Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

Hydrogen Behavior in Ti-Added Reduced Activation Ferritic-Martensitic Steels

Kang‑Mook Ryu,Dae Geon Lee,Joonoh Moon,Chang‑Hoon Lee,Tae‑Ho Lee,Jae Sang Lee,Dong‑Woo Suh 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.3

Hydrogen behavior and corresponding mechanical degradation were examined in TaTi-RAFM and EUROFER97 steels. Increased Ta content with Ti addition decelerates the hydrogen diffusion but increases the solubility in the lattice. It ismainly led by the higher fraction of Ta-rich MC carbides and dislocation density in TaTi-RAFM steel. Overall activationenergy of hydrogen trapping of investigated steels is evaluated to be 25.3 ~ 25.6 kJ/mol in the tempered condition. The activationenergy increases to nearly 30 kJ/mol when the steels are re-austenitized and quenched. Higher activation energy withincreased dislocation density indicates that the dislocation provides for trap site with higher activation energy than Ta-richMC carbide. Mechanical degradation by hydrogen with respect to the yield strength, tensile strength and uniform elongationcould not be observed in all investigated steels. The presence of hydrogen only has influence on the loss of post-uniformelongation. For a given charging time, the loss of post-uniform elongation is more remarkable in TaTi-RAFM steel due tothe larger hydrogen uptake.

Corifollitropin alfa versus daily recombinant fsh treatment for controlled ovarian stimulation in poor responders

( Chung Hoon Kim ),( Jei Won Moon ),( Jin Young Min ),( Jun Woo Ahn ),( Sung Hoon Kim ),( Hee Dong Chae ),( Byung Moon Kang1 ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: To compare the effect of long-acting recombinant FSH (rFSH), corifollitropin alfa with daily rFSH administered during 1st 7days of controlled ovarian stimulation (COS) using GnRH antagonist multiple dose protocol (MDP) in poor responders undergoing IVF/intracytoplasmic sperm injection (ICSI). 방법: In this prospective randomized study total of 90 poor responders who were scheduled for IVF/ICSI were enrolled and divided into the corifollitropin alfa group (study group) or the daily rFSH group (control group). The diagnosis of poor responder was based on the Bologna criteria of the 2011 ESHRE consensus. In all subjects, GnRH antagonist MDP was used for COS. 결과: There were no differences in patients` characteristics between the two groups. Duration of COS was comparable between the study and control groups. The numbers of oocytes retrieved and grade I or II embryos were also similar in the two groups. However, the number of mature oocytes was higher in the study group with a borderline significance (p< .07) and the ratio of mature oocytes among total oocytes retrieved was significantly higher in the study group of 78.6 ± 13.0%, compared with 61.2 ± 16.0% in control group (p< .001). There were no differences in the clinical pregnancy rate per cycle initiated, embryo implantation rate and miscarriage rate between the two groups. 결론: Corifollitropin alfa is at least as effective as daily rFSH treatment for COS using GnRH antagonist MDP, and may improve the synchrony of follicular development in poor responders undergoing IVF/ICSI. Therefore, corifollitropin alfa may be a feasible, patient-friendly alternative for poor responders.

질소이온주입에 의한 알루미늄의 표면개질특성

강혁진(Hyuk-Jin Kangㅠ),안성훈(Sung-Hoon Ahn),이재상(Jae-Sang Lee),김경균(Kyung-Gun Kim) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.5

The research on surface modification technology has been advanced to improve the properties of engineering materials. Ion implantation is a novel surface modification technology to enhance the mechanical, chemical and electrical properties of substrate’s surface using accelerated ions. In this research, nitrogen ions were implanted into aluminum substrates which would be used for mold of rubber materials. The composition of nitrogen ion implanted aluminum alloy and nitrogen ion distribution profile were analyzed by Auger Electron Spectroscopy (AES). To analyze the modified surface, properties such as hardness, friction coefficient, wear resistance, contact angle, and surface roughness were measured. Hardness of ion implanted specimens was higher than that of untreated specimens. Friction coefficient was reduced, and wear resistance was improved. From the experimental results, it can be expected that ion implantation of nitrogen enhances the surface properties of aluminum mold.

