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      • 동국의대에서 실시한 2002년 전염병관리실무과정에 대한 평가

        방미란,임현술,정해관,한영란,정철 대한보건협회 2003 대한보건연구 Vol.29 No.1

        Communicable diseases have recently reemerged, with new communicable diseases continually breakmg out on a global scale; threaten the health and economics of populations. The Korean National Institute of Health carries out Field Management Training Prcgrams (FMTP) to address this problem The objectives of this study were the evaluation of the understanding and satisfaction for this program, and recommendation for improvement strategies. We conducted a questionnaire survey of 80 persons who completed the FMTP, at Dongguk University, between March 1 and November 30, 2002. The data collected was analyzed by Student s t-statistics. The understanding of the curriculum was Well in 42 (52.5%) and Moderate in 24 persons (30.0%). The satisfaction with the curriculum was Moderate in 38 (47.5%) and Good in 30 persons (37.5%). The satisfaction for the period of education was Bad for 31 persons (38.7%), which accounted for the majority of cases. The mean scores, by Likert s scale, for the understanding and satisfaction of the curriculum were 3.70 (±0.71) and 3.32 (i0.721, respectively. The mean score for the epidemiological survey was the highest for satisfaction with the course, at 3.78 (±0.62). The mean value of satisfaction for curriculum in education of period was significantly higher in health department group than in nursing department group (P<0.05). From this survey it appears the respondents were satisfied with this program. The FMTP will be systematically revised for curriculums, and effort will be required to develop controls for communicable disease, both by the government and the university.

      • 원수 수질변화에 따른 정수장 응집제의 효율평가

        방미란,임봉수,배병욱,김태응 대전대학교 산업기술연구소 1998 산업기술연구소 論文集 Vol.9 No.2

        This study was carried to estimate the turbidity and organic removal efficiency of the coagulants, such as Alum, PACl, and PACS, depends on the variation of raw water quality. When turbidity, pH of the raw water quality were 1.0∼10.0NTU, 7.0NTU respectively, in other to get the goal water quality below 1.0NTU of turbidity, the optimum input doses of Alum, PACl, and PACS were 20∼30mg/ℓ, 10∼20mg/ℓ, and 10∼20 mg/ℓ, respectively. In that case of optimum input does, the removal efficiency of UV254 was about 30∼60%. When the turbidity, pH of the raw water quality were 10∼40NTU, around 7.0, respectively, the optimum input doses of PACl, and PACS were 30 mg/ℓ , 20 mg/ℓ, respectively But Alum, in other to get less than 2NTU of turbidity, was required to 50 mg/ℓ . In that case the removal efficiency of UV254 was also about 30∼60%.

      • 금강하구호에서 배수갑문 폐쇄 후 수질변화와 염소이온농도의 예측

        임봉수,김태응,방미란,유갑봉 大田大學校 環境問題硏究所 1998 환경문제연구소 논문집 Vol.3 No.-

        This study was carried out to forecast the chloride concentration and to investigate the water quality for industrial water supply after closing the sluice gate in Keum river estuary reservoir. Chloride concentration was dilluted by input flow, depended on outside chlorine mass than inside mass form reservoir body. The forecasting equation for chloride concentration is got Ci=3700·e ?? + 405/ ?? +2.5 without considering input chloride concentration from upstream river. The water quality in intake station for industrial water supply was satisfied for the standard for industrial water supply, but requried the physico-chemical treatment owing to maximum values of turbidity, pH, TS, Fe, Mn were exceed the standard.

      • The Meteorological Correlation Analysis of Abnormal Flight Operations at Domestic Airports

        Mi-Ran Kwak(곽미란0,Chul-Han Bang(방철한),Chee-Young Choi(최치영),Jong-Seok Kim(김종석) 한국산업경영시스템학회 2017 한국산업경영시스템학회 학술대회 Vol.2017 No.추계

        Since flight operations are determined by real-time weather conditions, the importance of weather information utilization in the airline industry is absolutely critical. Especially, abnormal flight operations due to the weather phenomenon is directly linked to a loss of airline, and also causes a deterioration in the quality of customer service. Therefore, this study analyzes occurrence conditions and correlates abnormal flight operations by the meteorological phenomenon at 4 major airports in Korea. Based on these results, it is aimed to provide a basis for stable flight operation to make the best decisions.

