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Caveolin‐1 deficiency induces premature senescence with mitochondrial dysfunction
Yu, Dongx2010,Min,Jung, Seung Hee,An, Hyoungx2010,Tae,Lee, Sungsoo,Hong, Jin,Park, Jun Sub,Lee, Hyun,Lee, Hwayeon,Bahn, Myeongx2010,Suk,Lee, Hyung Chul,Han, Nax2010,Kyung,Ko, Jesang,Lee, Jae BLACKWELL PUBLISHING 2017 AGING CELL Vol.16 No.4
<P><B>Summary</B></P><P>Paradoxical observations have been made regarding the role of caveolin‐1 (Cav‐1) during cellular senescence. For example, caveolin‐1 deficiency prevents reactive oxygen species‐induced cellular senescence despite mitochondrial dysfunction, which leads to senescence. To resolve this paradox, we re‐addressed the role of caveolin‐1 in cellular senescence in human diploid fibroblasts, A549, HCT116, and Cav‐1<SUP><I>−/−</I></SUP> mouse embryonic fibroblasts. Cav‐1 deficiency (knockout or knockdown) induced cellular senescence via a p53‐p21‐dependent pathway, downregulating the expression level of the cardiolipin biosynthesis enzymes and then reducing the content of cardiolipin, a critical lipid for mitochondrial respiration. Our results showed that Cav‐1 deficiency decreased mitochondrial respiration, reduced the activity of oxidative phosphorylation complex I (CI), inactivated SIRT1, and decreased the NAD<SUP>+</SUP>/NADH ratio. From these results, we concluded that Cav‐1 deficiency induces premature senescence via mitochondrial dysfunction and silent information regulator 2 homologue 1 (SIRT1) inactivation.</P>
Lee, Kimoon,Oh, Min Suk,Mun, Sungx2010,jin,Lee, Kwang H.,Ha, Tae Woo,Kim, Jae Hoon,Park, Sangx2010,Hee Ko,Hwang, Chix2010,Sun,Lee, Byoung H.,Sung, Myung M.,Im, Seongil WILEY‐VCH Verlag 2010 Advanced Materials Vol.22 No.30
<P><B>Direct quantitative mapping of the density‐of‐states</B>, named the photo‐excited charge‐collection technique, for the interface traps at the n‐ZnO and/or p‐pentacene thin‐film transistor channel is implemented by using monochromatic photons which are carried by optical fibers and are probed onto thin‐film transistors. </P>
Ko, Youngx2010,Ho,Kim, Jex2010,Hyung,Jin, Lix2010,Hua,Ko, Suk‐,Min,Kwon, Bongx2010,Joon,Kim, Joosung,Kim, Taek,Cho, Yongx2010,Hoon WILEY‐VCH Verlag 2011 ADVANCED MATERIALS Vol.23 No.45
<P>Electrically driven hybrid light‐emitting diodes (LEDs) consisting of quantum dots, wires, and wells based on the nanometer‐sized pyramid GaN structure are reported by Taek Kim, Yong‐Hoon Cho, and co‐workers on page 5364. The LEDs exhibit mixed emissions from InGaN quantum dots, wires, and wells formed at the tops, edges, and sidewalls of the pyramids, respectively. The hybrid LEDs containing low‐dimensional quantum structures provide a broad‐band, highly efficient visible lighting source. </P>
Ko, Kunx2010,Young,Baek, Seungx2010,Suk,Hwang, Seok‐,Ho John Wiley Sons, Ltd 2018 Polymer international Vol.67 No.7
<P><B>ABSTRACT</B></P><P>The newly designed methacrylic monomer series 4‐phthalimidocyclohexyl methacrylate (PCMA<B>),</B> 4‐hexahydrophthalimidocyclohexyl methacrylate (HPCMA) and 4‐hexahydro‐3,6‐methanophthalimidocyclohexyl methacrylate (HMPCMA) were synthesized. Their homopolymers and methyl methacrylate (MMA) based copolymer series were polymerized by free‐radical polymerization. The copolymer compositions were characterized using <SUP>1</SUP>H NMR spectra. The monomer reactivity ratios were calculated employing the Fineman−Ross (F‐T) and Kelen−Tüdös (K‐T) methods at low conversion. The values of <I>r</I><SUB>1</SUB> and <I>r</I><SUB>2</SUB> obtained by the F‐T and K‐T methods appear to be in close agreement (their average values are <I>r</I><SUB>1</SUB> = 1.3061 and <I>r</I><SUB>2</SUB> = 0.7336 for poly(PCMA‐<I>co</I>‐MMA), <I>r</I><SUB>1</SUB> = 1.5169 and <I>r</I><SUB>2</SUB> = 0.6840 for poly(HPCMA‐<I>co</I>‐MMA), <I>r</I><SUB>1</SUB> = 1.7748 and <I>r</I><SUB>2</SUB> = 0.5664 for poly(HMPCMA‐<I>co</I>‐MMA)) . The thermal stabilities and thermomechanical characteristics of the homopolymer and copolymer series were investigated by differential scanning calorimetry, thermogravimetric analysis and dynamic mechanical thermal analysis. © 2018 Society of Chemical Industry</P>
