실내외 다환방향족탄화수소(PAHs)의 농도조사에 관한 연구

박태술,김윤신,심규호,전준민 대진대학교 1994 大眞論叢 Vol.2 No.-

The purpose of this study was to measure indoor and outdoor concentrations of polycyclic aromatic hydrocarbons (PAHs) in office building in Seoul City. Fine (<2.5μm) and coarse (25>μm) particle samples were collected by PM-10 dichotomous sampler from January to Octerber, 1993 Respirable particulates sampling was taken place both inside and outside the office building The samples collected for 12-hour sampling schedule from 8 AM to 8 PM and from 8 PM to 8 AM were analyzed for PAHs. High performance liquid chromatography (HPLC) with UV detector (254nm) was used to determine twelve compounds of PAHs. The mean concentrations of indoor and outdoor respirable particulates were 768 μg/㎥ and 1099 μg/㎥. The mean concentrations of acenaphthylene at indoor and outdoor site were significantly higher than any other compounds, respectively. The mean concentrations of PAHs during daytime were higher than those level of where the mean concentrations of fine particle of PAHs were higher than those level of coarse particles. The mean outdoor concentrations of NAP, ACL, PHE, PY, BAA, BKF, BAP were highest in January, while the mean outdoor concentrations of AN, FLUR, CHRY, BBF, DAHA were highest in July and August

ICP(Inductively Coupled Plasma) 처리에 따른 n-type SiGe/Metal contact의 SBH(Schottky Barrier Height) 연구

김이곤,장호원,전창민,송영주,강진영,심규환,제정호,이종람 대한금속재료학회 2005 대한금속·재료학회지 Vol.43 No.2

The effect of surface treatment of n-type SiGe using the inductively coupled plasma (ICP) was studied by current-voltage and x-ray photoemission spectroscopy measurements. The ICP treatment produced surface oxides and point defects at the surface of SiGe. The x-ray photoemission spectroscopy measurements showed that atomic ratio of Ge/Si was increased after the etching treatment. These results provide the evidence that Si vacancies were produced at the etched surface. Si vacancies acting as donor for electrons resulted in shift of Fermi level to near the conduction band. As a result, Fermi level could be pinned at such Si vacancies, leading to the remarkable reduction of Schottky barrier height and the reduced dependence of Schottky barrier height on metal work function. (Received September 7, 2004)

만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구

강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.

허혈성 심질환에서 염증지표에 관한 연구

번정득,권영주,박상호,한대희,이상철,강진환,김명구,심규혁,최병조,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background : Atherosclerosis is the chief underlying cause of ischemic heart disease and there is increasing evidence that inflammation is an important determinant of the development of atherosclerosis. We assessed the levels of inflammatory markers in patients with ischemic heart disease and normal group who has normal coronary angiograms. Materials and Methods : Coronary angiography was performed in 142 patients. 107 patients of ischemic heart disease(stable angina pectoris 58, unstable angina pectoris 30, Acute myocardial infarction 19) and 38 normal control subjects. We assessed the level of inflammatory markers, such as CRP, ESR, fibrinogen and leukocyte. Results : CRP, ESR and fibrinogen values of the patients with stable angina pectoris and unstable angina pectoris were higher than that of normal control group, but there were no statistical significance. Leukocyte value of the patients with unstable angina pectoris(9003.3±701.5/mm^(3)) was significantly higher than that of the patients with stable angina pectoris(6685.5±245.8/mm^(3)) and normal control subjects(6394.3±235.1/mm^(3)). CRP, ESR and fibrinogen values of the patients with acute myocardial infarction were also higher than that of normal control subjects. CRP was 3.88±2.05 mg/dL in acute mocardial infarction group, and 0.29±0.15 mg/dL in normal control subject group(p<0.05). Fibrinogen was 541.6±45.1 mg/dL in acute myocardial infarction group, 321.4±25.6 mg/dL in normal control subject group(p<0.05). Leukocyte was 10942.1±737.6/mm^(3) in acute myocardial infarction group, 6394.3±235.1/mm^(3) in normal control subject group(p<0.05). Conclusions : This study demonstrate that CRP, fibrinogen and leukocyte values of acute myocardial infarction group were significantly higher than that of control group and stable, unstable argina pectoris group. Leucokyte values were significantly elevated in unstable angina group, but CRP values were not in unstable angina group.

