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Mohammadniaei, Mohsen,Go, Anna,Chavan, Sachin Ganpat,Koyappayil, Aneesh,Kim, Seong-Eun,Yoo, Hyun Jin,Min, Junhong,Lee, Min-Ho Elsevier 2019 Biosensors & bioelectronics Vol.141 No.-
<P><B>Abstract</B></P> <P>Development of a very sensitive biosensor is accompanied with an inevitable shrinkage in the linear detection range. Here, we developed an electrochemical biosensor with a novel methodology to detect microRNA-21 (miR21) at an ultralow level and broad linear detection range. A three-way junction RNA structure was designed harboring (i) a methylene blue (MB)-modified hairpin structure at its one leg to function as the sensing moiety and (ii) the other two legs to be further hybridized with barcode gold nanoparticles (MB/barG) as the signal amplifiers. Addition of target miR21 resulted in opening the hairpin moiety and subsequent hybridization with DNA-modified gold nanoflower/platinum electrode (GNF@Pt) to form the MB-3 sensor. Inspired by the relay-race run, to extend the dynamic detection range and increase the sensitivity of the biosensor, MB/barG was added to form the second detection modality (MBG-3). The combined sensor required very low sample volume (4 μL) and could identify 135 aM or 324 molecules of miR21 with the ability to operate within a wide linear range from 1 μM down to 500 aM. The fabricated GNF@Pt showed a remarkable conductivity compared with the gold nanoparticle-modified electrode. Addition of MB/barG boosted the electrochemical signal of the MB by almost 230 times. Moreover, a new protocol was introduced by the authors to increase the efficiency of microRNA extraction from the total serum. Possessing a sound selectivity and specificity towards single base-pair mutations, the developed biosensor could profile cancer development stages of two patient serums.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A novel relay-race mechanism was reported to extend the linear rangeand increase the sensitivity of microRNA detection. </LI> <LI> The barcode RNA-modified gold nanoparticle (MB-BarG) enhanced the electrochemical signal of the biosensor by ∼ 230 times. </LI> <LI> Using a newly-developed protocol, with CHAPS treatment, the efficiency of microRNA recovery from total serum was increased. </LI> <LI> The fabricated biosensor could profile different development stages of cancerous serums (breast and liver). </LI> </UL> </P>
Use of Nanoscale Materials for the Effective Prevention and Extermination of Bacterial Biofilms
이도현,서영민,Muhammad Saad Khan,황장선,조연호,손재우,이경우,박찬휘,Sachin Chavan,Assaf A. Gilad,최종훈 한국생물공학회 2018 Biotechnology and Bioprocess Engineering Vol.23 No.1
Biofilms have been shown to cause most human infections. The prevention and extermination of bacterial biofilms has always presented a major challenge in the clinic. The failure of traditional antibiotics and the development of bacterial resistance against these measures is on the rise. Nanoscale materials possess the advantage of presenting enhanced surface properties of bulk materials, and are emerging as effective agents for deterring microbial growth. This review article summarizes the fundamentals of bacterial growth, biofilm formation, mechanisms for antibacterial technologies, and usage of nanoparticles for the prevention and extermination of biofilms. Further research is required with respect to the appropriate usage of nanoparticles for the effective control of biofilms to save human lives and reduce healthcare costs.
황장선,손재우,서영민,조연호,이경우,이도현,Muhammad Saad Khan,Sachin Chavan,박찬휘,Anand Sharma,Assaf A. Gilad,최종훈 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.58 No.-
Bacterial infections and resistance against antibiotics are on the rise despite new drug development. New developments in the field of nanomedicine are proving to be an alternative for traditional antibiotics. Silica nanoparticles (SiNPs) have a promising role in emerging nanomedicine because of their low cytotoxicity and efficient drug delivery potential. In current study, we developed and analyzed silica nanoparticles of ∼50 nm in size that are capable of encapsulating small organic molecules and drugs, such as fluorescein isothiocyanate (FITC), doxorubicin (DOX), 4′, 6-diamidino-2-phenylindole (DAPI) and/or isoniazid (INH). Our drug delivery contains the anti-tuberculosis drug, INH, which is encapsulated in beta (β)-glucan-conjugated SiNPs. We focused on synthesizing and encapsulating SiNPs that have amine functional groups as well as the ability to conjugate with β-glucan molecules, making the nanocomplex both a drug carrier and a stimulus for host immune systems.
