http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
석병석(Suk, Byong-suk),민승용(Min, Seung-yong),권재욱(Kwon, Jae-wook),김창균(Kim, Chang-kyoon),문상만(Moon, Sang-man),최수진(Choi, Su-jin),구철회(Koo, Cheol-hea),김인규(Kim, In-kyu),류동영(Ryu, Dong-young) 한국항공우주연구원 2015 항공우주산업기술동향 Vol.13 No.2
시험용 달 궤도선의 발사 요구조건 사전 분석 단계로 최근 외국에서 발사한 달 탐사선의 발사 요구조건을 분석하였다. 일반적으로 달 탐사선의 발사 요구조건은 달 임무 궤도를 결정하는 중요한 요소이며, 또한 지구, 달, 태양의 상대적인 운동으로 인해 임무궤도 요구조건을 만족하는 발사 가능 시간이 주기적으로 반복되는 경향이 있다. 분석 결과 설정된 발사 요구조건들로부터 달 궤도선의 주 임무가 달의 남/북극 지역의 광학 관측 임을 간접적으로 알 수 있었다. 향후 우리나라 달 궤도선 발사 요구 조건 설정에 본 논문이 도움이 되길 기대한다. In the preliminary study on launch window requirement for Korea Path-finder Lunar Orbiter(KPLO), the recent foreign lunar orbiter’s lauch window requirement was analyzed. Normally, the launch requirements depends on the mission orbit. Based on the relationship between Moon, Earth, and Sun, the launch time will be available periodically to meet requirements. In this paper, it is understood that the launch window requirements come from payload mission requirements to take picture each poles of Moon. This paper might be a practical example to derive KPLO launch requirements in the future.
( Sang Hyun Song ),( Choon Hyuck David Kwon ),( Jae Won Joh ),( Jong Man Kim ),( Mill Jae Shin ),( Sung Joo Kim ),( Suk Koo Lee ),( Tae Suk Kim ),( Hyung Hwan Moon ),( Sang Hoon Lee ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Portal vein thrombosis (PVT) is a surgical challenge in liver transplantation (LTx). Presence of PVT was considered as a contraindication for LTx in some centers due to the controversy revolving around the long term outcome of these patients. Therefore, we studied the long term outcome of adult patients with PVT in LTx in a tertiary institution with specialized transplantation unit. Methods: There were 570 cases of adult liver transplantation between 2004 and 2009 in our institution. We excluded 99 cases of deceased donor liver transplantations to facilitate incidence, outcome and surgical management. There were 56 patients with existing PVT before 471 living donor liver transplantations. Patients with PVT were divided into 2 groups according to Yerdal`s classification, mild PVT group (Yerdel group 1 & 2) 43 cases and severe PVT group (Yerdel group 3 & 4) 13 cases. Results: Patients with PVT constituted 11.8% (n=56) in our cohort. When comparing between patients without and with PVT, we did not find statistical difference in terms of age, gender, Child-Pugh score, MELD score & indication for LTx (benign vs malignancy). Rate of PV complication was 3.4% in the non-PVT group and 8.9% in PVT group (p=0.047). Duration of operation and total amount of blood transfusion were also comparable between two groups. The overall survival of PVT group was not significantly different compared to the non-PVT group (p=0.059). Demographics of 43 cases of mild PVT (76.7%) and 13 cases of severe PVT (23.3%) were not different except in severe PVT group had more malignancy cases (27 cases vs 2 cases, p=0.011). The median overall survival of mild PVT group is comparable with non-PVT group (p=0.059) and the median overall survival of severe PVT group is 32 months (1-88) and non-PVT group is 41 months (1-93) (p=0.066). 5-year survival rate of severe PVT is about 60%. Conclusions: Existing PVT prior to liver transplantation does not lead to poorer long term outcome. However in severe cases, we need more careful approach. Therefore, PVT should not be a contraindication to liver transplantation.
