중국의 시각에서 바라본 부동산투자신탁에 관한 현안

Ze Ping Zhang 건국대학교 법학연구소 2013 一鑑法學 Vol.0 No.24

Effectiveness and Safety of Dabrafenib in the Treatment of 20 Chinese Children with BRAFV600E-Mutated Langerhans Cell Histiocytosis

Ying Yang,Dong Wang,Lei Cui,Hong-Hao Ma,Li Zhang,Hong-Yun Lian,Qing Zhang,Xiao-Xi Zhao,Li-Ping Zhang,Yun-Ze Zhao,Na Li,Tian-You Wang,Zhi-Gang Li,Rui Zhang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.1

Purpose We sought to investigate the effectiveness and safety of dabrafenib in children with BRAFV600E-mutated Langerhans cell histiocytosis (LCH). Materials and Methods A retrospective analysis was performed on 20 children with BRAFV600E-mutated LCH who were treated with dabrafenib. Results The median age at which the patients started taking dabrafenib was 2.3 years old (range, 0.6 to 6.5 years). The ratio of boys to girls was 2.3:1. The median follow-up time was 30.8 months (range, 18.9 to 43.6 months). There were 14 patients (70%) in the risk organ (RO)+ group and six patients (30%) in the RO– group. All patients were initially treated with traditional chemotherapy and then shifted to targeted therapy due to poor control of LCH or intolerance to chemotherapy. The overall objective response rate and the overall disease control rate were 65% and 75%, respectively. During treatment, circulating levels of cell-free BRAFV600E (cfBRAFV600E) became negative in 60% of the patients within a median period of 3.0 months (range, 1.0 to 9.0 months). Grade 2 or 3 adverse effects occurred in five patients. Conclusion Some children with BRAFV600E-mutated LCH may benefit from monotherapy with dabrafenib, especially high-risk patients with concomitant hemophagocytic lymphohistiocytosis and intolerance to chemotherapy. The safety of dabrafenib is notable. A prospective study with a larger sample size is required to determine the optimal dosage and treatment duration.

Ectopic Overexpression of COTE1 Promotes Cellular Invasion of Hepatocellular Carcinoma

Zhang, Hai,Huang, Chang-Jun,Tian, Yuan,Wang, Yu-Ping,Han, Ze-Guang,Li, Xiang-Cheng Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

Family with sequence similarity 189, member B (FAM189B), alias COTE1, a putative oncogene selected by microarray, for the first time was here found to be significantly up-regulated in hepatocellular carcinoma (HCC) specimens and HCC cell lines. mRNA expression of COTE1 in HCC samples and cell lines was detected by reverse transcription-polymerase chain reaction (RT-PCR) and real-time PCR, while protein expression of COTE1 in HCC tissues was assessed by immunohistochemistry. In addition, invasion of HCC cells was observed after overexpressing or silencing COTE1. In the total of 48 paired HCC specimens, compared with the adjacent non-cancer tissues, the expression of COTE1 was up-regulated in 31 (p<0.01). In HCC cell lines, COTE1 expression was significantly higher than in normal human adult liver (p<0.01). Overexpression of COTE1 enhanced HCC-derived LM6 and MHCC-L cellular invasion in vitro. In contrast, COTE1 knockdown via RNAi markedly suppressed these phenotypes, as documented in LM3 and MHCC-H HCC cells. Mechanistic analyses indicated that COTE1 could physically associate with WW domain oxidoreductase (WWOX), a tumor suppressor. COTE1 may be closely correlated with invasion of hepatocellular carcinoma (HCC) cells and thus may serve as an effective target for gene therapy.

SOH estimation of lithium-ion batteries based on least squares support vector machine error compensation model

Zhang, Ji'ang,Wang, Ping,Gong, Qingrui,Cheng, Ze The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.11

Accurate estimation of the state of health (SOH) of lithium-ion batteries is an important determinant of their safe and stable operation. In this paper, a method for the SOH estimation of lithium-ion batteries based on the least squares support vector machine error compensation model (LSSVM-ECM) is proposed. This method achieves a combination of an empirical degradation model and a data-driven method. Battery degradation can be divided into overall trends and local differences, where the former can be described by an empirical degradation model (EDM) established by the historical data of the battery capacity, while the latter can be mapped by a least squares support vector machine (LSSVM). An LSSVM-ECM is established, where the input is the time interval of the equal charging voltage rising (DV_DT) and the output is the fitting error of the EDM, which represents the local difference of the capacity degradation to dynamically compensate the prediction results of the EDM that represents the global trend in terms of the capacity degradation. Validations are carried out with battery data provided by Oxford and NASA datasets. Results show that the proposed method has a high prediction accuracy and a strong robustness.

