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The Interior Landscape Design using Wayfinding
Chung Sung-Hye 한국인간·식물·환경학회 2004 인간식물환경학회지 Vol.7 No.2
The heaJthcare facilities design must be curative, resotrative, and beneficia] for people. However, healthcare facilities environments are very complicated and often referred to as mazes. In a healthcare facilities situation, anxjety and stress can impair the ability to process infonnation such as not reading sings. Wayfinding system is an orientation for healthcare facilitiess environment. A wayfinding design program consists of an integrated series of components that includes interior landscape, signage, color, graphics, artwork, lighting, and architectural detailing. Each of these components reinforces the others to form a language of visuaJ cues that enables people to make navigational decisions at criticaJ junctions to their destinations. The purpose of the current study was to review the wayfinding design in heaJthcare facilities and determine whether an interior landscape design based on wayfinding strategy will improve indoor environment in healthcare facilities and heighten perceptions of users in helathcare facilites.
Ginsenoside Composition Changes in Ginseng Extracts by Different Ascorbic Acid Treatments
Sung Kwon Ko,Ok Sun Cho,Hye Min Bae,Uy Dong Sohn,Byung Ok Im,Soon Hyun Cho,Byung Wook Yang,Sung Hyun Chung,Wang Soo Shin,Boo Yong Lee 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.4
The purpose of this study was to develop a new preparation process for chemical transformation of ginseng saponin glycosides to prosapogenins. Ginseng and ginseng extracts were processed under several treatment conditions using ascorbic acid solution. Treating with ascorbic acid at pH 2-3 and above 80℃ increased the ginsenoside Rg<sub>3</sub> content of samples to over 3% as compared to other pH levels and temperatures. In addition, ginseng and ginseng extracts that were processed under a high ascorbic acid solution treatment condition (pH 2.0, 5 hr) contained more ginsenoside Rg3 (approximately 16 times) than those processed under a low ascorbic acid solution treatment condition (pH 3.0, 5 hr). The highest quantity of ginsenoside Rg<sub>3</sub> (3.434%) occurred when a sample of fine ginseng root extract (AG2-9) was processed with the ascorbic acid solution at pH 2.0 for 9 hr. However, there was no change in the amount of ginsenoside Rg<sub>3</sub> when fine ginseng root extracts were processed with ascorbic acid solution at pH 2.0 for over 9 hr. In conclusion, the results indicated that ascorbic acid treatment of ginseng extracts can produce a level of ginsenoside Rg<sub>3<sub> that is over 90-fold the amount found in commercial red ginseng.
( Hye Jeong Cho ),( Seung Kak Shin ),( Seong Hyun Shin ),( Hyun Kyun Kim ),( Dong Hae Chung ),( Oh Sang Kwon ),( Yun Soo Kim ),( Ju Hyun Kim ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Few models adequately induce both metabolic dysregulation and non-alcoholic steatohepatitis (NASH) with advanced fibrosis that reflect human disease. Recently, a long-term diet (rich in fructose, palmitate, cholesterol: FPC)-induced model, and a western diet plus chemical-induced model have been proposed. The aim of this study was to evaluate which model is more suitable for metabolic dysregulation or hepatic inflammation with fibrosis Methods: C57BL/6N mice were fed normal chow diet for 28 weeks (G1, n=5), FPC diet with 55% glucose/45% fructose solution for 28 weeks (G2, n=5), and FPC diet with 55% glucose/ 45% fructose solution plus CCl<sub>4</sub> [0.2 μl (0.32 μg)/g of body weight] for 12 weeks (G3, n=5). Pathologic evaluations for NASH and fibrosis were made based on the NASH CRN score. Hepatic fibrotic contents were quantified by Sirius red staining. Results: Significant change of body weight was observed between G1 for 28 weeks (Δ10.7±2.1) and G2 (Δ20.7±3.9, P=0.001). However, there was no difference between G1 for 12 weeks and G3. Alanine aminotransferase was higher in G2 (351.5±218.9 IU/L, P=0.007) and G3 (243±93.5, P=0.023) than G1 (30.2±2.1). Total cholesterol (267.2±88.0 vs. 116.7±19.8 mg/dL, P=0.017) and low-density lipoprotein (123.5±41.0 vs. 30.8±14.5 mg/dL, P=0.005) in G2 were higher than G3. NAS score in G3 was higher than G2 (7.2±0.8 vs. 4.8±1.1, P=0.005). Fibrosis score in G3 was higher than G2 (1.8±0.8 vs. 0.8±0.4, P=0.046). Sirius red stain (%) in G3 were higher in G2 (4.43±0.53 vs. 2.31±1.36, P=0.012). Conclusions: In the long-term FPC diet-induced model, metabolic dysfunction such as dyslipidemia was apparent, but the induction of NASH and fibrosis was insufficient. In FPC diet plus chemical-induced model, lipid profile changed relatively little, but was suitable for induction of NASH and fibrosis. Therefore, it seems to be important to select a suitable model according to the purpose of the study.