손재우,황장선,이도현,Muhammad Saad Khan,조연호,이경우,박찬휘,Sachin Chavan,서영민,최영현,김상수,김다솜,나도균,최종훈 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.3
Immunoassays are analytical methods using antibody-specific reactions to analyze samples. Due to recent developments in antibody technology, the scope of potential samples has expanded to not only proteins, but also low molecular-weight compounds, carbohydrates, lipids, and microorganisms. Immunoassays have the advantage of being highly sensitive, capable of detecting small amounts, and thus have potential for application in biosensors. Immunoassays using magnetic beads have been developed and can be converted to more diverse platforms than the existing limited well plate-based assay. Furthermore, magnetic bead immunoassays detect analytical samples more quickly, and are becoming one of the most suitable immunoassay tools applicable to biosensors. However, their development requires optimization for the improvement of detection ability for specific samples. Therefore, we propose a guideline for solving detection problems occurring in magnetic bead immunoassay optimization processes. It is aimed to be a good reference, enabling researchers performing such optimization more quickly and efficiently.
Pallavi Mahajan-Tatpate,Supriya Dhume,Naveenkumar Jayakumar,Yogesh Chendake,Sachin Chavan,Ramdas Khomane,Vinayak Wadagaonkar 대한환경공학회 2024 Environmental Engineering Research Vol.29 No.4
Separation of heavy metals to obtain potable water for domestic and agricultural applications is important considering health effects, bioaccumulation properties and applicability. The separation of Cr and Mn salts by Donnan exclusion are investigated using polysulfone (PSF) based membranes modified by anchoring ZnO nanoparticles. Use of Acid-treated ZnO nanoparticle enhnanced rejection properties for Cr and Mn (97.12 and 98.37%, respectively) for membranes based on 40% PSF, 8% PEG -400 and 0.8% ZnO. The use of polyethylene glycol (PEG)with molecular weight of 200 Da enhanced rejection properties to ~ 99%. This would provide excellent pathway for PSF membrane modification without affecting stability.Separation was dependent uponconcentrations of PSF, PEG, ZnO nanoparticles in dope solution, and bubble point pressure, pore size, number of pores, etc. Analysis of these properties and effect would provide pathway for design of membranes for heavy metal removal and process applications. Hence, they were analyzed using R studio multi-attribute linear regression model. Membrane performance regression analysis provided correlation with 95% fitting accuracy with 0.98 coefficient of regression, suggesting good relationship between predicted and observed data. This shows the applicability of model to save time and cost involved in designing membrane formation parameters and properties with optimized applicability.
Hwang, Jangsun,Son, Jaewoo,Seo, Youngmin,Jo, Yeonho,Lee, Kyungwoo,Lee, Dohyun,Khan, Muhammad Saad,Chavan, Sachin,Park, Chanhwi,Sharma, Anand,Gilad, Assaf A.,Choi, Jonghoon Elsevier 2018 Journal of industrial and engineering chemistry Vol.58 No.-
<P><B>Abstract</B></P> <P>Bacterial infections and resistance against antibiotics are on the rise despite new drug development. New developments in the field of nanomedicine are proving to be an alternative for traditional antibiotics. Silica nanoparticles (SiNPs) have a promising role in emerging nanomedicine because of their low cytotoxicity and efficient drug delivery potential. In current study, we developed and analyzed silica nanoparticles of ∼50nm in size that are capable of encapsulating small organic molecules and drugs, such as fluorescein isothiocyanate (FITC), doxorubicin (DOX), 4′, 6-diamidino-2-phenylindole (DAPI) and/or isoniazid (INH). Our drug delivery contains the anti-tuberculosis drug, INH, which is encapsulated in beta (β)-glucan-conjugated SiNPs. We focused on synthesizing and encapsulating SiNPs that have amine functional groups as well as the ability to conjugate with β-glucan molecules, making the nanocomplex both a drug carrier and a stimulus for host immune systems.</P> <P><B>Graphical abstract</B></P> <P>Beta-glucan modified silica nanoparticles carrying and secreting anti-tuberculosis drug molecules: SA treated Glu was presenting carboxyl groups on their surface while SiNPs encapsulating INH were terminated with amine groups. Glu and SiNPs were then conjugated with by EDC/NHS linkers. INH@SiNPs/Glu complexes released drug molecules while macrophages recognizing Glu secreted cytokines (Red arrows: Glu, Yellow arrows: INH encapsulated SiNPs: Right, Drug release profiling: Left).</P> <P>[DISPLAY OMISSION]</P>