온풍 조건에서 수분 탈락 정도에 따른 피부 분류 및 개선 방안에 대한 연구

권오선 ( Oh Sun Kwon ),강현종 ( Hyun Jong Kang ),한승민 ( Seung Min Han ),윤지선 ( Ji S Eon Yoon ),조웅희 ( Woong Hee Cho ),오주영 ( Joo Young Oh ),임준만 ( Jun Man Lim ),송영숙 ( Young Sook Song ),박선규 ( Sun Gyoo Park ) 대한화장품학회 2020 대한화장품학회지 Vol.46 No.2

피부를 탄력있고 부드럽게 하는 역할은 각질층에 존재하는 수분량에 의해 좌우된다. 피부 수분량은 냉온풍, 건조환경 등 다양한 환경 변화에 의해 영향을 받음이 알려져 있으나, 개인 피부 차이에 따른 피부수분량 변화와 회복 정도에 대해서는 많은 연구가 이루어 지지 않은 실정이다. 본 연구에서는 온풍 조건하에서 피시험자들의 피부 수분 탈락 및 회복 정도를 비교 평가하여 새로운 피부 타입을 제시하고, 온풍 조건에서 저하되는 피부 수분량을 개선 시켜주는 효능 물질을 개발하고자 하였다. 온풍 환경 조성을 위해, 건강한 피험자(남: 10 명, 여: 39 명, 25 세 - 63 세)의 전완부에 온풍(30 cm, 40 ℃, 6 m/s)을 30 min 간 피부에 노출시켜, 피부 수분량의 변화를 평가하였다. 26명(남: 4 명, 여: 22 명, 평균 연령: 42.7 ± 9.4)이 온풍 노출전에 비하여 온풍 노출 후 수분량이 유의하게 감소하며, 노출 후 30 min이 지나도 회복이 되지 않았다. 온풍노출 후 수분량이 떨어지는 피험자(여: 10 명)를 대상으로 보수력이 높은 크림을 3 주간 전완부에 적용한 이후 동일 온풍 조건하에서 피부 수분량을 측정한 결과, 노출 30 min 후 피부 수분량이 온풍 노출 전 수준으로 회복됨을 확인하였다. 본 연구를 통하여 피부는 건조 조건에서 쉽게 수분을 잃어버리는 피부(탈수형 피부)가 존재하는 것을 확인하였다. 이는 앞으로 화장품 개발을 보습 기능뿐만 아니라, 이러한 환경변화에 따른 피부수분이 쉽게 빠져나가는 피부(탈수형 피부)의 특성에 맞는 제품의 효능 개발이 필요함을 보여준다. Elasticity and softness of the skin depend on the level of moisture present in the stratum corneum, which is known to be affected by various environmental changes, such as cold and hot winds and dry environments. However, not many studies have been conducted on changes in skin moisture and the degree of recovery due to individual skin differences. In the present study, we aimed to investigate the effect of warm air heating on skin hydration levels and develop moisturizing formulas to improve lowered skin hydration levels. In order to deliver warm air heating condition, heating dryer (40 ℃, 6 m/s, 30 cm apart from forearm) was applied into inner forearm of healthy subjects (male: 10, female: 39, age: 25 - 63) Among 49 subjects, 26 subjects showed significantly lowered skin hydration levels until 30 min after warm air heating exposure (lowered group). In addition, moisturizing cream with high water holding capacity was applied to forearm of 10 subjects in lowered group for 3 weeks and skin hydration levels after warm air heating were significantly improved at the levels of before application of warm air heating. From this study, we found out that there is a skin type that skin hydration levels are significantly decreased under warm air heating condition (dehydrated skin) and this dehydrated skin can be improved by moisturizing formulas with high water holding capacity.

