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방진마스크의 Stainless steel arc 용접흄 여과효율에 관한 연구
송경석,권용식,한규태,정규혁,이용묵,유일재 한국산업위생학회 2001 한국산업보건학회지 Vol.11 No.1
The purpose of this study was to investigate for filtration efficiency of several dust masks, comparing with filtration efficiency certified by KOSHA(Korea Occupational Safety & Health Agency), and to require of the right use of protective respirator. Using a welding fume generator and chamber, several dust masks, which were widely used in the workplaces in korea, were tested for their filtering efficiency for stainless steel are welding fume. The filtration efficiency testing system consisted of a welding fume generator, a chamber and a filtration unit. The filtration unit was made of a mask which was inserted into the sampling cassette and another sampling cassette, which contained mixed cellulose ester filter paper. These two cassettes were connected with tubing. Stainless steel arc welding fume generator was delivered into an chamber. The welding fume in the chamber was passed into the filtration unit with flow rate of 30 liter/min. The welding fume filtration efficiency was evaluated by gravimetric measurement. Metal concentrations in the welding fume before and after filtration were measured with inductive coupling plasma analyzer. Following results were obtained: Filtration efficiency of welding fume for comm hygienic mas was 63.82% and the average efficiencies for A, B, C, D, E, F and G masks were 94.62% 96.58%, 83.20%, 82.76%, 77.25%, 86.55% and 93.22%, respectively. Our results indicate that dust masks used widely in the welding workplaces in korea are not proper for protecting worker's health and then the use of fume mask should be required.
Song, Kyung Seuk,Park, Kun Ho,Yoo, Gi Yong,Song, Sung-Ok,Kim, Hyun Woo,Kim, Jun Sung,Park, Jin Hong,Eu, Guk Joung,Hua, Jin,Cho, Hyun Sun,Hwang, Soon Kyung,Chang, Seung Hee,Tehrani, Arash Minai,Yu, Kye Korean Society of ToxicologyKorea Environmental Mu 2004 Toxicological Research Vol.19 No.3
Inhalation toxicity, mutagenicity, and immunotoxicity tests were performed using a smoke generation system to investigate the safety of Herbrette, a tobacco substitute made with the leaves of Perilla frutescens. ICR mice were exposed to nicotine-free Herbrette smoke with concentrations of 0 (control), 4.08 $\pm$ 1.32 mg/$m^3$ (low dose), 7.72 $\pm$ 2.14 mg/$m^3$ (medium dose) and 12.83 $\pm$ 1.69 mg/$m^3$ (high dose) total particulate matters (TPM) for 4 weeks. When compared to the control group, the body weights, organ weights in the exposed groups did not show any significant differences. However, certain change of several serum chemical data and biochemical parameters were observed, however, the changes were within normal physiological ranges. Moreover, no changes in organ weight, and no gross/microscopic changes were observed between the exposed and control groups. Salmonella typhimurium reverse mutation, in vivo chromosomal aberration and micronucleus assays revealed that Herbrette did not induce mutagenicity. Upon evaluation of peripheral cellular immunity of mice through in vitro lymphocyte proliferation assay, no significant difference was observed in mean stimulation index between the exposed and control groups. Taken together, our results strongly suggest that Herbrette may not cause toxicity on mice under current condition.
Kim, Beum-Seuk,Lim, Hyung-Ho,Song, Yun-Kyung,Sung, Yun-Hee,Kim, Sung-Eun,Chang, Hyun-Kyung,Shin, Mal-Soon,Kim, Chang-Ju,Lee, Hye-Jung,Kim, Dong-Hee Kyung Hee Oriental Medicine Research Center 2010 Oriental pharmacy and experimental medicine Vol.10 No.3
Lycii fructus is the fruit of Lycium chinense Miller and is part of the Solanaceae family. Lycii fructus produces various effects such as hypotensive, hypoglycemic, anti-pyretic, and anti-stress activities. Lycii fructus is known to contain betaine, carotene, nicotinic acid, zeaxanthin, and cerebroside. In the present study, the effects of Lycii fructus aqueous extract on lipopolysaccharide (LPS)-induced inflammation in murine raw 264.7 macrophage cells were investigated. In this study we utilized the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reverse transcriptionpolymerase chain reaction (RT-PCR), Western blotting, and nitric oxide (NO) detection. Lycii fructus aqueous extract suppressed NO production by inhibiting the LPS-induced expressions of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-$\alpha$) mRNA and iNOS protein in murine raw 264.7 macrophage cells. Also, Lycii fructus aqueous extract suppressed the activation of nuclear factor-kappa B (NF-${\kappa}B$) in the nucleus. These results demonstrated that Lycii fructus aqueous extract causes an anti-inflammatory effect that was likely produced by the suppression of iNOS expression through the down-regulation of NF-$\hat{e}B$ binding activity.
