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Hui Shen,Meng Guo,Lu Wang,Xinyue Cui 한국유전학회 2020 Genes & Genomics Vol.42 No.2
Objectives MUC16 (mucin 16, also known as CA-125, cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) has been predicted as tumor biomarker for therapy. We determined to investigate effects and regulatory mechanism of MUC16 on cervical tumorigenesis. Methods Expression levels of MUC16 in cervical cancer cell lines was analyzed via qRT-PCR (quantitative real-time polymerase chain reaction). Knockdown of MUC16 was conducted via shRNA (Short hairpin RNA) transfection. MTT and colony formation assays were used to investigate effect of MUC16 on cell proliferation. Wound healing assay was utilized to detect migration and transwell assay to detect invasion. The underlying mechanism was demonstrated via western blot analysis. Results MUC16 was elevated in cervical cancer cell lines. MUC16 knockdown inhibited cell proliferation, invasion and migration. Gain- and loss-of functional assays revealed that over-expression of MUC16 activated Janus Kinase 2 (JAK2)/ signal transducer and activator of transcription 3 (STAT3) via phosphorylation, thus facilitating cyclooxygenase-2 (COX-2) expression, while knockdown of MUC16 demonstrated the reverse effect on JAK2/STAT3 activation and COX-2 expression. Moreover, inhibition of JAK2/STAT3 attenuated the regulation of MUC16 on COX-2. Conclusions MUC16 enhanced proliferation and invasion of cervical cancer cells via JAK2/STAT3 phosphorylation-mediated cyclooxygenase-2 expression, suggesting the potential therapeutic target ability of MUC16 to treat cervical cancer.
Lu, Hui,Kim, Jong Pyo,Son, Sou Hwan,Park, Jung Hoon Elsevier 2010 Materials science and engineering B. Advanced Func Vol.166 No.2
<P><B>Abstract</B></P><P>The perovskite La<SUB>0.6</SUB>Sr<SUB>0.4</SUB>M<SUB>0.3</SUB>Fe<SUB>0.7</SUB>O<SUB>3−<I>δ</I></SUB> (M=Co, Ti) powders have been synthesized by the citrate gel method. The structural and chemical stability of the La<SUB>0.6</SUB>Sr<SUB>0.4</SUB>M<SUB>0.3</SUB>Fe<SUB>0.7</SUB>O<SUB>3−<I>δ</I></SUB> (M=Co, Ti) oxides were studied by X-ray diffraction (XRD), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) techniques. The electrical conductivities of the sintered La<SUB>0.6</SUB>Sr<SUB>0.4</SUB>M<SUB>0.3</SUB>Fe<SUB>0.7</SUB>O<SUB>3−<I>δ</I></SUB> (M=Co, Ti) ceramics were measured. The results demonstrate the chemical stability in H<SUB>2</SUB>/helium (He) atmosphere of the La<SUB>0.6</SUB>Sr<SUB>0.4</SUB>Ti<SUB>0.3</SUB>Fe<SUB>0.7</SUB>O<SUB>3−<I>δ</I></SUB> oxide is improved significantly compared to that of the La<SUB>0.6</SUB>Sr<SUB>0.4</SUB>Co<SUB>0.3</SUB>Fe<SUB>0.7</SUB>O<SUB>3−<I>δ</I></SUB> oxide. The incorporation of Ti<SUP>3+/4+</SUP> ions in the perovskite structure can significantly stabilize the neighboring oxygen octahedral due to the stronger bonding strength, leading to the enhanced structural and chemical stability of the La<SUB>0.6</SUB>Sr<SUB>0.4</SUB>Ti<SUB>0.3</SUB>Fe<SUB>0.7</SUB>O<SUB>3−<I>δ</I></SUB>. In addition, the perovskite La<SUB>0.6</SUB>Sr<SUB>0.4</SUB>M<SUB>0.3</SUB>Fe<SUB>0.7</SUB>O<SUB>3−<I>δ</I></SUB> (M=Co, Ti) oxides possess much higher chemical stability in CO<SUB>2</SUB>/He atmosphere than that of Ba<SUB>0.5</SUB>Sr<SUB>0.5</SUB>Co<SUB>0.8</SUB>Fe<SUB>0.2</SUB>O<SUB>3−<I>δ</I></SUB> oxide, in which the perovskite structure is destroyed completely in a flowing CO<SUB>2</SUB>-containing atmosphere.</P>
El estudio de la coligacin basado en el corpus
Hui-Chan Lu 한국스페인어문학회 2007 스페인어문학 Vol.0 No.45
El presente trabajo se dedica a estudiar la coligación, es decir, la asociación entre el léxico y la sintaxis, basándonos en el análisis de dos tipos de corpus, por un lado el de los aprendices taiwaneses, que representa la lengua adquirida, extrayendo datos del CAET (Corpus de Aprendices de Español Taiwaneses); y por otro, el de los hablantes nativos de español, chino e inglés, que representan la lengua natural, analizando los datos de tres corpus, el Corpus del Español, el Sinica Corpus y el British National Corpus). Nuestro objetivo será asimilar equitativamente de las dos variedades de lengua y ayudar a los aprendices taiwaneses que aprenden español como segunda lengua extranjera a aumentar su nivel léxico con eficacia. La contribución principal del presente estudio estriba en el hecho de relacionar cuatro corpus de diferentes aspectos para dar luz acerca de diversas cuestiones: el aprendizaje léxicogramatical, la identificación de la relación entre la lengua aprendida y la natural española, y el examen de diferentes factores que pueden intervenir en la adquisición de una segunda lengua extranjera.
