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Jong Soon Song,Dong Min Kim,Sang Heon Leε 한국방사성폐기물학회 2016 방사성폐기물학회지 Vol.14 No.4
원자력발전소 해체 시 발생하는 금속폐기물은 폐기물 중에서 많은 비중을 차지하고 있다. 본 연구에서는 국내 자체처분 규제 요건 및 국내 기관별 자체처분현황을 조사하였다. 실제 원자력발전소 해체 시 발생되는 금속폐기물의 자체처분을 위하여 RESRAD-RECYCLE 코드를 이용하였으며 26가지 시나리오에 대한 선량평가를 수행하였다. 평가결과는 원자력발전소 해체 시 자체처분 및 재활용에 관한 사전자료로서 활용가치가 있을 것으로 사료된다. 추후 자체처분을 통한 처분비용 저감효과 연구가 추가로 가능할 것으로 판단된다. The metal waste generated during nuclear power plant decommissioning constitutes a large proportion of the total radioactive waste. This study investigates the current status of domestic and international regulatory requirements for clearance and the clearance experience of domestic institutions. The RESRAD-RECYCLE code was used for analyzing the clearance of the metal wastes generated during actual nuclear power plant decommissioning, and assessment of the exposure dose of twenty-six scenarios was carried out. The evaluation results will be useful in preliminary analysis of clearance and recycling during nuclear power plant decommissioning. As a next step, the effects of reducing disposal costs by clearance can be studied.
Le Song,Qin Ouyang,Xianwen Huang,Hongbo Ma,Peng Chen,Lanping Shen,Xuan Wang 한국섬유공학회 2021 Fibers and polymers Vol.22 No.1
Lignin/polyacrylonitrile (PAN) composite precursors and PAN precursors were prepared by wet spinning and thenconverted into carbon fibers together under different carbonization temperatures. The microscopic morphology, mechanicalproperties and microstructure of the carbon fibers were studied. All the carbon fibers had dense structure without any visiblemacrovoids. Carbon fibers with tensile strength of 2.1 GPa and tensile modulus of 224 GPa were obtained from the lignin/PAN composite precursor by carbonizing at 1200 oC. Interestingly, the lignin/PAN-based carbon fibers had a unique uniformdisordered carbon structure. They were expected to be applied in the fields of electrothermal conversion and thermalinsulation, besides composites.
Protective effect Malus pumila Mill leaf polyphenols in reserpine-induced gastric ulcer in mice
Song, Jia-Le,Zhu, Kai,Feng, Xia,Zhao, Xin The Korean Society for Applied Biological Chemistr 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.2
The protective effect of polyphenols from Malus pumila leaf (MALP) on reserpine (10 mg/kg)-induced gastric ulcer in Kunming (KM) mice was investigated. Gastric juice secretion, pH of gastric juice, serum neuropeptides, including motilin (MOT), substance P (SP), vasoactive intestinal peptide (VIP), and somatostatin (SS) levels, as well as serum levels of inflammatory cytokines (TNF-${\alpha}$, IL-6, IL-12, and IFN-${\gamma}$) were measured. Gastric occludin and p38MAPK phosphorylation was analyzed by RT-PCR or Western blotting. MALP reduced reserpine-induced gastric juice secretion and increased the pH of gastric juice. MALP increased the serum levels of VIP and SS and reduced MOT, SP, and inflammatory cytokines in serum. It also modulated the gastric expression of occludin and p38MAPK phosphorylation in mice. These results suggest that MALP showed a protective effect against reserpine-induced ulcer in mice by reducing gastric juice secretion, modulating serum neuropeptide levels, attenuating serum inflammatory cytokines, and regulating gastric levels of occludin and p38MAPK phosphorylation.
A novel strain of porcine deltacoronavirus in Vietnam
Le, Van Phan,Song, Sok,An, Byung-Hyun,Park, Gyu-Nam,Pham, Ngoc Thach,Le, Dinh Quyen,Nguyen, Van Tam,Vu, Thi Thu Hang,Kim, Ki-Sun,Choe, SeEun,An, Dong-Jun Springer-Verlag 2018 Archives of virology Vol.163 No.1
<P>Two porcine deltacoronavirus (PDCoV) strains (Binh21 and HaNoi6) were isolated from two pig farms in North Vietnam. Phylogenetic analysis of the complete genomes and the Spike and Membrane genes revealed that the two Vietnam PDCoVs belong to the same lineage as PDCoVs from Thailand and Laos; however, the N genes belonged to the same lineage as PDCoVs from the USA, Korea, China, and Hong Kong. The recombination detection program subsequently identified the major parent (S5011 strain) and minor parent (HKU15-44 strain) of the two Vietnam PDCoV strains (p < 0.01).</P>
Song, Jia-Le,Choi, Jung-Ho,Seo, Jae-Hoon,Lim, Yaung-Iee,Park, Kun-Young 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.9
This study was conducted to investigate the preventive effects of different kanjangs (Korean soy sauces), including acid-hydrolyzed soy sauce (AHSS), fermented soy sauce (FSS), and fermented sesame sauce (FSeS), on 2% dextran sulfate sodium (DSS)-induced ulcerative colitis in C57BL/6J mice. The fermented sauces, particularly FSeS, significantly suppressed DSS-induced body weight loss, increased colon length, and decreased colon weight/length ratios. Histological observations suggested that the fermented sauces prevented edema, mucosal damage, and the loss of crypts induced by DSS compared to the control mice and animals fed AHSS. FSeS and FSS decreased the serum levels of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interferon-${\gamma}$ (IFN-${\gamma}$), interleukin (IL)-6, and IL-$17{\alpha}$. mRNA expression of these cytokines as well as that of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in colon mucosa was also inhibited by the two sauces. Our results suggest that fermented sauces, especially FSeS, exert an anticolitic effect partially by reducing the serum levels of proinflammatory cytokines and inhibiting the mRNA expression of these factors in the colon tissue of mice treated with DSS. However, AHSS did not protect against DSS-induced colitis. In addition, low-dose treatment (4 mL/kg) with the fermented sauces resulted in greater anticolitic effects than consumption of a high quantity (8 mL/kg) of the sauces.