학교폭력 피해자의 정신병 실태 조사

신성웅,권석우,신민섭,조수철 대한소아청소년정신의학회 2000 소아청소년정신의학 Vol.11 No.1

요 약 : 본 연구는 학교폭력의 피해자를 대상으로 정신병리에 대한 특성을 알아내고, 조기 정신병과의 관계를 규명함을 기본 목적으로 시행되었다. 더 나아가서는 조기정신병의 발견과 아울러, 조기 치료를 시행함으로써 심각한 정신병의 예방을 도모하고자 하였다. 서울시 전 구역 중 16개 중학교를 선정하여 중학교 1, 2학년 남 · 녀 학생에게 간이정신진단검사 피어스-해리스 자아상 검사의 인기도와 학교 적응 소척도, 저자들이 개발한 따돌림 척도를 배포하여 따돌림을 당하는 정도의 점수가 평균보다 통계적으로 유의하게 차이가 나는 대상을 선정하고, 이들 중에서 스스로 인기가 없다고 여기면서 정신병적 증상이 유의하게 높게 보고된 대상을 선정하여 '정신병의 전구기에 있는 군'으로 판정하여, 이들의 대상의 수를 계산하여 위험도를 산출하고, 정신병 전구기에 있다고 판단되는 대상의 임상적 특성을 상관 분석 및 회귀 분석을 통해 정신병적 증상과 관련된 임상적 척도들을 파악하였다. 결과는 다음과 같다. 1) 따돌림 척도에서 통계적으로 유의하게 높은 점수를 받은 군은 총 157명(5.3%)이었고, 그 중에서 47명(29.9%)이 간이정신진단검사의 정신병적 증상 수치가 유의하게 높았다. 따돌림 척도에서 높지 않은 점수를 보인 2,135명 중 정신병적 증상이 높은 군은 50명이어서,따돌림 척도에서 높게 나온 군의 정신병적 증상이 높게 나올 위험도(odds ratio)는 17.8이었다 이는 통계적으로 유의한 수치였다(X2=274.8, df=1 p<0.05). 즉 따돌림을 당한다고 호소한 집단은 정신병적 증상이 유의하게 높았고, 이를 통해 왕따 피해자는 정신병 발병 위험이 통계적으로 유의하게 높다고 할 수 있었다. 2) 자신은 남들에겐 인기도 없고, 따돌림을 당한다고 여기며 정신병적 증상을 가진 군(47명, 남자31명, 여자 16명)은 단순히 정신병적 증상이 높은 군에 비해 불안 척도,우울증 척도, 공격성, 대인 민감성 학교 및 사회 적응 척도, 강박증상 척도, 공포불안 척도, 정신병적 증상 신체적 증상 호소 등에서는 차이를 보이지 않았으나 자신이 따돌림을 받는다는 호소와 편집증은 더 높게 측정되었다. 그리고, 학교폭력 피해자 중에서 정신병적 증상이 유의하게 높게 측정되었고, 스스로 인기가 없다고 생각하는 대상들에서는, 불안 증상, 우울증, 공격성, 대인 예민성, 강박증상, 편집증, 신체 증상 호소 등이 정신병적 증상을 잘 설명해주었다(r2=0.93). 즉, 따돌림을 당한다고 호소한 집단은 정신병적 증상이 유의하게 높았고, 이를 통해 왕따 피해자는 정신병 발병 위험이 통계적으로 유의하게 높다고 할 수 있었다. 이를 통해서 따돌림과 같은 학교폭력 피해자가 불안 증상, 우울증, 공격성, 대인 예민성, 강박증상, 편집증, 신체 증상 호소와 같은 문제를 보였을 경우에는 정신병적 증상 유무와 학교 적응, 집중력 장애, 사고개념 형성 장애 등을 확인하여 정신병의 진단을 고려해야 한다고 할 수 있다. Objectives : The primary purpose of this study is to understand the psychopathology of the victims of school violence in terms of early psychosis. By doing this, the early detection of psychosis among the victims is possible, and early detection may lead to early intervention. Methods : Two-thousand and nine-hundred seventy two students from 16 middle schools in Seoul were asked to fill out questionnaire comprised of popularity and intellectual and school status of Piers-Harris Children's Self Concept Inventory, Symptom Check List-90-Revised, and Ostracism Scale. The subjects whose scores upon Ostracism Scale were higher than average by two standard deviation were labeled as 'Repelled and Isolated group', and subjects whose scores on popularity were significantly lower than average and whose scores on psychoticism of SCL-90-R were higher than average were defined as 'tentative early psychosis group'. Odds ratios were calculated from the numbers of subjects with and without high psychoticism scores and high ostracism scores. On the subjects of 'tentative early psychotic group', we examined every clinical characteristic and conducted correlation analysis and regression analysis in order to find out the risk factors and to construct theoretical model that explains the psychoticism scores. Results : The results were a follows : 1)Total 157(5.3%) subjects were rated significatntly higher on ostracism scale, and among them, 47 subjects(29.9%) were rated significantly higher than average on psychoticism scale, while only 50 subjects among 2,135 students who were rated within normal range showed significantly higher score on psychoticism scale. Odds ratio for psychotic group of isolated group were 17.82 and it was statistically significant. 2)Forty-seven subjects(31 boys, 16 girls) who were rated as they were unpopular and rejected from peers had significantly higher psychoticism scores. They were not significantly different from simply high psychoticism subjects in anxiety, social anhedonia scale, magical thinking, obsessive-compulsive symptoms, phobic anxiety, psychoticism, somatization, but showed higher ostracism scores and paranoid tendencies. Among school violence victims, who rated themselves unpopular and showed higher psychoticism scores, the psychoticism scores were mainly explained by anxiety, depression, hostility, interpersonal sensitivity, obsessive-compulsive symptoms, paranoid tendency, somatization scales(r2=0.93). Conclusion : Thus, it can be concluded that the subjects with higher ostracism score have the substantially high risk for psychosis development. By these results, we propose that school violence victims with anxiety, depression, hostility, interpersonal sensitivity, obsessive-compulsive symptoms, paranoid tendency, somatization should be tested individually considering school adjustment, attentional deficit, concept formation problems. KEY WORDS : School violence·Ostracism·Psychosis.

