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Lim, Jae Seok,Kim, Woo-il,Kang, Hoon-Chul,Kim, Se Hoon,Park, Ah Hyung,Park, Eun Kyung,Cho, Young-Wook,Kim, Sangwoo,Kim, Ho Min,Kim, Jeong A,Kim, Junho,Rhee, Hwanseok,Kang, Seok-Gu,Kim, Heung Dong,Kim, Nature Publishing Group 2015 Nature medicine Vol. No.
Focal cortical dysplasia type II (FCDII) is a sporadic developmental malformation of the cerebral cortex characterized by dysmorphic neurons, dyslamination and medically refractory epilepsy. It has been hypothesized that FCD is caused by somatic mutations in affected regions. Here, we used deep whole-exome sequencing (read depth, 412–668×) validated by site-specific amplicon sequencing (100–347,499×) in paired brain-blood DNA from four subjects with FCDII and uncovered a de novo brain somatic mutation, mechanistic target of rapamycin (MTOR) c.7280T>C (p.Leu2427Pro) in two subjects. Deep sequencing of the MTOR gene in an additional 73 subjects with FCDII using hybrid capture and PCR amplicon sequencing identified eight different somatic missense mutations found in multiple brain tissue samples of ten subjects. The identified mutations accounted for 15.6% of all subjects with FCDII studied (12 of 77). The identified mutations induced the hyperactivation of mTOR kinase. Focal cortical expression of mutant MTOR by in utero electroporation in mice was sufficient to disrupt neuronal migration and cause spontaneous seizures and cytomegalic neurons. Inhibition of mTOR with rapamycin suppressed cytomegalic neurons and epileptic seizures. This study provides, to our knowledge, the first evidence that brain somatic activating mutations in MTOR cause FCD and identifies mTOR as a treatment target for intractable epilepsy in FCD.
Sangwoo Kim,방재훈,최명식,Wansik Oum,Ali Mirzaei,Namgue Lee,Hyouk‑Chon Kwon,Dohyung Lee,Hyeongtag Jeon,Sang Sub Kim,Hyoun Woo Kim 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.3
We report the gas-sensing properties of pristine and SnS2functionalized TeO2nanowires (NWs). TeO2NWs were synthesizedby a vapor–liquid–solid growth method, and SnS2functionalization was performed using an atomic layer depositiontechnique followed by thermal treatment. Structural and morphological analyses verified the formation of pristine and SnS2functionalized TeO2NWs with desired composition, phase, and morphology. Interestingly, sensing results showed that thepristine TeO2NW gas sensor had better sensing properties relative to the SnS2functionalized TeO2NW gas sensor. Anunderlying sensing mechanism is explained in detail, and reasons for the decrease of sensing performance with the SnS2functionalized TeO2NW sensor was attributed to the coverage of TeO2surface by the SnS2nanoparticles.
KIM, JISUN,LIM, HAESOON,KIM, SANGWOO,CHO, HYEJUNG,KIM, YONG,LI, XIAOJIE,CHOI, HONGRAN,KIM, OKJOON Spandidos Publications 2016 Oncology Reports Vol.35 No.4
<P>We previously reported that photodynamic therapy (PDT) induces cell death in head and neck cancer through both autophagy and apoptosis. Regulation of cell death by autophagy and apoptosis is important to enhance the effects of PDT. Autophagy maintains a balance between cell death and PDT resistance. Downregulation of heat shock protein 27 (HSP27) induces PDT resistance in head and neck cancer cells. Furthermore, HSP70 regulates apoptosis during oxidative stress. However, the role of HSPs in PDT-induced cell death through autophagy and apoptosis is unclear. Therefore, in the present study, we investigated the effects of HSP27 and HSP70 on PDT-induced cell death of oral cancer cells through autophagy and apoptosis. Cancer cells were treated with hematoporphyrin at varying doses, followed by irradiation at 635 nm with an energy density of 5 mW/cm(2). We determined the changes in HSP expression by determining the levels of PARP-1 and LC3II in PDT-resistant cells. Furthermore, we assessed cell death signaling after downregulating HSPs by transfecting specific siRNAs. We observed that PDT decreased HSP27 expression but increased HSP70 expression in the head and neck cancer cells. Treatment of cells with LC3II and PARP-1 inhibitors resulted in upregulation of HSP70 and HSP27 expression, respectively. Downregulation of HSP27 and HSP70 induced cell death and PDT resistance through autophagy and apoptosis. Moreover, downregulation of HSP27 in PDT-resistant cells resulted in enhanced survival. These results indicate that the regulation of HSP27 and HSP70 plays a principal role in increasing the effects of PDT by inducing autophagic and apoptotic cell death.</P>