Hye Jin Lee(이혜진),Seong Jong Yoon(윤성종),Young Se Hyun(현영세),Hye Jin Kim(김혜진),Sung-Il Hwang(황성일),Joo-Seung Bae(배주승),Ki Wha Chung(정기화) 한국생명과학회 2013 생명과학회지 Vol.23 No.9
꽃게(Portunus trituberculatus)는 세계적으로 넓게 분포하는 갑각류로 모래나 돌멩이가 있는 해저에 서식한다. 본 연구는 서해의 4개 지점(영광, 태안, 소래, 연평도)에서 채집된 P. trituberculatus 281 개체에 대해 10 종류 microsatellite 좌위의 유전적 다형성을 조사하였다. 좌위당 대립유전자 수는 50-129개로 평균 69.5개였으며, 관측 및 예상 이형접합도는 각각 0.111-1.000 및 0.609-0.979 범위에 있었다. 좌위별 근친계수((Fis)는 -0.0207에서 0.8175 범위였다. 유전적 분화도(Fst)는 0.05보다 낮게 나타났는데, 이것은 4 꽃게 간의 유전적 분화(genetic differentiation)가 매우 낮은 이루어진 것으로 추정하게 한다. UPGMA을 이용한 계통도 작성에서도 4 그룹 간의 유전적 거리는 매우 가깝다는 결과를 얻을 수 있었다. 매우 높은 다형성과 집단간의 낮은 유전적 분화는 서해안의 꽃게 집단은 활발한 유전적 흐름(gene flow)이 일어나며, 그룹간 지리적 경계가 없음을 제시한다. The swimming crab, Portunus trituberculatus, inhabits seafloor habitats containing sand or pebbles and is widely distributed throughout the world. The present study investigated genetic polymorphisms of 10 microsatellites in 281 samples of P. trituberculatus collected from four locations along the coastal water of the Korean side of the Yellow Sea (Yeonggwang, Taean, Sorea, and Yeonpyeong-do Island). The number of alleles per locus ranged from 50 to 129, with a mean of 69.5. The observed and expected hetrozygosity varied from 0.111 to 1.000 and from 0.609 to 0.979, respectively. The inbreeding coefficients (Fis) varied among the loci from -0.0207 to 0.8175. The genetic differentiation (Fst) was less than 0.05 (range 0.0020-0.0124). Therefore, the four groups of P. trituberculatus appeared to exhibit little genetic differentiation. The lack of differentiation was confirmed in a phylogenetic tree constructed by the unweighted pair group method with the arithmetic average (UPGMA). The hypervariation between the populations and the lack of genetic differentiation may reflect active gene flow among the Yellow Sea populations and the absence of geographical boundaries. The highly polymorphic microsatellite loci will be useful for molecular and phylogenetic studies, as well as stock management, of swimming crab, which is an important fishery resource.
Validation and Determination of the Contents of Acetaldehyde and Formaldehyde in Foods
Hye-Seung Jeong,Hyun Chung,Sang-Hoon Song,Cho-Il Kim,Joon-Goo Lee,Young-Suk Kim 한국독성학회 2015 Toxicological Research Vol.31 No.3
The aim of this study was to develop an efficient quantitative method for the determination of acetaldehyde (AA) and formaldehyde (FA) contents in solid and liquid food matrices. The determination of those compounds was validated and performed using gas chromatography-mass spectrometry combined by solid phase micro-extraction after derivatization with O-(2,3,4,5,6-pentafluoro-benzyl)-hydroxylamine hydrochloride. Validation was carried out in terms of limit of detection, limit of quantitation, linearity, precision, and recovery. Then their contents were analyzed in various food samples including 15 fruits, 22 milk products, 31 alcohol-free beverages, and 13 alcoholic beverages. The highest contents of AA and FA were determined in a white wine (40,607.02 ng/g) and an instant coffee (1,522.46 ng/g), respectively.