Oxygen Uptake Rate Controlling Strategy Balanced with Oxygen Supply for Improving Coenzyme Q10 Production by Rhodobacter sphaeroides

Ze-Jian Wang,Xingzi Zhang,Ping Wang,Zhiwei Sui,Meijin Guo,Siliang Zhang,Yingping Zhuang 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.3

The effects of different oxygen uptake rates (OUR) on the physiological metabolism of Rhodobacter sphaeroides were investigated systematically in 50 L fermenters due to the significant influence on industrial coenzyme Q10 production under oxygen supply limitation. Meanwhile, the seriously decreased oxygen transfer rate caused by the increased broth viscosity was successfully prevented with OUR-directed continuous ammonium sulfate feeding in the late fermentation phase. The statistical analysis results showed that controlling OUR constantly at 45 ± 2.2 mmol/L/h by the oxygen supply level adjustment and the continuous ammonium sulfate feeding could greatly enhance Q10 production. This OUR-Stat controlling strategy successfully achieved the maximal coenzyme Q10 production (2584 ± 82 mg/L), which was 15.4% higher than that of the control. The highest specific CoQ10 content was 25.9 mg/(g DCW)), and the yield of CoQ10 to glucose consumption was up to 19.37 mg/g. These results demonstrated that the optimal OUR-Stat controlling strategy would be effective and economical for improving the industrial CoQ10 production.

Drug-induced hyperglycaemia and diabetes: pharmacogenomics perspectives

Mou-Ze Liu,Hai-Yan He,Jian-Quan Luo,Fa-Zhong He,Zhang-Ren Chen,Yi-Ping Liu,Da-Xiong Xiang,Hong-Hao Zhou,Wei Zhang 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.7

Drug-induced diabetes is widely reported inclinical conditions, and it is becoming a global issuebecause of its potential to increase the risk of severe cardiovascularcomplications. However, which drug mechanismsexert their diabetogenic effects and why the effectspresent significant inter-individual differences remain largelyunknown. Pharmacogenomics, which is the study ofhow genomic variation influences drug responses, providesan explanation for individual differences in drug-induceddiabetes. We highlight that pharmacogenomics can beinvolved in regulating the expression of genes in signalingpathways related to the pharmacokinetics or pharmacodynamicsof drugs or the pathogenesis of diabetes, contributingto the differences in drug-induced glucoseimpairment. The pharmacogenomics studies of the majordiabetogenic drugs are reviewed, including calcineurininhibitors, antipsychotics, hormones, and antihypertensivedrugs. We intend to elucidate the genetic basis of druginduceddiabetes and pave the way for the precise use ofthese drugs in the clinic.

Dynamics of excitons and carriers at the NPB/C60 interface by transient photocurrents

Li Ping,De Yang Xiu,Wu Bo,Zhang Yu,Jiang Ze Zhuan,Bao Xi,Huang Hai Shen 한국물리학회 2020 Current Applied Physics Vol.20 No.5

The transient photocurrent (TPC) technique was performed to explore the dynamics of excitons and carriers at organic active layer/buffer layer interfaces. A special device with ITO/PEIE/NPB/C60/Al structure was designed to study the interfacial processes at the NPB/C60 interface. An external electrical field was provided to neutralize the built-in electrical field of the device. Interestingly, a new phenomenon was observed, wherein the polarity of the TPC changed from negative to positive under an external electrical field. The initial negative signal was ascribed to exciton separation by the built-in field in C60, and the subsequent positive signal can be attributed to the diffusion of electrons that accumulate at the NPB/C60 interface. TPC measurements shown that further increasing the external electrical field causes polarity to change twice. Analyzing the two changes in polarity revealed that the NPB did not only extract holes from C60 but also provided an effective interface for exciton dissociation.

