러드 슈트, 세퍼레이트 슈트, 칼라리스 슈트로 유형화 되었다. 둘째, KBS, SBS, MBC의 TV 뉴스 여성 앵커가 착용한 슈트 사례는 테일러드 슈트 스타일은 KBS가 212회, 세퍼레이트 슈트 스타일은 MBC가 125회, 칼라리스 슈트 스타일은 MBC가 42회로 각 각 가장 많이 착용되었다. 셋째, TV 뉴스 여성 앵커가 착용한 슈 스타일의 이러한 사례들은 클래식, 양성적, 해체적, 개성적 슈트 스타일의 특성을 나타냈다. 이와 같은 연구 결과가 제시하는 시사점은 다양한 영역에서 여성의 사회 활동과 성공을 통한 지위 향상에 따라 시각적 이미지를 대표하는 패션으로 여성성이 절제된 슈트는 역동적인 활동적 이미지와 여성이라는 젠더의 인식보다 TV 뉴스 앵커로서 전문적 이미지를 강조할 수 있는 연출 효과를 높일 수 있다. 또한 방송사별 방송 분위기와 방식 경향과 시청자가 공감할 수 있는 유행을 반영한 패션 스타일 연출과 시청자에게 신뢰감과 호감을 줄 수 있는 이미지를 연출할 수 있다. This study is aimed at suggesting design understanding and implications through a suit case study for understanding the characteristics of broadcast costume styling of female anchors in the main news program of KBS, SBS, and MBC TV channels. The purpose of the study is first to understand symbolic images representing TV news female anchors and to typify the concept and composition of female suits for image production of female anchors from the perspective of the study. Second, the case of suits worn by female TV news anchors of terrestrial broadcasters KBS, SBS, and MBC is investigated and analyzed to derive characteristics. Third, we compare and analyze the suit style characteristics worn by TV news female anchors by broadcasters to understand the suit style of modern professional women and suggest implications. A total of 786 cases of female anchors of KBS, SBS, and MBC broadcasting companies on 262 days in 2020 were analyzed as follows. First, as a broadcast costume that emphasizes the professional image of TV news female anchors, the suit was typified into a tiled suit, a seperate suit, and a calaris suit through theoretical research. Second, the number of suits worn by female TV news anchors from KBS, SBS and MBC was 212 times for tiled suit styles, 125 for seperate suit styles, and 42 for colorless suit styles, respectively. Third, these examples of suit styles worn by TV news female anchors represented the characteristics of classical, positive, disruptive, and individual suit styles. These findings suggest that women's social activities and status improvements through success in various areas representing visual images, while feminine suits can enhance production to emphasize professional images as TV news anchors rather than dynamic active images and gender perception. In addition, it can produce fashion styles that reflect trends in broadcasting atmosphere and methods by broadcasters and trends that viewers can sympathize with, and create images that can give viewers credibility and favor.

초미세먼지 제거를 위한 유전체 분리판을 이용한 2 단 전기 집진기의 집진 성능 분석에 관한 수치적 연구

김세현(Se Hyun Kim),최호연(Ho Yeon Choi),박성현(Seong Hyun Park),박용갑(Yong Gap Park),하만영(Man Yeong Ha) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.8