Functional Graphene Derivatives for Chemotherapy-Based Synergistic Tumor Therapy

Xinyu Cui,Wenlong Cheng,Weili Xu,Wei Mu,XIAOJUN HAN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.11

Starting from simplex drug delivery system, the graphene oxide (GO) and reduced GO (rGO) materials have been developed to be "combo" nanoplatforms containing multiple therapeutic modalities, such as the targeted drug delivery, imaging, as well as photothermal therapy (PTT) due to their distinctive physical/chemical and optical properties including excellent biocompatibility, modifiable active groups, ultra-large surface area, and intense photothermal effect. The graphene-based nanoplatforms were used for the stimuli-responsive nanocarriers, showing excellent therapeutic effects activated by endogenous stimuli including low pH, overexpressed enzymes, biomolecules, elevated glutathione, and exogenous stimuli including light, magnetic/electric field, and ultrasound. More importantly, for multimodal synergistic therapy originated from the enhanced collaborative interactions among several monotherapy types, the obtained remarkable super-additive effects were not the results just through single therapy or their theoretical combination. In this review, the recent progresses of smart graphene-based nanoplatforms for integrated cancer therapy and bio-imaging are presented. Current challenges and future perspectives of graphene-based nanoplatforms in the biomedical field are also discussed.

Apatite Formation on Anodized Ti-6Al-4V Alloy in Simulated Body Fluid

Xinyu Cui,김현민,Masakazu Kawashita,Longbao Wang,Tianying Xiong,Tadashi Kokubo,Takashi Nakamura 대한금속·재료학회 2010 METALS AND MATERIALS International Vol.16 No.3

Titania layers were successfully prepared on the surfaces of Ti-6Al-4V alloy via anodic oxidation in H2SO4or Na2SO4 solutions at room temperature. The titania layers consisted of pure rutile or a mixture of anatase and rutile structures after the Ti-6Al-4V alloy had been anodized in 1.0 M H2SO4 solution at 150 V or 0.5M Na2SO4 solution at 100 or 130 V. Good apatite-forming ability was demonstrated in simulated body fluid. However, surface layers with mainly titanium metallic phase or a pure anatase structure did not possess the ability to induce apatite formation. Anodic oxidation is an effective method to prepare bioactive Ti-6Al-4V alloy that can be used as an artificial bone substitute under load-bearing applications.

Polydopamine Used as Hollow Capsule and Core-Shell Structures for Multiple Applications

Xinyu Cui,Yuanyuan Yin,Zuo Ma,Yongkui Yin,Yue Guan,Shengzhong Rong,Jinxia Gao,Yingying Niu,Miaojing Li 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.5

Polydopamine (PDA) capsule and core – shell structures with tailored structures and properties are of particular interests due to their multifunctions and potential applications as new colloidal structures in diverse fields. Among the available fabrication methods, PDA film onto colloidal particles followed by selective template removal has attracted extensive attention due to its advantages of precise control over the size, wall thickness and functions of the obtained capsules. The past several years has witnessed a rapid increase of research concerning the new fabrication strategies, functionalization and applications of this kind of capsules and core – shell structures, particularly in many fields such as drug delivery, catalysis, antibacterial, etc. In this review, the very recent progress of the capsule and core – shell structures based on PDA are summarized. There are basically two sections, including the fabrication process of PDA capsules, core – shell structures, and the various applications based on PDA.

Left-Dominant Arrhythmogenic Cardiomyopathy: A Rare and Frequently Misdiagnosed Cardiomyopathy Associated with Heart Failure

Chen Cui,Xinyu Wang,Shihua Zhao 아시아심장혈관영상의학회 2020 Cardiovascular Imaging Asia Vol.4 No.3

A 35-year-old male with 7-year history of exertional dyspnea and abdominal distention had frequent premature ventricular contractions detected by Holter monitoring. Cardiovascular magnetic resonance (CMR) imaging demonstrated a significantly dilated left ventricle (LV) with severely reduced global systolic function. Coronary arterial stenosis was excluded with CT coronary angiography. However, transmural late gadolinium enhancement was detected by CMR in the lateral wall of the LV. The patient received cardiac transplantation. The diagnosis of left dominant arrhythmogenic right ventricular cardiomyopathy was made.