춘천지역 모유 중 폴리브롬화디페닐에테르(PBDEs)의 이성체별 분포특성과 노출경로

Sung-Ug We(위성욱),In-Cheon Baek(백인천),Sang-Ah Park(박상아),Seong-Hoon Kang(강성훈),Yu-Jin Cho(조유진),Bong-Hui Cho(조봉회),Cho-Hee Yoon(윤조희),Ki-Ho Kim(김기호),Byung-Yoon Min(민병윤) 한국생명과학회 2010 생명과학회지 Vol.20 No.3

본 연구는 비교적 청정한 지역인 춘천시에 거주하는 일반인 모유 중 PBDEs의 노출 경로를 확인하기 위해 처음으로 시도된 연구이다. 본 연구지역의 모유 중 ∑PBDEs의 수준은 북아메리카지역에 비하여 낮은 수준이었으나 일부 아시아, 유럽국가와 유사하였다. 모유 내 PBDEs의 축적은 산모의 특성과 상관관계가 나타나지 않았으나, 상업용 PBDEs 제품을 포함하여 여러 복합적 인자에 의하여 노출되고 있었으며, 식품 섭취와 같은 식이노출은 한국인에 있어 중요한 노출 경로의 하나로 판단되었다. 따라서 본 연구 결과는 한국인의 PBDEs 노출 경로 파악에 중요한 정보를 제공하여, 장차 PBDEs 및 관련 브롬계 난연제의 노출에 따른 인체 위해성 평가를 수행함에 있어 중요한 참고자료가 될 것이다. 또한, 한국 내의 PBDEs에 대한 인체노출 경로를 명확하게 하기 위한 연구는 계속적으로 이루어져야 할 것이다. This study was carried out to investigate the exposure pathway of PBDEs in human breast milk collected from new mothers residing in Chuncheon, a comparatively clean area in Korea. The congeners of PBDE in 22 human breast milk samples were analyzed using a high resolution gas chromatography with a high resolution mass detector. The residue level of ΣPBDEs was higher in primipara subjects than in multipara subjects (p<0.05). The levels in this study were similar to those of people in some Asian and European countries, but were lower than those of people in north America. In the congener profiles, BDE-47 (mean contribution=36.1%) was predominant, followed by BDE-153 (27%), BDE-99 (11.7%), BDE-100 (11.1%), BDE-28 (7.9%) and BDE-183 (3.5%). The sum of BDE-47 and BDE-153 accounted for more than 50% of ΣPBDEs in most samples. BDE-47 was highly correlated with ΣPBDEs (r=0.94, p<0.001). No strong trend was observed between PBDE levels and a number of key biological factors (women’s age, weight, height and body mass index) examined in this study, however, weak correlations were observed in PBDE levels measured against dietary habits, particularly in fish consumption frequency. It seems that Korean people might be exposed to multiple sources including products of PBDEs, and particularly food resources.

Morphological Development of Larvae and Juveniles of Acanthopagrus schlegeli

Kang, Chung-Bae,Lee, Sung-Hoon,Hwang, Jae-Ho,Han, Kyeong-Ho The Korean Society of Developmental Biology 2014 발생과 생식 Vol.18 No.4

Newly hatched black porgy larvae (Acanthopagrus schlegeli) swam to the surface, with the mouth and anus still closed and were 1.90-2.11 mm (mean, 2.0 mm) in total length (TL). The larvae were 2.71-2.94 mm TL (mean, 2.82 mm) on day 2 after hatching. At this time, about two-thirds of the yolk was absorbed, the bladder and intestines had formed, and the mouth and anus were open. Total length was 4.32-4.66 mm (mean, 4.45 mm) at the post-larval stage on days 5-6 after hatching, and the yolk and oil globule were almost absorbed. The end of the notochord began to flex, and 6-8 caudal fin rays were visible. The larvae were 15.37-16.1 mm TL (mean, 15.83 mm) at the juvenile stage on days 30-32 after hatching, and the number of rays in all fins was completely revealed.