임신중 발견된 원발성 폐고혈압증 1예

황인후,최재웅,문찬희,황의경,민현조,송창섭 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.8

교량 탐사용 로봇 개발

김덕후,김효곤,조국,강민성,박상덕,손웅희 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

The purpose of maintaining of bridges was to secure of them and expend its life. They wereneeded to have a regular safety check. But, most parts of a bridge were not able to access easily for people so it was difficult to maintain. To improve it, the flight mechanism and mobile mechanism were combined to examine with moving when they were attaching to bridges up and down. The flight mechanism is a co-axial-rotor-helicopter shape that cut the body down and can be done hovering. The mobile mechanism was shaped to move every direction with holding the position of a robot. These robot platforms showed possibilities to use them not only for observation and patrol but they could be used for a new usage with transformation of flying robots. This paper was focused on location maintaining when a robot was examined a bridge. The flight mechanism would only have thrust and adhesive force, the mobile mechanism would be used for moving. Therefore, defining the mechanistic model of the mobile mechanism has proved the validity of the model through simulations and experiments.

α1,3-Gal Knock out Pigs Increases N-Glycolylneuraminic Acids

Jong-Yi Park,Mi-Ryung Park,Hong-Thuy Bui,Deug-Nam Kwon,Min-Hui Kang,Mihye Oh,Jae-Woong Han,Ssang-Goo Cho1,Chankyu Park,Hosup Shim,Hye-Min Kim,Man-Jong Kang,Jin-Ki Park,Jeong-Woong Lee,Kyung-Kwang Lee 한국동물번식학회 2012 Reproductive & Developmental Biology(Supplement) Vol.36 No.2s

In this study, we examined whether Hanganutziu-Deicher (H-D) antigens are important as an immunogenic non-a1,3-galactose (Gal) epitope in pigs with a disrupted a1,3- galactosyltransferase gene. The targeting efficiency of the AO blood genotype was achieved (2.2%) in pig fibroblast cells. A total of 1800 somatic cell nuclear transfer (SCNT) embryos were transferred to 10 recipients. One recipient developed to term and naturally delivered two piglets. The a1,3-galactosyltransferase activity in lung, liver, spleen, and testis of heterozygote a1,3-galactosyltransferase gene knockout (GalT-KO) pigs was significantly decreased, whereas brain and heart showed very low decreasing levels of a1,3- galactosyltransferase activity when compared to those of control. Enzyme-linked lectinosorbent assay showed that the heterozygote GalT-KO pig had more sialyla2,6- and sialyla2,3- linked glycan than the control. Furthermore, the heart, liver, and kidney of the heterozygote GalT-KO pig had a higher N-glycolylneuraminic acid (Neu5Gc) content than the control, whereas the lung of the heterozygote GalT-KO pig had Neu5Gc content similar to the control. Collectively, the data strongly indicated that Neu5Gc is a more critical xenoantigen to overcoming the next acute immune rejection in pig to human xenotransplantation.

