Happy Children’s Day

Ma Jia Yi 한국콘텐츠학회 2022 한국콘텐츠학회 ICCC 논문집 Vol.2022 No.12

Happy Children’s Day

Ma Jia Yi 한국콘텐츠학회 2022 ICCC International Digital Design Invitation Exhib Vol.2022 No.12

Intravoxel Incoherent Motion Magnetic Resonance Imaging for Assessing Parotid Gland Tumors: Correlation and Comparison with Arterial Spin Labeling Imaging

Ma Gao,Xu Xiao-Quan,Zhu Liu-Ning,Jiang Jia-Suo,Su Guo-Yi,Hu Hao,Bu Shou-Shan,Wu Fei-Yun 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.2

Objective: To compare and correlate the findings of intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging and arterial spin labeling (ASL) imaging in characterizing parotid gland tumors. Materials and Methods: We retrospectively reviewed 56 patients with parotid gland tumors evaluated by MR imaging. The true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and fraction of perfusion (f) values of IVIM imaging and tumor-to-parotid gland signal intensity ratio (SIR) on ASL imaging were calculated. Spearman rank correlation coefficient, chi-squared, Mann-Whitney U, and Kruskal-Wallis tests with the post-hoc Dunn-Bonferroni method and receiver operating characteristic curve assessments were used for statistical analysis. Results: Malignant parotid gland tumors showed significantly lower D than benign tumors (p = 0.019). Within subgroup analyses, pleomorphic adenomas (PAs) showed significantly higher D than malignant tumors (MTs) and Warthin’s tumors (WTs) (p < 0.001). The D* of WTs was significantly higher than that of PAs (p = 0.031). The f and SIR on ASL imaging of WTs were significantly higher than those of MTs and PAs (p < 0.05). Significantly positive correlation was found between SIR on ASL imaging and f (r = 0.446, p = 0.001). In comparison with f, SIR on ASL imaging showed a higher area under curve (0.853 vs. 0.891) in discriminating MTs from WTs, although the difference was not significant (p = 0.720). Conclusion: IVIM and ASL imaging could help differentiate parotid gland tumors. SIR on ASL imaging showed a significantly positive correlation with f. ASL imaging might hold potential to improve the ability to discriminate MTs from WTs.

Study on failure mechanism of line contact structures of nuclear graphite

Jia Shigang,Yi Yanan,Wang Lu,Liu Guangyan,Ma Qinwei,Sun Libin,Shi Li,Ma Shaopeng 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.8

Line contact structures, such as the contact between graphite brick and graphite tenon, widely exist in high-temperature gas-cooled reactors. Due to the stress concentration effect, the line contact area is one of the dangerous positions prone to failure in the nuclear reactor core. In this paper, the failure mechanism of line contact structures composed of IG11 nuclear graphite column and brick were investigated by means of experiment and finite element simulation. It was found that the failure process mainly includes three stages: firstly, the damage accumulation in nuclear graphite material led to the characteristic yielding of the line contact structure, but no macroscopic failure can be observed at this stage; secondly, the stresses near the contact area met Mohr failure criterion, and a crack initiated and propagated laterally in the contact zone, that is, local macroscopic failure occurred at this stage; finally, a second crack initiated in the contact area and developed in to a Y-shape, resulting in the final failure of the structure. This study lays a foundation for the structural design and safety assessment of hightemperature gas-cooled reactors

Determination of the energy contents and nutrient digestibility of corn, waxy corn and steam-flaked corn fed to growing pigs

Dongli Ma,Juntao Li,Chengfei Huang,Fengjuan Yang,Yi Wu,Ling Liu,Wei Jiang,Zhicheng Jia,Peijun Zhang,Xuezhen Liu,Shuai Zhang 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.10

Objective: The research was conducted to determine the digestible (DE) and metabolizable energy (ME) contents as well as the apparent total tract digestibility (ATTD) of nutrients in corn, waxy corn and steam-flaked corn fed to growing pigs. Methods: Eighteen growing pigs with initial body weight of 15.42±1.41 kg were randomly allotted to three diets including a corn diet, a waxy corn diet and a steam-flaked corn diet in a completely randomized design. Each treatment contained six replicates. The experiment lasted for 12 days, which comprised 7-d adaptation to diets followed by a 5-d total collection of feces and urine. The energy contents and the nutrient digestibility in three ingredients were calculated using direct method. Results: Compared to normal corn, both the amylose and dietary fiber contents in waxy corn were numerically lower, but the starch gelatinization degree was numerically greater. Moreover, the DE and ME contents as well as the ATTD of neutral detergent fiber and acid detergent fiber (ADF) in waxy corn were significantly greater (p<0.05) than those in normal corn when fed to growing pigs. Furthermore, the steam-flaked corn had greater (p<0.05) DE and ME contents, and ATTD of ether extract and ADF compared to normal corn. Conclusion: Both variety and processing procedure have influence on chemical compositions, energy contents and nutrient digestibility of corn. The waxy corn and steam-flaked corn had greater degree of starch gelatinization and DE and ME contents compared to normal corn when fed to growing pigs.