Regional Analysis of Chemical Vapor Deposition Using Direct Simulation Monte Carlo Method

Kang-In Lee(이강인),Hyun-Taek Lee(이현택),Jang-Yeob Lee(이장엽),Sung-Hoon Ahn(안성훈) (사)한국CDE학회 2015 한국 CAD/CAM 학회 학술발표회 논문집 Vol.2015 No.하계

Natural Course of Intra-abdominal Fluid Collections Following Minimally Invasive Left Sided Pancreatectomy

Sung Hwan Lee,Chang Moo Kang,Ho Kyoung Hwang,Sung Hoon Choi,Woo Jung Lee 한국간담췌외과학회 2014 한국간담췌외과학회 학술대회지 Vol.2014 No.4

Comparison of follitropin ${\beta}$ administered by a pen device with follitropin ${\beta}$ administered by a conventional syringe in patients undergoing IVF-ET

Kang, Hyuk-Jae,Kim, Chung-Hoon,Ahn, Jun-Woo,Lee, Hyang-Ah,Kim, Sung-Hoon,Chae, Hee-Dong,Kang, Byung-Moon The Korean Society for Reproductive Medicine 2011 Clinical and Experimental Reproductive Medicine Vol.38 No.1

Objective: To compare the effectiveness and convenience of a pen device for the self-administration of follitropin ${\beta}$ with a conventional syringe delivering follitropin ${\beta}$ solution in patients undergoing IVF-ET. Methods: GnRH agonist long protocol was used for controlled ovarian stimulation (COS) in all subjects. A total of 100 patients were randomized into the pen device group or the conventional syringe group on the first day of COS. Local tolerance reactions were assessed within 5 minutes, at 1 hour and at 3 hours after each injection. On the day of hCG injection, patients were asked to rate their overall pain and convenience experienced with self-injection on a visual anlaogue scale (VAS). Results: There were no differences in patients' characteristics between the two groups. The duration of COS was significantly shorter in the pen device group than in the conventional syringe group. Patients included in the pen device group needed a significantly smaller amount of follitropin ${\beta}$. However, no differences between the two groups were found in IVF results and pregnancy outcome. The incidence of local pain within 5 minutes, at 1 hour and at 3 hours after the injection was significantly lower in the pen device group. VAS scores indicated that injections using the pen device were significantly less painful and more convenient. Conclusion: The pen device for self-administration of follitropin ${\beta}$ is less painful, safer and more convenient for the patients, and can be more effective because of the shorter duration and smaller dose of follitropin ${\beta}$ when compared with the conventional syringe.

Peptide Nucleic Acid-Mediated Aggregation of Reduced Graphene Oxides and Label-Free Detection of DNA Mutation

Kang, Taegyeong,Choi, Hoon,Joo, Sang-Woo,Lee, So Yeong,Yoon, Kyong-Ah,Lee, Kangtaek American Chemical Society 2014 The Journal of physical chemistry B Vol.118 No.23

<P>We have investigated peptide nucleic acid (PNA)-mediated aggregation of reduced graphene oxide (rGO) sheets. Addition of PNA into suspension of rGOs resulted in aggregation of rGOs, which could be easily detected with the naked eye. To elucidate the mechanism of rGO aggregation, we monitored the reaction by transmission electron microscopy, zeta potential measurement, and UV–vis spectroscopy. Our findings suggest that PNA adsorbed on the rGO surface and then acted as a cross-linker to induce aggregation. We also tested the effects of different nucleic acids on rGO aggregation and found that not only the single-stranded DNA, but also the PNA-DNA complex, could stabilize the suspension against aggregation through electrostatic repulsion. Based on our understanding on rGO aggregation, we attempted to detect mutations in epidermal growth factor receptor (EGFR) by designing PNA probe to be complementary to the mutant type DNA sequence. Our results showed that PNA-mediated rGO aggregation could successfully be used to detect mutations in EGFR with high selectivity and sensitivity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpcbfk/2014/jpcbfk.2014.118.issue-23/jp501820j/production/images/medium/jp-2014-01820j_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp501820j'>ACS Electronic Supporting Info</A></P>