Genome-wide identification and evolution of TC1/Mariner in the silkworm (Bombyx mori) genome

Li‑Qin Xie,Ping‑Lan Wang,Shen‑Hua Jiang,Ze Zhang,Hua‑Hao Zhang 한국유전학회 2018 Genes & Genomics Vol.40 No.5

TC1/Mariner transposons belong to class II transposable elements (TEs) that use DNA-mediated “cut and paste” mechanism to transpose, and they have been identified in almost all organisms. Although silkworm (Bombyx mori) has a large amount of TC1/Mariner elements, the genome wide information of this superfamily in the silkworm is unknown. In this study, we have identified 2670 TC1/Mariner (Bmmar) elements in the silkworm genome. All the TEs were classified into 22 families by means of fgclust, a tool of repetitive sequence classification, seven of which was first reported in this study. Phylogenetic and structure analyses based on the catalytic domain (DDxD/E) of transposase sequences indicated that all members of TC1/Mariner were grouped into five subgroups: Mariner, Tc1, maT, DD40D and DD41D/E. Of these five subgroups, maT rather than Mariner possessed most members of TC1/Mariner (51.23%) in the silkworm genome. In particular, phylogenetic analysis and structure analysis revealed that Bmmar15 (DD40D) formed a new basal subgroup of TC1/Mariner element in insects, which was referred to as bmori. Furthermore, we concluded that DD40D appeared to intermediate between mariner and Tc1. Finally, we estimated the insertion time for each copy of TC1/Mariner in the silkworm and found that most of members were dramatically amplified during a period from 0 to 1 mya. Moreover, the detailed functional data analysis showed that Bmmar1, Bmmar6 and Bmmar9 had EST evidence and intact transposases. These implied that TC1/Mariner might have potential transpositional activity. In conclusion, this study provides some new insights into the landscape, origin and evolution of TC1/Mariner in the insect genomes.

Effect of the Gradual Distribution of Hardness on Self-Dressing of Cutting Tools

Hong-Yan Wu,Ping-Ze Zhang 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.-

It is fact that the more beavers' teeth bite, the sharper they are. According to the theory of bionics, 45-steel cutting tools were surface-modified by using the double-glow-plasma surface alloying process. Microstructure and cross-section micro-hardness of the alloying layers were investigated and their cutting performance was tested. The results show that bilayer alloying coatings with thickness of 35 μm, one layer of which is a transitional layer to improve the adhesion between layer and substrate, are formed on the 45 steel cutting tools. The micro-hardness of the alloying layer ranges from surface (2200 HV 0.025) to substrate (250 HV0.025), which is beneficial to the improvement of cutting ability through self-dressing during the cutting tests. It is fact that the more beavers' teeth bite, the sharper they are. According to the theory of bionics, 45-steel cutting tools were surface-modified by using the double-glow-plasma surface alloying process. Microstructure and cross-section micro-hardness of the alloying layers were investigated and their cutting performance was tested. The results show that bilayer alloying coatings with thickness of 35 μm, one layer of which is a transitional layer to improve the adhesion between layer and substrate, are formed on the 45 steel cutting tools. The micro-hardness of the alloying layer ranges from surface (2200 HV 0.025) to substrate (250 HV0.025), which is beneficial to the improvement of cutting ability through self-dressing during the cutting tests.

Effect of Nano-CaCO3 on the Sealing Efficiency of Grouts in Flowing Water Grouting

Yao-Hui Liu,Ping Yang,Ze-Bin Ouyang,Xiao Wei,Lisha Zhang 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.10

Flowing water grouting is a big challenge in the tunneling and underground engineering. To enhance the early strength and grouting effectiveness of slurry for flowing water grouting, nano-CaCO3 and fly ash were mixed with cement based grout. A series of physical simulation tests were conducted to simulate the flowing water grouting process in rough rock fracture, and investigate the effect of nano-CaCO3 content on the fluid pressure and sealing efficiency of grouts. Results of viscosity tests show that the viscosity of grouts decreased with an increase of nano-CaCO3 content. Scanning electron microscope (SEM) tests indicate that nano-CaCO3can promote the formation of fibrous hydrates and enhance the flowing water resistance of grouts. Increasing nano-CaCO3 content resulted in the first increase while later decrease of maximal fluid pressure (MFP) and sealing efficiency (SE) of grouts. Reducing water cement ratio of grouts and incorporating fly ash can effectively improve the SE of flowing water grouting.