The Physiological Occlusion of the Central Canal May Be a Prerequisite for Syringomyelia Formation

Chuan Jiang,Xinyu Wang,Chunli Lu,Qian Li,Longbing Ma,Wei Li,Shengyu Cui,Kang Li,Xiang Wang,Yuxin Feng,Fengzeng Jian 대한척추신경외과학회 2023 Neurospine Vol.20 No.4

Objective: Syringomyelia is a common central nervous system disease characterized by the dilation of the central canal (CC). Regarding the pathogenesis of syringomyelia, cerebrospinal fluid (CSF) circulation obstruction in the subarachnoid space (SAS) of the spinal cord has been widely accepted. However, clinical and animal studies on obstructing the CSF in SAS failed to form syringomyelia, challenging the theory of SAS obstruction. The precise pathogenesis remains unknown. Methods: We utilized an extradural compression rat model to investigate the pathogenesis underlying syringomyelia. Magnetic resonance imaging enabled detection of syringomyelia formation. To assess CSF flow within the SAS, Evans blue was infused into the cisterna magna. Histological analysis allowed morphological examination of the CC. Furthermore, CSF flow through the CC was traced using Ovalbumin Alexa-Flour 647 conjugate (OAF-647). Scanning electron microscopy (SEM) enabled visualization of ependymal cilia. Results: The findings showed that the dura mater below the compression segment exhibited lighter coloration relative to the region above the compression, indicative of partial obstruction within the SAS. However, the degree of SAS occlusion did not significantly differ between syringomyelia (SM-Y group) and those without (SM-N group). Intriguingly, hematoxylin and eosin staining and CSF tracing revealed occlusion of the CC accompanied by reduced CSF flow in the SM-Y group compared to SM-N and control groups. SEM images uncovered impairment of ependymal cilia inside the syringomyelia. Conclusion: CC occlusion may represent a physiological prerequisite for syringomyelia formation, while SAS obstruction serves to initiate disease onset. The impairment of ependymal cilia appears to facilitate progression of syringomyelia.

Novel asymmetric duty modulation for DAB converters to improve light load efficiency

Feng Wang,Xinyu Cui,Fang Zhuo,Jiachen Tian,Zhi Zheng,Ruixin Xu 전력전자학회 2023 JOURNAL OF POWER ELECTRONICS Vol.23 No.4

In a DC distribution network, the solid-state transformer (SST) and energy storage systems require an isolated bidirectionalDC–DC converter (IBDC). Among the many IBDCs, the dual active bridge (DAB) converter has been widely studied dueto its advantages in terms of high power density and high efficiency. The traditional control strategy for DAB is phase shiftcontrol. However, when the primary and secondary side voltages do not match, the soft-switching characteristic and increasingcurrent in the phase shift control affect the application of DAB in scenarios involving input and output voltage changes. To improve the above-mentioned defects, a novel asymmetric duty modulation (ADM) control is proposed in this paper. Among the various multi-variable ADM controls, the two-variable ADM control is simple, but its current is higher under light loads. To improve this defect, this paper introduces trapezoidal modulation (TZM) control proposed for phase shift control into ADM to form a similar TZM (STZM) control corresponding to TZM control. This paper first expounds the basic principle of STZM control. On this basis, its basic characteristics are researched. With current stress as the optimization goal, an optimal STZM (OSTZM) control scheme with minimum current stress is proposed, and the effectiveness of the theoretical analysis is verified on the experimental bench. The result shows that STZM control can improve efficiency under light loads by reducing the current and ensuring full ZVS.