Hahm, Suk Gyu,Kang, Namx2010,Goo,Kwon, Wonsang,Kim, Kyungtae,Ko, Yongx2010,Gi,Ahn, Seonyoung,Kang, Beomx2010,Goo,Chang, Taihyun,Lee, Jaex2010,Suk,Ree, Moonhor WILEY‐VCH Verlag 2012 Advanced materials Vol.24 No.8
<P><B>A novel polymer, poly(2‐(<I>N</I> ‐carbazolyl)ethyl methacrylate) end‐capped with fullerene (PCzMA‐C<SUB>60</SUB>)</B>, has been synthesized via living anionic polymerization. Electrically programmable flash memory devices were easily fabricated with this polymer by using solution coating and metal deposition. This polymer was found in these devices to exhibit bipolar and unipolar switching behaviors with a high ON/OFF current ratio, a long retention time, high reliability, and low power consumption. The excellent properties and easy processability of this polymer open up the possibility of the mass production of high performance nonvolatile memory devices at low cost.</P>
Park, Hwangseo,Jung, Suk‐,Kyeong,Yu, Keum R.,Kim, Ju H.,Kim, Yongx2010,Sam,Ko, Jeong H.,Park, Byoung C.,Kim, Seung J. Blackwell Publishing Ltd 2011 Chemical biology & drug design Vol.78 No.4
<P>Despite a series of persuasive experimental evidence for the involvement of eyes absent protein tyrosine phosphatases in various human cancers, no small‐molecule inhibitor has been reported so far. We have identified seven novel inhibitors of eyes absent homologue 2 (Eya2) with IC<SUB>50</SUB> values ranging from 1 to 70 μ<SMALL>m</SMALL> by the virtual screening with docking simulations and enzyme inhibition assay. Atomic charges of the active‐site Mg<SUP>2+</SUP> ion complex are calculated to enhance the accuracy of docking simulations. The newly discovered inhibitors are structurally diverse and have various chelating groups for the Mg<SUP>2+</SUP> ion. The interactions with the amino acid residues responsible for the stabilizations of the inhibitors in the active site of Eya2 are addressed in detail.</P>
Control of electromechanical properties of multilayer ceramic capacitors for vibration reduction
Ohm, Wonx2010,Suk,Kim, Dongjoon,Ko, Byungx2010,Han,Park, Nox2010,Cheol Wiley-Blackwell 2018 Journal of the American Ceramic Society Vol.101 No.5
<P>A multilayer ceramic capacitor (MLCC) contains layers of ceramics as the dielectric materials. It has been known that Class 2 MLCCs, made of ferroelectric ceramics such as barium titanate, tend to suffer from electromechanical coupling hence vibration, which leads to the generation of acoustic humming noise, a source of annoyance in many modern electronic devices. In this article, a repoling method to control the electromechanical properties and the resulting vibration of MLCCs is presented. The repoling protocol hinges on the understanding that two independent mechanisms are responsible for the electromechanical coupling in MLCCs: piezoelectricity and electrostriction of the ceramic layers. The vibration due to piezoelectricity is linearly proportional to the input voltage, whereas the vibration due to electrostriction shows a quadratic dependence. Given the DC bias and the AC input voltage under normal operating conditions, the vibration is composed of the fundamental component at the frequency of the AC input and the second harmonic component spawned by the quadratic nonlinearity of electrostriction. It is demonstrated that by engineering the coefficients of piezoelectricity and electrostriction of the ceramic layers through a carefully designed repoling treatment, vibration reduction can be achieved for both the fundamental and second harmonic components. Especially, the fundamental component of vibration can be reduced significantly, as the piezoelectric effect is made to offset the electrostrictive effect.</P>