90-Day Inhalation Toxicity of Dimethylamine in F344 Rats
Song, Kyung-Seuk,Park, Kun-Ho,Kim, Jeong-Hyun,Han, Dong-Un,Chae, Chan-Hee,Park, Sung-Jin,Kim, Hyun-Woo,Kim, Jun-Sung,Park, Jin-Hong,Eu, Guk-Joung,Hua, Jin,Cho, Hyun-Sun,Hwang, Soon-Kyung Korean Society of ToxicologyKorea Environmental Mu 2005 Toxicological Research Vol.21 No.2
Dimethylamine (DMA) is a widely used commodity chemical with few toxicity data. Groups of 10 male and female F-344 rats were exposed by inhalation to 0, 5, 10, 20, 40 and 80 ppm of DMA for 6 hrs/day, 5 days/week for 90 days. The changes of body weight, organ weight, hematology, clinical chemistry, and histopathological changes were evaluated after the exposure. As the results, the body weight was significantly decreased at 80 ppm in male and female rats (p<0.05). The absolute lung weight showed no statistically significant changes in any group. In contrast, the relative lung weight significantly increased at 80 ppm in male and female rats (p<0.05). Erythrocytes, mean cell hemoglobin, leukocytes, neutrophil, and platelet numbers were significantly increased in male and female at 40 or 80 ppm of DMA (p<0.05, p<0.01). In addition, the serum values of total protein, urea nitrogen were increased in male and creatine kinase, total protein were increased in female rats at 40 or 80 ppm (p<0.05, p<0.01). Histopathological examinations of the male and female lung samples showed slight hyperplasia and congestion at 80 ppm. Taken together, our study revealed that maximum tolerated dose of DMA would be over 40 ppm.
Kyung Seuk Song,Kun Ho Park,Gi Yong Yoo,Sung-Ok Song,Hyun Woo Kim,Jun Sung Kim,Jin Hong Park,Guk Joung Eu,Jin Hua,Hyun Sun Cho,Soon Kyung Hwang,Seung Hee Chang,Arash Minai Tehrani,Kyeong Nam Yu,Chan H 한국독성학회 2004 Toxicological Research Vol.20 No.4
Inhalation toxicity, mutagenicity, and immunotoxicity tests were performed using a smoke generation system to investigate the safety of Herbrette, a tobacco substitute made with the leaves of Perilla frutescens. ICR mice were exposed to nicotine-free Herbrette smoke with concentrations of 0 (control), 4.08 ± 1.32 mg/㎥ (low dose), 7.72 ± 2.14 mg/㎥ (medium dose) and 12.83 ± 1.69 mg/㎥ (high dose) total particulate matters (TPM) for 4 weeks. When compared to the control group, the body weights, organ weights in the exposed groups did not show any significant differences. However, certain change of several serum chemical data and biochemical parameters were observed, however, the changes were within normal physiological ranges. Moreover, no changes in organ weight, and no gross/microscopic changes were observed between the exposed and control groups. Salmonella typhimurium reverse mutation, in vivo chromosomal aberration and micronucleus assays revealed that Herbrette did not induce mutagenicity. Upon evaluation of peripheral cellular immunity of mice through in vitro lymphocyte proliferation assay, no significant difference was observed in mean stimulation index between the exposed and control groups. Taken together, our results strongly suggest that Herbrette may not cause toxicity on mice under current condition.
