서비스 공급사슬에서 의사결정자 비합리성 모형화

Mengdie Zhang,서용원 한국생산관리학회 2014 한국생산관리학회 학술대회 논문집 Vol.2014 No.-

Alpha radionuclide-chelated radioimmunotherapy promoters enable local radiotherapy/chemodynamic therapy to discourage cancer progression

Jiajia Zhang,Feize Li,Yuzhen Yin,Ning Liu,Mengqin Zhu,Han Zhang,Weihao Liu,Mengdie Yang,Shanshan Qin,Xin Fan,Yuanyou Yang,Kun Zhang,Fei Yu 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4

Background: Astatine-211 is an α-emitter with high-energy α-ray and high cytotoxicity for cancer cells. However, the targeted alpha therapy (TAT) also suffers from insufficient systematic immune activation, resulting in tumor metastasis and relapse. Combined immune checkpoint blockade (ICB) with chemodynamic therapy (CDT) could boost antitumor immunity, which may magnify the immune responses of TAT. This study aims to discourage tumor metastasis and relapse by tri-model TAT-CDT-ICB strategy. Methods: We successfully designed Mn-based radioimmunotherapy promoters (211At-ATE-MnO2-BSA), which are consisting of 211At, MnO2 and bovine serum albumin (BSA). The efficacy of 211At-ATE-MnO2-BSA was studied as monotherapy or in combination with anti-PD-L1 in both metastatic and relapse models. The immune effects of radioimmunotherapy promoters on cytotoxic T lymphocytes and dendritic cells (DCs) were analyzed by flow cytometry. Enzymelinked immunosorbent assay and immunofluorescence were used to explore the underlying mechanism. Results: Such radioimmunotherapy promoters could not only enhance the therapeutic outcomes of TAT and CDT, but also induce robust anti-cancer immune activity by activating dendritic cells. More intriguingly, 211At-ATE-MnO2-BSA could effectively suppress the growths of primary tumors and distant tumors when combined with immune checkpoint inhibitors. Conclusions: The tri-model TAT-CDT-ICB strategy provides a long-term immunological memory, which can protect against tumor rechallenge after eliminating original tumors. Therefore, this work presents a novel approach for TATCDT-ICB tri-modal cancer therapy with repressed metastasis and relapse in clinics.

Optimization of Mix Proportion of Self-compacting Concrete Based on Single Fluid Model

Xiuzhi Zhang,Chong Zhang,Mengdi Bi,Haibo Yang,Hailong Sun,Ru Mu 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.3

The study aims to optimize the mix proportion of self-compacting concrete according to the workability and compressive strength. Firstly, based on computational fluid dynamics, the flowability and filling ability of self-compacting concrete were simulated by the single-fluid model to verify the single-fluid model. And then, the simulation of casting a pre-cambered composite beam was carried out. In the end, the mix proportion was optimized considering the filling ability and the compressive strength of self-compacting concrete. The results showed that increasing sand rate can improve the workability and decrease the rheological parameters of self-compacting concrete. The mixture with a 45% sand ratio in the case of 3% silica fume alone or 43% sand ratio in the case of 30% granulated blast furnace slag and 3% silica fume had adequate filling ability and excellent long term compressive strength. Moreover, the model can be used to simulate the filling ability and passing capacity of self-compacting concrete and the maximum error between the simulation results and the actual measured value is 4.80%. When the concrete mixture is considered to be uniform, namely, without considering the effect of the aggregates, the single-fluid model can simulate the casting of self-compacting concrete.

Effects of Fengliao-Changweikang in Diarrheapredominant Irritable Bowel Syndrome Rats and Its Mechanism Involving Colonic Motility

( Mengdi Jia ),( Xiaofang Lu ),( Zhengfang Wang ),( Luqing Zhao ),( Shengsheng Zhang ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2018 Journal of Neurogastroenterology and Motility (JNM Vol.24 No.3

