화학적 거세 및 갑상선 기능조절이 닭의 산육성 증진에 미치는 효과에 관한 연구

이규승,김관영,권순기 忠南大學校 1971 論文集 Vol.10 No.-

This experiment was conducted to improve the meat production and quality of cockerels by controling the function of thyroid and gonad with the hormone preparations. Three weeks old 180 Rhode island red cockerels were divided into six group : iodocasein treatment group, tapazol treatment group, D.E.S. treatment group, D.E.S.+iodocasein treatment group, D.E.S.+tapazol treatment group and control group. Each group was then divided into two groups of 4 weeks and 8 weeks after treatment, arranging the cockerels 15 each. Iodocasein of 0.25 per cent of the basal ration and tapazol in dose of 0.3 ㎎ per Kg of body weight were administered with the basal ration, and 0.75 ㎎ of D.E.S. was implanted subcutaneously at the head. Body weight was measured weekly to investigate the growth rate and daily gain. Sacrifice was done at the certain days after treatment, and carcass percentage and organ weight were observed. Histological observation on thyroid and gonad was conducted at the same time. The results obtained areas follows; 1. The body weight of D. E. S. group, Tap. group and D. E. S. +Tap. group at the end of experimental period were 1452.37±17.61g and 1473.53±16.18g respectively, showing the increasing significance with P<0.05 as compared with 1305.93±21.67g of control group. Iodo. group and D.E.S.+Iodo. group were lighter than control group, but no significance was recognized. 2. Daily gain and carcass percentage were changed as a similar tendency, showing the significance with P<0.05 after 4 weeks and no significance after 8 weeks. Generally high value was obtained in the group treated with D.E.S. and tapazol. 3. Among the meat compositions any marked difference was not recognized in moisture and crude ash cntents of the experimental groups. Crude protein contents were comparatively more in control group (19.87%) than in treatment groups. As compared with 3.39% of control group, crude fat contents of Tap. grop, D. E. S. group anud D. E. S. +Tap. group were 4.44%, 4.22% and 5.35% respectively. 4. Improved effects on feed convertion rate were obtained in the groups treated with D.E.S. and tapazol. D.E.S.+Tap. group was best : 2.61 on the mean. 5. Comb and wattle weights were changed as a similar tendency, showing the significance with p<0.01 after 4 and 8 weeks. Those of all treatment groups were lighter than of control group, particularly in the groups treated with D.E.S. they were atrophied extremely. 6. Generally weights of head, heart, spleen, gizzard and liver were in proportion to body weight. 7. Whole viscera weight showed the significance with p<0.01 among the treatment groups after 4 and 8 weeks. Those of the groups treated with tapazol and D.E.S. were heavier than of control group. 8. Cloacal thymus weight showed the significance with p<0.05. That of control group was heaviest, being heavier after 4 weeks than after 8 weeks. Meat production and quality cockerels was improved successively by decreasing more or less the function of thyroid and gonad with tapazol and D.E.S. treatment. Only use of tapazol or D.E.S. was fairly effective. Because the iodocasein administration caused the growth restraint and derease of fats, it was worthless for practical application.

The microRNA miR-124 inhibits vascular smooth muscle cell proliferation by targeting S100 calcium-binding protein A4 (S100A4)

Choe, N.,Kwon, D. H.,Shin, S.,Kim, Y. S.,Kim, Y. K.,Kim, J.,Ahn, Y.,Eom, G. H.,Kook, H. Elsevier Science B.V., Amsterdam. 2017 FEBS letters Vol.591 No.7

<P>S100 calcium-binding protein A4 (S100A4) induces proliferation and migration of vascular smooth muscle cells (VSMCs). We aimed to find the microRNA regulating S100A4 expression. S100A4 transcripts are abruptly increased in the acute phase of carotid arterial injury 1 day later (at day 1) but gradually decreases at days 7 and 14. Bioinformatics analysis reveals that miR-124 targets S100A4. VSMC survival is attenuated by miR-124 mimic but increased by miR-124 inhibitor. miR-124 decreases immediately after carotid arterial injury but dramatically increases at days 7 and 14. miR-124 inhibitor-induced cell proliferation is blocked by S100A4 siRNA, whereas miR-124-induced cell death is recovered by S100A4. Our findings suggest that miR-124 is a novel regulator of VSMC proliferation and may play a role in the development of neointimal proliferation.</P>

Involvement of S6K1 in mitochondria function and structure in HeLa cells

Park, J.,Tran, Q.,Mun, K.,Masuda, K.,Kwon, S.H.,Kim, S.H.,Kim, D.H.,Thomas, G.,Park, J. Pergamon Press ; Elsevier Science Ltd 2016 Cellular signalling Vol.28 No.12

