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- 저자 : Shanshan Qin (검색결과 2 건)
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Transparent and Self-Powered Multistage Sensation Matrix for Mechanosensation Application
Zhang, Qian,Jiang, Tao,Ho, Donghae,Qin, Shanshan,Yang, Xixi,Cho, Jeong Ho,Sun, Qijun,Wang, Zhong Lin American Chemical Society 2018 ACS NANO Vol.12 No.1
<P>Electronic skin based on a multimodal sensing array is ready to detect various stimuli in different categories by utilizing highly sensitive materials, sophisticated geometry designs, and integration of multifunctional sensors. However, it is still difficult to distinguish multiple and complex mechanical stimuli in a local position by conventional multimodal E-skin, which is significantly important in the signals’ feedback of robotic fine motions and human–machine interactions. Here, we present a transparent, flexible, and self-powered multistage sensation matrix based on piezoelectric nanogenerators constructed in a crossbar design. Each sensor cell in the matrix comprises a layer of piezoelectric polymer sandwiched between two graphene electrodes. The simple lamination design allows sequential multistage sensation in one sensing cell, including compressive/tensile strain and detaching/releasing area. Further structure engineering on PDMS substrate allows the sensor cell to be highly sensitive to the applied pressures, representing the minimum sensing pressure below 800 Pa. As the basic combinations of compressive/tensile strains or detaching/releasing represent individual output signals, the proposed multistage sensors are capable of decoding to distinguish external complex motions. The proposed self-powering multistage sensation matrix can be used universally as an autonomous invisible sensory system to detect complex motions of the human body in local position, which has promising potential in movement monitoring, human–computer interaction, humanoid robots, and E-skins.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2018/ancac3.2018.12.issue-1/acsnano.7b06126/production/images/medium/nn-2017-06126z_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn7b06126'>ACS Electronic Supporting Info</A></P>
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Jiajia Zhang,Feize Li,Yuzhen Yin,Ning Liu,Mengqin Zhu,Han Zhang,Weihao Liu,Mengdie Yang,Shanshan Qin,Xin Fan,Yuanyou Yang,Kun Zhang,Fei Yu 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: Astatine-211 is an α-emitter with high-energy α-ray and high cytotoxicity for cancer cells. However, the targeted alpha therapy (TAT) also suffers from insufficient systematic immune activation, resulting in tumor metastasis and relapse. Combined immune checkpoint blockade (ICB) with chemodynamic therapy (CDT) could boost antitumor immunity, which may magnify the immune responses of TAT. This study aims to discourage tumor metastasis and relapse by tri-model TAT-CDT-ICB strategy. Methods: We successfully designed Mn-based radioimmunotherapy promoters (211At-ATE-MnO2-BSA), which are consisting of 211At, MnO2 and bovine serum albumin (BSA). The efficacy of 211At-ATE-MnO2-BSA was studied as monotherapy or in combination with anti-PD-L1 in both metastatic and relapse models. The immune effects of radioimmunotherapy promoters on cytotoxic T lymphocytes and dendritic cells (DCs) were analyzed by flow cytometry. Enzymelinked immunosorbent assay and immunofluorescence were used to explore the underlying mechanism. Results: Such radioimmunotherapy promoters could not only enhance the therapeutic outcomes of TAT and CDT, but also induce robust anti-cancer immune activity by activating dendritic cells. More intriguingly, 211At-ATE-MnO2-BSA could effectively suppress the growths of primary tumors and distant tumors when combined with immune checkpoint inhibitors. Conclusions: The tri-model TAT-CDT-ICB strategy provides a long-term immunological memory, which can protect against tumor rechallenge after eliminating original tumors. Therefore, this work presents a novel approach for TATCDT-ICB tri-modal cancer therapy with repressed metastasis and relapse in clinics.
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