Background/Aims This study was designed to investigate the effect of Fengliao-Changweikang (FLCWK) in diarrhea-predominant irritable bowel syndrome (IBS-D) rats and explore its underlying mechanisms. Methods IBS-D model rats were induced by neonatal maternal separation (NMS) combined with restraint stress (RS). In in vivo experiments, the model rats were randomly divided into 5 groups: NMS + RS, FLCWK (low dose, middle dose, and high dose), and pinaverium bromide. The normal control (no handling) rats were classified as the NH group. The therapeutic effect of FLCWK was evaluated by fecal characteristics, electromyographic response and abdominal withdrawal reflex scores. In in vitro experiments, the model rats were randomly divided into 2 groups: NMS + RS, FLCWK (middle dose), and no handling rats were used as the NH group. The differences in basic tension and ACh-induced tension of isolated colonic longitudinal smooth muscle strips (CLSMs) among the 3 groups were observed. In addition, different inhibitors (nifedipine, TMB-8, L-NAME, methylene blue, and 4-AP) were pretreated to explore the underlying mechanisms. Results In in vivo experiments, fecal characteristics, electromyographic response, and abdominal withdrawal reflex scores significantly improved in the FLCWK group, compared with the NMS + RS group. In in vitro experiments, the basic tension and ACh-induced tension of CLSMs in IBS-D rats were significantly inhibited by FLCWK. After pre-treatment with different inhibitors, the ACh-induced tension of CLSMs in each group showed no significant difference. Conclusions FLCWK manifested curative effect in IBS-D rats by inhibiting colonic contraction. The underlying mechanisms may be related to regulatory pathway of nitric oxide/cGMP/Ca²⁺ and specific potassium channels. (J Neurogastroenterol Motil 2018;24:479-489)

Crowd escape event detection based on Direction-Collectiveness Model

( Mengdi Wang ),( Faliang Chang ),( Youmei Zhang ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.9

Crowd escape event detection has become one of the hottest problems in intelligent surveillance filed. When the ‘escape event’ occurs, pedestrians will escape in a disordered way with different velocities and directions. Based on these characteristics, this paper proposes a Direction-Collectiveness Model to detect escape event in crowd scenes. First, we extract a set of trajectories from video sequences by using generalized Kanade-Lucas-Tomasi key point tracker (gKLT). Second, a Direction-Collectiveness Model is built based on the randomness of velocity and orientation calculated from the trajectories to express the movement of the crowd. This model can describe the movement of the crowd adequately. To obtain a generalized crowd escape event detector, we adopt an adaptive threshold according to the Direction-Collectiveness index. Experiments conducted on two widely used datasets demonstrate that the proposed model can detect the escape events more effectively from dense crowd.

The prognostic significance of tumor-infiltrating lymphocytes in cervical cancer

Mengdi He,Yiying Wang,Guodong Zhang,Kankan Cao,Moran Yang,Haiou Liu 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.3

Objective: To predict the prognosis of cervical cancer, we constructed a novel model with 5specific cell types and identified a potential biomarker. Methods: We employed CIBERSORT and xCell method to evaluate the abundances of 23cells types in tumor microenvironment. Five specific cell types were filtrated to determinedifferent immunotypes by applying least absolute shrinkage and selection operator (LASSO)Cox regression method. The expression of immune checkpoints (ICPs) and effectors werevalidated by immunohistochemistry. Correlation analysis was performed to examine therelevance between PIK3CA mutational status and ICPs. Results: Unsupervised clustering of patients on the basis of tumor infiltrating lymphocytesand fibroblasts identified patients with shorter overall survival (OS) (hazard ratio[HR]=3.0729; 95% confidence interval [CI]=1.5103–6.2522; p=0.0118). An immunoscore(IS) signature consisting of 5 immune cell types infiltrating in tumor core (CD8T, activatedNK cells, neutrophils, activated mast cells, macrophages) was constructed using LASSO Coxregression analysis. Receiver operating characteristic curves confirmed that the area underthe curve of IS was significantly higher to that of International Federation of Gynecology andObstetrics staging alone (0.637 vs. 0.55). Survival analysis revealed patients in high IS groupexhibited a poorer OS (HR=3.0113; 95% CI=1.8746–4.8373; p<0.0001). The multivariateanalysis indicated the IS was an independent prognostic factor. In addition, the lower ISrelated to higher expression of ICPs and neoantigen load. Conclusions: The identification of IS in cervical cancer tissues could facilitate patient riskstratification and selection of immunotherapeutic responses, but more prospective studiesare needed to assess its reliability.

Guaranteed Fault-estimation Algorithm Based on Interval Set Inversion Observer Filtering

Ziyun Wang,Mengdi Zhang,Yuqian Chen,Yan Wang,Zhicheng Ji 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.11

A guaranteed fault-estimation algorithm based on interval set inversion observer filtering is proposed for linear discrete-time systems with unknown but bounded disturbance and noise. The minimal conservative interval observer is designed by minimizing the F-norm of the state error. Vector Boolean operations and dimensional operations are used to develop a new interval set inversion algorithm to further contract the guaranteed interval estimation results of the observer. The computational complexity, memory requirements, and accuracy of the proposed algorithm are also analyzed. Finally, simulation examples are provided to verify the efficiency and practicability of the proposed algorithm.

