황색포도알균에 의한 감염성 심내막염의 임상적 특성

백경란 ( Kyong Ran Peck ),송재훈 ( Jae Hoon Song ),김은석 ( Eun Seok Kim ),주은정 ( Eun Jeong Joo ),하영은 ( Young Eun Ha ),위유미 ( Yu Mi Wi ),정혜숙 ( Hae Suk Cheong ),이진서 ( Jin Seo Lee ),강철인 ( Cheol In Kang ),정두련 ( Doo 대한내과학회 2009 대한내과학회지 Vol.76 No.3

Background/Aims: The risk factors and clinical outcome of infective endocarditis (IE) have changed over the past few decades. Recently, the incidence of Staphylococcus aureus IE (SAIE) has increased. We investigated the clinical and microbiological characteristics and clinical outcomes of SAIE. Methods: All patient cases that were diagnosed as IE according to the modified Duke criteria in Samsung Medical Center during the period of January 1995 to December 2006 were reviewed retrospectively. The clinical and microbiological characteristics of patients with SAIE were compared to those of non-SAIE patients with IE. Results: We enrolled 304 patients with IE. Of these, 240 cases were IE culture-positive, including 73 cases of SAIE. The mean age of patients with SAIE was 48.15±19.87 years, with male patients accounting for 71.2% of our study group. Congenital heart disease (8.2%) was less common among SAIE patients. Hospital-acquired IE was significantly more common in SAIE than in non-SAIE cohorts (p<0.05). Surgical treatment was performed in 33 cases (45.2%). Valvular regurgitation with heart failure was the most frequent cause of surgery (39.3%). Twenty-three cases exhibited complications, including extra cardiac embolization (16.4%) and heart failure (5.6%). Fever persisting for a period longer than seven days was more common among those in the SAIE group. Twelve patients (16.4%) died and four patients (5.4%) were discharged without hope of improvement. The in-hospital mortality rate was higher among SAIE patients (17.3%) compared to that among non-SAIE patients (11%), although this comparison was not statistically distinct (p>0.05). Methicillin resistance and non-surgical treatment were significant risk factors for in-hospital mortality. Conclusions: SAIE is more strongly associated with systemic embolization, persistent fever, and longer hospital stays compared to non-SAIE. Further studies are warranted to evaluate adequate treatment and to improve the outcome of patients with SAIE. (Korean J Med 76:329-337, 2009)

A case of de novo duplication of 15q24-q26.3

Eun Young Kim,Yu Kyong Kim,Mi Kyoung Kim,Ji Mi Jung,Ga Won Jeon,김혜란,신종범 대한소아청소년과학회 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.6

Distal duplication, or trisomy 15q, is an extremely rare chromosomal disorder characterized by prenatal and postnatal overgrowth, mental retardation, and craniofacial malformations. Additional abnormalities typically include an unusually short neck, malformations of the fingers and toes, scoliosis and skeletal malformations, genital abnormalities,particularly in affected males, and, in some cases, cardiac defects. The range and severity of symptoms and physical findings may vary from case to case, depending upon the length and location of the duplicated portion of chromosome 15q. Most reported cases of duplication of the long arm of chromosome 15 frequently have more than one segmental imbalance resulting from unbalanced translocations involving chromosome 15 and deletions in another chromosome, as well as other structural chromosomal abnormalities. We report a female newborn with a de novo duplication, 15q24-q26.3, showing intrauterine overgrowth, a narrow asymmetric face with down-slanting palpebral fissures, a large, prominent nose, and micrognathia, arachnodactyly, camptodactyly, congenital heart disease, hydronephrosis, and hydroureter. Chromosomal analysis showed a 46,XX,inv(9)(p12q13),dup(15)(q24q26.3). Array comparative genomic hybridization analysis revealed a gain of 42 clones on 15q24-q26.3. This case represents the only reported patient with a de novo 15q24-q26.3 duplication that did not result from an unbalanced translocation and did not have a concomitant monosomic component in Korea.

Analysis of Toxic metals in Pickled Foods from South Korea

Yu Min Park,Yun Mi Dang,Ga Hyun Lee,Chung Mi Lee,Ji Yeon Choi,Eun Yeong Nho,Kyong Su Kim 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

An Adult Case of Chronic Active Epstein-Barr Virus Infection with Interstitial Pneumonitis

( Eun Jeong Joo ),( Young Eun Ha ),( Dong Sik Jung ),( Hae Suk Cheong ),( Yu Mi Wi ),( Jae Hoon Song ),( Kyong Ran Peck ) 대한내과학회 2011 The Korean Journal of Internal Medicine Vol.26 No.4