Biological characterization of mesenchymal stem cells from bovine umbilical cord
Hui Xiong,Wei Jun Guan,Yue Hui Ma,Chunyu Bai,Shuang Wu,Yuhua Gao,Taofeng Lu,Qingyun Hu 한국통합생물학회 2014 Animal cells and systems Vol.18 No.1
Mesenchymal stem cells (MSCs) are multi-potential cells that are able to proliferate and differentiate into othercell types. Much research has been done on the MSCs from the umbilical cord (UCMSCs) in human, mice, andavian, but little literature has been published about these cells in big livestock. Here, we choose Luxi cattle asthe experimental animal, we describe an external culture of the UCMSCs from it and summarize the biologicalcharacteristics of these cells, e.g., morphologic appearance, surface antigens, colony-forming ability, geneexpression, and differentiation potential were detected via using immunofluorescence and reverse transcriptionpolymerase chain reaction (RT-PCR). The induced cells, osteoblast, lipoblast, hepatocyte, islet cells, andneurocyte were identified by Alizarin red staining, Oil-red-O staining, Periodic acid-schiff staining, andDithizone staining and RT-PCR detection for specific genes. Results suggest that biological characteristics ofthe UCMSCs were similar to those of MSCs previously analyzed. The primary UCMSCs were sub-cultured topassage 32, the UCMSCs expressed gene CD29, CD44, CD73, CD90, and CD166, induced cells illustratedtypical staining, and expressed specific genes, which indicate that the UCMSCs could be a novel alternativesource of MSCs for experimental and clinical applications.
Lu Hui,Li Fen,Zhu Xiaoming,Tang Jihong,Lyu Baoqian,Wu Shaoying 한국곤충학회 2021 Entomological Research Vol.51 No.9
Spraying insecticides by unmanned aerial vehicle (UAV) is an effective method to prevent and control Spodoptera frugiperda. This study investigated the influences of different UAV types, spray adjuvants, spray times, maize growth periods, and insecticides on S. frugiperda in three cities, Hainan Province, China. The results showed that at least two times are needed to spray insecticides using UAVs when controlling the S. frugiperda. Both UAVs had a substantially higher control effect and lower cost than artificial spray methods. Oil spray adjuvant Refei was more suitable for both UAVs than Tiancheng to control pests. Chlorantraniliprole had the best control effect of up to 90%. The control effects at the seedling stage and small bell stage of S. frugiperda were 94.3% and 91.3%, respectively. Spraying at 7:00 am and 7:00 pm by UAVof T20 had good control effect on S. frugiperda in three cities.
Lu, Hui-Chuan,Liu, Kai-Ling,Yeh, Chien-Ting,Chen, Ya-Jie Institute for Corpus Research 2022 Asia pacific journal of corpus research Vol.3 No.1
This study aims to apply corpus-based approach to analyze The Yellow Wall-Paper and Herland written by Charlotte Perkins Gilman, a women's rights activist in the late nineteenth-century America. Although both works have attracted feminists' attention to the woman question that concerned Gilman, discussion on her language features and their relation to the literary themes of these two works is still in need. In this corpus-based analysis, we argue that the main themes of different literary works can be revealed through linguistic patterns identified by number and gender features of nouns and pronouns in the contrast of two works and a balanced corpus. The linguistic features (number and gender) have been related with two themes, the 'group and individual' and the 'feminine and masculine', and are further interpreted in terms of mothering and feminine consciousness. By adopting linguistic approach, our study provides quantitative and qualitative evidence to verify the established themes and arguments of these literary texts.
Complex dental anomalies in a belatedly diagnosed cleidocranial dysplasia patient
Lu, Hui,Zeng, Binghui,Yu, Dongsheng,Jing, Xiangyi,Hu, Bin,Zhao, Wei,Wang, Yiming Korean Academy of Oral and Maxillofacial Radiology 2015 Imaging Science in Dentistry Vol.46 No.1
Cleidocranial dysplasia (CCD) is a rare congenital disorder, typically characterized by persistently open skull sutures, aplastic or hypoplastic clavicles, and supernumerary teeth. Mutations in the gene encoding the runt-related transcription factor 2 (RUNX2) protein are responsible for approximately two thirds of CCD patients. We report a 20-year-old CCD patient presenting not only with typical skeletal changes, but also complex dental anomalies. A previously undiagnosed odontoma, 14 supernumerary teeth, a cystic lesion, and previously unreported fused primary teeth were discovered on cone-beam computed tomography (CBCT) scans. Mutation analysis identified the causal c.578G>A (p.R193Q) mutation in the RUNX2 gene. At 20 years of age, the patient had already missed the optimal period for dental intervention. This report describes the complex dental anomalies in a belatedly diagnosed CCD patient, and emphasizes the significance of CBCT assessment for the detection of dental anomalies and the importance of early treatment to achieve good outcomes.