Recent advances in heighten sulfur resistance of SCR catalysts: A review

Ling Zhao,Yu Zhang,Mengdi Kang 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.1

NOx removal by selective catalytic reduction (SCR) technology is a research hotspot in the field of environmental catalysis, and this method is dominated by catalysts. However, denitrification catalyst is easy to be polluted by the presence of SO₂, which seriously restricts its practical industrial application. This review focuses on the latest domestic and foreign research results and advancement in improving sulfur resistance of deNOx catalysts, reveals the sulfur poisoning mechanism and regeneration process, as well as introduces the positive role of quantum chemistry in the field of sulfur resistance. In view of the questions set forth in this review, the future development direction of deNOx catalysts is prospected, which provides valuable scientific guidance for the design and development of efficient and practical sulfur resistant deNOx catalysts.

Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ

Hongming Li,Yumei Qiu,Mengdie Xie,Changsheng Ouyang,Xiaoyun Ding,Hao Zhang,Wei Dong,Yinhua Xiong,Xilan Tang 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.1

This study aimed to observe the protective effect of momordicine I, a triterpenoid compound extracted from momordica charantia L., on isoproterenol (ISO)-induced hypertrophy in rat H9c2 cardiomyocytes and investigate its potential mechanism. Treatment with 10 μM ISO induced cardiomyocyte hypertrophy as evidenced by increased cell surface area and protein content as well as pronounced upregulation of fetal genes including atrial natriuretic peptide, β-myosin heavy chain, and α-skeletal actin; however, those responses were markedly attenuated by treatment with 12.5 μg/ml momordicine I. Transcriptome experiment results showed that there were 381 and 447 differentially expressed genes expressed in comparisons of model/control and momordicine I intervention/model, respectively. GO enrichment analysis suggested that the anti-cardiomyocyte hypertrophic effect of momordicine I may be mainly associated with the regulation of metabolic processes. Based on our transcriptome experiment results as well as literature reports, we selected glycerophospholipid metabolizing enzymes group VI phospholipase A2 (PLA2G6) and diacylglycerol kinase ζ (DGK-ζ) as targets to further explore the potential mechanism through which momordicine I inhibited ISO-induced cardiomyocyte hypertrophy. Our results demonstrated that momordicine I inhibited ISO-induced upregulations of mRNA levels and protein expressions of PLA2G6 and DGK-ζ. Collectively, momordicine I alleviated ISO-induced cardiomyocyte hypertrophy, which may be related to its inhibition of the expression of glycerophospholipid metabolizing enzymes PLA2G6 and DGK-ζ.

Design of carbonized unidirectional polyimide aerogel for CO2 capture: Effect of pore morphology/topology on CO2 capture

Xinfu Zhao,Yihao Nie,Xibin Yi,Shimo Yu,Jing Zhang,Xiaochan Liu,Zhipeng Yuan,Sijia Liu,Jian Zhang,Guoliang Dou,Mengdi Wang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-

Design of efficient CO2 adsorbent is an effective way to capture CO2. Bamboo-derived activated carbon isa promising CO2 adsorbent. Inspired by this, carbonized unidirectional polyimide (CUPI) aerogels werenewly designed by the ice templating method using directional freezing technology. The pore propertyof CUPI aerogel can be tuned by changing the solidification velocity, and a series of CUPI aerogels weredesigned to explore the CO2 capture performance in view of pore morphology/topology. As a result,the obtained CUPI-8 exhibits higher CO2 adsorption capacity compared to carbonized polyimide aerogelsdue to the synergistic effect of micropores and lamellar pores. Specially, the CO2 adsorption capacity overCUPI-8 can be up to 5.75 mmol/g at 20 bar and 298 K. Furthermore, the adsorption isotherm of CUPI-8still shows an upward trend even nearly 20 bar. The isosteric adsorption heat (Qst) value of CUPI-8 isnearly in the ideal scope of 30–50 kJ mol1. The efficient CO2 adsorption performance and good chemicalstability of CUPI aerogel makes it a promising absorbent for practical application. This work provides anew opportunity for researching the effect of pore morphology/topology and the synergistic effect ofhierarchical pores on CO2 capture.