Mapping QTLs for Tissue Culture Response of Mature Wheat Embryos

Haiyan Jia,Dalong Yi,Jie Yu,Shulin Xue,Yang Xiang,Caiqin Zhang,Zhengzhi Zhang,Lixia Zhang,Zhengqiang Ma 한국분자세포생물학회 2007 Molecules and cells Vol.23 No.3

Long non-coding RNAs in Sus scrofa ileum under starvation stress

Wang Shu,Ma Yi Jia,Li Yong Shi,Ge Xu Sheng,Lu Chang,Cai Chunbo,Yang Yang,Zhao Yan,Liang Guo Ming,Guo Xiaohong,Cao Guoqing,Li Bugao,Gao Pengfei 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.7

Objective: In this study, we aimed to identify long non-coding RNAs (lncRNAs) that play important roles in starvation stress, analyze their functions, and discover potential molecular targets to alleviate starvation stress to provide a theoretical reference for subsequent in-depth research. Methods: We generated a piglet starvation stress animal model. Nine Yorkshire weaned piglets were randomly divided into a long-term starvation stress group (starved for 72 h), short-term starvation stress group (starved for 48 h), and the control group. LncRNA libraries were constructed using high-throughput sequencing of piglet ileums. Results: We obtained 11,792 lncRNAs, among which, 2,500 lncRNAs were novel. In total, 509 differentially expressed (DE)lncRNAs were identified in this study. Target genes of DElncRNAs were predicted via cis and trans interactions, and functional and pathway analyses were performed. Gene ontology functions and Kyoto encyclopedia of genes and genomes analysis revealed that lncRNA-targeted genes mainly participated in metabolic pathways, cellular processes, immune system processes, digestive systems, and transport activities. To reveal the mechanism underlying starvation stress, the interaction network between lncRNAs and their targets was constructed based on 26 DElncRNAs and 72 DEmRNAs. We performed an interaction network analysis of 121 DElncRNA–DEmRNA pairs with a Pearson correlation coefficient greater than 0.99. Conclusion: We found that MSTRG.19894.13, MSTRG.16726.3, and MSTRG.12176.1 might play important roles in starvation stress. This study not only generated a library of enriched lncRNAs in piglets, but its outcomes also provide a strong foundation to screen key lncRNAs involved in starvation stress and a reference for subsequent in-depth research. Objective: In this study, we aimed to identify long non-coding RNAs (lncRNAs) that play important roles in starvation stress, analyze their functions, and discover potential molecular targets to alleviate starvation stress to provide a theoretical reference for subsequent in-depth research.Methods: We generated a piglet starvation stress animal model. Nine Yorkshire weaned piglets were randomly divided into a long-term starvation stress group (starved for 72 h), short-term starvation stress group (starved for 48 h), and the control group. LncRNA libraries were constructed using high-throughput sequencing of piglet ileums.Results: We obtained 11,792 lncRNAs, among which, 2,500 lncRNAs were novel. In total, 509 differentially expressed (DE)lncRNAs were identified in this study. Target genes of DElncRNAs were predicted via cis and trans interactions, and functional and pathway analyses were performed. Gene ontology functions and Kyoto encyclopedia of genes and genomes analysis revealed that lncRNA-targeted genes mainly participated in metabolic pathways, cellular processes, immune system processes, digestive systems, and transport activities. To reveal the mechanism underlying starvation stress, the interaction network between lncRNAs and their targets was constructed based on 26 DElncRNAs and 72 DEmRNAs. We performed an interaction network analysis of 121 DElncRNA–DEmRNA pairs with a Pearson correlation coefficient greater than 0.99.Conclusion: We found that MSTRG.19894.13, MSTRG.16726.3, and MSTRG.12176.1 might play important roles in starvation stress. This study not only generated a library of enriched lncRNAs in piglets, but its outcomes also provide a strong foundation to screen key lncRNAs involved in starvation stress and a reference for subsequent in-depth research.