기능성 위장장애 환자의 소화불량 제증상 치료에 있어서 콤비짐^(�)정의 임상효과
김동의,주재환,추상우,김형륵,조철균,김영진,김현종,김신곤 中央醫學社 1996 中央醫學 Vol.61 No.12
Functional dyspepsia has been considered, until recently, to be a nebulous syndrome, in part because of the lack of a structural explanation for the symptoms and because of the apparent heterogeneity of the patients labeled with this diagnosis. Although many definitions have been offered, there is now reasonable consensus that dyspepsia refers to persistent or recurrent pain or discomfort that is centered on the upper abdomen ; the discomfort may be characterized by postprandial fullness, early satiety, nausea or upper abdominal bloating. The diagnosis of dyspepsia must not be restricted to those with meal-related symptoms because there is no clinical condition, including chronic peptic ulceration, in which the symptoms are exclusively confined to the postprandial period. The majority of the patients with chronic or recurrent dyspepsia do not have a peptic ulcer or any other recognized structural or biochemical abnormality that definitely explains the symptoms ; these patients are classified as having functional dyspepsia. Ideally, therapy for functional dyspepsia should be targeted at correcting an individual's underlying pathophysiologic disturbances. However, the mechanisms that produce symptoms in patients with functional dyspepsia remain poorly understood. A polyvalent digestive product Combizym� has a powerful combination of enzymes with broad activity and broad pH spectrum. It acts from the stomach to the small intestine and has a complete digestive effect on protein, carbohyrate and fat. We treated Combizym� in patients with functional dyspepsia with open, noncomparative study. The results are as follows ; 1. The improvement of the symptoms were 96.4 % in nausea and vomiting, 92.6 % in bloating, other symptoms were also improved over 75 %. 2. There was only mild pruritus in a patient and others were well tolerated during the experiment. 3. Overall improvement rate was 86.7 % of 30 patients. In conclusion, Combizym� is a safe and effective digestive drug in patients with functional dyspepsia.
기판의 크기가 마이크로스트립 패치 안테나의 방사특성에 미치는 효과
김상우(SangWoo Kim),김태영(Tae-Young Kim),김부균(Boo-Gyoun Kim),신종덕(Jong-Dug Shin),김세윤(Se-Yun Kim) 대한전자공학회 2007 電子工學會論文誌-TC (Telecommunications) Vol.44 No.11
기판의 크기가 마이크로스트립 패치 안테나의 방사특성에 미치는 영향에 대하여 알아보았다. 기판의 폭을 고정시키고 길이를 변화시킬 때 방사패턴 특성이 크게 변화하나 기판 길이를 고정시키고 폭을 변화시킬 때는 방사패턴 특성이 거의 변화하지 않음을 볼 수 있었다. 기판 크기에 따른 방사패턴 특성의 변화는 기판 두께가 두꺼울 때가 작을 때보다 더 큼을 볼 수 있었다. Effect of finite substrate plane on the radiation characteristics of microstrip patch antennas is investigated. The variation of the characteristics of the radiation pattern due to the change of the length of a substrate is much larger than that due to the change of the width of a substrate. As the thickness of a substrate increases, the characteristics of the radiation pattern reveal more sensitive for the change of the size of a substrate.
정량펌프에서의 cavitation발생 억제를 위한 수치 해석적 연구
김상우(Sangwoo Kim),김진욱(Jinwook Kim),김도연(Doyoen Kim),이도형(Dohyung Lee) 한국유체기계학회 2009 유체기계 연구개발 발표회 논문집 Vol.2009 No.-
Diaphragm metering pump has been known to allow exact amount of flow rate by combining two sets of the pumps and superposing the two different phase of flow rate. However, contrary to the direct plunge type metering pump, the diaphragm type of metering pump is known to yield pulsation due to indirect pushing mechanism via working fluid between piston & diaphragm. The working fluid could get easily involved with cavitation because of rapid change of piston movement and abrupt fluid passage area change. The research was devoted to reducing pulsation in diaphragm metering pump by the use of numerical analysis. The numerical study was conducted by considering unsteady, incompressible, turbulent (k-ε model) flow with moving boundary. Pressure drop at peculiar point of the flow field is focal point of research in order to reduce cavitation. Successful pulsation reduction through geometry modification, is validated by the actual experiments that revealed overall performance of the system with & without modification.