      • KCI등재

        Age-related Effects of Heroin on Gene Expression in the Hippocampus and Striatum of Cynomolgus Monkeys

        Mi Ran Choi,Yeung-Bae Jin,Sol Hee Bang,Chang-Nim Im,Youngjeon Lee,Han-Na Kim,Kyu-Tae Chang,이상래,김대진 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.1

        Objective: The aim of this study was to investigate differentially expressed genes and their functions in the hippocampus and striatum after heroin administration in cynomolgus macaques of different ages. Methods: Cynomolgus monkeys were divided by age as follows: 1 year (A1, n = 2); 3 to 4 years (A2, n = 2); 6 to 8 years (A3, n = 2); and older than 11 years (A4, n = 2). After heroin was injected intramuscularly into the monkeys (0.6 mg/kg), we performed large-scale transcriptome profiling in the hippocampus (H) and striatum (S) using RNA sequencing technology. Some genes were validated with real-time quantitative PCR. Results: In the hippocampus, the gene expression of A1H was similar to that of A4H, while the gene expression of A2H was similar to that of A3H. Genes associated with the mitogen-activated protein kinase signaling pathway (STMN1, FGF14, and MAPT) and -aminobutyric acid-ergic synapses (GABBR2 and GAD1) were differentially expressed among control and heroin-treated animals. Differential gene expression between A1S and A4S was the least significant, while differential gene expression between A3S and A2S was the most significant. Genes associated with the neurotrophin signaling pathway (NTRK1 and NGFR), autophagy (ATG5), and dopaminergic synapses (AKT1) in the striatum were differentially expressed among control and heroin-treated animals. Conclusion: These results suggest that even a single heroin exposure can cause differential gene expression in the hippocampus and striatum of nonhuman primates at different ages.