90-Day Inhalation Toxicity of Dimethylamine in F344 Rats
Kyung Seuk Song,Kun Ho Park,Jeong Hyun Kim,Dong Un Han,Chan Hee Chae,Sung Jin Park,Hyun Woo Kim,Jun Sung Kim,Jin Hong Park,Guk Joung Eu,Jin Hua,Hyun Sun Cho,Soon Kyung Hwang,Seung Hee Chang,Kyeong Nam 한국독성학회 2005 Toxicological Research Vol.21 No.2
Dimethylamine (DMA) is a widely used commodity chemical with few toxicity data. Groups of 10 male and female F-344 rats were exposed by inhalation to 0, 5, 10, 20, 40 and 80 ppm of DMA for 6 hrs/day, 5 days/week for 90 days. The changes of body weight, organ weight, hematology, clinical chemistry, and histopathological changes were evaluated after the exposure. As the results, the body weight was significantly decreased at 80 ppm in male and female rats (p<0.05). The absolute lung weight showed no statistically significant changes in any group. In contrast, the relative lung weight significantly increased at 80 ppm in male and female rats (p<0.05). Erythrocytes, mean cell hemoglobin, leukocytes, neutrophil, and platelet numbers were significantly increased in male and female at 40 or 80 ppm of DMA (p<0.05, p<0.01). In addition, the serum values of total protein, urea nitrogen were increased in male and creatine kinase, total protein were increased in female rats at 40 or 80 ppm (p<0.05, p<0.01). Histopathological examinations of the male and female lung samples showed slight hyperplasia and congestion at 80 ppm. Taken together, our study revealed that maximum tolerated dose of DMA would be over 40 ppm
A Twenty-Eight Days Inhalation Toxicity Study of N-decane in Sprague Dawley Rats
Rim, Kyung Taek,Kim, Hyeon Young,Song, Kyung Seuk,Chung, Yong Hyun,Chang, Hee Kyung,Han, Jeong Hee,Lee, Sung Bae,Chun, Yoon Seok,Lee, Yong Mook,Yu, Il Je 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.4
N-decane은 지방족탄화수소로 다른 탄화수소들과 같이 혼합된 형태로 존재하며 페인트 제거제나 드라이 크리닝 제품에 사용된다 최근의 본 연구팀이 실시한 전자산업계의 MSDS 신뢰성조사 결과에 따르면 세정제의 사용 경향은 과거의 방향족 탄화수소나 CFC, HCFC에서 C_10 이상의 지방족탄화수소 물질로 변화되고 있는 경향을 보여주었다 Stoddard solvent나 나프타 같은 탄화수소 혼합물에 대한 작업 환경노출기준은 설정되어있지만 n-decane에 대해서는 제한적인 독성자료 밖에 없으며 작업환경노출기준은 설정되어 있지 않다 따라서 작업환경에 대한 적절한 관리기준제시와 독성학적 자료를 제공하기 위해 n-decane을 28일 반복 홉입독성시험을 실시하였다 6주령 흰쥐로 체중이 229±10g되는 숫컷과 165±7g되는 암컷 흰쥐를 4개 용량군 즉 대조군, 저농도군(50ppm), 중농도군(200ppm), 고농도군(800ppm)(각군당 10마리)으로 설정하여 하루 6시간, 주 5일로 4주간 홉입쳄버에서 노출시켰다 28일간 노출 후 n-decane의 노출용량에 따른 암수의 체중에는 유의한 변화가 없었으며 유의한 혈액학적 생화학적 변화도 발견되지 않았다 고농도로 노출된 수컷 몇 마리에서 고환 세정관에서의 공포화(vacuolization)가 발견되었으나, 간 신장, 비장, 폐, 부신, 심장, 뇌 등 다른 장기에 대한 조직병리학적 검사에서는 뚜렷한 조직병리학적인 변화를 발견할 수 없었다
Beum-Seuk Kim,임형호,Yun-Kyung Song,성윤희,김성은,장현경,신말순,김창주,이혜정,김동희 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.3
Lycii fructus is the fruit of Lycium chinense Miller and is part of the Solanaceae family. Lycii fructus produces various effects such as hypotensive, hypoglycemic, anti-pyretic, and anti-stress activities. Lycii fructus is known to contain betaine, carotene, nicotinic acid, zeaxanthin, and cerebroside. In the present study, the effects of Lycii fructus aqueous extract on lipopolysaccharide (LPS)-induced inflammation in murine raw 264.7 macrophage cells were investigated. In this study we utilized the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reverse transcription-polymerase chain reaction (RT-PCR), Western blotting, and nitric oxide (NO) detection. Lycii fructus aqueous extract suppressed NO production by inhibiting the LPS-induced expressions of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) mRNA and iNOS protein in murine raw 264.7 macrophage cells. Also, Lycii fructus aqueous extract suppressed the activation of nuclear factor-kappa B (NF-κB) in the nucleus. These results demonstrated that Lycii fructus aqueous extract causes an anti-inflammatory effect that was likely produced by the suppression of iNOS expression through the down-regulation of NF-êB binding activity.