The major biological function of mitochondria is to generate cellular energy through oxidative phosphorylation. Apart from cellular respiration, mitochondria also play a key role in signaling processes, including aging and cancer metabolism. It has been shown that S6K1-knockout mice are resistant to obesity due to enhanced beta-oxidation, with an increased number of large mitochondria. Therefore, in this report, the possible involvement of S6K1 in regulating mitochondria dynamics and function has been investigated in stable lenti-shS6K1-HeLa cells. Interestingly, S6K1-stably depleted HeLa cells showed phenotypical changes in mitochondria morphology. This observation was further confirmed by detailed image analysis of mitochondria shape. Corresponding molecular changes were also observed in these cells, such as the induction of mitochondrial fission proteins (Drp1 and Fis1). Oxygen consumption is elevated in S6K1-depeleted HeLa cells and FL5.12 cells. In addition, S6K1 depletion leads to enhancement of ATP production in cytoplasm and mitochondria. However, the relative ratio of mitochondrial ATP to cytoplasmic ATP is actually decreased in lenti-shS6K1-HeLa cells compared to control cells. Lastly, induction of mitophagy was found in lenti-shS6K1-HeLa cells with corresponding changes of mitochondria shape on electron microscope analysis. Taken together, our results indicate that S6K1 is involved in the regulation of mitochondria morphology and function in HeLa cells. This study will provide novel insights into S6K1 function in mitochondria-mediated cellular signaling.

Modeling and simulation of HTS cables for scattering parameter analysis

Bang, S.S.,Lee, G.S.,Kwon, G.Y.,Lee, Y.H.,Chang, S.J.,Lee, C.K.,Sohn, S.,Park, K.,Shin, Y.J. North-Holland 2016 Physica. C, Superconductivity Vol.530 No.-

<P>Most of modeling and simulation of high temperature superconducting (HTS) cables are inadequate for high frequency analysis since focus of the simulation's frequency is fundamental frequency of the power grid, which does not reflect transient characteristic. However, high frequency analysis is essential process to research the HTS cables transient for protection and diagnosis of the HTS cables. Thus, this paper proposes a new approach for modeling and simulation of HTS cables to derive the scattering parameter (S-parameter), an effective high frequency analysis, for transient wave propagation characteristics in high frequency range. The parameters sweeping method is used to validate the simulation results to the measured data given by a network analyzer (NA). This paper also presents the effects of the cable-to-NA connector in order to minimize the error between the simulated and the measured data under ambient and superconductive conditions. Based on the proposed modeling and simulation technique, S-parameters of long-distance HTS cables can be accurately derived in wide range of frequency. The results of proposed modeling and simulation can yield the characteristics of the HTS cables and will contribute to analyze the HTS cables. (C) 2016 Elsevier B.V. All rights reserved.</P>

Control of electrical properties and gate bias stress stability in solution-processed a-IZO TFTs by Zr doping

Choi, W.S.,Jo, H.,Kwon, M.S.,Jung, B.J. Elsevier 2014 CURRENT APPLIED PHYSICS Vol.14 No.12

Zr-doped indium zinc oxide (IZO) thin film transistors (TFTs) are fabricated via a solution process with different Zr doping ratios. The addition of Zr suppressed the carrier concentration in the IZO films, which was confirmed by Hall Effect measurements. As the amount of Zr was increased in the oxide active layer of TFTs, the subthreshold swing (S.S) reduced, the ON/OFF ratio improved, and the threshold voltage (V<SUB>th</SUB>) shifted positively. Moreover, the starting points of the ON state for TFTs near the point zero gate voltage could be controlled by the addition of Zr. The 0.3% Zr-doped IZO TFT exhibited a high saturation mobility of 7.0 cm<SUP>2</SUP> V<SUP>-1</SUP> s<SUP>-1</SUP>, ON/OFF ratio of 2.6 x 10<SUP>6</SUP> and S.S of 0.57 V/decade compared the IZO TFT with 10.1 cm<SUP>2</SUP> V<SUP>-1</SUP> s<SUP>-1</SUP>, 1.7 x 10<SUP>6</SUP> and 0.75 V/decade. The Zr effect of the gate bias stability was examined. Zr-doped IZO TFTs were relatively unstable under a positive bias stress (PBS), whereas they showed good stability at a negative bias stress (NBS). The gate bias stability of the oxide TFTs were compared with the extracted parameters through a stretched-exponential equation. The characteristic trapping time under NBS of 0.3% Zr-doped IZO TFTs was improved from 8.3 x 10<SUP>4</SUP> s for the IZO TFT to 3.1 x 10<SUP>5</SUP> s.

