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Single-Port Robotic Cholecystectomy: Early Experience from 8 Cases
( Hyung Jun Kwon ),( Horyon Kong ),( Sang Geol Kim ),( Yun Jin Hwang ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Single-port laparoscopic cholecystectomy (SPLC) is a technical concept to reduced pain and improve cosmetic results when compared to multi-port cholecystectomy. However, SPLC is associated with technical limitation due to the enhanced complexity of the approach and limited number of specialized instruments or platforms. On the other hand, using a robotic platform may overcome these problems and enable more precise surgical actions by increasing freedom of movement and by restoring intuitive instrument control. In this presentation, we report the early clinical experience of our first 8 sing-port robotic cholecystectomy (SPRC) cases. Methods: Between November 2016 and February 2017, eight patients underwent SPRC with the da Vinci Xi robot and single-site instrumentation. We retrospectively reviewed clinical data on those patients. Results: All of 8 patients had completion of SPRC. Seven patients were female and one was male. Average patient age was 43.3±11.8 years and BMI was 22.4±1.4 kg/m2. Three patients (37.5%) were diagnosed with chronic calculous cholecystitis. Three patients (37.5%) underwent operation for polypoid lesions of the gallbladder. One patient (12.5%) was diagnosed with acute calculous cholecystitis. The mean operation time (skin-to-skin) was 83.9±30.7 min, docking time was 13.25±8.1 min, and console time was 42.1±26.4 min. The intraoperative blood loss was negligible. The mean Visual Analog Pain Scale score 6hr after the surgery was 2.9±0.4. The mean length of hospital stay average postoperative hospital stay was 2.3±1.0 day. There were no intraoperative complication and one patient developed seroma on port site. Conclusions: Robotic single-port cholecystectomy appears feasible and safe in our early experience.
실용음악 전공 학생들의 발성치료 전후 성대 및 음성 특성 비교
황연신,심미란,김철준,최용석,김상연,최찬호,선동일,Hwang, Yeon Shin,Shim, Mi Ran,Kim, Chul Jun,Choi, Yong Suk,Kim, Sang Yeon,Choi, Chan Ho,Sun, Dong Il 대한후두음성언어의학회 2016 대한후두음성언어의학회지 Vol.27 No.2
Background and Objectives : Many students major in applied music singing have various difficulties in phonation when they sing or perform. But the studies about this cause are lack. The purpose of this study is whether singing voice therapy based on vocal music is effective or not to applied music singing students that have difficulties in phonation. Materials and Methods : Singing voice therapy program had been done to 8 students major in applied music singing during 7 weeks. We did laryngeal stroboscope, perceptual, acoustic and aerodynamic examination before and after singing voice therapy to this students. And we studied post examination results have differences or improvements compared to pre examination results. Results : Four male students don't have effective improvement after singing voice therapy but they shows slight improvement in aerodynamic examination values compared to pre examination values. Four female students shows improvement in aerodynamic examination values and pitch range increasing. Above all, one student's vocal nodules disappeared after singing voice therapy. Conclusion : Singing voice therapy based on music singing is very effective to the students major in applied music singing. Above all, their curriculum in applied music singing should include phonation training based on music singing before training perform and technic practices.
Jun-Im Song,Sung-Jin Hwang,Haewon Moon,In-Young An 한국동물분류학회 2012 Animal Systematics, Evolution and Diversity Vol.28 No.2
Some gorgonians in the families, Primnoidae and Isididae within the suborder Calcaxonia were collected from subtidal zones between depths of 10 and 45 m in the coastal regions of King Sejong Station (62°13′S, 058° 47′W), Korea Polar Research Institute of Korea Ocean Research and Development Institute (KORDI) by SCUBA diving from 2009 to 2011. Three species in the Primnoidae, Arntzia gracilis (Molander, 1929), Thouarella (Thouarella) antarctica (Valenciennes, 1846) and Onogorgia nodosa (Molander, 1929), and also one species in the family Isididae, Tenuisis microspiculata (Molander, 1929) are newly recorded to octocorallian fauna in Marian Cove and Potter Cove of King George Island. These four species have been described in detail.