Chronic active Epstein-Barr virus (CAEBV) infection is characterized by persistent infectious mononucleosis-like symptoms, an unusual pattern of Epstein-Barr virus (EBV) antibodies, detection of the EBV genome in affected tissues or peripheral blood, and chronic illness that cannot be attributed to any other known disease. This is the first reported Korean case of an immunocompetent adult with CAEBV-associated interstitial pneumonitis. A 28-year-old female was admitted with a fever that persisted for 3 weeks. She had multiple lymphadenopathy, hepatosplenomegaly, pancytopenia, and elevated serum aminotransferase levels. Serology for antibodies was positive and chest computed tomography showed diffuse ground glass opacities in both lungs. Histopathology of the lung tissue showed lymphocyte infiltration, and EBV DNA was detected in those lymphocytes using in situ hybridization with an EBV-encoded RNA probe. After 1 month of hospitalization, she improved without specific treatment.

Preparation of LiFePO4 Using Chitosan and its Cathodic Properties for Rechargeable Li-ion Batteries

Kyong-Soo Hong,Seong Mi Yu,Myoung Gyu Ha,안창원,Tae Eun Hong,Jong Sung Jin,Hyun Gyu Kim,정의덕,Yang-Soo Kim,Hae-Jin Kim,도칠훈,양호순,Hee Jung 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.8

The LiFePO4 powder was synthesized by using the solid state reaction method with Fe(C2O4)․2H2O, (NH4)2HPO4, Li2CO3, and chitosan as a carbon precursor material for a cathode of a lithium-ion battery. The chitosan added LiFePO4 powder was calcined at 350 oC for 5 hours and then 800 oC for 12 hours for the calcination. Then we calcined again at 800 oC for 12 hours. We characterized the synthesized compounds via the crystallinity, the valence states of iron ions, and their shapes using TGA, XRD, SEM, TEM, and XPS. We found that the synthesized powders were carbon-coated using TEM images and the iron ion is substituted from 3+ to 2+ through XPS measurements. We observed voltage characteristics and initial charge-discharge characteristics according to the C rate in LiFePO4 batteries. The obtained initial specific capacity of the chitosan added LiFePO4 powder is 110 mAh/g, which is much larger than that of LiFePO4 only powder.

Antimicrobial Resistance of Clinically Important Bacteria Isolated from Gyeonggi Areas

Kyong-Nae Yu(유경래),Chang-Eun Park(박창은) 한국엔터테인먼트산업학회 2013 한국엔터테인먼트산업학회논문지 Vol.7 No.3

최근 세균 감염에서 병원성 박테리아가 다양한 항생제에 저항력 있게 나타난다. 이는 항생제의 남용으로 인한 항생제 내성균의 출현이 증가하는 경향을 보인다. 2009년에서 2011년까지 경기도에 위치한 일부 병원에서 조사한 임상에서 다빈도로 분리된 균주의 내성률을 분석한 결과이다. E. coli, K. pneumoniae, P.aeruginosa, A. baumannii, S. aureus, E. faecalis의 분리균에서 조사하였고, 다양한 항생제에 저항성을 보였다. 특히, S. aureus에서 oxacillin의 내성이 4.8%로 꾸준히 증가하였으며 ciprofloxacin도 내성이 2.5%의 증가를 보였다. E. faecalis는 penicillin G의 내성이 7.6% 증가하였으며 tetracycline이 81.1%로 가장 높은 내성을 보였다. E. coli와 K. pneumoniae는 ESBL(Extended-spectrum β-lactamase)에 대해 각각 21.3%, 26.1%의 내성률로 꾸준히 증가는 것으로 나타났다. P. aeruginosa는 piperacillin/tazobactam에 대해 내성이 17.5% 증가하였다. 최근 중요한 A. baumannii에서도 imipenem의 내성은 20% 증가했다. 결론적으로, 본 연구는 임상에서 자주 분리되는 병원성 균들의 내성률의 증가 추이를 분석하였다. 따라서 장기적인으로 내성률에 대한 표본감시 및 병원 유형별, 시기별로 항생제별 내성률을 조사하여 향후 임상치료에 중요한 자료로 활용될 수 있을 것으로 사료된다. In recent pathogenic bacteria appears so a variety of antibiotic resistant. The reason of increasing trend of the antibiotic resistant bacteria appearance is caused by abusing the antibiotics. The result of clinically isolated stains appeared high frequency rate in Gyeonggi province local hospitals from 2009 to 2011. We studied the isolated E. coli, K. pneumoniae, P. aeruginosa, A. baumannii, S. aureus and E. faecalis which were resistant to multiple kinds of antibiotics. The S.aureus has steadily increased to 4.8% the oxacillin resistant also ciprofloxacin resistant showed an increase of 2.5%. E. faecalis has augmented penicillin G resistant to 7.6% and showed the highest tetracycline resistant to 81.1%. For each of E. coli and K. pneumoniae the ESBL resistant to 21.3%, 26.1% has shown a steadily increase. P. aeruginosa piperacillin/tazobactam resistant increased to 17.5%. In A. baumannii imipenem resistant augmented to 20%. In conclusion, this study showed an increase in the antibiotics resistant rate of frequently detected in clinical pathogenic bacteria. Thus, the sample monitoring of long-term resistant rate and the resistant rate of hospital type, period that needs to be researched.