Breast Tissue Reconstruction Using Polycaprolactone Ball Scaffolds in a Partial Mastectomy Pig Model

Shim Kyu-Sik,Ryu Da Hye,조한샘,김기범,Kim Do-Hyun,Park Yong-Kyu,Heo Min,Cho Hee-Eun,윤을식,이원재,노태석,송승용,백우열 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.4

BACKGROUND: Breast cancer patients suffer from lowered quality of life (QoL) after surgery. Breast conservancy surgery (BCS) such as partial mastectomy is being practiced and studied as an alternative to solve this problem. This study confirmed breast tissue reconstruction in a pig model by fabricating a 3-dimensional (3D) printed Polycaprolactone spherical scaffold (PCL ball) to fit the tissue resected after partial mastectomy. METHODS: A 3D printed Polycaprolactone spherical scaffold with a structure that can help adipose tissue regeneration was produced using computer-aided design (CAD). A physical property test was conducted for optimization. In order to enhance biocompatibility, collagen coating was applied and a comparative study was conducted for 3 months in a partial mastectomy pig model. RESULTS: In order to identify adipose tissue and fibroglandular tissue, which mainly constitute breast tissue, the degree of adipose tissue and collagen regeneration was confirmed in a pig model after 3 months. As a result, it was confirmed that a lot of adipose tissue was regenerated in the PCL ball, whereas more collagen was regenerated in the collagen-coated Polycaprolactone spherical scaffold (PCL–COL ball). In addition, as a result of confirming the expression levels of TNF-a and IL-6, it was confirmed that PCL ball showed higher levels than PCL–COL ball. CONCLUSION: Through this study, we were able to confirm the regeneration of adipose tissue through a 3-dimensional structure in a pig model. Studies were conducted on medium and large-sized animal models for the final purpose of clinical use and reconstruction of human breast tissue, and the possibility was confirmed.

총수담관 협착을 유발한 만성췌장염 2예

정규원(Kyu Won Chung),선희식(Hee Sik Sun),정진우(Jin Woo Jeong),심규식(Kyu Sik Shim),채현석(Hyun Suk Chae),강숙영(Sook Young Kang),한석원(Sun Won Han),박영민(Yong Min Park),주상용(Sang Yong Ju),심상인(Sang In Shim) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2

Chronic pancreatitis is mainly caused by chronic alcohol abuse and increases in incidence. The disease is characterized as epigastric pain radiating to back which is precipitated by alcohol inges- tion, and there may be nausea, vomiting, constipation, and mild jaundice with dark urine. The complications of chronic pancreatitis are diabetes mellitus, steatorrhea, pancreatic calcifica- tion, biliary obstruction, pseudocyst, peptic ulcer, abscess, carcinoma of pancreas, ascites and GI bleeding, etc. Since Riedel reported the case of common bile duct obstruction in chronic pancreatitis in 1892, there have been reported allmost 100 cases of common bile duct obstruction in pancreatitis. We report 2 cases of common bile duct obstruction caused by chronic pancreatitis without above complications.

링레이저 자이로의 바이어스 안정도 개선을 위한 몸체진동 잡음 연구

심규민(Kyu-Min Shim),김천중(Cheon-Joong Kim) 제어로봇시스템학회 2006 제어·로봇·시스템학회 논문지 Vol.12 No.11

Metal Injection Molding 공정으로 제조된 IN 713C 합금의 고온 기계적 특성

심민철 ( Min Chul Shim ),김규식 ( Kyu Sik Kim ),조규상 ( Kyu Sang Cho ),김지식 ( Ji Sik Kim ),이기안 ( Kee Ahn Lee ) 대한금속재료학회(구 대한금속학회) 2014 대한금속·재료학회지 Vol.52 No.5

We fabricated the IN 713C alloy by a metal injection molding (MIM) process and investigated the high temperature tensile properties. The microstructure of the MIMed IN 713C alloy mainly consisted of γ, γ′ and carbides. 0.98% (area fraction) of the pores was observed near the surface of the specimen, whereas 0.27% of the pores were located in the interior of the specimens. Tensile tests were conducted from room temperature to 900℃. The result of the tensile tests showed that this alloy had similar or somewhat higher strengths (YS: 734 MPa, UTS: 968 MPa, elongation: 7.16% at room temperature) from RT to 700℃ than those of cast IN 713C alloys. Above 700℃, however, strengths decreased rapidly with an increasing temperature (lower than those of cast IN 713C). The observation results of fractography revealed that the tensile fracture of the MIMed IN 713C alloy started near the surface defects and then the initial crack pro-pagated along the inter-particle region where oxides were observed regardless of deformation temperatures.

링레이저 자이로의 몸체진동 검출센서를 이용한 dither-stripping 연구

심규민(Kyu-Min Shim),임후장(Hoo-Jang Lim) 한국항공우주학회 2003 韓國航空宇宙學會誌 Vol.31 No.5