Effects of sevoflurane on collagen production and growth factor expression in rats with an excision wound

LEE, H.-J.,KWON, J.-Y.,SHIN, S.-W.,BAEK, S.-H.,CHOI, K.-U.,JEON, Y.-H.,KIM, W.-S.,BAE, J.-H.,CHOI, H.-J.,KIM, H.-K.,BAIK, S.-W. Blackwell Publishing Ltd 2010 Acta anaesthesiologica Scandinavica Vol.54 No.7

<P>Background</P><P>Sevoflurane is a widely used inhalation anesthetic, but there are no studies on its effect on the wound-healing process. This study was undertaken to evaluate the effect of exposure time to sevoflurane on wound healing.</P><P>Method</P><P>Male Sprague–Dawley rats were used. Two circular full-thickness skin defects 8 mm in diameter were made on the dorsum of the rats. The animals were divided into six groups according to exposed gas type and time: S1 (sevoflurane, 1 h), S4 (sevoflurane, 4 h), S8 (sevoflurane, 8 h), O1 (oxygen, 1 h), O4 (oxygen, 4 h), and O8 (oxygen, 8 h). The surface area of the wounds was measured 0, 1, 3, and 7 days after surgery. Separately, the mean blood pressures (MBP) and arterial oxygen pressures (PaO<SUB>2</SUB>) were monitored during the sevoflurane exposure. Collagen type I production and transforming growth factor-β1 (TGF-β1) and basic fibroblast growth factor (bFGF) expression on the wound surface were analyzed. Routine histological analysis was also performed.</P><P>Result</P><P>Exposure duration to sevoflurane had no influence on MBP and PaO<SUB>2</SUB>. The reduction in wound size and collagen type I production was delayed in S8. The expression of TGF-β1 and bFGF on the wound surface in S8 was significantly attenuated in S8. The histology of the S8 demonstrated a delayed healing status.</P><P>Conclusions</P><P>Prolonged exposure to sevoflurane might alter the inflammatory phase of the wound-healing process by attenuation of growth factor expression such as TGF-β1 and bFGF and subsequently by reduced collagen production.</P>

Gd₂O₂S:Tb의 동시 계수 도플러 양전자 소멸법에 의한 결함 특성

이종용,배석환,김재홍,권준현,Lee, C.Y.,Bae, S.H.,Kim, J.H.,Kwon, J.H. 한국재료학회 2006 한국재료학회지 Vol.16 No.7

Coincidence Doppler Broadening (CDB) of positron annihilation spectroscopy was applied to analyze defects in the chemical state of Department of Physics, $Gd_2O_2S$:Tb intensifying screens. The screen samples were irradiated by 80 MV X-rays in hospital and were used for 0, 2, 4, and 6 years respectively. There was a positive relationship between the S-parameter values and time of exposure to X-rays. Most of the defects were indicated to have been generated by X-rays. A 1D CDB was developed in order to reduce the background noise, and the S-parameter values of the $Gd_2O_2S$:Tb intensifying screens, using the 1D CDB, varied between 0.4974 and 0.4991.

두개의 수직격판을 가진 밀폐공간내에서의 자연대류 열전달

권순석,권용일 동아대학교 공과대학 부설 한국자원개발연구소 1991 硏究報告 Vol.15 No.1

A numerical investigation has been made of two dimensional natural convection heat transfer from a rectangular enclousure with two vertical partitions. Results have been obtained for dimensionless partition spacings, S/L〓0.2-0.8 and for dimenionless partition lengths, ℓ/L〓0.1-0.4 and also for partition materials of fiber, glass and stainless steel. 1. The dimensionless partition spacing that occurs the minimum heat transfer in a rectangular enclousure is S/L〓0.6 for fiber, S/L〓0.7 for glass and S/L〓0.5 for stainless steel. 2. AS partition spacings increase, the flow pattern in a rectangular enclousure is changed from muti-cellular flow to uni-cellular flow for fiber and glass. 3. Partition lengths with the minimum heat transfer in case of fiber and glass in a rectangular enclousure occurs at ℓ/L〓0.2 respectively.

Experimental Approach to Explosive Nucloeosynthesis with RI Beams

S. Kubono,Y. Yamaguchi,G. Amadio,S. Hayakawa,Y. Wakabayashi,Y. Kurihara,J. J. He,A. Saito,H. Fujikawa,Le Hong Khiem,M. Niikura,T. Teranishi,N. Iwasa,S. Kato,S. Nishimura,C. S. Lee,Y. K. Kwon,I. S. Hah 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.1