      • 일부 농촌 주민의 영아 엎어 재우기 실태

        방미란,임현술 東國大學校醫學硏究所 2003 東國醫學 Vol.10 No.2

        우리나라 농촌지역에서는 전통적으로 영아들을 바로 재웠는데, 최근 젊은 주부들 사이에 영아의 두상을 아름답게 하려는 목적으로 영아들을 엎어 재우는 경향이 있다. 서양에서는 대부분 영아를 엎어 재웠으나, 영아 엎어 재우기가 영아 돌연사 증후군의 위험을 증가시킨다는 보고와 함께 영아 바로 재우기 캠페인을 벌이고 있다. 따라서 본 조사는 우리나라 일부 농촌 주민의 영아 엎어 재우기 실태를 파악하고자 하였다. 경상북도 울진군 북면 및 포항시 기계면에 거주하는 30세 이상 기혼 여성 688명을 대상으로 자기 기입 방식의 설문지를 이용하여 조사하였다. 대상자의 평균 연령은 56.5(±14.1)세였으며, 교육수준은 초등학교 졸업 이하가 491명(71.4%)이었다. 대상자의 흡연율은 1.6%이었고, 음주율은 24.3%이었다. 전체 688명의 대상자는 총 2,795명의 영아를 출산하였으며, 영아 사망의 경험이 있는 대상자는 161명(23.6%)으로 총 255명의 영아 사망이 있었다. 영아를 재우는 자세에 대한 분포는 '바로 재우기만 시행한 경우'가 635명(92.3%), '엎어 재우기만 시행한 경우'가 27명(3.9%)이었다. 영아를 바로 재운 이유는 '과거부터 계속 바로 키워왔기 때문에'가 571명(86.5%)이었으며, 엎어서 재운 이유는 '두상을 아름답게 하기 위해서'가 27명(51.9%)이었다. 영아를 엎어서 재운 경우, 영아가 갑자기 사망할 가능성이 높다는 사실에 대한 인식 여부는 '알고 있지 않다'라고 응답한 대상자가 370명(53.8%)으로 절반 이상을 차지하였다. 영아를 재운 주 양상은 '부모와 함께 잤다'가 533명(77.5%)으로 가장 높았다. 현재 우리나라는 영아 엎어 재우기에 대한 정확한 실태조사 및 영아 돌연사 증후군을 예방하기 위한 대책이 미흡한 실정이다. 따라서 교육과 홍보를 통해 영아 바로 재우기를 실시함으로서 영아 돌연사 증후군을 사전에 예방하고 더 나아가 원인 규명을 위한 노력 및 연구가 필요하다. 본 조사는 일부 지역농촌 주민들을 대상으로 한 것이기 때문에 도시지역, 고학력, 신세대 주민들을 포함한 광범위한 연구가 필요하리라 생각한다. Objectives: It is traditional, in Korean villages to make the infants sleep in a supine position. However, these days, it has become the trend for young housewives to sleep in a prone position to be rounded head shape of infants. This study was carried out to investigate the status of the prone sleeping position in a Korean village. Methods: A self-administered questionnaire survey was administered to 688 married women, over the age of 30 years, in Buk-myeon, Uljin-gun and Gigye-myeon, Pohang-si, Gyeongsangbuk-do, in 2001 and 2002. Results: The prevalence of smoking and drinking were 11 (1.6%) and 167 cases (24.3%), respectively. The proportions sleeping in the supine and prone positions were 635 (92.3%) and 27 cases (3.9%), respectively. The main reason given for sleeping in a supine position, in 571 (86.5%) of cases was 'it has always been done in the past' and the main reason given for sleeping in a prone position, in 27 (51.9%) of cases was 'the influence of Western countries'. When asked if they recognized the risks of sleeping in a prone position, 370 cases (53.8%) answered 'don't know'. Conclusions: In our study, the proportion of questioned of those sleeping in a prone position was small. However, the prone sleeping position has been associated with an increased risk of SIDS. There is a need for education and campaigns regarding the effects of sleeping in a supine position, and further studies will be required to find the causes of unknown death.

      • SCIESCOPUSKCI등재

        Chronic saponin treatment attenuates damage to the pancreas in chronic alcohol-treated diabetic rats

        Mi Ran Choi,Su Min Kwak,Sol Hee Bang,Jo-Eun Jeong,Dai-Jin Kim 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.4

        Background: Chronic heavy alcohol consumption may raise the risk of developing type 2 diabetes mellitus. Saponins inhibit apoptosis of pancreatic islet cells and reduce lipid parameters. The present study was designed to investigate the effect of saponin on chronic ethanol-treated diabetic rats. Methods: LongeEvans Tokushima Fatty (LETO) and Otsuka LongeEvans Tokushima Fatty (OLETF) rats were pair-fed a LiebereDeCarli diet with and without 5% ethanol for 12 wks. Two weeks after starting the pair-feeding with the LiebereDeCarli diet, intraperitoneal injection of saponin was performed for 10 wks. To perform the experiments, rats were divided as follows: LETO-Control (LC), LETO-Ethanol (LE), LETOEthanol-Saponin (LES), OLETF-Control (OC), OLETF-Ethanol (OE), and OLETF-Ethanol-Saponin (OES). Results: The weights of epididymal and mesenteric fat tissue in LES and OES rats were the lightest from among the LETO and OLETF groups, respectively. The secretion of alanine aminotransferase and cholesterol in OES rats decreased significantly compared to their secretion in OC and OE rats, respectively. The islets of the pancreas in LE and OE rats showed clean, unclear, and smaller morphology compared to those of LC, LES, OC, and OES rats. In addition, the expression of insulin in the islets of the pancreas in LC, LES, OC, and OES rats was higher than in LE and OE rats. Conclusion: Saponin may not only be helpful in alleviating the rapid progress of diabetes due to chronic alcohol consumption in diabetic patients, but may also show potential as an antidiabetic drug candidate for diabetic patients who chronically consume alcohol.

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