Sang-Ho Jeon,Sunhwa Park,Da-Hee Song,Jong-yeon Hwang,Moon-su Kim,Hun-Je Jo,Deok-hyun Kim,Gyeong-Mi Lee,Ki-In Kim,Hye-Jin Kim,Tae-Seung Kim,Hyen-Mi Chung,Hyun-Koo Kim 한국토양비료학회 2017 한국토양비료학회지 Vol.50 No.5
To establish new metal groundwater standard, 5 metals such as aluminum, chromium, iron, manganese, and selenium were evaluated by Chemical Ranking Of groundWater pollutaNts (CROWN) including possibility of exposure, toxicity, interest factor, connection standard for other media, and data reliability. 430 groundwater samples in 2013 and 2014 were collected semiannually from 110 groundwater wells and they were analyzed for selenium, manganese, iron, chromium, and aluminum. For this study, 430 groundwater samples were categorized into 3 geological distribution features, such as igneous, metamorphic, and sedimentary rock region and geological background levels were divided by pre-selection methods. For the results, the average concentrations of aluminum, chromium, iron, manganese, and selenium in 430 groundwater samples were 0.0008 mg L<SUP>-1</SUP>, 0.0001 mg L<SUP>-1</SUP>, 0.174 mg L<SUP>-1</SUP>, 0.083 mg L<SUP>-1</SUP>, and 0.0004 mg L<SUP>-1</SUP><SUP></SUP>, respectively. In addition, among various geologies, average concentration of selenium was the highest in igneous rock region, average concentrations of chromium, manganese and aluminum were the greatest in sedimentary rock region, and average concentration of iron was the most high in metamorphic rock region. As a result of the geological background concentration with pre-selection method, background concentrations of selenium and aluminum in groundwater samples were the highest from sedimentary rock as 0.0010 mg L<SUP>-1</SUP> and 0.0029 mg L<SUP>-1</SUP> and background concentrations of manganese and iron in groundwater samples were the greatest from metamorphic rock as 0.460 mg L<SUP>-1</SUP> and 1.574 mg L<SUP>-1</SUP>, and no chromium background concentration in groundwater samples was found from all geology.
Application of expert system for smart livestock production management: A review
Sung Wook Lee,Md Nasim Reza,Sun-Ok Chung,Ho-Sung An,Ye Rin Lee,Sung Soo Kim,Hye Won Seo,Chang Uk Cheon 사단법인 한국정밀농업학회 2023 정밀농업과학기술지 Vol.5 No.1
Globally, the population is expanding, whereas the agricultural labor population is decreasing due to the population aging. In addition, as a result of the liberalization of trade restrictions, prices for food and livestock are becoming less competitive, and the effects of climate change are becoming more pronounced. As a result, there is a growing expectation for the livestock industry to adopt cutting-edge technologies in order to maximize efficiency and output. This paper reviewed the current livestock industry based on the livestock environment management, feeding management, disease prediction and management, and the field of manure treatment. Applications and justifications for expert systems in the livestock sector were also discussed, as were examples and justifications for effective mechanization and automation systems. The paper also covered the anticipated future applications of the expert system and conducts an analysis of the current use cases.
Sang Mi Park,Eun Hye Jung,Jae Kwang Kim,Kyung Hwan Jegal,Chung A Park,Il Je Cho,Sang Chan Kim 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.3
Background: Previously, we reported that Korean Red Ginseng inhibited liver fibrosis in mice and reduced the expressions of fibrogenic genes in hepatic stellate cells (HSCs). The present study was undertaken to identify the major ginsenoside responsible for reducing the numbers of HSCs and the underlying mechanism involved. Methods: Using LX-2 cells (a human immortalized HSC line) and primary activated HSCs, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide) assays were conducted to examine the cytotoxic effects of ginsenosides. H₂O₂ productions, glutathione contents, lactate dehydrogenase activities, mitochondrial membrane permeabilities, apoptotic cell subpopulations, caspase-3/-7 activities, transferase dUTP nick end labeling (TUNEL) staining, and immunoblot analysis were performed to elucidate the molecular mechanism responsible for ginsenoside-mediated cytotoxicity. Involvement of the AMPactivated protein kinase (AMPK)-related signaling pathway was examined using a chemical inhibitor and small interfering RNA (siRNA) transfection. Results and conclusion: Of the 11 ginsenosides tested, 20S-protopanaxadiol (PPD) showed the most potent cytotoxic activity in both LX-2 cells and primary activated HSCs. Oxidative stress-mediated apoptosis induced by 20S-PPD was blocked by N-acetyl-L-cysteine pretreatment. In addition, 20S-PPD concentration-dependently increased the phosphorylation of AMPK, and compound C prevented 20SPPD-induced cytotoxicity and mitochondrial dysfunction. Moreover, 20S-PPD increased the phosphorylation of liver kinase B1 (LKB1), an upstream kinase of AMPK. Likewise, transfection of LX-2 cells with LKB1 siRNA reduced the cytotoxic effect of 20S-PPD. Thus, 20S-PPD appears to induce HSC apoptosis by activating LKB1eAMPK and to be a therapeutic candidate for the prevention or treatment of liver fibrosis.