Jia-Le Song,이정숙,김희영,정병진,정종성,허태곤,박건영 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.4
The chemopreventive effects of various mixed cereal grain (MCG) samples on azoxymethane (AOM, 10 mg/kg) and dextran sulfate sodium (DSS, 0.02 g/mL)-induced colorectal cancer (CRC) in C57BL/6J mice were studied. The main MCG preparation consisted of fermented brown rice (FBR), glutinous brown rice, glutinous Sorghum bicolor, glutinous Panicum miliaceum, Coix lacryma-jobi, and black soybean at an appropriate mixing ratio. Other MCG preparations contained rice coated with 5% Phellinus linteus and 5% Curcuma longa (MCG-PC) or 10% Phellinus linteus (MCG-P) or 10% Curcuma longa (MCG-C). Consumption of dietary MCG-PC by CRC mice significantly increased colon length, decreased the ratio of colon weight to length, and reduced the number of colon tumors. Similar effects, although to a lower extent, were observed in CRC mice fed with MCG-P, followed by those fed with MCG-C, MCG, FBR, or white rice. MCG-PC significantly suppressed colonic neoplasia and decreased the levels of various cytokines (tumor necrosis factor: Tnf, interleukin 1 beta: Il1b, interleukin 6: Il6, and interferon gamma: Ifnγ) in serum and colon tissue of the CRC mice. In addition, MCG-PC increased the mRNA expressions of tumor suppressor protein p53 (Tp53) and cyclin-dependent kinase inhibitor 1A (Cdkn1a), activated pro-apoptotic caspase 3 (Casp3), and reduced expressions of both mRNA and protein of inducible nitric oxide synthase 2 (Nos2), prostaglandin-endoperoxide synthase 2 (Ptgs2), and cyclin D1 (Ccnd1) in colon tissue. These findings suggest that compared with other cereal grain preparations, MCG-PC had a greater activity against AOM/DSS-induced CRC by reducing intestinal inflammation and modulating the expression of certain carcinogenesis related factors (Nos2, Ptgs2, Tp53, Cdkn1a, Ccnd1, and Casp3) in colon tissue of CRC mice.
Jia-Le Song,Jung-Ho Choi,Jae-Hoon Seo,Jeung-Ha Kil,Kun-Young Park 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.2
BACKGROUND/OBJECTIVES: This study was performed to investigate the in vitro antioxidant and cytoprotective effects of fermented sesame sauce (FSeS) against hydrogen peroxide (H2O2)-induced oxidative damage in renal proximal tubule LLC-PK1 cells. MATERIALS/METHODS: 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical (<SUP>?</SUP>OH), and H₂O₂ scavenging assay was used to evaluate the in vitro antioxidant activity of FSeS. To investigate the cytoprotective effect of FSeS against H₂O₂-induced oxidative damage in LLC-PK1 cells, the cellular levels of reactive oxygen species (ROS), lipid peroxidation, and endogenous antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-px) were measured. RESULTS: The ability of FSeS to scavenge DPPH, <SUP>?</SUP>OH and H2O2 was greater than that of FSS and AHSS. FSeS also significantly inhibited H₂O₂-induced (500 μM) oxidative damage in the LLC-PK1 cells compared to FSS and AHSS (P < 0.05). Following treatment with 100 μg/mL of FSeS and FSS to prevent H2O2-induced oxidation, cell viability increased from 56.7% (control) to 83.7% and 75.6%, respectively. However, AHSS was not able to reduce H2O2-induced cell damage (viability of the AHSS-treated cells was 54.6%). FSeS more effectively suppressed H2O2-induced ROS generation and lipid peroxidation compared to FSS and AHSS (P < 0.05). Compared to the other sauces, FSeS also significantly increased cellular CAT, SOD, and GSH-px activities and mRNA expression (P < 0.05). CONCULUSIONS: These results from the present study suggest that FSeS is an effective radical scavenger and protects against H2O2-induced oxidative damage in LLC-PK1 cells by reducing ROS levels, inhibiting lipid peroxidation, and stimulating antioxidant enzyme activity.