Effect of Run Ze Tonic in Mice with Kidney-Yin Deficiency

Shuo Liu,Si-yao Ma,Wen-yi Zhu,Jia Liang,Hong Meng 한국피부과학연구원 2021 아시안뷰티화장품학술지 Vol.19 No.1

목적: 본 연구는 Run Ze Tonic의 신장-음 결핍 마우스의 갑상선 호르몬, 부신 기능, 성 호르몬 및 주기적 뉴클레오티드에 미치는 영향을 관찰하고자 한다. 방법: ICR 마우스를 정상 대조군, 모델 그룹, Run Ze Tonic 고용량 그룹, 중간 용량 그룹 및 저용량 그룹으로 분류하였으며, 매 그룹은 20마리씩 구성하였다. 신장-음 결핍 마우스 모델은 연속 10 일 동안 1 일 1 회 레보 티록신 나트륨을 위내 직접 투여에 의해 확립되었다. 각 그룹의 마우스의 일반특징 및 체중을 관찰하고 장기지수를 측정하였다. 그리고 ELISA 방법으로 테트라 요오 도티 로닌 (T4), 트리 요오 도티 로닌 (T3), 갑상선 호르몬 (TSH), 코르티코 트로 핀 방출 호르몬 (CRH), 부 신피질 자극 호르몬 (ACTH), 코르티 코스 테론 (CORT), 테스토스테론 (T), 에스트라 디올 (E2), 고리 형 아데노신 모노 포스페이트 (cAMP) , 사 이 클릭 구아노 신 모노 포스페이트 (cGMP)를 측정하였다. 결과: Run Ze Tonic 고용량군은 신장-음결핍 마우스의 일반적인 신체 징후를 개선하고, 체중을 증가시키고(p<0.05), TSH 함량을 증가시킨다(p<0.01). 고용량 군에서 T3 및 T4 수치가 유의하게 감소하 였으며(p<0.01), ACTH 수준도 유의하게 감소하였다(p<0.05). 신장 음 결핍 암컷 마우스는 고용량 군에서 성 호르몬 E2 및 E2/T 비 율이 유의하게 감소(p<0.01)하였다. 신장 음이 결핍 된 수컷 마우스의 경우 고용량 군에서 성 호르몬 T함량이 유의하게 증가되었다 (p<0.05). 그리고 고용량 군에서 고리 형 뉴클레오티드 시스템의 cAMP 수치가 감소하였다(p<0.01). 결론: Run Ze Tonic은 내분비 계에서 호르몬 수치 장애, 부신 피질 기능 및 에너지 대사 균형을 조절하여 음양을 키우고 신장을 강화하는 역할을 할 수 있다고 사료된다. Purpose: To observe the effects of Run Ze Tonic on thyroid hormone, adrenal function, sex hormones and cyclic nucleotide of mice with kidney-yin deficiency. Methods: ICR mice were randomly grouped into normal control group, model group, Run Ze Tonic high dose group, the middle dose group and low dose group, male and female in half. The kidney-yin deficiency mice models were established by intragastric administration of levothyroxine sodium before intragastric administration of corresponding drugs once a day for 10 consecutive days. One day after the last administration, the effects were observed by measuring weight. And tetraiodothyronine (T4), triiodothyronine (T3), thyrotropin (TSH), corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), corticosterone (CORT), testosterone (T), estradiol (E2), cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP) were tested by ELISA method. Results: Compared with the model group, the body weight, TSH level increased significantly (p <0.01, p<0.05), and T3, T4, ACTH level decreased significantly in high dose group (p <0.01, p <0.05). The E2 level in female decreased significantly in high dose group (p <0.01), the same as the ratio of E2/T (p <0.01). The T level in male increased significantly in high dose group (p <0.01), the same as the ratio of E2/T (p <0.01). And cAMP level decreased in the high dose group(p <0.05). Conclusion: Run Ze Tonic may play the role of nourishing yin and strengthening kidney by adjusting hormone level disorder, adrenal cortex function and balancing energy metabolism in endocrine system.

Clinical Application of MRI in an Animal Bone Graft Model

Xiaochen Liu,Wenxiao Jia,Gele Jin,Hong Wang,Jingxu Ma,Yunling Wang,Yi Yang,Wei Deng 한국자기학회 2013 Journal of Magnetics Vol.18 No.2

We aim to monitor vascularization of early bone perfusion following rabbit lumbar intertransverse bone graft fusion surgery using magnetic resonance imaging assessment. Correlation with graft survival status was evaluated by histological method. Experimental animals were randomly divided into three groups and the model was established by operating bilateral lumbar intertransverse bone graft with different types of bone graft substitute material. The lumbar intertransverse area of three groups of rabbits was scanned via MRI. In addition, histological examinations were performed at the 6<SUP>th</SUP> week after surgery and the quantitative analysis of the osteogenesis in different grafted area was carried out by an image analysis system. The MRI technique can be used for early postoperative evaluation of vascularized bone graft perfusion after transplantation of different bone materials, whereas histological examination allows direct visualization of the osteogenesis process.

Intracerebral Hemorrhage Progression Score: A Novel Risk Score to Predict Neurological Deterioration after Intracerebral Hemorrhage

Ruijun Ji,Linlin Wang,Feifei Ma,Wenjuan Wang,Yanfang Liu,Runhua Zhang,Dandan Wang,Jiaokun Jia,Hao Feng,Gaifen Liu,Yi Ju,Jingjing Lu,Xingquan Zhao 대한뇌졸중학회 2022 Journal of stroke Vol.24 No.2

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