Drp1-Zip1 Interaction Regulates Mitochondrial Quality Surveillance System

Cho, Hyo Min,Ryu, Jae Ryun,Jo, Youhwa,Seo, Tae Woong,Choi, Ye Na,Kim, June Hoan,Chung, Jee Min,Cho, Bongki,Kang, Ho Chul,Yu, Seong-Woon,Yoo, Soon Ji,Kim, Hyun,Sun, Woong Elsevier Science B.V., Amsterdam. 2019 Molecular cell Vol.73 No.2

The Analysis of Risk Factors for Postoperative Complications after Neoadjuvant Chemoradiation followed by Curative Resection with TME for Locally Advanced Rectal Cancer

Min Soo Cho,Chang Woo Kim,Hyun Ah Jang,Sung Uk Bae,Woong Sub Koom,Min Kyu Jung,Se Jin Baek,Hyuk Hur,Byung Soh Min,Joong Bae Ahn,Seung Hyuk Baik,Nam Kyu Kim 대한종양외과학회 2013 대한임상종양학회 학술대회지 Vol.2013 No.10

An Intractable Caustic Esophageal Stricture Successfully Managed with Sequential Treatment Comprising Incision with an Insulated-Tip Knife, Balloon Dilation, and an Oral Steroid

Woong Ki Lee,Byung Sun Kim,Min A Yang,So Hee Yun,Young Jae Lee,Ji Woong Kim,Jin Woong Cho 대한소화기내시경학회 2016 Clinical Endoscopy Vol.49 No.6

Bougie or balloon dilation is a good short-term treatment for caustic esophageal strictures, although recurrence after dilation occurs inapproximately 30% of these cases. Therefore, long-term treatment options are required in some cases, and endoscopic incisional therapyhas been used for patients with an anastomotic stricture in the gastrointestinal tract. A 58-year-old woman presented with severeswallowing diffculty because of a caustic esophageal stricture, which was caused by accidental exposure to anhydrous acetic acid atinfancy. She had undergone several previous bougie and balloon dilations but the stricture did not improve. We performed sequentialtreatment comprising incision with an insulated-tip knife, balloon dilation, and an oral steroid, which resulted in the patient’s symptomsmarkedly improving. Thus, we report this case of an intractable caustic esophageal stricture, which was successfully treated usingcombined endoscopic sequential treatment.

Effects of Fish Meal Replacement with Alternative Protein Sources on Growth PerformaNce, Feed Utilization and Biochemical Parameters of Juvenile Red Seabream (Pagrus major)

Min-Uk Cho,Buddhi E. Gunathilaka,Kang-Woong Kim,Seunghan Lee,Seong-Mok Jeong,Sang-Woo Hur,Sang-Min Lee 한국식품영양과학회 2022 한국식품영양과학회 학술대회발표집 Vol.2022 No.10

새로운 MEN1 유전자 돌연변이가 증명된 위, 십이지장, 췌장의 신경내분비종양

양민아 ( Min A Yang ),이웅기 ( Woong Ki Lee ),신홍식 ( Hong Shik Shin ),박성현 ( Sung Hyun Park ),김병선 ( Byung Sun Kim ),김지웅 ( Ji Woong Kim ),조진웅 ( Jin Woong Cho ),윤소희 ( So Hee Yun ) 대한소화기학회 2017 대한소화기학회지 Vol.69 No.3

Multiple endocrine neoplasia type 1 (MEN1) syndrome is a relatively rare disease, characterized by the occurrence of multiple endocrine tumors in the parathyroid and pituitary glands as well as the pancreas. Here, we report a case of MEN1 with neuroendocrine tumors (NETs) in the stomach, duodenum, and pancreas. A 53-year-old man visited our hospital to manage gastric NET. Five years prior to his visit, he had undergone surgery for incidental meningioma. His brother had pancreatic nodules and a history of surgery for adrenal adenoma. His brother`s daughter also had pancreatic nodules, but had not undergone surgery. The lesion was treated by endoscopic submucosal dissection and diagnosed as a grade 1 NET. Another small NET was detected in the second duodenal portion, resected by endoscopic submucosal dissection, which was also diagnosed as a grade 1 NET. During evaluation, three nodules were detected in the pancreas, and no evidence of pituitary, parathyroid tumors, or metastasis was observed. After surgery, the pancreatic lesions were diagnosed as NETs, with the same immunohistochemical patterns as those of the stomach and duodenum. Genetic testing was performed, and a heterozygous mutation was detected in the MEN1 gene, which is located on 11q13. (Korean J Gastroenterol 2017;69:181-186)