Experimental efforts to investigate stellar reactions under high-temperature and high density conditions have been made as a major program using the RI beams from the Center for Nuclear Study (CNS) low-energy in-flight RI beam separator (CRIB) at University of Tokyo in order to understand the evolution of the universe, as well as various stellar phenomena. Specically, two subjects of hydrogen burning are discussed here. One is a reaction study of the pp-chain and the second is of the explosive hydrogen burning, the rp-process. Some s-wave resonances have been identified by the thick target method in the crucial reaction processes in the hydrogen burning. The resonant scattering with the thick target method also succeeded in identifying inelastic resonant scattering, giving proton widths for the first excited state of the target nucleus. This provided very efficiently the reaction rate estimate for the process under high-temperature equilibrium conditions. Possibilities of the CRIB facility in near future are also briey discussed. Experimental efforts to investigate stellar reactions under high-temperature and high density conditions have been made as a major program using the RI beams from the Center for Nuclear Study (CNS) low-energy in-flight RI beam separator (CRIB) at University of Tokyo in order to understand the evolution of the universe, as well as various stellar phenomena. Specically, two subjects of hydrogen burning are discussed here. One is a reaction study of the pp-chain and the second is of the explosive hydrogen burning, the rp-process. Some s-wave resonances have been identified by the thick target method in the crucial reaction processes in the hydrogen burning. The resonant scattering with the thick target method also succeeded in identifying inelastic resonant scattering, giving proton widths for the first excited state of the target nucleus. This provided very efficiently the reaction rate estimate for the process under high-temperature equilibrium conditions. Possibilities of the CRIB facility in near future are also briey discussed.

왕겨에 의한 신령버섯균사체 액체배양액의 생쥐 항복수암성 증가

Young S. Kim(김영숙),Wook J. Jang(장욱진),Md. A. Rakib(라키브),Jung M. Kwon(권정민),Chae R. Ahn(안채린),So Y. Kim(김소영),Yong U. Cho(조용운),Young K. Ha(하영권),Jeong O. Kim(김정옥),Yeong L. Ha(하영래) 한국생명과학회 2010 생명과학회지 Vol.20 No.9

왕겨가 Agaricus blazei Murill (AB: 신령버섯)균사체 액체배양 추출물의 항암성을 증가시키는지에 관한 연구를 수행하였다. AB균사체를 대두박을 기본으로 한 액체배지에 다양한 조건으로 배양하여, β-glucan 함량, Brix, 균사체를 측정하여 적정 생육조건을 선정하고, 이들의 열수추출물의 S-180 cell로 유도한 mouse 복수암에 대한 항암성을 조사하였다. AB균사체는 25℃에서 5일간 배양하였을 때 최적 생육을 나타내었고, 이 배양물이 다른 조건에서 배양한 배양물보다 우수한 항암성을 나타내었다. AB균사체의 생육 및 항암성은 변온배양에 따른 효과는 없었다. 따라서 이 최적배양조건(25℃, 5일 배양)에서 AB균사체를 1% 왕겨분말이 함유된 액체배지에 배양하고, 이의 열수 추출물의 항암성을 검증하였다. 1% 왕겨가 함유된 액체배지에서 배양한 열수추출물의 항암성은 왕겨가 함유되지 않은 배지의 열수추출물보다 항암성이 유의성 있게 증가되었다(p<0.05). 왕겨의 첨가는 AB균사체의 생육을 오히려 촉진시켰다. 이 결과는 왕겨가 AB균사체 뿐 만 아니라 다른 버섯균사체 액체배양물의 항암성 증진을 위한 원료로 활용될 수 있을 것임을 의미한다. The effects of rice hull (RH) powder on the anticarcinogenic activity of submerged-liquid cultures of Agaricus blazei Murill (AB) were assessed for mouse ascites cancers induced by mouse Sarcoma S-180 (S-180) cancer cells. Optimal growth of AB mycelia in the basal liquid culture medium, containing soybean meal, was achieved by culturing at 25℃ for 5 days, when evaluated by β-glucan content, Brix, and mycelial weight, relative to other culture conditions. Hot-water extract (HWE) of the submergedliquid culture of AB mycelia grown at 25℃ for 5 days exhibited a stronger anticarcinogenic activity, relative to HWE from other culture conditions. No such effects were obtained from AB mycelial cultures by alternative temperature-controlling cultures. Both cytotoxicity for S-180 cells and anticarcinogenic potentials for mouse ascites cancer of the HWE from AB mycelia grown in the basal medium containing 1% RH powder for 5 days at 25℃ were significantly (p<0.05) enhanced, relative to HWE from the AB mycelia culture of the basal medium without RH powder. These results indicate that HWE of submerged-liquid culture of AB mycelia, incubated in media containing 1% RH powder at 25℃ for 5 days, enhanced anticarcinogenic activity against S-180 cell-induced mouse ascites cancer, and suggest that RH powder is an excellent ingredient for the improvement of the anticarcinogenic potentials of the submerged-liquid culture of mushroom mycelia.