Jun Seop Yun,Hyeeun Song,Nam Hee Kim,So Young Cha,Kyu Ho Hwang,Jae Eun Lee,Cheol-Hee Jeong,Sang Hyun Song,Seonghun Kim,조은애산드라,김현실,육종인 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.12
A structural protein of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), nucleocapsid (N) protein is phosphorylated by glycogen synthase kinase (GSK)-3 on the serine/arginine (SR) rich motif located in disordered regions. Although phosphorylation by GSK-3β constitutes a critical event for viral replication, the molecular mechanism underlying N phosphorylation is not well understood. In this study, we found the putative alpha-helix L/FxxxL/AxxRL motif known as the GSK-3 interacting domain (GID), found in many endogenous GSK-3β binding proteins, such as Axins, FRATs, WWOX, and GSKIP. Indeed, N interacts with GSK-3β similarly to Axin, and Leu to Glu substitution of the GID abolished the interaction, with loss of N phosphorylation. The N phosphorylation is also required for its structural loading in a virus-like particle (VLP). Compared to other coronaviruses, N of Sarbecovirus lineage including bat RaTG13 harbors a CDK1-primed phosphorylation site and Gly-rich linker for enhanced phosphorylation by GSK-3β. Furthermore, we found that the S202R mutant found in Delta and R203K/G204R mutant found in the Omicron variant allow increased abundance and hyper-phosphorylation of N. Our observations suggest that GID and mutations for increased phosphorylation in N may have contributed to the evolution of variants.
Study on the Relationship between Iris Constitution and Apolipoprotein E Gene Polymorphism
Sung-Do Kang,Woo-Jun Hwang,Kyung-A Kim,Kyung-Sik Kim,Ho-Sub Lee,Jong-Uk Kim,Sung-Yong Choi,Kyong-Son Jin 대한한의학회 2003 대한한의학회지 Vol.24 No.4
Iridology, one of complementary and alternative medicine (CAM), is the diagnosis of the medical conditions through noting irregularities of the pigmentation in the iris. Iridological constitution has a strong familial aggregation and is implicated in heredity. Apolipoprotein E (apoE) gene polymorphism is one of the most well studied genetic markers of vascular disease. Then I investigated the relationship between iridological constitution and apoE polymorphism. I classified 87 hypertensives patients with family history of cerebral infarction and 79 controls according to Iris constitution, and determined apoE genotype. Neurogenic type in hypertensives was 32.2% compared with 16.5% in controls (P<0.001). No differences in the apoE genotypes frequencies were observed in patients compared with that in controls ( 2=0.726, df=2, P=0.696). However, in population with 3/ 4 genotype, the frequency of neurogenic constitution was significantly higher in hypertensives than in controls (60% vs. 0%) ( 2=5.265, df=1, P=0.022). These results could be implied that apo E 3/ 4 genotype and neurogenic Iris constitution are risk factors for hypertension.
Hwang, Seon-Ung,Kim, Kyu-Jun,Kim, Eunhye,Yoon, Junchul David,Park, Kyu Mi,Jin, Minghui,Han, Yongquan,Kim, Mirae,Lee, Gabsang,Hyun, Sang-Hwan Elsevier 2018 Theriogenology Vol.113 No.-
<P><B>Abstract</B></P> <P>Lysophosphatidic acid (LPA) is a phospholipid-derived signaling molecule with biological activities, such as stimulating cell proliferation, differentiation and migration. In the present study, we examined the effect of LPA on porcine oocytes during <I>in vitro</I> maturation (IVM) and subsequent embryonic development following parthenogenetic activation (PA) and <I>in vitro</I> fertilization (IVF). During IVM, the maturation medium was supplemented with various concentrations of LPA (0, 10, 30, and 60 μM). After 42 h of IVM, the 30 μM LPA-treated group showed a significant (<I>P</I> <<I>0.05</I>) increase in nuclear maturation and intracellular glutathione (GSH) levels compared with the other groups. The 30 μM LPA-treated group exhibited a significant decrease in intracellular reactive oxygen species (ROS) levels compared with the other groups. In PA, the 30 μM LPA-treated group had significantly higher cleavage (CL) and blastocyst (BL) rates compared with those of the other LPA-treated groups. In IVF, the 30 μM LPA-treated group had significantly higher CL and BL rates than the other LPA-treated groups. The expression of the developmental competence gene (proliferating cell nuclear antigen<I>, PCNA</I>) in the oocytes and cumulus cells of the individuals in the 30 μM LPA-treated group was significantly increased compared with the control group. In addition, the specific expression of urokinase Plasminogen Activator (uPA) and uPA Receptor (<I>uPAR</I>) in cumulus cells was significantly increased in the 30 μM LPA-treated group. The western blotting results revealed that LPA improves the activities of p38 mitogen-activated protein kinase (MAPK) and epidermal growth factor (EGF) by enhanced phosphorylation. In conclusion, treatment with 30 μM LPA during IVM promotes enhances the EGF-EGFR signaling pathway, resulting in cumulus cell expansion. And then, this treatment improves the developmental potential of PA and IVF porcine embryos by enhancing nuclear and cytoplasmic maturation and reducing ROS.</P>