Kwon, Byoung Mog,Bae, Yun Soo,Han, Mi Young,Park, Young Mee,Yoo, Ji Yun,Lee, Sang Seop,Lee, Kyung Im,Jeong, Moon Jin 생화학분자생물학회 1998 BMB Reports Vol.34 No.6
In the present study, an in vitro ELISA system to assess the interaction between Src homology (SH)2 domains and phosphotyrosine that contain peptides was established using purified GST-conjugated SH2 proteins and synthetic biotinylated phosphotyrosine that contain oligopeptides. The SH2 domains bound the relevant phosphopeptides that were immobilized in the streptavidin-coated microtiter plate in a highly specific and dose-dependent manner. The epidermal growth factor receptor (EGFR)-, T antigen (T Ag)-, and platelet-derived growth factor receptor (PDGFR)-derived phosphopeptides interacted with the growth factor receptor binding protein (Grb)2/ SH2, Lck/SH2, and phosphatidyl inositol 3-kinase (PI3K) p85/SH2, respectively. No cross-reactions were observed. Competitive inhibition experiments showed that a short phosphopeptide of only four amino acids was long enough to determine the binding specificity. Optimal concentrations of the GST-SH2 fusion protein and phosphopeptide in this new ELISA system for screening the binding blockers were chosen at 2nM and 500nM, respectively. When two candidate compounds were tested in our ELISA system, they specifically inhibited the Lck/ SH2 and/or p85/SH2 binding to the relevant phosphopeptides. Our results indicate that this ELISA system could be used as an easy screening method for the discovery of specific binding blockers of protein-protein interactions via SH2 domains.
Nonvolatile Memory Application of Monodispersed Ferritin as a Template for Iron Nanocrystal
( Moon Jae Kwon ),( Hye Jun Choi ),( Man Chang ),( Seung Jae Jung ),( Hyun Sang Hwang ) 대한금속재료학회 ( 구 대한금속학회 ) 2007 ELECTRONIC MATERIALS LETTERS Vol.3 No.3
In this letter, we report on the fabrication of a uniform nanocrystal with the introduction of a ferritin template. Due to the identical shape and dimension of ferritin molecules, It is possible to obtain well-controlled nanocrystals after the outer shell elimination. A closely-packed ferritin monolayer was formed through a new droplet evaporation technique and the density was estimated as 6×1011cm-2. We also adopted high pressure (HP) H2 annealing to reduce the ferritin core and the complete reduction was verified via X-ray photoelectron spectroscopy (XPS) analysis. A fabricated nanocrystal memory containing a ferritin core showed significantly improved memory characteristics, including a fast program/erase(P/E) speed and a stable memory window up to 104 s at 85℃ (data retention) and 104 P/E cycles (endurance).
A Study on How to Improve Magnesium Anodizing Process with High Biocompatibility
Sang-jun Kwon,Jin-young Hur,Chang-Myeon Lee,Kwan-seop Jang,Sung-mo Moon,Hong-kee Lee 한국표면공학회 2015 한국표면공학회지 Vol.48 No.5
Anodization of die-casted AZ91D magnesium alloy was carried out using silicate based electrolyte solution instead of fluoride based solution to improve biocompatibility of oxidized layers. The anodic layer obtained from silicate based solution has smaller size of pore and smoother surface, resulting in lower corrosion rate in simulate body solution (SBF). Effect of enhanced structural and chemical properties in oxidized layer on biocompatibility was carefully considered.
Moon, Hui-Sung,Kwon, Kiho,Kim, Seung-Il,Han, Hyunju,Sohn, Joohyuk,Lee, Soohyeon,Jung, Hyo-Il Royal Society of Chemistry 2011 Lab on a chip Vol.11 No.6
<P>Circulating tumor cells (CTCs) are highly correlated with the invasive behavior of cancer, so their isolations and quantifications are important for biomedical applications such as cancer prognosis and measuring the responses to drug treatments. In this paper, we present the development of a microfluidic device for the separation of CTCs from blood cells based on the physical properties of cells. For use as a CTC model, we successfully separated human breast cancer cells (MCF-7) from a spiked blood cell sample by combining multi-orifice flow fractionation (MOFF) and dielectrophoretic (DEP) cell separation technique. Hydrodynamic separation takes advantage of the massive and high-throughput filtration of blood cells as it can accommodate a very high flow rate. DEP separation plays a role in precise post-processing to enhance the efficiency of the separation. The serial combination of these two different sorting techniques enabled high-speed continuous flow-through separation without labeling. We observed up to a 162-fold increase in MCF-7 cells at a 126 µL min<SUP>−1</SUP> flow rate. Red and white blood cells were efficiently removed with separation efficiencies of 99.24% and 94.23% respectively. Therefore, we suggest that our system could be used for separation and detection of CTCs from blood cells for biomedical applications.</P> <P>Graphic Abstract</P><P>We developed a microfluidic device for separating CTCs from blood by combining multi-orifice flow fractionation (MOFF) and dielectrophoresis (DEP) which enables high-speed continuous flow-through separation without any labeling. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0lc00345j'> </P>