Comparative Analyses of the Volatile Organic Compounds of Hemerocallis fulva and Veratrum japonicum

Eun Yeong Nho,Joon Ho Hong,Cheong Mi Lee,Ga Hyun Lee,Ji Yeon Choi,Yu Min Park,Yun Mi Dang,Kyong Su Kim 한국식품영양과학회 2017 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

Obstetric factors associated with non-cephalic presentation in late pregnancy

( Yu Mi Shin ),( Eun Ji Oh ),( Kyong-no Lee ),( Hyeon Ji Kim ),( Jee Yoon Park ),( Kyung Joon Oh ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Objective: To determine the factors affecting fetal presentation through prediction model Methods: A retrospective cohort study was performed in pregnant women who had visited Seoul National University Bundang Hospital for prenatal check-ups from October 2018 to November 2021. Triplet pregnancies (n=27) and the cases without ultrasonography results (n=5) were excluded. The ultrasonography reports with fetal presentation throughout the pregnancy were collected and anayzed. Various obstetric information was reviewed through electronic medical records. Results: There were 2,543 cases of fetuses with ultrasonography after 32 weeks of gestation and the proportions of cephalic, breech, and transverse presentation were 84.7% (2,154), 13.1% (332), and 2.2% (57), respectively. In the analysis to compare the obstetric factors between those with cephalic presentation and with non-cephalic presentation in late pregnancy, maternal age, pre-pregnancy body mass index, the rates of nulliparity, twin pregnancy, hypertensive disorder in pregnancy, history of previous non-cephalic presentation and small-for-gestational age (SGA) were significantly higher in non-cephalic group than cephalic group (all p-value < 0.05). However, the rates of previous vaginal delivery and alleged myoma uteri were significantly lower in non-cephalic group (both p-value < 0.05). In multivariate analysis, twin pregnancy was associated with higher rate of non-cephalic presentation with odds ratio (OR) 2.8, 95% confidence interval (CI) 2.0-4.0, and p-value <0.001. The non-presenting twin (Twin B) (OR 1.5, 95% CI 1.1-2.1, p=0.012) and previous non-cephalic presentation (OR 4.5, 95% CI 1.7-11.6, p=0.002) were significantly associated with increased rate of non-cephalic presentation as well. Conclusion: Twin pregnancy and previous history of non-cephalic presentation baby seemed to increase the possibility of non-cephalic presentation in late pregnancy. In twin pregnancy, especially the second twin was the independent risk factor for non-cephalic presentation

Analysis of Trace Elements in Korean Pork by ICP-MS and Application Techniques for Geographic

Yu Min Park,Cheong Mi Lee,Eun Yeong Nho,Ji Yeon Choi,Jong-Hyun Jung,Young-Chul Jung,Kyong Su Kim 한국식품영양과학회 2017 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

Comparisons of antioxidant activities on fruiting bodies and mycelia of the medicinal mushrooms, Phellinus linteus strains and Phellinus baumii

Kyong-Jin Min,A-Min Kwak,E-Eun Jeong,Hae-lin Yu,Mi-Rae Shin,Hee-Wan Kang 한국버섯학회 2017 버섯 Vol.21 No.1

This study aimed to investigate antioxidant activity of various extracts from fruiting bodies and mycelia of two Phellinus linteus strains and P. baumii. The Phellinus strains have cultivated on oak and mulberry logs. The fruiting bodies species were harvested from each Phellinus strain and used in this study. The tested items include: 2, 2’-azinobis[3-ethylbenzthiazoline]-6-sulfonic acid (ABTS), free radical scavenging assay and determination of total phenolics contents (TPC), ferric reducing antioxidant power assay (FRAP), and DPPH (1, 1-diphenyl-2- picrylhydrazyl) radical-scavenging activities. Different extractions with 60% Ethyl alcohol, 70% methyl alcohol and heat water were done on the mycellial and fruiting bodies samples of the mushroom species. The methyl alcohol extraction from fruiting body of P. linteus KACC93057P displayed the highest antioxidant activity on ABTS, FRAP, and DPPH assays. The ethyl acetate fraction was concentrated and subjected to an ODS column chromatography, followed by Sephadex LH-20 column chromatography. Finally six compounds 1-6 were detected by preparative reversed-phase HPLC.