Study of a hybrid modular exhaust turbocharging system and its application on an 8-cylinder marine diesel engine

Kun Zhang,Xinyu Huang,Sai He,Kangyao Deng,Yi Cui,Aiqiang Luo 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.6

For turbocharging engines, the structure of the exhaust system directly affects the flow and energy transfer process of the exhaust gas, which has a big influence on the turbocharger performance. To evaluate the performance of various kinds of exhaust systems, two indicators, “available energy loss coefficient” and “pressure wave interference coefficient”, are proposed to evaluate the steady flow loss and transient flow anti-interference characteristics. Two kinds of exhaust system modular, Modular pulse converter (MPC) and Modular multi-purpose pulse converter (MMPC), are analyzed and compared by the three-dimensional calculation. The results show that the MMPC structure has a smaller available energy loss and a better anti-interference performance in the exhaust process. To solve the problems of scavenging interferences and exhaust temperature discrepancy on a highly boosted 8-cylinder marine diesel engine, a Hybrid modular exhaust (HME) system is proposed. Effects of MMPC, HME and MIXPC (Mixed pulse converter) on the engine performance are compared by one-dimensional simulation. This is followed by an engine test for performance comparison between MMPC and HME, which shows that the HME system can effectively relieve the problems of scavenging interference, and the maximum exhaust temperature discrepancy of all cylinders is reduced from 60°C to 31°C under the rated condition.

Emulsifying properties of different soy hull pectin polysaccharides and application in mayonnaise

Jun Li,Huaitian Cui,Xinyue Xu,Jiayi Li,Miaomiao Lu,Xijie Guan,Danshi Zhu,He Liu 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.6

Soy hull pectic polysaccharide (SHPP) is a kindof biological macromolecule prepared from soy hull, whichhas certain thickening and gel properties. In present study,SHPP was extracted with citric acid and sodium citratefrom soybean hulls under the assistance of microwave,respectively. SHPPs were then compared with commercialpectin polysaccharide to test their emulsification ability. The emulsion prepared from SHPP extracted with sodiumcitrate has the best emulsifying effect, small particle sizeand uniform distribution. The rheological properties andparticle size distribution of mayonnaise did not changesignificantly after the addition of different SHPPs andcommercial pectin polysaccharides. However, microscopicobservations revealed that the droplets were more uniformlydistributed in the mayonnaise after the addition ofSHPP extracted with sodium citrate under the assistance ofmicrowave and commercial pectin APC141. SHPPextracted with sodium citrate may play an important role inmaintaining emulsion stability in the future.

Optimization design of graphene with adjustable hydrophilic properties by finite elements analysis

Shixun Sun,Jiaming Song,Naiyu Cui,Xinyue Lu,Xuehan Li,Heng Zhang,Heng Bo Jiang 대한치과재료학회 2021 대한치과기재학회 학술대회 Vol.2021 No.4

MUC16 facilitates cervical cancer progression via JAK2/STAT3 phosphorylation‑mediated cyclooxygenase‑2 expression

Hui Shen,Meng Guo,Lu Wang,Xinyue Cui 한국유전학회 2020 Genes & Genomics Vol.42 No.2

Objectives MUC16 (mucin 16, also known as CA-125, cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) has been predicted as tumor biomarker for therapy. We determined to investigate effects and regulatory mechanism of MUC16 on cervical tumorigenesis. Methods Expression levels of MUC16 in cervical cancer cell lines was analyzed via qRT-PCR (quantitative real-time polymerase chain reaction). Knockdown of MUC16 was conducted via shRNA (Short hairpin RNA) transfection. MTT and colony formation assays were used to investigate effect of MUC16 on cell proliferation. Wound healing assay was utilized to detect migration and transwell assay to detect invasion. The underlying mechanism was demonstrated via western blot analysis. Results MUC16 was elevated in cervical cancer cell lines. MUC16 knockdown inhibited cell proliferation, invasion and migration. Gain- and loss-of functional assays revealed that over-expression of MUC16 activated Janus Kinase 2 (JAK2)/ signal transducer and activator of transcription 3 (STAT3) via phosphorylation, thus facilitating cyclooxygenase-2 (COX-2) expression, while knockdown of MUC16 demonstrated the reverse effect on JAK2/STAT3 activation and COX-2 expression. Moreover, inhibition of JAK2/STAT3 attenuated the regulation of MUC16 on COX-2. Conclusions MUC16 enhanced proliferation and invasion of cervical cancer cells via JAK2/STAT3 phosphorylation-mediated cyclooxygenase-2 expression, suggesting the potential therapeutic target ability of MUC16 to treat cervical cancer.